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Protein

IQ domain-containing protein C

Gene

IQCC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
IQ domain-containing protein C
Gene namesi
Name:IQCC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:25545. IQCC.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134868161.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 466466IQ domain-containing protein CPRO_0000282545Add
BLAST

Proteomic databases

MaxQBiQ4KMZ1.
PaxDbiQ4KMZ1.
PRIDEiQ4KMZ1.

PTM databases

PhosphoSiteiQ4KMZ1.

Expressioni

Gene expression databases

BgeeiQ4KMZ1.
CleanExiHS_IQCC.
GenevestigatoriQ4KMZ1.

Organism-specific databases

HPAiHPA028602.
HPA028686.

Interactioni

Protein-protein interaction databases

BioGridi120843. 1 interaction.
STRINGi9606.ENSP00000291358.

Structurei

3D structure databases

ProteinModelPortaliQ4KMZ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 3530IQPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 IQ domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG28569.
GeneTreeiENSGT00390000017195.
HOGENOMiHOG000113096.
HOVERGENiHBG103168.
InParanoidiQ4KMZ1.
OMAiCVRGFLV.
OrthoDBiEOG7288QW.
PhylomeDBiQ4KMZ1.
TreeFamiTF330928.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
[Graphical view]
SMARTiSM00015. IQ. 1 hit.
[Graphical view]
PROSITEiPS50096. IQ. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q4KMZ1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPELLVRKV SALQACVRGF LVRRQFQSLR AEYEAIVREV EGDLGTLQWT
60 70 80 90 100
EGRIPRPRFL PEKAKSHQTW KAGDRVANPE QGLWNHFPCE ESEGEATWEE
110 120 130 140 150
MVLKKSGESS ANQGSLCRDH SSWLQMKQNR KPSQEKTRDT TRMENPEATD
160 170 180 190 200
QRLPHSQPQL QELQYHRSHL AMELLWLQQA INSRKEYLLL KQTLRSPEAG
210 220 230 240 250
PIREEPRVFL EHGEQACERD QSQPSAPLED QSYRDRTTGE LEQEDDSCHR
260 270 280 290 300
VKSPHRSPGS LATTQKNIAG AKCREPCYSK SGPPSSIPSN SQALGDRLTK
310 320 330 340 350
GPDDGRQTFG GTCLLQMKIL EDQTPRGLKP RNHCPRKSRT QLSALYEDSN
360 370 380 390 400
IKEMSPRKLD HKEPDCRTVR TQELGLSEDH IIWDGTLGGP EHSVLDLWRT
410 420 430 440 450
KPPKGQAPTD RSSRDGTSNE PSHEGQKKQR TIPWRSKSPE ILSSTKAGCT
460
GEEQWRGRPW KTEPPG
Length:466
Mass (Da):53,032
Last modified:April 3, 2007 - v2
Checksum:i7282732CE4FA4F83
GO
Isoform 2 (identifier: Q4KMZ1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     231-466: Missing.

Note: No experimental confirmation available.

Show »
Length:230
Mass (Da):26,719
Checksum:iB348209BE081E09D
GO
Isoform 3 (identifier: Q4KMZ1-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     14-14: Q → QVRGRARGSQ...PDQGNGKSLK

Note: No experimental confirmation available.

Show »
Length:546
Mass (Da):61,966
Checksum:iC765EBDA9BC8DF82
GO

Sequence cautioni

The sequence AK307853 differs from that shown. Reason: Erroneous termination at position 323. Translated as Gln.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti201 – 2011P → S in BAA91674. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti209 – 2091F → C.1 Publication
Corresponds to variant rs3903683 [ dbSNP | Ensembl ].
VAR_031411
Natural varianti217 – 2171C → Y.1 Publication
Corresponds to variant rs12032332 [ dbSNP | Ensembl ].
VAR_031412
Natural varianti464 – 4641P → L.1 Publication
Corresponds to variant rs41306593 [ dbSNP | Ensembl ].
VAR_031413

