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Protein

TBC1 domain family member 10B

Gene

TBC1D10B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as GTPase-activating protein for RAB3A, RAB22A, RAB27A, AND RAB35. Does not act on RAB2A and RAB6A.2 Publications

GO - Molecular functioni

  • GTPase activator activity Source: UniProtKB
  • Rab GTPase binding Source: GO_Central

GO - Biological processi

  • activation of GTPase activity Source: GO_Central
  • intracellular protein transport Source: GO_Central
  • regulation of GTPase activity Source: UniProtKB
  • regulation of vesicle fusion Source: GO_Central
  • retrograde transport, endosome to Golgi Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
TBC1 domain family member 10B
Alternative name(s):
Rab27A-GAP-beta
Gene namesi
ORF Names:FP2461
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:24510. TBC1D10B.

Subcellular locationi

  • Cytoplasm 1 Publication

  • Note: In melanocytes, located at the periphery of cells.

GO - Cellular componenti

  • cytosol Source: GOC
  • endomembrane system Source: GO_Central
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi409 – 4091R → L: Loss of GAP activity. 1 Publication

Organism-specific databases

PharmGKBiPA142670835.

Polymorphism and mutation databases

BioMutaiTBC1D10B.
DMDMi294862492.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 808808TBC1 domain family member 10BPRO_0000315716Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei22 – 221PhosphoserineCombined sources
Modified residuei141 – 1411PhosphoserineBy similarity
Modified residuei152 – 1521PhosphothreonineBy similarity
Modified residuei658 – 6581PhosphoserineCombined sources
Modified residuei661 – 6611PhosphoserineCombined sources
Modified residuei678 – 6781PhosphoserineCombined sources
Modified residuei687 – 6871PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ4KMP7.
MaxQBiQ4KMP7.
PaxDbiQ4KMP7.
PeptideAtlasiQ4KMP7.
PRIDEiQ4KMP7.

PTM databases

iPTMnetiQ4KMP7.
PhosphoSiteiQ4KMP7.

Expressioni

Gene expression databases

BgeeiQ4KMP7.
CleanExiHS_TBC1D10B.
ExpressionAtlasiQ4KMP7. baseline and differential.
GenevisibleiQ4KMP7. HS.

Organism-specific databases

HPAiHPA048894.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117476. 10 interactions.
IntActiQ4KMP7. 3 interactions.
STRINGi9606.ENSP00000386538.

Structurei

3D structure databases

ProteinModelPortaliQ4KMP7.
SMRiQ4KMP7. Positions 326-561.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini360 – 548189Rab-GAP TBCPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili716 – 78267Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi7 – 175169Pro-richAdd
BLAST
Compositional biasi677 – 6826Poly-Pro

Sequence similaritiesi

Contains 1 Rab-GAP TBC domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2221. Eukaryota.
ENOG410XPSR. LUCA.
GeneTreeiENSGT00760000119202.
HOVERGENiHBG070028.
InParanoidiQ4KMP7.
KOiK19944.
OMAiTGPSGTC.
OrthoDBiEOG7RJPR8.
PhylomeDBiQ4KMP7.
TreeFamiTF313293.

Family and domain databases

InterProiIPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
PROSITEiPS50086. TBC_RABGAP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q4KMP7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
METGTAPLVA PPRRHGAPAA PSPPPRGSRA GPVVVVAPGP PVTTATSAPV
60 70 80 90 100
TLVAPGEARP AWVPGSAETS APAPAPAPAP APAVTGSTVV VLTLEASPEA
110 120 130 140 150
PKPQLPSGPE SPEPAAVAGV ETSRALAAGA DSPKTEEARP SPAPGPGTPT
160 170 180 190 200
GTPTRTPSRT APGALTAKPP LAPKPGTTVA SGVTARSASG QVTGGHGAAA
210 220 230 240 250
ATSASAGQAP EDPSGPGTGP SGTCEAPVAV VTVTPAPEPA ENSQDLGSTS
260 270 280 290 300
SLGPGISGPR GQAPDTLSYL DSVSLMSGTL ESLADDVSSM GSDSEINGLA
310 320 330 340 350
LRKTDKYGFL GGSQYSGSLE SSIPVDVARQ RELKWLDMFS NWDKWLSRRF
360 370 380 390 400
QKVKLRCRKG IPSSLRAKAW QYLSNSKELL EQNPGKFEEL ERAPGDPKWL
410 420 430 440 450
DVIEKDLHRQ FPFHEMFAAR GGHGQQDLYR ILKAYTIYRP DEGYCQAQAP
460 470 480 490 500
VAAVLLMHMP AEQAFWCLVQ ICDKYLPGYY SAGLEAIQLD GEIFFALLRR
510 520 530 540 550
ASPLAHRHLR RQRIDPVLYM TEWFMCIFAR TLPWASVLRV WDMFFCEGVK
560 570 580 590 600
IIFRVALVLL RHTLGSVEKL RSCQGMYETM EQLRNLPQQC MQEDFLVHEV
610 620 630 640 650
TNLPVTEALI ERENAAQLKK WRETRGELQY RPSRRLHGSR AIHEERRRQQ
660 670 680 690 700
PPLGPSSSLL SLPGLKSRGS RAAGGAPSPP PPVRRASAGP APGPVVTAEG
710 720 730 740 750
LHPSLPSPTG NSTPLGSSKE TRKQEKERQK QEKERQKQEK EREKERQKQE
760 770 780 790 800
KEREKQEKER EKQEKERQKQ EKKAQGRKLS LRRKADGPPG PHDGGDRPSA

EARQDAYF
Note: No experimental confirmation available. Gene prediction based on similarity to mouse ortholog.
Length:808
Mass (Da):87,199
Last modified:April 20, 2010 - v3
Checksum:i50D8884B8E3BBFBE
GO
Isoform 2 (identifier: Q4KMP7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-575: Missing.

Note: No experimental confirmation available.
Show »
Length:233
Mass (Da):26,577
Checksum:i7EF7FD363D887C28
GO

Sequence cautioni

The sequence AAH50523.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH63112.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH72453.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH93814.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH93816.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH98419.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAQ15206.1 differs from that shown. Reason: Frameshift at positions 154, 379 and 401. Curated
The sequence BAA92086.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB14454.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAH16638.1 differs from that shown.Probable cloning artifact.Curated
The sequence EAW52256.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti187 – 1871S → G in AAH50523 (PubMed:15489334).Curated
Sequence conflicti350 – 3501F → L in AAQ15206 (PubMed:15498874).Curated
Sequence conflicti669 – 6691G → D in BAH16638 (PubMed:19077034).Curated
Sequence conflicti690 – 6901P → S in BAH16638 (PubMed:19077034).Curated
Sequence conflicti761 – 7611E → G in AAH50523 (PubMed:15489334).Curated
Sequence conflicti761 – 7611E → G in AAH63112 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 575575Missing in isoform 2. 1 PublicationVSP_030670Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL117408 mRNA. Translation: CAB55908.1.
AC106782 Genomic DNA. No translation available.
CH471192 Genomic DNA. Translation: EAW52256.1. Sequence problems.
AK002101 mRNA. Translation: BAA92086.1. Different initiation.
AK023192 mRNA. Translation: BAB14454.1. Different initiation.
BC050523 mRNA. Translation: AAH50523.2. Different initiation.
BC063112 mRNA. Translation: AAH63112.1. Different initiation.
BC072453 mRNA. Translation: AAH72453.2. Different initiation.
BC093814 mRNA. Translation: AAH93814.1. Different initiation.
BC093816 mRNA. Translation: AAH93816.1. Different initiation.
BC098419 mRNA. Translation: AAH98419.1. Different initiation.
AB449895 mRNA. Translation: BAH16638.1. Sequence problems.
AF370370 mRNA. Translation: AAQ15206.1. Frameshift.
CCDSiCCDS10676.2. [Q4KMP7-1]
PIRiT17218.
RefSeqiNP_056342.3. NM_015527.3. [Q4KMP7-1]
UniGeneiHs.632182.

Genome annotation databases

EnsembliENST00000409939; ENSP00000386538; ENSG00000169221. [Q4KMP7-1]
GeneIDi26000.
KEGGihsa:26000.
UCSCiuc002dxu.3. human. [Q4KMP7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL117408 mRNA. Translation: CAB55908.1.
AC106782 Genomic DNA. No translation available.
CH471192 Genomic DNA. Translation: EAW52256.1. Sequence problems.
AK002101 mRNA. Translation: BAA92086.1. Different initiation.
AK023192 mRNA. Translation: BAB14454.1. Different initiation.
BC050523 mRNA. Translation: AAH50523.2. Different initiation.
BC063112 mRNA. Translation: AAH63112.1. Different initiation.
BC072453 mRNA. Translation: AAH72453.2. Different initiation.
BC093814 mRNA. Translation: AAH93814.1. Different initiation.
BC093816 mRNA. Translation: AAH93816.1. Different initiation.
BC098419 mRNA. Translation: AAH98419.1. Different initiation.
AB449895 mRNA. Translation: BAH16638.1. Sequence problems.
AF370370 mRNA. Translation: AAQ15206.1. Frameshift.
CCDSiCCDS10676.2. [Q4KMP7-1]
PIRiT17218.
RefSeqiNP_056342.3. NM_015527.3. [Q4KMP7-1]
UniGeneiHs.632182.

3D structure databases

ProteinModelPortaliQ4KMP7.
SMRiQ4KMP7. Positions 326-561.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117476. 10 interactions.
IntActiQ4KMP7. 3 interactions.
STRINGi9606.ENSP00000386538.

PTM databases

iPTMnetiQ4KMP7.
PhosphoSiteiQ4KMP7.

Polymorphism and mutation databases

BioMutaiTBC1D10B.
DMDMi294862492.

Proteomic databases

EPDiQ4KMP7.
MaxQBiQ4KMP7.
PaxDbiQ4KMP7.
PeptideAtlasiQ4KMP7.
PRIDEiQ4KMP7.

Protocols and materials databases

DNASUi26000.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000409939; ENSP00000386538; ENSG00000169221. [Q4KMP7-1]
GeneIDi26000.
KEGGihsa:26000.
UCSCiuc002dxu.3. human. [Q4KMP7-1]

Organism-specific databases

CTDi26000.
GeneCardsiTBC1D10B.
H-InvDBHIX0012950.
HGNCiHGNC:24510. TBC1D10B.
HPAiHPA048894.
MIMi613620. gene.
neXtProtiNX_Q4KMP7.
PharmGKBiPA142670835.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2221. Eukaryota.
ENOG410XPSR. LUCA.
GeneTreeiENSGT00760000119202.
HOVERGENiHBG070028.
InParanoidiQ4KMP7.
KOiK19944.
OMAiTGPSGTC.
OrthoDBiEOG7RJPR8.
PhylomeDBiQ4KMP7.
TreeFamiTF313293.

Miscellaneous databases

ChiTaRSiTBC1D10B. human.
GenomeRNAii26000.
PROiQ4KMP7.
SOURCEiSearch...

Gene expression databases

BgeeiQ4KMP7.
CleanExiHS_TBC1D10B.
ExpressionAtlasiQ4KMP7. baseline and differential.
GenevisibleiQ4KMP7. HS.

Family and domain databases

InterProiIPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
PROSITEiPS50086. TBC_RABGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  2. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta and Teratocarcinoma.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain, Ovary, PNS and Uterus.
  6. "Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity."
    Ishibashi K., Kanno E., Itoh T., Fukuda M.
    Genes Cells 14:41-52(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 170-808, FUNCTION, MUTAGENESIS OF ARG-409.
    Tissue: Brain.
  7. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 281-808 (ISOFORM 1).
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-678, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Identification of EPI64 as a GTPase-activating protein specific for Rab27A."
    Itoh T., Fukuda M.
    J. Biol. Chem. 281:31823-31831(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  10. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-678, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-658; SER-661 AND SER-687, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-658; SER-661 AND SER-687, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-661 AND SER-687, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  15. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-658; SER-678 AND SER-687, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma and Erythroleukemia.
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22; SER-678 AND SER-687, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTB10B_HUMAN
AccessioniPrimary (citable) accession number: Q4KMP7
Secondary accession number(s): B9A6L0
, Q6IN54, Q6P530, Q71RG7, Q86VC5, Q9H8Z2, Q9NUN6, Q9UFP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 20, 2010
Last modified: July 6, 2016
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.