Q4KMZ1 (IQCC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
IQ domain-containing protein C

Gene names

Name:

IQCC

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	466 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Contains 1 IQ domain.
Sequence caution	The sequence AK307853 differs from that shown. Reason: Erroneous termination at position 323. Translated as Gln.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q4KMZ1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q4KMZ1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     231-466: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q4KMZ1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     14-14: Q → QVRGRARGSQ...PDQGNGKSLK

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 466	466	IQ domain-containing protein C		PRO_0000282545
Regions
	Domain	6 – 35	30	IQ
Natural variations
	Alternative sequence	14	1	Q → QVRGRARGSQDFSFREIMGS RTWTSQRDATTFSPLTARQP LEIPAVPNRAEESWDPRTPC PARPHSHHTLAPDQGNGKSL K in isoform 3.		VSP_046123
	Alternative sequence	231 – 466	236	Missing in isoform 2.		VSP_024176
	Natural variant	209	1	F → C. Ref.2 Corresponds to variant rs3903683 [ dbSNP | Ensembl ].		VAR_031411
	Natural variant	217	1	C → Y. Ref.4 Corresponds to variant rs12032332 [ dbSNP | Ensembl ].		VAR_031412
	Natural variant	464	1	P → L. Ref.4 Corresponds to variant rs41306593 [ dbSNP | Ensembl ].		VAR_031413
Experimental info
	Sequence conflict	201	1	P → S in BAA91674. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 3, 2007. Version 2. Checksum: 7282732CE4FA4F83	FASTA	466	53,032
	10 20 30 40 50 60 MEPELLVRKV SALQACVRGF LVRRQFQSLR AEYEAIVREV EGDLGTLQWT EGRIPRPRFL 70 80 90 100 110 120 PEKAKSHQTW KAGDRVANPE QGLWNHFPCE ESEGEATWEE MVLKKSGESS ANQGSLCRDH 130 140 150 160 170 180 SSWLQMKQNR KPSQEKTRDT TRMENPEATD QRLPHSQPQL QELQYHRSHL AMELLWLQQA 190 200 210 220 230 240 INSRKEYLLL KQTLRSPEAG PIREEPRVFL EHGEQACERD QSQPSAPLED QSYRDRTTGE 250 260 270 280 290 300 LEQEDDSCHR VKSPHRSPGS LATTQKNIAG AKCREPCYSK SGPPSSIPSN SQALGDRLTK 310 320 330 340 350 360 GPDDGRQTFG GTCLLQMKIL EDQTPRGLKP RNHCPRKSRT QLSALYEDSN IKEMSPRKLD 370 380 390 400 410 420 HKEPDCRTVR TQELGLSEDH IIWDGTLGGP EHSVLDLWRT KPPKGQAPTD RSSRDGTSNE 430 440 450 460 PSHEGQKKQR TIPWRSKSPE ILSSTKAGCT GEEQWRGRPW KTEPPG
	Isoform 2 [UniParc]. Checksum: B348209BE081E09D	FASTA	230	26,719
	10 20 30 40 50 60 MEPELLVRKV SALQACVRGF LVRRQFQSLR AEYEAIVREV EGDLGTLQWT EGRIPRPRFL 70 80 90 100 110 120 PEKAKSHQTW KAGDRVANPE QGLWNHFPCE ESEGEATWEE MVLKKSGESS ANQGSLCRDH 130 140 150 160 170 180 SSWLQMKQNR KPSQEKTRDT TRMENPEATD QRLPHSQPQL QELQYHRSHL AMELLWLQQA 190 200 210 220 230 INSRKEYLLL KQTLRSPEAG PIREEPRVFL EHGEQACERD QSQPSAPLED
	Isoform 3 [UniParc]. Checksum: C765EBDA9BC8DF82	FASTA	546	61,966
	10 20 30 40 50 60 MEPELLVRKV SALQVRGRAR GSQDFSFREI MGSRTWTSQR DATTFSPLTA RQPLEIPAVP 70 80 90 100 110 120 NRAEESWDPR TPCPARPHSH HTLAPDQGNG KSLKACVRGF LVRRQFQSLR AEYEAIVREV 130 140 150 160 170 180 EGDLGTLQWT EGRIPRPRFL PEKAKSHQTW KAGDRVANPE QGLWNHFPCE ESEGEATWEE 190 200 210 220 230 240 MVLKKSGESS ANQGSLCRDH SSWLQMKQNR KPSQEKTRDT TRMENPEATD QRLPHSQPQL 250 260 270 280 290 300 QELQYHRSHL AMELLWLQQA INSRKEYLLL KQTLRSPEAG PIREEPRVFL EHGEQACERD 310 320 330 340 350 360 QSQPSAPLED QSYRDRTTGE LEQEDDSCHR VKSPHRSPGS LATTQKNIAG AKCREPCYSK 370 380 390 400 410 420 SGPPSSIPSN SQALGDRLTK GPDDGRQTFG GTCLLQMKIL EDQTPRGLKP RNHCPRKSRT 430 440 450 460 470 480 QLSALYEDSN IKEMSPRKLD HKEPDCRTVR TQELGLSEDH IIWDGTLGGP EHSVLDLWRT 490 500 510 520 530 540 KPPKGQAPTD RSSRDGTSNE PSHEGQKKQR TIPWRSKSPE ILSSTKAGCT GEEQWRGRPW KTEPPG

