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Protein

Anoctamin-6

Gene

ANO6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes.By similarity5 Publications

Enzyme regulationi

Exhibits synergistic gating by Ca2+ and voltage. Inhibited by some non-specific cation channel blockers such as: ruthenium red, 2-aminoethyl diphenylborinate (2APB), gadolinium and cadmium ions (By similarity).By similarity

GO - Molecular functioni

  1. calcium activated cation channel activity Source: UniProtKB
  2. intracellular calcium activated chloride channel activity Source: UniProtKB
  3. phospholipid scramblase activity Source: Ensembl
  4. voltage-gated chloride channel activity Source: UniProtKB
  5. voltage-gated ion channel activity Source: UniProtKB

GO - Biological processi

  1. activation of blood coagulation via clotting cascade Source: UniProtKB
  2. blood coagulation Source: UniProtKB
  3. bone mineralization involved in bone maturation Source: Ensembl
  4. calcium activated galactosylceramide scrambling Source: Ensembl
  5. calcium activated phosphatidylcholine scrambling Source: Ensembl
  6. calcium activated phosphatidylserine scrambling Source: Ensembl
  7. cation transport Source: UniProtKB
  8. chloride transmembrane transport Source: GOC
  9. chloride transport Source: UniProtKB
  10. dendritic cell chemotaxis Source: Ensembl
  11. ion transmembrane transport Source: Reactome
  12. phosphatidylserine exposure on blood platelet Source: UniProtKB
  13. phospholipid scrambling Source: UniProtKB
  14. positive regulation of endothelial cell apoptotic process Source: UniProtKB
  15. regulation of anion transmembrane transport Source: GOC
  16. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Lipid transport, Transport

Keywords - Ligandi

Chloride

Enzyme and pathway databases

ReactomeiREACT_160189. Stimuli-sensing channels.
REACT_268444. Orphan transporters.

Protein family/group databases

TCDBi1.A.17.1.4. the calcium-dependent chloride channel (ca-clc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Anoctamin-6
Alternative name(s):
Small-conductance calcium-activated nonselective cation channel
Short name:
SCAN channel
Transmembrane protein 16F
Gene namesi
Name:ANO6
Synonyms:TMEM16F
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:25240. ANO6.

Subcellular locationi

  1. Cell membrane 4 Publications; Multi-pass membrane protein 4 Publications

  2. Note: Shows an intracellular localization according to PubMed:22075693.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 294294CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei295 – 31521HelicalSequence AnalysisAdd
BLAST
Topological domaini316 – 37560ExtracellularSequence AnalysisAdd
BLAST
Transmembranei376 – 39621HelicalSequence AnalysisAdd
BLAST
Topological domaini397 – 45458CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei455 – 47521HelicalSequence AnalysisAdd
BLAST
Topological domaini476 – 51338ExtracellularSequence AnalysisAdd
BLAST
Transmembranei514 – 53421HelicalSequence AnalysisAdd
BLAST
Topological domaini535 – 55117CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei552 – 57221HelicalSequence AnalysisAdd
BLAST
Topological domaini573 – 66997ExtracellularSequence AnalysisAdd
BLAST
Transmembranei670 – 69021HelicalSequence AnalysisAdd
BLAST
Topological domaini691 – 72535CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei726 – 74621HelicalSequence AnalysisAdd
BLAST
Topological domaini747 – 82478ExtracellularSequence AnalysisAdd
BLAST
Transmembranei825 – 84521HelicalSequence AnalysisAdd
BLAST
Topological domaini846 – 91065CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: UniProtKB
  2. chloride channel complex Source: UniProtKB
  3. extracellular vesicular exosome Source: UniProtKB
  4. intracellular Source: UniProtKB
  5. membrane Source: UniProtKB
  6. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Scott syndrome (SCTS)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA mild bleeding disorder due to impaired surface exposure of procoagulant phosphatidylserine (PS) on platelets and other blood cells, following activation with Ca(2+)-elevating agents.

See also OMIM:262890

Organism-specific databases

MIMi262890. phenotype.
Orphaneti806. Scott syndrome.
PharmGKBiPA164715690.

Polymorphism and mutation databases

BioMutaiANO6.
DMDMi116242820.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 910910Anoctamin-6PRO_0000191757Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi329 – 3291N-linked (GlcNAc...)Sequence Analysis
Glycosylationi361 – 3611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi493 – 4931N-linked (GlcNAc...)1 Publication
Glycosylationi777 – 7771N-linked (GlcNAc...)Sequence Analysis
Glycosylationi790 – 7901N-linked (GlcNAc...)Sequence Analysis
Glycosylationi802 – 8021N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ4KMQ2.
PaxDbiQ4KMQ2.
PRIDEiQ4KMQ2.

