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Protein

Oxidation resistance protein 1

Gene

Oxr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in protection from oxidative damage.

GO - Molecular functioni

  • oxidoreductase activity Source: MGI

GO - Biological processi

  • adult walking behavior Source: MGI
  • cellular response to hydroperoxide Source: MGI
  • negative regulation of neuron apoptotic process Source: MGI
  • oxidation-reduction process Source: GOC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Oxidation resistance protein 1
Alternative name(s):
Protein C7
Gene namesi
Name:Oxr1
Synonyms:C7, Gm1238
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2179326. Oxr1.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: MGI
  • nucleolus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 866866Oxidation resistance protein 1PRO_0000231646Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei90 – 901PhosphoserineBy similarity
Modified residuei118 – 1181PhosphothreonineCombined sources
Modified residuei201 – 2011PhosphoserineCombined sources
Modified residuei202 – 2021PhosphoserineBy similarity
Modified residuei204 – 2041PhosphoserineCombined sources
Modified residuei294 – 2941PhosphoserineCombined sources
Modified residuei334 – 3341PhosphoserineCombined sources
Modified residuei336 – 3361PhosphoserineCombined sources
Modified residuei341 – 3411PhosphothreonineCombined sources
Modified residuei346 – 3461PhosphoserineCombined sources
Modified residuei488 – 4881PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ4KMM3.
MaxQBiQ4KMM3.
PaxDbiQ4KMM3.
PRIDEiQ4KMM3.

PTM databases

iPTMnetiQ4KMM3.

Expressioni

Tissue specificityi

Highly expressed in brain and testis.1 Publication

Gene expression databases

BgeeiQ4KMM3.
CleanExiMM_OXR1.
ExpressionAtlasiQ4KMM3. baseline and differential.
GenevisibleiQ4KMM3. MM.

Interactioni

Protein-protein interaction databases

IntActiQ4KMM3. 2 interactions.
MINTiMINT-4124419.
STRINGi10090.ENSMUSP00000105926.

Structurei

3D structure databases

ProteinModelPortaliQ4KMM3.
SMRiQ4KMM3. Positions 100-143, 701-866.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini98 – 14144LysMPROSITE-ProRule annotationAdd
BLAST
Domaini213 – 26856GRAMAdd
BLAST
Domaini730 – 865136TLDAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni543 – 57028Mediates oxidative antimutator activityBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi205 – 2084Poly-Glu

Sequence similaritiesi

Belongs to the OXR1 family.Curated
Contains 1 GRAM domain.Curated
Contains 1 LysM domain.PROSITE-ProRule annotation
Contains 1 TLD domain.Curated

Phylogenomic databases

eggNOGiKOG2372. Eukaryota.
ENOG4111QBZ. LUCA.
GeneTreeiENSGT00410000025363.
HOGENOMiHOG000060321.
HOVERGENiHBG065488.
InParanoidiQ4KMM3.
OMAiGPKEDST.
OrthoDBiEOG77M8PQ.
PhylomeDBiQ4KMM3.
TreeFamiTF313530.

Family and domain databases

Gene3Di3.10.350.10. 1 hit.
InterProiIPR018392. LysM_dom.
IPR006571. TLDc_dom.
[Graphical view]
PfamiPF01476. LysM. 1 hit.
PF07534. TLD. 1 hit.
[Graphical view]
SMARTiSM00257. LysM. 1 hit.
SM00584. TLDc. 1 hit.
[Graphical view]
SUPFAMiSSF54106. SSF54106. 1 hit.
PROSITEiPS51782. LYSM. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q4KMM3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSVSNLSWLK KKSQSVDITA PGFNPLGGAG KQAPQASKPP APKTPIIEEE
60 70 80 90 100
QNNSANTQKH PSRKSELKRF YTIDTGQKKT LDKKDGRRMS FQKPKGTIEY
110 120 130 140 150
TVESRDSLNS IALKFDTTPN ELVQLNKLFS RAVVTGQVLY VPDPEYVSSV
160 170 180 190 200
ESSPSLSPVS PLSPTSSEAE FDKTTTPDVA HPKEAPPAST VSGIRPARVV
210 220 230 240 250
SSTSEEEEAF TEKFLKINCK YITIGKGTVS GVLLVTPNNI MFDPHKTDPL
260 270 280 290 300
VQENGCEEYG IMCPMEEVMS AAMYKEILDS KIKESLPIEL DQLSGRGSCH
310 320 330 340 350
SKKATGVSAE DADPRARDQG NDSASTAPRS TEESLSEDAF TESELSPIRE
360 370 380 390 400
ELLSSEPRQE KSSDASSESV QTVSQMEVQS LTATSEAANV PDRTSSNPGA
410 420 430 440 450
LSHETGLSGL ETATKGGDKA TESLQEVSGP KEQSTEVKGQ DNQDSSHQES
460 470 480 490 500
SLQQEAGEDS VSSGETVELK EKPAVLKDQQ GQELKRDSET EVEELRKLWK
510 520 530 540 550
THSMQQAKQQ RDTIQQVSQR ESKHSSAAAD AHGEGSSLLK EKRRHRLHKF
560 570 580 590 600
LCLRVGKPMR KTFVSQASAT MQQYAQRDKK HEYWFAVPQE RTDHLYAFFI
610 620 630 640 650
QWSPEIYAED SGEYTREPGF IVVKKMDESE ANEAPAGEAA AREWEVVSVA
660 670 680 690 700
EYHRRIDALN TEELRTLCRR LQITTREDIN SKQVAPAKAD LEPESFRPNL
710 720 730 740 750
SDPSELLLPD QIEKLTKHLP PRTIGYPWTL VYGTGKHGTS LKTLYRTMTG
760 770 780 790 800
LDTPVLMVIK DSDGQVFGAL ASEPFKVSDG FYGTGETFVF TFCPEFEVFK
810 820 830 840 850
WTGDNMFFIK GDMDSLAFGG GGGEFALWLD GDLYHGRSHS CKTFGNHTLS
860
KKEDFFIQDI EIWAFE
Length:866
Mass (Da):95,912
Last modified:April 20, 2010 - v3
Checksum:i15FB6B37144B1668
GO
Isoform 2 (identifier: Q4KMM3-2) [UniParc]FASTAAdd to basket

