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Protein

Bcl-2-like protein 11

Gene

bcl2l11

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Induces apoptosis and anoikis.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosisUniRule annotation

Enzyme and pathway databases

ReactomeiR-XTR-111446 Activation of BIM and translocation to mitochondria
R-XTR-111453 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
R-XTR-193648 NRAGE signals death through JNK

Names & Taxonomyi

Protein namesi
Recommended name:
Bcl-2-like protein 11UniRule annotation
Short name:
Bcl2-L-11UniRule annotation
Alternative name(s):
Bcl2-interacting mediator of cell deathUniRule annotation
Gene namesi
Name:bcl2l11Imported
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-990117 bcl2l11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MembraneUniRule annotation, MitochondrionUniRule annotation

Expressioni

Gene expression databases

BgeeiENSXETG00000029957

Interactioni

Subunit structurei

Forms heterodimers with a number of antiapoptotic Bcl-2 proteins including MCL1, BCL2, BCL2L1 isoform Bcl-X(L), BCL2A1/BFL-1.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000007652

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 44Bim_NInterPro annotationAdd BLAST41
Domaini133 – 164Bclx_interactInterPro annotationAdd BLAST32

Sequence similaritiesi

Belongs to the Bcl-2 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG410IZKS Eukaryota
ENOG410Y8GB LUCA
GeneTreeiENSGT00390000003178
HOVERGENiHBG018248
KOiK16341
OMAiAEDHPQM
OrthoDBiEOG091G0XD3
TreeFamiTF335898

Family and domain databases

InterProiView protein in InterPro
IPR014771 Apoptosis_Bim_N
IPR017288 Bcl-2-like_11
IPR015040 Bcl-x_interacting_BH3_dom
PfamiView protein in Pfam
PF08945 Bclx_interact, 1 hit
PF06773 Bim_N, 1 hit
PIRSFiPIRSF037827 Bcl-2-like_p11, 1 hit

Sequencei

Sequence statusi: Complete.

Q4KMV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKQPSVLSP DCNSGEGGQL QSTSRQHSHR PLRRGAPTSL SSPFQGNQSD
60 70 80 90 100
EGGSSSASTP WGPTISPYSP SSFVNRSPHC MLVRGSSLVS KTSSGYFSFE
110 120 130 140 150
VSPGPVSCDK STQTPSPPCQ AFNHLLSAMA DRNPVNQMSP ELWIAQELRR
160 170 180 190
IGDDFNASFS PRRGIFNNLP RPLDNDQVII LRVLRFIIRL ILRL
Length:194
Mass (Da):21,196
Last modified:August 2, 2005 - v1
Checksum:i51308CCE9E4376DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAMC01070429 Genomic DNA No translation available.
BC098324 mRNA Translation: AAH98324.1
RefSeqiNP_001027511.1, NM_001032340.1
XP_012818535.1, XM_012963081.2
UniGeneiStr.41297

Genome annotation databases

EnsembliENSXETT00000007652; ENSXETP00000007652; ENSXETG00000029957
GeneIDi613103
KEGGixtr:613103

Similar proteinsi

Entry informationi

Entry nameiQ4KMV9_XENTR
AccessioniPrimary (citable) accession number: Q4KMV9
Entry historyiIntegrated into UniProtKB/TrEMBL: August 2, 2005
Last sequence update: August 2, 2005
Last modified: February 28, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health