PTM databases

PhosphoSiteiQ4KMQ2.

Expressioni

Tissue specificityi

Expressed in embryonic stem cell, fetal liver, retina, chronic myologenous leukemia and intestinal cancer.1 Publication

Gene expression databases

BgeeiQ4KMQ2.
CleanExiHS_ANO6.
ExpressionAtlasiQ4KMQ2. baseline and differential.
GenevestigatoriQ4KMQ2.

Organism-specific databases

HPAiHPA038958.

Interactioni

Protein-protein interaction databases

BioGridi128218. 8 interactions.
IntActiQ4KMQ2. 1 interaction.
MINTiMINT-5001391.
STRINGi9606.ENSP00000391417.

Family & Domainsi

Sequence similaritiesi

Belongs to the anoctamin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG320103.
GeneTreeiENSGT00760000119015.
HOGENOMiHOG000006509.
HOVERGENiHBG069519.
InParanoidiQ4KMQ2.
OMAiMNDFYIV.
OrthoDBiEOG7BS48W.
PhylomeDBiQ4KMQ2.
TreeFamiTF314265.

Family and domain databases

InterProiIPR007632. Anoctamin.
[Graphical view]
PANTHERiPTHR12308. PTHR12308. 1 hit.
PfamiPF04547. Anoctamin. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q4KMQ2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKKMSRNVLL QMEEEEDDDD GDIVLENLGQ TIVPDLGSLE SQHDFRTPEF
60 70 80 90 100
EEFNGKPDSL FFNDGQRRID FVLVYEDESR KETNKKGTNE KQRRKRQAYE
110 120 130 140 150
SNLICHGLQL EATRSVLDDK LVFVKVHAPW EVLCTYAEIM HIKLPLKPND
160 170 180 190 200
LKNRSSAFGT LNWFTKVLSV DESIIKPEQE FFTAPFEKNR MNDFYIVDRD
210 220 230 240 250
AFFNPATRSR IVYFILSRVK YQVINNVSKF GINRLVNSGI YKAAFPLHDC
260 270 280 290 300
KFRRQSEDPS CPNERYLLYR EWAHPRSIYK KQPLDLIRKY YGEKIGIYFA
310 320 330 340 350
WLGYYTQMLL LAAVVGVACF LYGYLNQDNC TWSKEVCHPD IGGKIIMCPQ
360 370 380 390 400
CDRLCPFWKL NITCESSKKL CIFDSFGTLV FAVFMGVWVT LFLEFWKRRQ
410 420 430 440 450
AELEYEWDTV ELQQEEQARP EYEARCTHVV INEITQEEER IPFTAWGKCI
460 470 480 490 500
RITLCASAVF FWILLIIASV IGIIVYRLSV FIVFSAKLPK NINGTDPIQK
510 520 530 540 550
YLTPQTATSI TASIISFIII MILNTIYEKV AIMITNFELP RTQTDYENSL
560 570 580 590 600
TMKMFLFQFV NYYSSCFYIA FFKGKFVGYP GDPVYWLGKY RNEECDPGGC
610 620 630 640 650
LLELTTQLTI IMGGKAIWNN IQEVLLPWIM NLIGRFHRVS GSEKITPRWE
660 670 680 690 700
QDYHLQPMGK LGLFYEYLEM IIQFGFVTLF VASFPLAPLL ALVNNILEIR
710 720 730 740 750
VDAWKLTTQF RRLVPEKAQD IGAWQPIMQG IAILAVVTNA MIIAFTSDMI
760 770 780 790 800
PRLVYYWSFS VPPYGDHTSY TMEGYINNTL SIFKVADFKN KSKGNPYSDL
810 820 830 840 850
GNHTTCRYRD FRYPPGHPQE YKHNIYYWHV IAAKLAFIIV MEHVIYSVKF
860 870 880 890 900
FISYAIPDVS KRTKSKIQRE KYLTQKLLHE NHLKDMTKNM GVIAERMIEA
910
VDNNLRPKSE
Length:910
Mass (Da):106,165
Last modified:October 17, 2006 - v2
Checksum:i8F7F1CB78FAAEB78
GO
Isoform 2 (identifier: Q4KMQ2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     23-23: I → IGDVPASRRPFLTPHTHLPSSL

Note: No experimental confirmation available.

