SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q4KMQ2

- ANO6_HUMAN

UniProt

Q4KMQ2 - ANO6_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Anoctamin-6

Gene
ANO6, TMEM16F
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes.5 Publications

Enzyme regulationi

Exhibits synergistic gating by Ca2+ and voltage. Inhibited by some non-specific cation channel blockers such as: ruthenium red, 2-aminoethyl diphenylborinate (2APB), gadolinium and cadmium ions By similarity.

GO - Molecular functioni

  1. calcium activated cation channel activity Source: UniProtKB
  2. intracellular calcium activated chloride channel activity Source: UniProt
  3. voltage-gated chloride channel activity Source: UniProt
  4. voltage-gated ion channel activity Source: UniProtKB

GO - Biological processi

  1. activation of blood coagulation via clotting cascade Source: UniProtKB
  2. blood coagulation Source: UniProtKB
  3. cation transport Source: UniProt
  4. chloride transmembrane transport Source: GOC
  5. chloride transport Source: UniProt
  6. ion transmembrane transport Source: Reactome
  7. phosphatidylserine exposure on blood platelet Source: UniProtKB
  8. phospholipid scrambling Source: UniProtKB
  9. positive regulation of endothelial cell apoptotic process Source: UniProt
  10. regulation of anion transport Source: GOC
  11. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Enzyme and pathway databases

ReactomeiREACT_160189. Stimuli-sensing channels.

Protein family/group databases

TCDBi1.A.17.1.4. the calcium-dependent chloride channel (ca-clc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Anoctamin-6
Alternative name(s):
Small-conductance calcium-activated nonselective cation channel
Short name:
SCAN channel
Transmembrane protein 16F
Gene namesi
Name:ANO6
Synonyms:TMEM16F
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:25240. ANO6.

Subcellular locationi

Cell membrane; Multi-pass membrane protein
Note: Shows an intracellular localization according to 1 Publication.4 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 294294Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei295 – 31521Helical; Reviewed predictionAdd
BLAST
Topological domaini316 – 37560Extracellular Reviewed predictionAdd
BLAST
Transmembranei376 – 39621Helical; Reviewed predictionAdd
BLAST
Topological domaini397 – 45458Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei455 – 47521Helical; Reviewed predictionAdd
BLAST
Topological domaini476 – 51338Extracellular Reviewed predictionAdd
BLAST
Transmembranei514 – 53421Helical; Reviewed predictionAdd
BLAST
Topological domaini535 – 55117Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei552 – 57221Helical; Reviewed predictionAdd
BLAST
Topological domaini573 – 66997Extracellular Reviewed predictionAdd
BLAST
Transmembranei670 – 69021Helical; Reviewed predictionAdd
BLAST
Topological domaini691 – 72535Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei726 – 74621Helical; Reviewed predictionAdd
BLAST
Topological domaini747 – 82478Extracellular Reviewed predictionAdd
BLAST
Transmembranei825 – 84521Helical; Reviewed predictionAdd
BLAST
Topological domaini846 – 91065Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. chloride channel complex Source: UniProt
  2. extracellular vesicular exosome Source: UniProt
  3. intracellular Source: UniProtKB
  4. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Scott syndrome (SCTS) [MIM:262890]: A mild bleeding disorder due to impaired surface exposure of procoagulant phosphatidylserine (PS) on platelets and other blood cells, following activation with Ca(2+)-elevating agents.
Note: The disease is caused by mutations affecting the gene represented in this entry.

Organism-specific databases

MIMi262890. phenotype.
Orphaneti806. Scott syndrome.
PharmGKBiPA164715690.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 910910Anoctamin-6PRO_0000191757Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi329 – 3291N-linked (GlcNAc...) Reviewed prediction
Glycosylationi361 – 3611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi493 – 4931N-linked (GlcNAc...)1 Publication
Glycosylationi777 – 7771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi790 – 7901N-linked (GlcNAc...) Reviewed prediction
Glycosylationi802 – 8021N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ4KMQ2.
PaxDbiQ4KMQ2.
PRIDEiQ4KMQ2.

PTM databases

PhosphoSiteiQ4KMQ2.

