Reviewed, UniProtKB/Swiss-Prot Q4KMQ2 (ANO6_HUMAN)

Names and origin

Protein names

Recommended name:
    Anoctamin-6
Alternative name(s):
    Transmembrane protein 16F

Gene names

Name:	ANO6
Synonyms:	TMEM16F

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	910 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May act as a calcium-activated chloride channel.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Tissue specificity	Expressed in embryonic stem cell, fetal liver, retina, chronic myologenous leukemia and intestinal cancer. Ref.4
Sequence similarities	Belongs to the anoctamin family.

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane
Ligand	Calcium Chloride
Molecular function	Chloride channel Ionic channel
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ion transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	chloride channel complex Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW chloride channel activity Inferred from electronic annotation. Source: UniProtKB-KW chloride ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 910	910	Anoctamin-6		PRO_0000191757
Regions
	Topological domain	1 – 294	294	Cytoplasmic Potential
	Transmembrane	295 – 315	21	Potential
	Topological domain	316 – 375	60	Extracellular Potential
	Transmembrane	376 – 396	21	Potential
	Topological domain	397 – 454	58	Cytoplasmic Potential
	Transmembrane	455 – 475	21	Potential
	Topological domain	476 – 513	38	Extracellular Potential
	Transmembrane	514 – 534	21	Potential
	Topological domain	535 – 551	17	Cytoplasmic Potential
	Transmembrane	552 – 572	21	Potential
	Topological domain	573 – 669	97	Extracellular Potential
	Transmembrane	670 – 690	21	Potential
	Topological domain	691 – 725	35	Cytoplasmic Potential
	Transmembrane	726 – 746	21	Potential
	Topological domain	747 – 824	78	Extracellular Potential
	Transmembrane	825 – 845	21	Potential
	Topological domain	846 – 910	65	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	329	1	N-linked (GlcNAc...) Potential
	Glycosylation	361	1	N-linked (GlcNAc...) Potential
	Glycosylation	493	1	N-linked (GlcNAc...) Ref.6
	Glycosylation	777	1	N-linked (GlcNAc...) Potential
	Glycosylation	790	1	N-linked (GlcNAc...) Potential
	Glycosylation	802	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	128	1	A → T: dbSNP rs2162321.		VAR_028109
Experimental info
	Sequence conflict	837	1	F → L in AAH98410. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q4KMQ2-1 [UniParc]. Last modified October 17, 2006. Version 2. Checksum: 8F7F1CB78FAAEB78	FASTA	910	106,165
	10 20 30 40 50 60 MKKMSRNVLL QMEEEEDDDD GDIVLENLGQ TIVPDLGSLE SQHDFRTPEF EEFNGKPDSL 70 80 90 100 110 120 FFNDGQRRID FVLVYEDESR KETNKKGTNE KQRRKRQAYE SNLICHGLQL EATRSVLDDK 130 140 150 160 170 180 LVFVKVHAPW EVLCTYAEIM HIKLPLKPND LKNRSSAFGT LNWFTKVLSV DESIIKPEQE 190 200 210 220 230 240 FFTAPFEKNR MNDFYIVDRD AFFNPATRSR IVYFILSRVK YQVINNVSKF GINRLVNSGI 250 260 270 280 290 300 YKAAFPLHDC KFRRQSEDPS CPNERYLLYR EWAHPRSIYK KQPLDLIRKY YGEKIGIYFA 310 320 330 340 350 360 WLGYYTQMLL LAAVVGVACF LYGYLNQDNC TWSKEVCHPD IGGKIIMCPQ CDRLCPFWKL 370 380 390 400 410 420 NITCESSKKL CIFDSFGTLV FAVFMGVWVT LFLEFWKRRQ AELEYEWDTV ELQQEEQARP 430 440 450 460 470 480 EYEARCTHVV INEITQEEER IPFTAWGKCI RITLCASAVF FWILLIIASV IGIIVYRLSV 490 500 510 520 530 540 FIVFSAKLPK NINGTDPIQK YLTPQTATSI TASIISFIII MILNTIYEKV AIMITNFELP 550 560 570 580 590 600 RTQTDYENSL TMKMFLFQFV NYYSSCFYIA FFKGKFVGYP GDPVYWLGKY RNEECDPGGC 610 620 630 640 650 660 LLELTTQLTI IMGGKAIWNN IQEVLLPWIM NLIGRFHRVS GSEKITPRWE QDYHLQPMGK 670 680 690 700 710 720 LGLFYEYLEM IIQFGFVTLF VASFPLAPLL ALVNNILEIR VDAWKLTTQF RRLVPEKAQD 730 740 750 760 770 780 IGAWQPIMQG IAILAVVTNA MIIAFTSDMI PRLVYYWSFS VPPYGDHTSY TMEGYINNTL 790 800 810 820 830 840 SIFKVADFKN KSKGNPYSDL GNHTTCRYRD FRYPPGHPQE YKHNIYYWHV IAAKLAFIIV 850 860 870 880 890 900 MEHVIYSVKF FISYAIPDVS KRTKSKIQRE KYLTQKLLHE NHLKDMTKNM GVIAERMIEA 910 VDNNLRPKSE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed: 16541075] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 772-910. Tissue: Adipose tissue.
[4]	"Identification and characterization of TMEM16E and TMEM16F genes in silico." Katoh M., Katoh M. Int. J. Oncol. 24:1345-1349(2004) [PubMed: 15067359] [Abstract] Cited for: TISSUE SPECIFICITY.
[5]	"TMEM16A confers receptor-activated calcium-dependent chloride conductance." Yang Y.D., Cho H., Koo J.Y., Tak M.H., Cho Y., Shim W.-S., Park S.P., Lee J., Lee B., Kim B.-M., Raouf R., Shin Y.K., Oh U. Nature 455:1210-1215(2008) [PubMed: 18724360] [Abstract] Cited for: IDENTIFICATION AS PUTATIVE CHLORIDE CHANNEL.
[6]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed: 19159218] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-493, MASS SPECTROMETRY. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AC009248 Genomic DNA. No translation available. BC098410 mRNA. Translation: AAH98410.1. AL833405 mRNA. Translation: CAD38638.1.
IPI	IPI00151710.
RefSeq	NP_001020527.2. NP_001136150.1. NP_001136151.1. NP_001136152.1.
UniGene	Hs.696326
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q4KMQ2.
PTM databases
PhosphoSite	Q4KMQ2.
Proteomic databases
PRIDE	Q4KMQ2.
Genome annotation databases
Ensembl	ENST00000320560; ENSP00000320087; ENSG00000177119; Homo sapiens. [Genome view]
GeneID	196527.
KEGG	hsa:196527.
UCSC	uc001roo.1. human.
Organism-specific databases
CTD	196527.
GeneCards	GC12P043897.
HGNC	HGNC:25240. ANO6.
MIM	608663. gene.
PharmGKB	PA134912608.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q4KMQ2.
HOVERGEN	Q4KMQ2.
Gene expression databases
ArrayExpress	Q4KMQ2.
Bgee	Q4KMQ2.
CleanEx	HS_ANO6.
Genevestigator	Q4KMQ2.
Family and domain databases
InterPro	IPR007632. DUF590. [Graphical view]
PANTHER	PTHR12308. DUF590. 1 hit.
Pfam	PF04547. DUF590. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	89521.
SOURCE	Search...

Entry information

Entry name

ANO6_HUMAN

Accession

Primary (citable) accession number: Q4KMQ2
Secondary accession number(s): A6NNM6, Q8N3Q2

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 13, 2005
Last sequence update:	October 17, 2006
Last modified:	November 24, 2009
This is version 43 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.