Show »
Length:931
Mass (Da):108,433
Checksum:i6F0149C7FB67A371
GO
Isoform 3 (identifier: Q4KMQ2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MKKMSRNVLLQMEEEEDDDDGDI → MFCAA

Note: Gene prediction based on EST data.

Show »
Length:892
Mass (Da):103,966
Checksum:i9FC6A98229E57118
GO
Isoform 4 (identifier: Q4KMQ2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     843-910: HVIYSVKFFI...VDNNLRPKSE → YLALLPRLGH...PCFSVSNFLS

Note: Gene prediction based on EST data.

Show »
Length:929
Mass (Da):108,102
Checksum:i5B77123875916E01
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti837 – 8371F → L in AAH98410 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti128 – 1281A → T.
Corresponds to variant rs2162321 [ dbSNP | Ensembl ].
VAR_028109

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2323MKKMS…DDGDI → MFCAA in isoform 3. CuratedVSP_046819Add
BLAST
Alternative sequencei23 – 231I → IGDVPASRRPFLTPHTHLPS SL in isoform 2. 1 PublicationVSP_042893
Alternative sequencei843 – 91068HVIYS…RPKSE → YLALLPRLGHSGMILAHCNL RLPVDCCMCYRFVDEIRLLE QLTSDFIDSLYYIFSISIIS IFFSVTFFFLLLSLGPTPCF SVSNFLS in isoform 4. CuratedVSP_046820Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009248 Genomic DNA. No translation available.
AC009778 Genomic DNA. No translation available.
AC063924 Genomic DNA. No translation available.
BC098410 mRNA. Translation: AAH98410.1.
BC136445 mRNA. Translation: AAI36446.1.
AL833405 mRNA. Translation: CAD38638.1.
CCDSiCCDS31782.1. [Q4KMQ2-1]
CCDS44865.1. [Q4KMQ2-4]
CCDS44866.1. [Q4KMQ2-3]
CCDS55819.1. [Q4KMQ2-2]
RefSeqiNP_001020527.2. NM_001025356.2. [Q4KMQ2-1]
NP_001136150.1. NM_001142678.1. [Q4KMQ2-3]
NP_001136151.1. NM_001142679.1. [Q4KMQ2-4]
NP_001191732.1. NM_001204803.1. [Q4KMQ2-2]
UniGeneiHs.505339.

Genome annotation databases

EnsembliENST00000320560; ENSP00000320087; ENSG00000177119. [Q4KMQ2-1]
ENST00000423947; ENSP00000409126; ENSG00000177119. [Q4KMQ2-2]
ENST00000425752; ENSP00000391417; ENSG00000177119. [Q4KMQ2-4]
ENST00000441606; ENSP00000413137; ENSG00000177119. [Q4KMQ2-3]
GeneIDi196527.
KEGGihsa:196527.
UCSCiuc001roo.3. human. [Q4KMQ2-1]
uc010sld.1. human.
uc010slf.2. human. [Q4KMQ2-2]

Polymorphism and mutation databases

BioMutaiANO6.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009248 Genomic DNA. No translation available.
AC009778 Genomic DNA. No translation available.
AC063924 Genomic DNA. No translation available.
BC098410 mRNA. Translation: AAH98410.1.
BC136445 mRNA. Translation: AAI36446.1.
AL833405 mRNA. Translation: CAD38638.1.
CCDSiCCDS31782.1. [Q4KMQ2-1]
CCDS44865.1. [Q4KMQ2-4]
CCDS44866.1. [Q4KMQ2-3]
CCDS55819.1. [Q4KMQ2-2]
RefSeqiNP_001020527.2. NM_001025356.2. [Q4KMQ2-1]
NP_001136150.1. NM_001142678.1. [Q4KMQ2-3]
NP_001136151.1. NM_001142679.1. [Q4KMQ2-4]
NP_001191732.1. NM_001204803.1. [Q4KMQ2-2]
UniGeneiHs.505339.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128218. 8 interactions.
IntActiQ4KMQ2. 1 interaction.
MINTiMINT-5001391.
STRINGi9606.ENSP00000391417.

Protein family/group databases

TCDBi1.A.17.1.4. the calcium-dependent chloride channel (ca-clc) family.

PTM databases

PhosphoSiteiQ4KMQ2.

Polymorphism and mutation databases

BioMutaiANO6.
DMDMi116242820.

