Q4KMR2 (Q4KMR2_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Jagged 1 (Alagille syndrome) EMBL AAH98393.1

Gene names

Name:

JAG1 EMBL AAH98393.1

Organism

Homo sapiens (Human) EMBL AAH98393.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1218 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Domain	EGF-like domain RuleBase RU000458 SAAS SAAS018097 Repeat SAAS SAAS006209
PTM	Disulfide bond SAAS SAAS018097
Gene Ontology (GO)
Biological process	Notch signaling pathway Inferred from electronic annotation. Source: InterPro multicellular organismal development Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: InterPro
Molecular function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q4KMR2 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: 8E1E45A42253E5CB	FASTA	1,218	133,874
	10 20 30 40 50 60 MRSPRTRGRS GRPLSLLLAL LCALRAKVCG ASGQFELEIL SMQNVNGELQ NGNCCGGARN 70 80 90 100 110 120 PGDRKCTRDE CDTYFKVCLK EYQSRVTAGG PCSFGSGSTP VIGGNTFNLK ASRGNDRNRI 130 140 150 160 170 180 VLPFSFAWPR SYTLLVEAWD SSNDTVQPDS IIEKASHSGM INPSRQWQTL KQNTGVAHFE 190 200 210 220 230 240 YQIRVTCDDY YYGFGCNKFC RPRDDFFGHY ACDQNGNKTC MEGWMGPECN RAICRQGCSP 250 260 270 280 290 300 KHGSCKLPGD CRCQYGWQGL YCDKCIPHPG CVHGICNEPW QCLCETNWGG QLCDKDLNYC 310 320 330 340 350 360 GTHQPCLNGG TCSNTGPDKY QCSCPEGYSG PNCEIAEHAC LSDPCHNRGS CKETSLGFEC 370 380 390 400 410 420 ECSPGWTGPT CSTNIDDCSP NNCSHGGTCQ DLVNGFKCVC PPQWTGKTCQ LDANECEAKP 430 440 450 460 470 480 CVNAKSCKNL IASYYCDCLP GWMGQNCDIN INDCLGQCQN DASCRDLVNG YRCICPPGYA 490 500 510 520 530 540 GDHCERDIDE CASNPCLNGG HCQNEINRFQ CLCPTGFSGN LCQLDIDYCE PNPCQNGAQC 550 560 570 580 590 600 YNRASDYFCK CPEDYEGKNC SHLKDHCRTT PCEVIDSCTV AMASNDTPEG VRYISSNVCG 610 620 630 640 650 660 PHGKCKSQSG GKFTCDCNKG FTGTYCHENI NDCESNPCRN GGTCIDGVNS YKCICSDGWE 670 680 690 700 710 720 GAYCETNIND CSQNPCHNGG TCRDLVNDFY CDCKNGWKGK TCHSRDSQCD EATCNNGGTC 730 740 750 760 770 780 YDEGDAFKCM CPGGWEGTTC NIARNSSCLP NPCHNGGTCV VNGESFTCVC KEGWEGPICA 790 800 810 820 830 840 QNTNDCSPHP CYNSGTCVDG DNWYRCECAP GFAGPDCRIN INECQSSPCA FGATCVDEIN 850 860 870 880 890 900 GYRCVCPPGH SGAKCQEVSG RPCITMGSVI RDGAKWDDDC NTCQCLNGRI ACSKVWCGPR 910 920 930 940 950 960 PCLLHKGHSE CPSGQSCIPI LDDQCFVHPC TGVGECRSSS LQPVKTKCTS DSYYQDNCAN 970 980 990 1000 1010 1020 ITFTFNKEMM SPGLTTEHIC SELRNLNILK NVSAEYSIYI ACEPSPSANN EIHVAISAED 1030 1040 1050 1060 1070 1080 IRDDGNPIKE ITDKIIDLVS KRDGNSSLIA AVAEVRVQRR PLKNRTDFLV PLLSSVLTVA 1090 1100 1110 1120 1130 1140 WICCLVTAFY WCLRKRRKPG SHTHSASEDN TTNNVREQLN QIKNPIEKHG ANTVPIKDYE 1150 1160 1170 1180 1190 1200 NKNSKMSKIR THNSEVEEDD MDKHQQKARF AKQPAYTLVD REEKPPNGTL TKHPNWTNKQ 1210 DNRDLESAQS LNRMEYIV

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta EMBL AAH98393.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC098393 mRNA. Translation: AAH98393.1.
IPI	IPI00099650.
UniGene	Hs.224012. Hs.728907.
3D structure databases
ProteinModelPortal	Q4KMR2.
SMR	Q4KMR2. Positions 186-335.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4KMR2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
GeneTree	ENSGT00600000084060.
HOVERGEN	HBG031645.
Gene expression databases
ArrayExpress	Q4KMR2.
Family and domain databases
InterPro	IPR001774. DSL. IPR006209. EGF. IPR006210. EGF-like. IPR001881. EGF-like_Ca-bd. IPR013032. EGF-like_reg_CS. IPR000152. EGF-type_Asp/Asn_hydroxyl_site. IPR000742. EGF_3. IPR018097. EGF_Ca-bd_CS. IPR011651. Notch_ligand_N. IPR001007. VWF_C. [Graphical view]
Pfam	PF01414. DSL. 1 hit. PF00008. EGF. 9 hits. PF07645. EGF_CA. 1 hit. PF07657. MNNL. 1 hit. [Graphical view]
SMART	SM00051. DSL. 1 hit. SM00181. EGF. 6 hits. SM00179. EGF_CA. 10 hits. SM00214. VWC. 1 hit. [Graphical view]
PROSITE	PS00010. ASX_HYDROXYL. 10 hits. PS51051. DSL. 1 hit. PS00022. EGF_1. 16 hits. PS01186. EGF_2. 12 hits. PS50026. EGF_3. 15 hits. PS01187. EGF_CA. 8 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q4KMR2_HUMAN

Accession

Primary (citable) accession number: Q4KMR2

Entry history

Integrated into UniProtKB/TrEMBL:	August 2, 2005
Last sequence update:	August 2, 2005
Last modified:	January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.