Expressioni

Tissue specificityi

Expressed in embryonic stem cell, fetal liver, retina, chronic myologenous leukemia and intestinal cancer.1 Publication

Gene expression databases

ArrayExpressiQ4KMQ2.
BgeeiQ4KMQ2.
CleanExiHS_ANO6.
GenevestigatoriQ4KMQ2.

Organism-specific databases

HPAiHPA038958.

Interactioni

Protein-protein interaction databases

BioGridi128218. 2 interactions.
IntActiQ4KMQ2. 1 interaction.
MINTiMINT-5001391.
STRINGi9606.ENSP00000391417.

Structurei

3D structure databases

ProteinModelPortaliQ4KMQ2.

Family & Domainsi

Sequence similaritiesi

Belongs to the anoctamin family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG320103.
HOGENOMiHOG000006509.
HOVERGENiHBG069519.
InParanoidiQ4KMQ2.
OMAiQDYHLQP.
OrthoDBiEOG7BS48W.
PhylomeDBiQ4KMQ2.
TreeFamiTF314265.

Family and domain databases

InterProiIPR007632. Anoctamin.
[Graphical view]
PANTHERiPTHR12308. PTHR12308. 1 hit.
PfamiPF04547. Anoctamin. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q4KMQ2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MKKMSRNVLL QMEEEEDDDD GDIVLENLGQ TIVPDLGSLE SQHDFRTPEF    50
EEFNGKPDSL FFNDGQRRID FVLVYEDESR KETNKKGTNE KQRRKRQAYE 100
SNLICHGLQL EATRSVLDDK LVFVKVHAPW EVLCTYAEIM HIKLPLKPND 150
LKNRSSAFGT LNWFTKVLSV DESIIKPEQE FFTAPFEKNR MNDFYIVDRD 200
AFFNPATRSR IVYFILSRVK YQVINNVSKF GINRLVNSGI YKAAFPLHDC 250
KFRRQSEDPS CPNERYLLYR EWAHPRSIYK KQPLDLIRKY YGEKIGIYFA 300
WLGYYTQMLL LAAVVGVACF LYGYLNQDNC TWSKEVCHPD IGGKIIMCPQ 350
CDRLCPFWKL NITCESSKKL CIFDSFGTLV FAVFMGVWVT LFLEFWKRRQ 400
AELEYEWDTV ELQQEEQARP EYEARCTHVV INEITQEEER IPFTAWGKCI 450
RITLCASAVF FWILLIIASV IGIIVYRLSV FIVFSAKLPK NINGTDPIQK 500
YLTPQTATSI TASIISFIII MILNTIYEKV AIMITNFELP RTQTDYENSL 550
TMKMFLFQFV NYYSSCFYIA FFKGKFVGYP GDPVYWLGKY RNEECDPGGC 600
LLELTTQLTI IMGGKAIWNN IQEVLLPWIM NLIGRFHRVS GSEKITPRWE 650
QDYHLQPMGK LGLFYEYLEM IIQFGFVTLF VASFPLAPLL ALVNNILEIR 700
VDAWKLTTQF RRLVPEKAQD IGAWQPIMQG IAILAVVTNA MIIAFTSDMI 750
PRLVYYWSFS VPPYGDHTSY TMEGYINNTL SIFKVADFKN KSKGNPYSDL 800
GNHTTCRYRD FRYPPGHPQE YKHNIYYWHV IAAKLAFIIV MEHVIYSVKF 850
FISYAIPDVS KRTKSKIQRE KYLTQKLLHE NHLKDMTKNM GVIAERMIEA 900
VDNNLRPKSE 910
Length:910
Mass (Da):106,165
Last modified:October 17, 2006 - v2
Checksum:i8F7F1CB78FAAEB78
GO
Isoform 2 (identifier: Q4KMQ2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     23-23: I → IGDVPASRRPFLTPHTHLPSSL

Note: No experimental confirmation available.

Show »
Length:931
Mass (Da):108,433
Checksum:i6F0149C7FB67A371
GO
Isoform 3 (identifier: Q4KMQ2-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MKKMSRNVLLQMEEEEDDDDGDI → MFCAA

Note: Gene prediction based on EST data.

Show »
Length:892
Mass (Da):103,966
Checksum:i9FC6A98229E57118
GO
Isoform 4 (identifier: Q4KMQ2-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     843-910: HVIYSVKFFI...VDNNLRPKSE → YLALLPRLGH...PCFSVSNFLS

Note: Gene prediction based on EST data.