Also known as: C7B

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: Missing.

Show »
Length:778
Mass (Da):86,240
Checksum:iDEB2C7A23699830B
GO
Isoform 3 (identifier: Q4KMM3-3) [UniParc]FASTAAdd to basket

Also known as: C7A

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: Missing.
     646-672: Missing.

Show »
Length:751
Mass (Da):83,016
Checksum:i797716DA0A254741
GO
Isoform 4 (identifier: Q4KMM3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     646-672: Missing.

Show »
Length:839
Mass (Da):92,688
Checksum:iE8D5AA39662B4252
GO

Sequence cautioni

The sequence AAH03927.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH98491.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAE34619.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti107 – 1093SLN → PLY in AAK29400 (PubMed:11237729).Curated
Sequence conflicti156 – 1561L → H in AAK29400 (PubMed:11237729).Curated
Sequence conflicti308 – 3081S → A in AAH89183 (PubMed:15489334).Curated
Sequence conflicti308 – 3081S → A in AAH98491 (PubMed:15489334).Curated
Sequence conflicti435 – 4373TEV → PEI in AAH89183 (PubMed:15489334).Curated
Sequence conflicti435 – 4373TEV → PEI in AAH98491 (PubMed:15489334).Curated
Sequence conflicti451 – 4511S → L in AAH89183 (PubMed:15489334).Curated
Sequence conflicti451 – 4511S → L in AAH98491 (PubMed:15489334).Curated
Sequence conflicti814 – 8141D → G in AAH98491 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8888Missing in isoform 2 and isoform 3. 2 PublicationsVSP_039015Add
BLAST
Alternative sequencei646 – 67227Missing in isoform 3 and isoform 4. 2 PublicationsVSP_039016Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF324899 mRNA. Translation: AAK30368.1.
AF333985 mRNA. Translation: AAK29400.1.
AK158703 mRNA. Translation: BAE34619.1. Different initiation.
BC003927 mRNA. Translation: AAH03927.1. Different initiation.
BC089183 mRNA. Translation: AAH89183.1.
BC098491 mRNA. Translation: AAH98491.1. Different initiation.
CCDSiCCDS27448.1. [Q4KMM3-2]
CCDS49598.1. [Q4KMM3-1]
CCDS49600.1. [Q4KMM3-3]
RefSeqiNP_001123635.1. NM_001130163.1. [Q4KMM3-3]
NP_001123636.1. NM_001130164.1.
NP_001123637.1. NM_001130165.1.
NP_001123638.1. NM_001130166.1. [Q4KMM3-1]
NP_570955.1. NM_130885.2. [Q4KMM3-2]
XP_011243780.1. XM_011245478.1. [Q4KMM3-4]
UniGeneiMm.254267.

Genome annotation databases

EnsembliENSMUST00000022918; ENSMUSP00000022918; ENSMUSG00000022307. [Q4KMM3-2]
ENSMUST00000090095; ENSMUSP00000087553; ENSMUSG00000022307. [Q4KMM3-3]
ENSMUST00000090096; ENSMUSP00000087554; ENSMUSG00000022307. [Q4KMM3-3]
ENSMUST00000110297; ENSMUSP00000105926; ENSMUSG00000022307. [Q4KMM3-1]
ENSMUST00000179393; ENSMUSP00000136923; ENSMUSG00000022307. [Q4KMM3-3]
GeneIDi170719.
KEGGimmu:170719.
UCSCiuc007vot.2. mouse. [Q4KMM3-1]
uc007vpa.1. mouse. [Q4KMM3-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF324899 mRNA. Translation: AAK30368.1.
AF333985 mRNA. Translation: AAK29400.1.
AK158703 mRNA. Translation: BAE34619.1. Different initiation.
BC003927 mRNA. Translation: AAH03927.1. Different initiation.
BC089183 mRNA. Translation: AAH89183.1.
BC098491 mRNA. Translation: AAH98491.1. Different initiation.
CCDSiCCDS27448.1. [Q4KMM3-2]
CCDS49598.1. [Q4KMM3-1]
CCDS49600.1. [Q4KMM3-3]
RefSeqiNP_001123635.1. NM_001130163.1. [Q4KMM3-3]
NP_001123636.1. NM_001130164.1.
NP_001123637.1. NM_001130165.1.
NP_001123638.1. NM_001130166.1. [Q4KMM3-1]
NP_570955.1. NM_130885.2. [Q4KMM3-2]
XP_011243780.1. XM_011245478.1. [Q4KMM3-4]
UniGeneiMm.254267.

3D structure databases

ProteinModelPortaliQ4KMM3.
SMRiQ4KMM3. Positions 100-143, 701-866.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ4KMM3. 2 interactions.
MINTiMINT-4124419.
STRINGi10090.ENSMUSP00000105926.

PTM databases

iPTMnetiQ4KMM3.

Proteomic databases

EPDiQ4KMM3.
MaxQBiQ4KMM3.
PaxDbiQ4KMM3.
PRIDEiQ4KMM3.

Protocols and materials databases

DNASUi170719.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022918; ENSMUSP00000022918; ENSMUSG00000022307. [Q4KMM3-2]
ENSMUST00000090095; ENSMUSP00000087553; ENSMUSG00000022307. [Q4KMM3-3]
ENSMUST00000090096; ENSMUSP00000087554; ENSMUSG00000022307. [Q4KMM3-3]
ENSMUST00000110297; ENSMUSP00000105926; ENSMUSG00000022307. [Q4KMM3-1]
ENSMUST00000179393; ENSMUSP00000136923; ENSMUSG00000022307. [Q4KMM3-3]
GeneIDi170719.
KEGGimmu:170719.
UCSCiuc007vot.2. mouse. [Q4KMM3-1]
uc007vpa.1. mouse. [Q4KMM3-3]

Organism-specific databases

CTDi55074.
MGIiMGI:2179326. Oxr1.

Phylogenomic databases

eggNOGiKOG2372. Eukaryota.
ENOG4111QBZ. LUCA.
GeneTreeiENSGT00410000025363.
HOGENOMiHOG000060321.
HOVERGENiHBG065488.
InParanoidiQ4KMM3.
OMAiGPKEDST.
OrthoDBiEOG77M8PQ.
PhylomeDBiQ4KMM3.
TreeFamiTF313530.

Miscellaneous databases

ChiTaRSiOxr1. mouse.
PROiQ4KMM3.
SOURCEiSearch...

Gene expression databases

BgeeiQ4KMM3.
CleanExiMM_OXR1.
ExpressionAtlasiQ4KMM3. baseline and differential.
GenevisibleiQ4KMM3. MM.

Family and domain databases

Gene3Di3.10.350.10. 1 hit.
InterProiIPR018392. LysM_dom.
IPR006571. TLDc_dom.
[Graphical view]
PfamiPF01476. LysM. 1 hit.
PF07534. TLD. 1 hit.
[Graphical view]
SMARTiSM00257. LysM. 1 hit.
SM00584. TLDc. 1 hit.
[Graphical view]
SUPFAMiSSF54106. SSF54106. 1 hit.
PROSITEiPS51782. LYSM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "C7, a novel nucleolar protein, is the mouse homologue of the Drosophila late puff product L82 and an isoform of human OXR1."
    Fischer H., Zhang X.U., O'Brien K.P., Kylsten P., Engvall E.
    Biochem. Biophys. Res. Commun. 281:795-803(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Kidney.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
    Strain: CD-1.
    Tissue: Mammary gland and Neural stem cell.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-118; SER-201; SER-204; SER-294; SER-334; SER-336; THR-341; SER-346 AND SER-488, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiOXR1_MOUSE
AccessioniPrimary (citable) accession number: Q4KMM3
Secondary accession number(s): Q5FWW1
, Q99L06, Q99MK1, Q99MP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 20, 2010
Last modified: June 8, 2016
This is version 100 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.