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Reviewed, UniProtKB/Swiss-Prot Q4KMQ2 (ANO6_HUMAN)

Last modified November 24, 2009. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Anoctamin-6
Alternative name(s):
    Transmembrane protein 16F
Gene names
Name: ANO6
Synonyms: TMEM16F
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length910 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

May act as a calcium-activated chloride channel.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Tissue specificity

Expressed in embryonic stem cell, fetal liver, retina, chronic myologenous leukemia and intestinal cancer. Ref.4

Sequence similarities

Belongs to the anoctamin family.

Ontologies

Keywords
   Biological processIon transport
Transport
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
   LigandCalcium
Chloride
   Molecular functionChloride channel
Ionic channel
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological procession transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentchloride channel complex

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functioncalcium ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

chloride channel activity

Inferred from electronic annotation. Source: UniProtKB-KW

chloride ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 910910Anoctamin-6
PRO_0000191757

Regions

Topological domain1 – 294294Cytoplasmic Potential
Transmembrane295 – 31521 Potential
Topological domain316 – 37560Extracellular Potential
Transmembrane376 – 39621 Potential
Topological domain397 – 45458Cytoplasmic Potential
Transmembrane455 – 47521 Potential
Topological domain476 – 51338Extracellular Potential
Transmembrane514 – 53421 Potential
Topological domain535 – 55117Cytoplasmic Potential
Transmembrane552 – 57221 Potential
Topological domain573 – 66997Extracellular Potential
Transmembrane670 – 69021 Potential
Topological domain691 – 72535Cytoplasmic Potential
Transmembrane726 – 74621 Potential
Topological domain747 – 82478Extracellular Potential
Transmembrane825 – 84521 Potential
Topological domain846 – 91065Cytoplasmic Potential

Amino acid modifications

Glycosylation3291N-linked (GlcNAc...) Potential
Glycosylation3611N-linked (GlcNAc...) Potential
Glycosylation4931N-linked (GlcNAc...) Ref.6
Glycosylation7771N-linked (GlcNAc...) Potential
Glycosylation7901N-linked (GlcNAc...) Potential
Glycosylation8021N-linked (GlcNAc...) Potential

Natural variations

Natural variant1281A → T: dbSNP rs2162321.
VAR_028109

Experimental info

Sequence conflict8371F → L in AAH98410. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q4KMQ2-1 [UniParc].

Last modified October 17, 2006. Version 2.
Checksum: 8F7F1CB78FAAEB78

FASTA910106,165
        10         20         30         40         50         60 
MKKMSRNVLL QMEEEEDDDD GDIVLENLGQ TIVPDLGSLE SQHDFRTPEF EEFNGKPDSL 

        70         80         90        100        110        120 
FFNDGQRRID FVLVYEDESR KETNKKGTNE KQRRKRQAYE SNLICHGLQL EATRSVLDDK 

       130        140        150        160        170        180 
LVFVKVHAPW EVLCTYAEIM HIKLPLKPND LKNRSSAFGT LNWFTKVLSV DESIIKPEQE 

       190        200        210        220        230        240 
FFTAPFEKNR MNDFYIVDRD AFFNPATRSR IVYFILSRVK YQVINNVSKF GINRLVNSGI 

       250        260        270        280        290        300 
YKAAFPLHDC KFRRQSEDPS CPNERYLLYR EWAHPRSIYK KQPLDLIRKY YGEKIGIYFA 

       310        320        330        340        350        360 
WLGYYTQMLL LAAVVGVACF LYGYLNQDNC TWSKEVCHPD IGGKIIMCPQ CDRLCPFWKL 

       370        380        390        400        410        420 
NITCESSKKL CIFDSFGTLV FAVFMGVWVT LFLEFWKRRQ AELEYEWDTV ELQQEEQARP 

       430        440        450        460        470        480 
EYEARCTHVV INEITQEEER IPFTAWGKCI RITLCASAVF FWILLIIASV IGIIVYRLSV 

       490        500        510        520        530        540 
FIVFSAKLPK NINGTDPIQK YLTPQTATSI TASIISFIII MILNTIYEKV AIMITNFELP 

       550        560        570        580        590        600 
RTQTDYENSL TMKMFLFQFV NYYSSCFYIA FFKGKFVGYP GDPVYWLGKY RNEECDPGGC 

       610        620        630        640        650        660 
LLELTTQLTI IMGGKAIWNN IQEVLLPWIM NLIGRFHRVS GSEKITPRWE QDYHLQPMGK 

       670        680        690        700        710        720 
LGLFYEYLEM IIQFGFVTLF VASFPLAPLL ALVNNILEIR VDAWKLTTQF RRLVPEKAQD 

       730        740        750        760        770        780 
IGAWQPIMQG IAILAVVTNA MIIAFTSDMI PRLVYYWSFS VPPYGDHTSY TMEGYINNTL 

       790        800        810        820        830        840 
SIFKVADFKN KSKGNPYSDL GNHTTCRYRD FRYPPGHPQE YKHNIYYWHV IAAKLAFIIV 

       850        860        870        880        890        900 
MEHVIYSVKF FISYAIPDVS KRTKSKIQRE KYLTQKLLHE NHLKDMTKNM GVIAERMIEA 

       910 
VDNNLRPKSE 

« Hide

References

« Hide 'large scale' references
[1]"The finished DNA sequence of human chromosome 12."
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. expand/collapse author list , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
Nature 440:346-351(2006) [PubMed: 16541075] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 772-910.
Tissue: Adipose tissue.
[4]"Identification and characterization of TMEM16E and TMEM16F genes in silico."
Katoh M., Katoh M.
Int. J. Oncol. 24:1345-1349(2004) [PubMed: 15067359] [Abstract]
Cited for: TISSUE SPECIFICITY.
[5]"TMEM16A confers receptor-activated calcium-dependent chloride conductance."
Yang Y.D., Cho H., Koo J.Y., Tak M.H., Cho Y., Shim W.-S., Park S.P., Lee J., Lee B., Kim B.-M., Raouf R., Shin Y.K., Oh U.
Nature 455:1210-1215(2008) [PubMed: 18724360] [Abstract]
Cited for: IDENTIFICATION AS PUTATIVE CHLORIDE CHANNEL.
[6]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed: 19159218] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-493, MASS SPECTROMETRY.
Tissue: Liver.

Cross-references

Sequence databases

AC009248 Genomic DNA. No translation available.
BC098410 mRNA. Translation: AAH98410.1.
AL833405 mRNA. Translation: CAD38638.1.
IPIIPI00151710.
RefSeqNP_001020527.2.
NP_001136150.1.
NP_001136151.1.
NP_001136152.1.
UniGeneHs.696326

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ4KMQ2.

PTM databases

PhosphoSiteQ4KMQ2.

Proteomic databases

PRIDEQ4KMQ2.

Genome annotation databases

EnsemblENST00000320560; ENSP00000320087; ENSG00000177119; Homo sapiens. [Genome view]
GeneID196527.
KEGGhsa:196527.
UCSCuc001roo.1. human.

Organism-specific databases

CTD196527.
GeneCardsGC12P043897.
HGNCHGNC:25240. ANO6.
MIM608663. gene.
PharmGKBPA134912608.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ4KMQ2.
HOVERGENQ4KMQ2.

Gene expression databases

ArrayExpressQ4KMQ2.
BgeeQ4KMQ2.
CleanExHS_ANO6.
GenevestigatorQ4KMQ2.

Family and domain databases

InterProIPR007632. DUF590.
[Graphical view]
PANTHERPTHR12308. DUF590. 1 hit.
PfamPF04547. DUF590. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio89521.
SOURCESearch...

Entry information

Entry nameANO6_HUMAN
AccessionPrimary (citable) accession number: Q4KMQ2
Secondary accession number(s): A6NNM6, Q8N3Q2
Entry history
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: October 17, 2006
Last modified: November 24, 2009
This is version 43 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents