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Protein

Bcl-2-like protein 11

Gene

bcl2l11

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Induces apoptosis and anoikis.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosisUniRule annotation

Enzyme and pathway databases

ReactomeiR-XTR-111446. Activation of BIM and translocation to mitochondria.
R-XTR-111453. BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members.
R-XTR-193648. NRAGE signals death through JNK.

Names & Taxonomyi

Protein namesi
Recommended name:
Bcl-2-like protein 11UniRule annotation
Short name:
Bcl2-L-11UniRule annotation
Alternative name(s):
Bcl2-interacting mediator of cell deathUniRule annotation
Gene namesi
Name:bcl2l11Imported
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-990117. bcl2l11.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MembraneUniRule annotation, MitochondrionUniRule annotation

Expressioni

Gene expression databases

BgeeiENSXETG00000029957.

Interactioni

Subunit structurei

Forms heterodimers with a number of antiapoptotic Bcl-2 proteins including MCL1, BCL2, BCL2L1 isoform Bcl-X(L), BCL2A1/BFL-1.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000007652.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 44Bim_NInterPro annotationAdd BLAST41
Domaini133 – 164Bclx_interactInterPro annotationAdd BLAST32

Sequence similaritiesi

Belongs to the Bcl-2 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG410IZKS. Eukaryota.
ENOG410Y8GB. LUCA.
GeneTreeiENSGT00390000003178.
HOVERGENiHBG018248.
OMAiAEDHPQM.
OrthoDBiEOG091G0XD3.
TreeFamiTF335898.

Family and domain databases

InterProiView protein in InterPro
IPR014771. Apoptosis_Bim_N.
IPR017288. Bcl-2-like_11.
IPR015040. Bcl-x_interacting_BH3_dom.
PfamiView protein in Pfam
PF08945. Bclx_interact. 1 hit.
PF06773. Bim_N. 1 hit.
PIRSFiPIRSF037827. Bcl-2-like_p11. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4KMV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKQPSVLSP DCNSGEGGQL QSTSRQHSHR PLRRGAPTSL SSPFQGNQSD
60 70 80 90 100
EGGSSSASTP WGPTISPYSP SSFVNRSPHC MLVRGSSLVS KTSSGYFSFE
110 120 130 140 150
VSPGPVSCDK STQTPSPPCQ AFNHLLSAMA DRNPVNQMSP ELWIAQELRR
160 170 180 190
IGDDFNASFS PRRGIFNNLP RPLDNDQVII LRVLRFIIRL ILRL
Length:194
Mass (Da):21,196
Last modified:August 2, 2005 - v1
Checksum:i51308CCE9E4376DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAMC01070429 Genomic DNA. No translation available.
BC098324 mRNA. Translation: AAH98324.1.
RefSeqiNP_001027511.1. NM_001032340.1.
XP_012818535.1. XM_012963081.2.
UniGeneiStr.41297.

Genome annotation databases

EnsembliENSXETT00000007652; ENSXETP00000007652; ENSXETG00000029957.
GeneIDi613103.

Similar proteinsi

Entry informationi

Entry nameiQ4KMV9_XENTR
AccessioniPrimary (citable) accession number: Q4KMV9
Entry historyiIntegrated into UniProtKB/TrEMBL: August 2, 2005
Last sequence update: August 2, 2005
Last modified: November 22, 2017
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported