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Protein

Cell adhesion molecule-related/down-regulated by oncogenes

Gene

CDON

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_21402. CDO in myogenesis.
REACT_268573. Ligand-receptor interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell adhesion molecule-related/down-regulated by oncogenes
Gene namesi
Name:CDON
Synonyms:CDO
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:17104. CDON.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 963938ExtracellularSequence AnalysisAdd
BLAST
Transmembranei964 – 98421HelicalSequence AnalysisAdd
BLAST
Topological domaini985 – 1287303CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Holoprosencephaly 11 (HPE11)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability.

See also OMIM:614226
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti684 – 6841T → S in HPE11. 1 Publication
Corresponds to variant rs145983470 [ dbSNP | Ensembl ].
VAR_066497
Natural varianti689 – 6891P → A in HPE11. 1 Publication
VAR_066498
Natural varianti691 – 6911V → M in HPE11. 1 Publication
VAR_066499
Natural varianti780 – 7801V → E in HPE11. 1 Publication
VAR_066500
Natural varianti790 – 7901T → A in HPE11. 1 Publication
VAR_066501
Natural varianti940 – 9401S → R in HPE11. 1 Publication
VAR_066502

Keywords - Diseasei

Disease mutation, Holoprosencephaly

Organism-specific databases

MIMi614226. phenotype.
Orphaneti93925. Alobar holoprosencephaly.
93924. Lobar holoprosencephaly.
280200. Microform holoprosencephaly.
93926. Midline interhemispheric variant of holoprosencephaly.
220386. Semilobar holoprosencephaly.
280195. Septopreoptic holoprosencephaly.
PharmGKBiPA26328.

Polymorphism and mutation databases

BioMutaiCDON.
DMDMi308153422.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 12871262Cell adhesion molecule-related/down-regulated by oncogenesPRO_0000234054Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi50 ↔ 97PROSITE-ProRule annotation
Glycosylationi88 – 881N-linked (GlcNAc...)Sequence Analysis
Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi141 ↔ 191PROSITE-ProRule annotation
Glycosylationi180 – 1801N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi243 ↔ 290PROSITE-ProRule annotation
Glycosylationi287 – 2871N-linked (GlcNAc...)Sequence Analysis
Glycosylationi294 – 2941N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi333 ↔ 380PROSITE-ProRule annotation
Glycosylationi342 – 3421N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi426 ↔ 500PROSITE-ProRule annotation
Glycosylationi427 – 4271N-linked (GlcNAc...)Sequence Analysis
Glycosylationi570 – 5701N-linked (GlcNAc...)Sequence Analysis
Glycosylationi873 – 8731N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ4KMG0.
PaxDbiQ4KMG0.
PRIDEiQ4KMG0.

PTM databases

PhosphoSiteiQ4KMG0.

Expressioni

Gene expression databases

BgeeiQ4KMG0.
CleanExiHS_CDON.
ExpressionAtlasiQ4KMG0. baseline and differential.
GenevisibleiQ4KMG0. HS.

Organism-specific databases

HPAiCAB012422.
HPA017377.

Interactioni

Subunit structurei

Part of a complex that contains BOC, CDON, NEO1, cadherins and CTNNB1. Interacts with NTN3 (By similarity). Interacts with PTCH1 (By similarity). Interacts with GAS1 (By similarity). Interacts with DHH, IHH and SHH.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ABL1P005192EBI-7016840,EBI-375543

Protein-protein interaction databases

BioGridi119165. 8 interactions.
DIPiDIP-57226N.
IntActiQ4KMG0. 1 interaction.
MINTiMINT-2795255.
STRINGi9606.ENSP00000263577.

Structurei

Secondary structure

1
1287
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi831 – 8377Combined sources
Beta strandi839 – 8413Combined sources
Beta strandi843 – 8486Combined sources
Helixi852 – 8543Combined sources
Beta strandi861 – 8688Combined sources
Helixi874 – 8763Combined sources
Beta strandi878 – 8836Combined sources
Beta strandi887 – 8915Combined sources
Beta strandi899 – 90810Combined sources
Beta strandi919 – 9224Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3D1MX-ray1.70C/D826-924[»]
3N1FX-ray1.60C/D826-924[»]
3N1QX-ray2.89C/D/F826-924[»]
ProteinModelPortaliQ4KMG0.
SMRiQ4KMG0. Positions 721-817, 826-924.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ4KMG0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 11486Ig-like C2-type 1Add
BLAST
Domaini120 – 20485Ig-like C2-type 2Add
BLAST
Domaini225 – 30379Ig-like C2-type 3Add
BLAST
Domaini310 – 39687Ig-like C2-type 4Add
BLAST
Domaini405 – 516112Ig-like C2-type 5Add
BLAST
Domaini579 – 67799Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini723 – 82199Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini826 – 926101Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 3 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG150729.
GeneTreeiENSGT00800000124026.
HOGENOMiHOG000060072.
HOVERGENiHBG081073.
InParanoidiQ4KMG0.
OMAiVSDTQIM.
OrthoDBiEOG7MD4PB.
PhylomeDBiQ4KMG0.
TreeFamiTF332268.

Family and domain databases

Gene3Di2.60.40.10. 8 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF00041. fn3. 3 hits.
PF07679. I-set. 3 hits.
[Graphical view]
SMARTiSM00060. FN3. 3 hits.
SM00409. IG. 1 hit.
SM00408. IGc2. 4 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q4KMG0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHPDLGPLCT LLYVTLTILC SSVSSDLAPY FTSEPLSAVQ KLGGPVVLHC
60 70 80 90 100
SAQPVTTRIS WLHNGKTLDG NLEHVKIHQG TLTILSLNSS LLGYYQCLAN
110 120 130 140 150
NSIGAIVSGP ATVSVAVLGD FGSSTKHVIT AEEKSAGFIG CRVPESNPKA
160 170 180 190 200
EVRYKIRGKW LEHSTENYLI LPSGNLQILN VSLEDKGSYK CAAYNPVTHQ
210 220 230 240 250
LKVEPIGRKL LVSRPSSDDV HILHPTHSQA LAVLSRSPVT LECVVSGVPA
260 270 280 290 300
PQVYWLKDGQ DIAPGSNWRR LYSHLATDSV DPADSGNYSC MAGNKSGDVK
310 320 330 340 350
YVTYMVNVLE HASISKGLQD QIVSLGATVH FTCDVHGNPA PNCTWFHNAQ
360 370 380 390 400
PIHPSARHLT AGNGLKISGV TVEDVGMYQC VADNGIGFMH STGRLEIEND
410 420 430 440 450
GGFKPVIITA PVSAKVADGD FVTLSCNASG LPVPVIRWYD SHGLITSHPS
460 470 480 490 500
QVLRSKSRKS QLSRPEGLNL EPVYFVLSQA GASSLHIQAV TQEHAGKYIC
510 520 530 540 550
EAANEHGTTQ AEASLMVVPF ETNTKAETVT LPDAAQNDDR SKRDGSETGL
560 570 580 590 600
LSSFPVKVHP SAVESAPEKN ASGISVPDAP IILSPPQTHT PDTYNLVWRA
610 620 630 640 650
GKDGGLPINA YFVKYRKLDD GVGMLGSWHT VRVPGSENEL HLAELEPSSL
660 670 680 690 700
YEVLMVARSA AGEGQPAMLT FRTSKEKTAS SKNTQASSPP VGIPKYPVVS
710 720 730 740 750
EAANNNFGVV LTDSSRHSGV PEAPDRPTIS TASETSVYVT WIPRANGGSP
760 770 780 790 800
ITAFKVEYKR MRTSNWLVAA EDIPPSKLSV EVRSLEPGST YKFRVIAINH
810 820 830 840 850
YGESFRSSAS RPYQVVGFPN RFSSRPITGP HIAYTEAVSD TQIMLKWTYI
860 870 880 890 900
PSSNNNTPIQ GFYIYYRPTD SDNDSDYKRD VVEGSKQWHM IGHLQPETSY
910 920 930 940 950
DIKMQCFNEG GESEFSNVMI CETKVKRVPG ASEYPVKDLS TPPNSLGSGG
960 970 980 990 1000
NVGPATSPAR SSDMLYLIVG CVLGVMVLIL MVFIAMCLWK NRQQNTIQKY
1010 1020 1030 1040 1050
DPPGYLYQGS DMNGQMVDYT TLSGASQING NVHGGFLTNG GLSSGYSHLH
1060 1070 1080 1090 1100
HKVPNAVNGI VNGSLNGGLY SGHSNSLTRT HVDFEHPHHL VNGGGMYTAV
1110 1120 1130 1140 1150
PQIDPLECVN CRNCRNNNRC FTKTNSTFSS SPPPVVPVVA PYPQDGLEMK
1160 1170 1180 1190 1200
PLSHVKVPVC LTSAVPDCGQ LPEESVKDNV EPVPTQRTCC QDIVNDVSSD
1210 1220 1230 1240 1250
GSEDPAEFSR GQEGMINLRI PDHLQLAKSC VWEGDSCAHS ETEINIVSWN
1260 1270 1280
ALILPPVPEG CAEKTMWSPP GIPLDSPTEV LQQPRET
Length:1,287
Mass (Da):139,147
Last modified:October 5, 2010 - v2
Checksum:iB7870C66F5224BBE
GO
Isoform 2 (identifier: Q4KMG0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1212-1234: Missing.

Show »
Length:1,264
Mass (Da):136,527
Checksum:i79AB36E0B52C61D7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti75 – 751V → I in AAC34901 (PubMed:9214393).Curated
Sequence conflicti75 – 751V → I in AAH98583 (PubMed:15489334).Curated
Sequence conflicti265 – 2651G → E in AAH98583 (PubMed:15489334).Curated
Sequence conflicti300 – 3001K → E in AAC34901 (PubMed:9214393).Curated
Sequence conflicti669 – 6691L → I in AAC34901 (PubMed:9214393).Curated
Sequence conflicti1244 – 12441I → N in AAH98583 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti66 – 661K → R.
Corresponds to variant rs7122277 [ dbSNP | Ensembl ].
VAR_056038
Natural varianti162 – 1621E → K.
Corresponds to variant rs3740909 [ dbSNP | Ensembl ].
VAR_056039
Natural varianti351 – 3511P → A.
Corresponds to variant rs35665264 [ dbSNP | Ensembl ].
VAR_056040
Natural varianti684 – 6841T → S in HPE11. 1 Publication
Corresponds to variant rs145983470 [ dbSNP | Ensembl ].
VAR_066497
Natural varianti686 – 6861A → V.
Corresponds to variant rs12274923 [ dbSNP | Ensembl ].
VAR_056041
Natural varianti689 – 6891P → A in HPE11. 1 Publication
VAR_066498
Natural varianti691 – 6911V → M in HPE11. 1 Publication
VAR_066499
Natural varianti780 – 7801V → E in HPE11. 1 Publication
VAR_066500
Natural varianti790 – 7901T → A in HPE11. 1 Publication
VAR_066501
Natural varianti940 – 9401S → R in HPE11. 1 Publication
VAR_066502

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1212 – 123423Missing in isoform 2. 1 PublicationVSP_018201Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004841 mRNA. Translation: AAC34901.2.
AP000821 Genomic DNA. No translation available.
AP000842 Genomic DNA. No translation available.
BC098583 mRNA. Translation: AAH98583.1.
CCDSiCCDS58192.1. [Q4KMG0-1]
CCDS8468.1. [Q4KMG0-2]
PIRiT03097.
RefSeqiNP_001230526.1. NM_001243597.1. [Q4KMG0-1]
NP_058648.4. NM_016952.4. [Q4KMG0-2]
XP_011541164.1. XM_011542862.1. [Q4KMG0-1]
XP_011541165.1. XM_011542863.1. [Q4KMG0-1]
XP_011541166.1. XM_011542864.1. [Q4KMG0-1]
XP_011541167.1. XM_011542865.1. [Q4KMG0-1]
XP_011541168.1. XM_011542866.1. [Q4KMG0-2]
UniGeneiHs.38034.

Genome annotation databases

EnsembliENST00000263577; ENSP00000263577; ENSG00000064309. [Q4KMG0-2]
ENST00000392693; ENSP00000376458; ENSG00000064309.
GeneIDi50937.
KEGGihsa:50937.
UCSCiuc001qdc.4. human. [Q4KMG0-2]
uc009zbw.3. human. [Q4KMG0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004841 mRNA. Translation: AAC34901.2.
AP000821 Genomic DNA. No translation available.
AP000842 Genomic DNA. No translation available.
BC098583 mRNA. Translation: AAH98583.1.
CCDSiCCDS58192.1. [Q4KMG0-1]
CCDS8468.1. [Q4KMG0-2]
PIRiT03097.
RefSeqiNP_001230526.1. NM_001243597.1. [Q4KMG0-1]
NP_058648.4. NM_016952.4. [Q4KMG0-2]
XP_011541164.1. XM_011542862.1. [Q4KMG0-1]
XP_011541165.1. XM_011542863.1. [Q4KMG0-1]
XP_011541166.1. XM_011542864.1. [Q4KMG0-1]
XP_011541167.1. XM_011542865.1. [Q4KMG0-1]
XP_011541168.1. XM_011542866.1. [Q4KMG0-2]
UniGeneiHs.38034.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3D1MX-ray1.70C/D826-924[»]
3N1FX-ray1.60C/D826-924[»]
3N1QX-ray2.89C/D/F826-924[»]
ProteinModelPortaliQ4KMG0.
SMRiQ4KMG0. Positions 721-817, 826-924.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119165. 8 interactions.
DIPiDIP-57226N.
IntActiQ4KMG0. 1 interaction.
MINTiMINT-2795255.
STRINGi9606.ENSP00000263577.

PTM databases

PhosphoSiteiQ4KMG0.

Polymorphism and mutation databases

BioMutaiCDON.
DMDMi308153422.

Proteomic databases

MaxQBiQ4KMG0.
PaxDbiQ4KMG0.
PRIDEiQ4KMG0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263577; ENSP00000263577; ENSG00000064309. [Q4KMG0-2]
ENST00000392693; ENSP00000376458; ENSG00000064309.
GeneIDi50937.
KEGGihsa:50937.
UCSCiuc001qdc.4. human. [Q4KMG0-2]
uc009zbw.3. human. [Q4KMG0-1]

Organism-specific databases

CTDi50937.
GeneCardsiGC11M125866.
H-InvDBHIX0035847.
HGNCiHGNC:17104. CDON.
HPAiCAB012422.
HPA017377.
MIMi608707. gene.
614226. phenotype.
neXtProtiNX_Q4KMG0.
Orphaneti93925. Alobar holoprosencephaly.
93924. Lobar holoprosencephaly.
280200. Microform holoprosencephaly.
93926. Midline interhemispheric variant of holoprosencephaly.
220386. Semilobar holoprosencephaly.
280195. Septopreoptic holoprosencephaly.
PharmGKBiPA26328.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG150729.
GeneTreeiENSGT00800000124026.
HOGENOMiHOG000060072.
HOVERGENiHBG081073.
InParanoidiQ4KMG0.
OMAiVSDTQIM.
OrthoDBiEOG7MD4PB.
PhylomeDBiQ4KMG0.
TreeFamiTF332268.

Enzyme and pathway databases

ReactomeiREACT_21402. CDO in myogenesis.
REACT_268573. Ligand-receptor interactions.

Miscellaneous databases

ChiTaRSiCDON. human.
EvolutionaryTraceiQ4KMG0.
GeneWikiiCDON.
GenomeRNAii50937.
NextBioi53379.
PROiQ4KMG0.
SOURCEiSearch...

Gene expression databases

BgeeiQ4KMG0.
CleanExiHS_CDON.
ExpressionAtlasiQ4KMG0. baseline and differential.
GenevisibleiQ4KMG0. HS.

Family and domain databases

Gene3Di2.60.40.10. 8 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF00041. fn3. 3 hits.
PF07679. I-set. 3 hits.
[Graphical view]
SMARTiSM00060. FN3. 3 hits.
SM00409. IG. 1 hit.
SM00408. IGc2. 4 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "CDO: an oncogene-, serum-, and anchorage-regulated member of the Ig/fibronectin type III repeat family."
    Kang J.-S., Gao M., Feinleib J.L., Cotter P.D., Guadagno S.N., Krauss R.S.
    J. Cell Biol. 138:203-213(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Fetal brain and Fetal lung.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  4. "The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla."
    McLellan J.S., Zheng X., Hauk G., Ghirlando R., Beachy P.A., Leahy D.J.
    Nature 455:979-983(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 826-924 IN COMPLEX WITH SHH, INTERACTION WITH SHH.
  5. "All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner."
    Kavran J.M., Ward M.D., Oladosu O.O., Mulepati S., Leahy D.J.
    J. Biol. Chem. 285:24584-24590(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 826-924 IN COMPLEXES WITH IHH AND DHH, INTERACTION WITH IHH AND DHH.
  6. "Mutations in CDON, encoding a hedgehog receptor, result in holoprosencephaly and defective interactions with other hedgehog receptors."
    Bae G.U., Domene S., Roessler E., Schachter K., Kang J.S., Muenke M., Krauss R.S.
    Am. J. Hum. Genet. 89:231-240(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS HPE11 SER-684; ALA-689; MET-691; GLU-780; ALA-790 AND ARG-940.

Entry informationi

Entry nameiCDON_HUMAN
AccessioniPrimary (citable) accession number: Q4KMG0
Secondary accession number(s): O14631
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: October 5, 2010
Last modified: July 22, 2015
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.