Proteomic databases

MaxQBiQ4KMQ2.
PaxDbiQ4KMQ2.
PRIDEiQ4KMQ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320560; ENSP00000320087; ENSG00000177119. [Q4KMQ2-1]
ENST00000423947; ENSP00000409126; ENSG00000177119. [Q4KMQ2-2]
ENST00000425752; ENSP00000391417; ENSG00000177119. [Q4KMQ2-4]
ENST00000441606; ENSP00000413137; ENSG00000177119. [Q4KMQ2-3]
GeneIDi196527.
KEGGihsa:196527.
UCSCiuc001roo.3. human. [Q4KMQ2-1]
uc010sld.1. human.
uc010slf.2. human. [Q4KMQ2-2]

Organism-specific databases

CTDi196527.
GeneCardsiGC12P045609.
H-InvDBHIX0010565.
HGNCiHGNC:25240. ANO6.
HPAiHPA038958.
MIMi262890. phenotype.
608663. gene.
neXtProtiNX_Q4KMQ2.
Orphaneti806. Scott syndrome.
PharmGKBiPA164715690.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG320103.
GeneTreeiENSGT00760000119015.
HOGENOMiHOG000006509.
HOVERGENiHBG069519.
InParanoidiQ4KMQ2.
OMAiMNDFYIV.
OrthoDBiEOG7BS48W.
PhylomeDBiQ4KMQ2.
TreeFamiTF314265.

Enzyme and pathway databases

ReactomeiREACT_160189. Stimuli-sensing channels.
REACT_268444. Orphan transporters.

Miscellaneous databases

ChiTaRSiANO6. human.
GenomeRNAii196527.
NextBioi89521.
PROiQ4KMQ2.
SOURCEiSearch...

Gene expression databases

BgeeiQ4KMQ2.
CleanExiHS_ANO6.
ExpressionAtlasiQ4KMQ2. baseline and differential.
GenevestigatoriQ4KMQ2.

Family and domain databases

InterProiIPR007632. Anoctamin.
[Graphical view]
PANTHERiPTHR12308. PTHR12308. 1 hit.
PfamiPF04547. Anoctamin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Placenta and Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 772-910 (ISOFORM 1/2).
    Tissue: Adipose tissue.
  4. "Identification and characterization of TMEM16E and TMEM16F genes in silico."
    Katoh M., Katoh M.
    Int. J. Oncol. 24:1345-1349(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  5. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-493.
    Tissue: Liver.
  6. Cited for: FUNCTION, SUBCELLULAR LOCATION.
  7. "Calcium-dependent phospholipid scrambling by TMEM16F."
    Suzuki J., Umeda M., Sims P.J., Nagata S.
    Nature 468:834-838(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INVOLVEMENT IN SCOTT SYNDROME.
  8. "Physiological roles and diseases of Tmem16/Anoctamin proteins: are they all chloride channels?"
    Duran C., Hartzell H.C.
    Acta Pharmacol. Sin. 32:685-692(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  9. Cited for: REVIEW.
  10. "Anoctamin 6 is an essential component of the outwardly rectifying chloride channel."
    Martins J.R., Faria D., Kongsuphol P., Reisch B., Schreiber R., Kunzelmann K.
    Proc. Natl. Acad. Sci. U.S.A. 108:18168-18172(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  11. "ANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are intracellular proteins."
    Duran C., Qu Z., Osunkoya A.O., Cui Y., Hartzell H.C.
    Am. J. Physiol. 302:C482-C493(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  12. "The anoctamin (TMEM16) gene family: calcium-activated chloride channels come of age."
    Winpenny J.P., Gray M.A.
    Exp. Physiol. 97:175-176(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  13. "The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels."
    Scudieri P., Sondo E., Ferrera L., Galietta L.J.
    Exp. Physiol. 97:177-183(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW, ABSENCE OF CALCIUM-ACTIVATED CHLORIDE CHANNEL ACTIVITY.
  14. Cited for: REVIEW, FUNCTION.
  15. "Anoctamins are a family of Ca2+ activated Cl- channels."
    Tian Y., Schreiber R., Kunzelmann K.
    J. Cell Sci. 125:4991-4998(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiANO6_HUMAN
AccessioniPrimary (citable) accession number: Q4KMQ2
Secondary accession number(s): A6NNM6
, B9EGG0, E7ENK4, E9PB30, E9PCT2, Q8N3Q2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: October 17, 2006
Last modified: April 29, 2015
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.