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Q4KMQ2

- ANO6_HUMAN

UniProt

Q4KMQ2 - ANO6_HUMAN

Protein

Anoctamin-6

Gene

ANO6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 2 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes.5 Publications

    Enzyme regulationi

    Exhibits synergistic gating by Ca2+ and voltage. Inhibited by some non-specific cation channel blockers such as: ruthenium red, 2-aminoethyl diphenylborinate (2APB), gadolinium and cadmium ions By similarity.By similarity

    GO - Molecular functioni

    1. calcium activated cation channel activity Source: UniProtKB
    2. intracellular calcium activated chloride channel activity Source: UniProt
    3. voltage-gated chloride channel activity Source: UniProt
    4. voltage-gated ion channel activity Source: UniProtKB

    GO - Biological processi

    1. activation of blood coagulation via clotting cascade Source: UniProtKB
    2. blood coagulation Source: UniProtKB
    3. cation transport Source: UniProt
    4. chloride transmembrane transport Source: GOC
    5. chloride transport Source: UniProt
    6. ion transmembrane transport Source: Reactome
    7. phosphatidylserine exposure on blood platelet Source: UniProtKB
    8. phospholipid scrambling Source: UniProtKB
    9. positive regulation of endothelial cell apoptotic process Source: UniProt
    10. regulation of anion transport Source: GOC
    11. transmembrane transport Source: Reactome

    Keywords - Molecular functioni

    Chloride channel, Ion channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Transport

    Keywords - Ligandi

    Chloride

    Enzyme and pathway databases

    ReactomeiREACT_160189. Stimuli-sensing channels.

    Protein family/group databases

    TCDBi1.A.17.1.4. the calcium-dependent chloride channel (ca-clc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Anoctamin-6
    Alternative name(s):
    Small-conductance calcium-activated nonselective cation channel
    Short name:
    SCAN channel
    Transmembrane protein 16F
    Gene namesi
    Name:ANO6
    Synonyms:TMEM16F
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:25240. ANO6.

    Subcellular locationi

    Cell membrane 4 Publications; Multi-pass membrane protein 4 Publications
    Note: Shows an intracellular localization according to PubMed:22075693.

    GO - Cellular componenti

    1. chloride channel complex Source: UniProt
    2. extracellular vesicular exosome Source: UniProt
    3. intracellular Source: UniProtKB
    4. membrane Source: UniProtKB
    5. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Scott syndrome (SCTS) [MIM:262890]: A mild bleeding disorder due to impaired surface exposure of procoagulant phosphatidylserine (PS) on platelets and other blood cells, following activation with Ca(2+)-elevating agents.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Organism-specific databases

    MIMi262890. phenotype.
    Orphaneti806. Scott syndrome.
    PharmGKBiPA164715690.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 910910Anoctamin-6PRO_0000191757Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi329 – 3291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi361 – 3611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi493 – 4931N-linked (GlcNAc...)1 Publication
    Glycosylationi777 – 7771N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi790 – 7901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi802 – 8021N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ4KMQ2.
    PaxDbiQ4KMQ2.
    PRIDEiQ4KMQ2.

    PTM databases

    PhosphoSiteiQ4KMQ2.

    Expressioni

    Tissue specificityi

    Expressed in embryonic stem cell, fetal liver, retina, chronic myologenous leukemia and intestinal cancer.1 Publication

    Gene expression databases

    ArrayExpressiQ4KMQ2.
    BgeeiQ4KMQ2.
    CleanExiHS_ANO6.
    GenevestigatoriQ4KMQ2.

    Organism-specific databases

    HPAiHPA038958.

    Interactioni

    Protein-protein interaction databases

    BioGridi128218. 2 interactions.
    IntActiQ4KMQ2. 1 interaction.
    MINTiMINT-5001391.
    STRINGi9606.ENSP00000391417.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4KMQ2.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 294294CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini316 – 37560ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini397 – 45458CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini476 – 51338ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini535 – 55117CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini573 – 66997ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini691 – 72535CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini747 – 82478ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini846 – 91065CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei295 – 31521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei376 – 39621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei455 – 47521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei514 – 53421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei552 – 57221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei670 – 69021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei726 – 74621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei825 – 84521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the anoctamin family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG320103.
    HOGENOMiHOG000006509.
    HOVERGENiHBG069519.
    InParanoidiQ4KMQ2.
    OMAiQDYHLQP.
    OrthoDBiEOG7BS48W.
    PhylomeDBiQ4KMQ2.
    TreeFamiTF314265.