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-433 (ISOFORM 3). Tissue: Caudate nucleus.
[2]	Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT CYS-209. Tissue: Synovium.
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS TYR-217 AND LEU-464.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK001409 mRNA. Translation: BAA91674.1. AK307853 mRNA. No translation available. AK223272 mRNA. Translation: BAD96992.1. AL049795 Genomic DNA. Translation: CAI22058.1. BC098250 mRNA. Translation: AAH98250.1. BC098260 mRNA. Translation: AAH98260.1. BC098317 mRNA. Translation: AAH98317.1. BC098366 mRNA. Translation: AAH98366.1.
IPI	IPI00018690. IPI00844471. IPI00930108.
RefSeq	NP_001153514.1. NM_001160042.1. NP_060604.2. NM_018134.2.
UniGene	Hs.274356.
3D structure databases
ProteinModelPortal	Q4KMZ1.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000291358.
PTM databases
PhosphoSite	Q4KMZ1.
Polymorphism databases
DMDM	143339942.
Proteomic databases
PaxDb	Q4KMZ1.
PRIDE	Q4KMZ1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000291358; ENSP00000291358; ENSG00000160051. ENST00000537469; ENSP00000442291; ENSG00000160051.
GeneID	55721.
KEGG	hsa:55721.
UCSC	uc001bum.2. human. uc009vua.2. human.
Organism-specific databases
CTD	55721.
GeneCards	GC01P032671.
HGNC	HGNC:25545. IQCC.
HPA	HPA028602. HPA028686.
neXtProt	NX_Q4KMZ1.
PharmGKB	PA134868161.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG28569.
HOGENOM	HOG000113096.
HOVERGEN	HBG103168.
InParanoid	Q4KMZ1.
OrthoDB	EOG4RJG1C.
PhylomeDB	Q4KMZ1.
Gene expression databases
ArrayExpress	Q4KMZ1.
Bgee	Q4KMZ1.
CleanEx	HS_IQCC.
Genevestigator	Q4KMZ1.
Family and domain databases
InterPro	IPR000048. IQ_motif_EF-hand-BS. [Graphical view]
SMART	SM00015. IQ. 1 hit. [Graphical view]
PROSITE	PS50096. IQ. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	55721.
NextBio	60623.

Entry information

Entry name

IQCC_HUMAN

Accession

Primary (citable) accession number: Q4KMZ1
Secondary accession number(s): F5H7T8 , Q4KMS3, Q4KMZ5, Q53FL2, Q5TFJ8, Q9NVS3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2007
Last sequence update:	April 3, 2007
Last modified:	May 29, 2013
This is version 58 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.