Show »
Length:929
Mass (Da):108,102
Checksum:i5B77123875916E01
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti128 – 1281A → T.
Corresponds to variant rs2162321 [ dbSNP | Ensembl ].
VAR_028109

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2323MKKMS…DDGDI → MFCAA in isoform 3. VSP_046819Add
BLAST
Alternative sequencei23 – 231I → IGDVPASRRPFLTPHTHLPS SL in isoform 2. VSP_042893
Alternative sequencei843 – 91068HVIYS…RPKSE → YLALLPRLGHSGMILAHCNL RLPVDCCMCYRFVDEIRLLE QLTSDFIDSLYYIFSISIIS IFFSVTFFFLLLSLGPTPCF SVSNFLS in isoform 4. VSP_046820Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti837 – 8371F → L in AAH98410. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC009248 Genomic DNA. No translation available.
AC009778 Genomic DNA. No translation available.
AC063924 Genomic DNA. No translation available.
BC098410 mRNA. Translation: AAH98410.1.
BC136445 mRNA. Translation: AAI36446.1.
AL833405 mRNA. Translation: CAD38638.1.
CCDSiCCDS31782.1. [Q4KMQ2-1]
CCDS44865.1. [Q4KMQ2-4]
CCDS44866.1. [Q4KMQ2-3]
CCDS55819.1. [Q4KMQ2-2]
RefSeqiNP_001020527.2. NM_001025356.2. [Q4KMQ2-1]
NP_001136150.1. NM_001142678.1. [Q4KMQ2-3]
NP_001136151.1. NM_001142679.1. [Q4KMQ2-4]
NP_001191732.1. NM_001204803.1. [Q4KMQ2-2]
UniGeneiHs.505339.

Genome annotation databases

EnsembliENST00000320560; ENSP00000320087; ENSG00000177119. [Q4KMQ2-1]
ENST00000423947; ENSP00000409126; ENSG00000177119. [Q4KMQ2-2]
ENST00000425752; ENSP00000391417; ENSG00000177119. [Q4KMQ2-4]
ENST00000435642; ENSP00000413840; ENSG00000177119. [Q4KMQ2-4]
ENST00000441606; ENSP00000413137; ENSG00000177119. [Q4KMQ2-3]
GeneIDi196527.
KEGGihsa:196527.
UCSCiuc001roo.3. human. [Q4KMQ2-1]
uc010slf.2. human. [Q4KMQ2-2]

Polymorphism databases

DMDMi116242820.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC009248 Genomic DNA. No translation available.
AC009778 Genomic DNA. No translation available.
AC063924 Genomic DNA. No translation available.
BC098410 mRNA. Translation: AAH98410.1 .
BC136445 mRNA. Translation: AAI36446.1 .
AL833405 mRNA. Translation: CAD38638.1 .
CCDSi CCDS31782.1. [Q4KMQ2-1 ]
CCDS44865.1. [Q4KMQ2-4 ]
CCDS44866.1. [Q4KMQ2-3 ]
CCDS55819.1. [Q4KMQ2-2 ]
RefSeqi NP_001020527.2. NM_001025356.2. [Q4KMQ2-1 ]
NP_001136150.1. NM_001142678.1. [Q4KMQ2-3 ]
NP_001136151.1. NM_001142679.1. [Q4KMQ2-4 ]
NP_001191732.1. NM_001204803.1. [Q4KMQ2-2 ]
UniGenei Hs.505339.

3D structure databases

ProteinModelPortali Q4KMQ2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 128218. 2 interactions.
IntActi Q4KMQ2. 1 interaction.
MINTi MINT-5001391.
STRINGi 9606.ENSP00000391417.

Protein family/group databases

TCDBi 1.A.17.1.4. the calcium-dependent chloride channel (ca-clc) family.

PTM databases

PhosphoSitei Q4KMQ2.

Polymorphism databases

DMDMi 116242820.