    Family and domain databases

    InterProiIPR007632. Anoctamin.
    [Graphical view]
    PANTHERiPTHR12308. PTHR12308. 1 hit.
    PfamiPF04547. Anoctamin. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q4KMQ2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKKMSRNVLL QMEEEEDDDD GDIVLENLGQ TIVPDLGSLE SQHDFRTPEF    50
    EEFNGKPDSL FFNDGQRRID FVLVYEDESR KETNKKGTNE KQRRKRQAYE 100
    SNLICHGLQL EATRSVLDDK LVFVKVHAPW EVLCTYAEIM HIKLPLKPND 150
    LKNRSSAFGT LNWFTKVLSV DESIIKPEQE FFTAPFEKNR MNDFYIVDRD 200
    AFFNPATRSR IVYFILSRVK YQVINNVSKF GINRLVNSGI YKAAFPLHDC 250
    KFRRQSEDPS CPNERYLLYR EWAHPRSIYK KQPLDLIRKY YGEKIGIYFA 300
    WLGYYTQMLL LAAVVGVACF LYGYLNQDNC TWSKEVCHPD IGGKIIMCPQ 350
    CDRLCPFWKL NITCESSKKL CIFDSFGTLV FAVFMGVWVT LFLEFWKRRQ 400
    AELEYEWDTV ELQQEEQARP EYEARCTHVV INEITQEEER IPFTAWGKCI 450
    RITLCASAVF FWILLIIASV IGIIVYRLSV FIVFSAKLPK NINGTDPIQK 500
    YLTPQTATSI TASIISFIII MILNTIYEKV AIMITNFELP RTQTDYENSL 550
    TMKMFLFQFV NYYSSCFYIA FFKGKFVGYP GDPVYWLGKY RNEECDPGGC 600
    LLELTTQLTI IMGGKAIWNN IQEVLLPWIM NLIGRFHRVS GSEKITPRWE 650
    QDYHLQPMGK LGLFYEYLEM IIQFGFVTLF VASFPLAPLL ALVNNILEIR 700
    VDAWKLTTQF RRLVPEKAQD IGAWQPIMQG IAILAVVTNA MIIAFTSDMI 750
    PRLVYYWSFS VPPYGDHTSY TMEGYINNTL SIFKVADFKN KSKGNPYSDL 800
    GNHTTCRYRD FRYPPGHPQE YKHNIYYWHV IAAKLAFIIV MEHVIYSVKF 850
    FISYAIPDVS KRTKSKIQRE KYLTQKLLHE NHLKDMTKNM GVIAERMIEA 900
    VDNNLRPKSE 910
    Length:910
    Mass (Da):106,165
    Last modified:October 17, 2006 - v2
    Checksum:i8F7F1CB78FAAEB78
    GO
    Isoform 2 (identifier: Q4KMQ2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         23-23: I → IGDVPASRRPFLTPHTHLPSSL

    Note: No experimental confirmation available.

    Show »
    Length:931
    Mass (Da):108,433
    Checksum:i6F0149C7FB67A371
    GO
    Isoform 3 (identifier: Q4KMQ2-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-23: MKKMSRNVLLQMEEEEDDDDGDI → MFCAA

    Note: Gene prediction based on EST data.

    Show »
    Length:892
    Mass (Da):103,966
    Checksum:i9FC6A98229E57118
    GO
    Isoform 4 (identifier: Q4KMQ2-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         843-910: HVIYSVKFFI...VDNNLRPKSE → YLALLPRLGH...PCFSVSNFLS

    Note: Gene prediction based on EST data.

    Show »
    Length:929
    Mass (Da):108,102
    Checksum:i5B77123875916E01
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti837 – 8371F → L in AAH98410. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti128 – 1281A → T.
    Corresponds to variant rs2162321 [ dbSNP | Ensembl ].
    VAR_028109

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2323MKKMS…DDGDI → MFCAA in isoform 3. CuratedVSP_046819Add
    BLAST
    Alternative sequencei23 – 231I → IGDVPASRRPFLTPHTHLPS SL in isoform 2. 1 PublicationVSP_042893
    Alternative sequencei843 – 91068HVIYS…RPKSE → YLALLPRLGHSGMILAHCNL RLPVDCCMCYRFVDEIRLLE QLTSDFIDSLYYIFSISIIS IFFSVTFFFLLLSLGPTPCF SVSNFLS in isoform 4. CuratedVSP_046820Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC009248 Genomic DNA. No translation available.
    AC009778 Genomic DNA. No translation available.
    AC063924 Genomic DNA. No translation available.
    BC098410 mRNA. Translation: AAH98410.1.
    BC136445 mRNA. Translation: AAI36446.1.
    AL833405 mRNA. Translation: CAD38638.1.
    CCDSiCCDS31782.1. [Q4KMQ2-1]
    CCDS44865.1. [Q4KMQ2-4]
    CCDS44866.1. [Q4KMQ2-3]
    CCDS55819.1. [Q4KMQ2-2]
    RefSeqiNP_001020527.2. NM_001025356.2. [Q4KMQ2-1]
    NP_001136150.1. NM_001142678.1. [Q4KMQ2-3]
    NP_001136151.1. NM_001142679.1. [Q4KMQ2-4]
    NP_001191732.1. NM_001204803.1. [Q4KMQ2-2]
    UniGeneiHs.505339.

    Genome annotation databases

    EnsembliENST00000320560; ENSP00000320087; ENSG00000177119. [Q4KMQ2-1]
    ENST00000423947; ENSP00000409126; ENSG00000177119. [Q4KMQ2-2]
    ENST00000425752; ENSP00000391417; ENSG00000177119. [Q4KMQ2-4]
    ENST00000441606; ENSP00000413137; ENSG00000177119. [Q4KMQ2-3]
    GeneIDi196527.
    KEGGihsa:196527.
    UCSCiuc001roo.3. human. [Q4KMQ2-1]
    uc010slf.2. human. [Q4KMQ2-2]

    Polymorphism databases

    DMDMi116242820.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC009248 Genomic DNA. No translation available.
    AC009778 Genomic DNA. No translation available.
    AC063924 Genomic DNA. No translation available.
    BC098410 mRNA. Translation: AAH98410.1 .
    BC136445 mRNA. Translation: AAI36446.1 .
    AL833405 mRNA. Translation: CAD38638.1 .
    CCDSi CCDS31782.1. [Q4KMQ2-1 ]
    CCDS44865.1. [Q4KMQ2-4 ]
    CCDS44866.1. [Q4KMQ2-3 ]
    CCDS55819.1. [Q4KMQ2-2 ]
    RefSeqi NP_001020527.2. NM_001025356.2. [Q4KMQ2-1 ]
    NP_001136150.1. NM_001142678.1. [Q4KMQ2-3 ]
    NP_001136151.1. NM_001142679.1. [Q4KMQ2-4 ]
    NP_001191732.1. NM_001204803.1. [Q4KMQ2-2 ]
    UniGenei Hs.505339.

    3D structure databases

    ProteinModelPortali Q4KMQ2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128218. 2 interactions.
    IntActi Q4KMQ2. 1 interaction.
    MINTi MINT-5001391.
    STRINGi 9606.ENSP00000391417.

    Protein family/group databases

    TCDBi 1.A.17.1.4. the calcium-dependent chloride channel (ca-clc) family.

    PTM databases

    PhosphoSitei Q4KMQ2.

    Polymorphism databases

    DMDMi 116242820.

    Proteomic databases

    MaxQBi Q4KMQ2.
    PaxDbi Q4KMQ2.
    PRIDEi Q4KMQ2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000320560 ; ENSP00000320087 ; ENSG00000177119 . [Q4KMQ2-1 ]
    ENST00000423947 ; ENSP00000409126 ; ENSG00000177119 . [Q4KMQ2-2 ]
    ENST00000425752 ; ENSP00000391417 ; ENSG00000177119 . [Q4KMQ2-4 ]
    ENST00000441606 ; ENSP00000413137 ; ENSG00000177119 . [Q4KMQ2-3 ]
    GeneIDi 196527.
    KEGGi hsa:196527.
    UCSCi uc001roo.3. human. [Q4KMQ2-1 ]
    uc010slf.2. human. [Q4KMQ2-2 ]

    Organism-specific databases

    CTDi 196527.
    GeneCardsi GC12P045609.
    H-InvDB HIX0010565.
    HGNCi HGNC:25240. ANO6.
    HPAi HPA038958.
    MIMi 262890. phenotype.
    608663. gene.
    neXtProti NX_Q4KMQ2.
    Orphaneti 806. Scott syndrome.
    PharmGKBi PA164715690.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG320103.
    HOGENOMi HOG000006509.
    HOVERGENi HBG069519.
    InParanoidi Q4KMQ2.
    OMAi QDYHLQP.
    OrthoDBi EOG7BS48W.
    PhylomeDBi Q4KMQ2.
    TreeFami TF314265.

    Enzyme and pathway databases

    Reactomei REACT_160189. Stimuli-sensing channels.

    Miscellaneous databases

    ChiTaRSi ANO6. human.
    GenomeRNAii 196527.
    NextBioi 89521.
    PROi Q4KMQ2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q4KMQ2.
    Bgeei Q4KMQ2.
    CleanExi HS_ANO6.
    Genevestigatori Q4KMQ2.

    Family and domain databases

    InterProi IPR007632. Anoctamin.
    [Graphical view ]
    PANTHERi PTHR12308. PTHR12308. 1 hit.
    Pfami PF04547. Anoctamin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Placenta and Testis.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 772-910 (ISOFORM 1/2).
      Tissue: Adipose tissue.
    4. "Identification and characterization of TMEM16E and TMEM16F genes in silico."
      Katoh M., Katoh M.
      Int. J. Oncol. 24:1345-1349(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    5. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-493.
      Tissue: Liver.
    6. Cited for: FUNCTION, SUBCELLULAR LOCATION.
    7. "Calcium-dependent phospholipid scrambling by TMEM16F."
      Suzuki J., Umeda M., Sims P.J., Nagata S.
      Nature 468:834-838(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INVOLVEMENT IN SCOTT SYNDROME.
    8. "Physiological roles and diseases of Tmem16/Anoctamin proteins: are they all chloride channels?"
      Duran C., Hartzell H.C.
      Acta Pharmacol. Sin. 32:685-692(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    9. Cited for: REVIEW.
    10. "Anoctamin 6 is an essential component of the outwardly rectifying chloride channel."
      Martins J.R., Faria D., Kongsuphol P., Reisch B., Schreiber R., Kunzelmann K.
      Proc. Natl. Acad. Sci. U.S.A. 108:18168-18172(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    11. "ANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are intracellular proteins."
      Duran C., Qu Z., Osunkoya A.O., Cui Y., Hartzell H.C.
      Am. J. Physiol. 302:C482-C493(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    12. "The anoctamin (TMEM16) gene family: calcium-activated chloride channels come of age."
      Winpenny J.P., Gray M.A.
      Exp. Physiol. 97:175-176(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    13. "The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels."
      Scudieri P., Sondo E., Ferrera L., Galietta L.J.
      Exp. Physiol. 97:177-183(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW, ABSENCE OF CALCIUM-ACTIVATED CHLORIDE CHANNEL ACTIVITY.
    14. Cited for: REVIEW, FUNCTION.
    15. "Anoctamins are a family of Ca2+ activated Cl- channels."
      Tian Y., Schreiber R., Kunzelmann K.
      J. Cell Sci. 125:4991-4998(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiANO6_HUMAN
    AccessioniPrimary (citable) accession number: Q4KMQ2
    Secondary accession number(s): A6NNM6
    , B9EGG0, E7ENK4, E9PB30, E9PCT2, Q8N3Q2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2005
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 91 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3