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei14 – 141Q → QVRGRARGSQDFSFREIMGS RTWTSQRDATTFSPLTARQP LEIPAVPNRAEESWDPRTPC PARPHSHHTLAPDQGNGKSL K in isoform 3. 1 PublicationVSP_046123
Alternative sequencei231 – 466236Missing in isoform 2. 1 PublicationVSP_024176Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001409 mRNA. Translation: BAA91674.1.
AK307853 mRNA. No translation available.
AK223272 mRNA. Translation: BAD96992.1.
AL049795 Genomic DNA. Translation: CAI22058.1.
BC098250 mRNA. Translation: AAH98250.1.
BC098260 mRNA. Translation: AAH98260.1.
BC098317 mRNA. Translation: AAH98317.1.
BC098366 mRNA. Translation: AAH98366.1.
CCDSiCCDS355.1. [Q4KMZ1-1]
CCDS53293.1. [Q4KMZ1-3]
RefSeqiNP_001153514.1. NM_001160042.1. [Q4KMZ1-3]
NP_060604.2. NM_018134.2. [Q4KMZ1-1]
UniGeneiHs.274356.

Genome annotation databases

EnsembliENST00000291358; ENSP00000291358; ENSG00000160051. [Q4KMZ1-1]
ENST00000537469; ENSP00000442291; ENSG00000160051. [Q4KMZ1-3]
GeneIDi55721.
KEGGihsa:55721.
UCSCiuc001bum.2. human. [Q4KMZ1-1]

Polymorphism databases

DMDMi143339942.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001409 mRNA. Translation: BAA91674.1.
AK307853 mRNA. No translation available.
AK223272 mRNA. Translation: BAD96992.1.
AL049795 Genomic DNA. Translation: CAI22058.1.
BC098250 mRNA. Translation: AAH98250.1.
BC098260 mRNA. Translation: AAH98260.1.
BC098317 mRNA. Translation: AAH98317.1.
BC098366 mRNA. Translation: AAH98366.1.
CCDSiCCDS355.1. [Q4KMZ1-1]
CCDS53293.1. [Q4KMZ1-3]
RefSeqiNP_001153514.1. NM_001160042.1. [Q4KMZ1-3]
NP_060604.2. NM_018134.2. [Q4KMZ1-1]
UniGeneiHs.274356.

3D structure databases

ProteinModelPortaliQ4KMZ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120843. 1 interaction.
STRINGi9606.ENSP00000291358.

PTM databases

PhosphoSiteiQ4KMZ1.

Polymorphism databases

DMDMi143339942.

Proteomic databases

MaxQBiQ4KMZ1.
PaxDbiQ4KMZ1.
PRIDEiQ4KMZ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000291358; ENSP00000291358; ENSG00000160051. [Q4KMZ1-1]
ENST00000537469; ENSP00000442291; ENSG00000160051. [Q4KMZ1-3]
GeneIDi55721.
KEGGihsa:55721.
UCSCiuc001bum.2. human. [Q4KMZ1-1]

Organism-specific databases

CTDi55721.
GeneCardsiGC01P032671.
HGNCiHGNC:25545. IQCC.
HPAiHPA028602.
HPA028686.
neXtProtiNX_Q4KMZ1.
PharmGKBiPA134868161.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG28569.
GeneTreeiENSGT00390000017195.
HOGENOMiHOG000113096.
HOVERGENiHBG103168.
InParanoidiQ4KMZ1.
OMAiCVRGFLV.
OrthoDBiEOG7288QW.
PhylomeDBiQ4KMZ1.
TreeFamiTF330928.

Miscellaneous databases

GenomeRNAii55721.
NextBioi60623.
PROiQ4KMZ1.

Gene expression databases

BgeeiQ4KMZ1.
CleanExiHS_IQCC.
GenevestigatoriQ4KMZ1.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
[Graphical view]
SMARTiSM00015. IQ. 1 hit.
[Graphical view]
PROSITEiPS50096. IQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-433 (ISOFORM 3).
    Tissue: Caudate nucleus.
  2. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT CYS-209.
    Tissue: Synovium.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS TYR-217 AND LEU-464.

Entry informationi

Entry nameiIQCC_HUMAN
AccessioniPrimary (citable) accession number: Q4KMZ1
Secondary accession number(s): F5H7T8
, Q4KMS3, Q4KMZ5, Q53FL2, Q5TFJ8, Q9NVS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: January 7, 2015
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.