Proteomic databases

MaxQBi Q4KMQ2.
PaxDbi Q4KMQ2.
PRIDEi Q4KMQ2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000320560 ; ENSP00000320087 ; ENSG00000177119 . [Q4KMQ2-1 ]
ENST00000423947 ; ENSP00000409126 ; ENSG00000177119 . [Q4KMQ2-2 ]
ENST00000425752 ; ENSP00000391417 ; ENSG00000177119 . [Q4KMQ2-4 ]
ENST00000435642 ; ENSP00000413840 ; ENSG00000177119 . [Q4KMQ2-4 ]
ENST00000441606 ; ENSP00000413137 ; ENSG00000177119 . [Q4KMQ2-3 ]
GeneIDi 196527.
KEGGi hsa:196527.
UCSCi uc001roo.3. human. [Q4KMQ2-1 ]
uc010slf.2. human. [Q4KMQ2-2 ]

Organism-specific databases

CTDi 196527.
GeneCardsi GC12P045609.
H-InvDB HIX0010565.
HGNCi HGNC:25240. ANO6.
HPAi HPA038958.
MIMi 262890. phenotype.
608663. gene.
neXtProti NX_Q4KMQ2.
Orphaneti 806. Scott syndrome.
PharmGKBi PA164715690.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG320103.
HOGENOMi HOG000006509.
HOVERGENi HBG069519.
InParanoidi Q4KMQ2.
OMAi QDYHLQP.
OrthoDBi EOG7BS48W.
PhylomeDBi Q4KMQ2.
TreeFami TF314265.

Enzyme and pathway databases

Reactomei REACT_160189. Stimuli-sensing channels.

Miscellaneous databases

ChiTaRSi ANO6. human.
GenomeRNAii 196527.
NextBioi 89521.
PROi Q4KMQ2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q4KMQ2.
Bgeei Q4KMQ2.
CleanExi HS_ANO6.
Genevestigatori Q4KMQ2.

Family and domain databases

InterProi IPR007632. Anoctamin.
[Graphical view ]
PANTHERi PTHR12308. PTHR12308. 1 hit.
Pfami PF04547. Anoctamin. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Placenta and Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 772-910 (ISOFORM 1/2).
    Tissue: Adipose tissue.
  4. "Identification and characterization of TMEM16E and TMEM16F genes in silico."
    Katoh M., Katoh M.
    Int. J. Oncol. 24:1345-1349(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  5. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-493.
    Tissue: Liver.
  6. Cited for: FUNCTION, SUBCELLULAR LOCATION.
  7. "Calcium-dependent phospholipid scrambling by TMEM16F."
    Suzuki J., Umeda M., Sims P.J., Nagata S.
    Nature 468:834-838(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INVOLVEMENT IN SCOTT SYNDROME.
  8. "Physiological roles and diseases of Tmem16/Anoctamin proteins: are they all chloride channels?"
    Duran C., Hartzell H.C.
    Acta Pharmacol. Sin. 32:685-692(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  9. Cited for: REVIEW.
  10. "Anoctamin 6 is an essential component of the outwardly rectifying chloride channel."
    Martins J.R., Faria D., Kongsuphol P., Reisch B., Schreiber R., Kunzelmann K.
    Proc. Natl. Acad. Sci. U.S.A. 108:18168-18172(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  11. "ANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are intracellular proteins."
    Duran C., Qu Z., Osunkoya A.O., Cui Y., Hartzell H.C.
    Am. J. Physiol. 302:C482-C493(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  12. "The anoctamin (TMEM16) gene family: calcium-activated chloride channels come of age."
    Winpenny J.P., Gray M.A.
    Exp. Physiol. 97:175-176(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  13. "The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels."
    Scudieri P., Sondo E., Ferrera L., Galietta L.J.
    Exp. Physiol. 97:177-183(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW, ABSENCE OF CALCIUM-ACTIVATED CHLORIDE CHANNEL ACTIVITY.
  14. Cited for: REVIEW, FUNCTION.
  15. "Anoctamins are a family of Ca2+ activated Cl- channels."
    Tian Y., Schreiber R., Kunzelmann K.
    J. Cell Sci. 125:4991-4998(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiANO6_HUMAN
AccessioniPrimary (citable) accession number: Q4KMQ2
Secondary accession number(s): A6NNM6
, B9EGG0, E7ENK4, E9PB30, E9PCT2, Q8N3Q2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: October 17, 2006
Last modified: September 3, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi