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Protein

Cell adhesion molecule-related/down-regulated by oncogenes

Gene

CDON

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-375170. CDO in myogenesis.
R-HSA-5632681. Ligand-receptor interactions.
R-HSA-5635838. Activation of SMO.
SIGNORiQ4KMG0.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell adhesion molecule-related/down-regulated by oncogenes
Gene namesi
Name:CDON
Synonyms:CDO
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:17104. CDON.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 963ExtracellularSequence analysisAdd BLAST938
Transmembranei964 – 984HelicalSequence analysisAdd BLAST21
Topological domaini985 – 1287CytoplasmicSequence analysisAdd BLAST303

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Holoprosencephaly 11 (HPE11)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability.
See also OMIM:614226
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_066497684T → S in HPE11. 1 PublicationCorresponds to variant rs145983470dbSNPEnsembl.1
Natural variantiVAR_066498689P → A in HPE11. 1 PublicationCorresponds to variant rs387906995dbSNPEnsembl.1
Natural variantiVAR_066499691V → M in HPE11. 1 PublicationCorresponds to variant rs139323558dbSNPEnsembl.1
Natural variantiVAR_066500780V → E in HPE11. 1 PublicationCorresponds to variant rs387906996dbSNPEnsembl.1
Natural variantiVAR_066501790T → A in HPE11. 1 PublicationCorresponds to variant rs387906997dbSNPEnsembl.1
Natural variantiVAR_066502940S → R in HPE11. 1 PublicationCorresponds to variant rs369673018dbSNPEnsembl.1

Keywords - Diseasei

Disease mutation, Holoprosencephaly

Organism-specific databases

DisGeNETi50937.
MalaCardsiCDON.
MIMi614226. phenotype.
OpenTargetsiENSG00000064309.
Orphaneti93925. Alobar holoprosencephaly.
93924. Lobar holoprosencephaly.
280200. Microform holoprosencephaly.
93926. Midline interhemispheric variant of holoprosencephaly.
220386. Semilobar holoprosencephaly.
280195. Septopreoptic holoprosencephaly.
PharmGKBiPA26328.

Polymorphism and mutation databases

BioMutaiCDON.
DMDMi308153422.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000023405426 – 1287Cell adhesion molecule-related/down-regulated by oncogenesAdd BLAST1262

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi50 ↔ 97PROSITE-ProRule annotation
Glycosylationi88N-linked (GlcNAc...)Sequence analysis1
Glycosylationi100N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi141 ↔ 191PROSITE-ProRule annotation
Glycosylationi180N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi243 ↔ 290PROSITE-ProRule annotation
Glycosylationi287N-linked (GlcNAc...)Sequence analysis1
Glycosylationi294N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi333 ↔ 380PROSITE-ProRule annotation
Glycosylationi342N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi426 ↔ 500PROSITE-ProRule annotation
Glycosylationi427N-linked (GlcNAc...)Sequence analysis1
Glycosylationi570N-linked (GlcNAc...)Sequence analysis1
Glycosylationi873N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ4KMG0.
MaxQBiQ4KMG0.
PaxDbiQ4KMG0.
PeptideAtlasiQ4KMG0.
PRIDEiQ4KMG0.

PTM databases

iPTMnetiQ4KMG0.
PhosphoSitePlusiQ4KMG0.

Expressioni

Gene expression databases

BgeeiENSG00000064309.
CleanExiHS_CDON.
ExpressionAtlasiQ4KMG0. baseline and differential.
GenevisibleiQ4KMG0. HS.

Organism-specific databases

HPAiCAB012422.
HPA017377.

Interactioni

Subunit structurei

Part of a complex that contains BOC, CDON, NEO1, cadherins and CTNNB1. Interacts with NTN3 (By similarity). Interacts with PTCH1 (By similarity). Interacts with GAS1 (By similarity). Interacts with DHH, IHH and SHH.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ABL1P005192EBI-7016840,EBI-375543

Protein-protein interaction databases

BioGridi119165. 11 interactors.
DIPiDIP-57226N.
IntActiQ4KMG0. 1 interactor.
MINTiMINT-2795255.
STRINGi9606.ENSP00000263577.

Structurei

Secondary structure

11287
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi831 – 837Combined sources7
Beta strandi839 – 841Combined sources3
Beta strandi843 – 848Combined sources6
Helixi852 – 854Combined sources3
Beta strandi861 – 868Combined sources8
Helixi874 – 876Combined sources3
Beta strandi878 – 883Combined sources6
Beta strandi887 – 891Combined sources5
Beta strandi899 – 908Combined sources10
Beta strandi919 – 922Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3D1MX-ray1.70C/D826-924[»]
3N1FX-ray1.60C/D826-924[»]
3N1QX-ray2.89C/D/F826-924[»]
ProteinModelPortaliQ4KMG0.
SMRiQ4KMG0.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ4KMG0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 114Ig-like C2-type 1Add BLAST86
Domaini120 – 204Ig-like C2-type 2Add BLAST85
Domaini225 – 303Ig-like C2-type 3Add BLAST79
Domaini310 – 396Ig-like C2-type 4Add BLAST87
Domaini405 – 516Ig-like C2-type 5Add BLAST112
Domaini579 – 677Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST99
Domaini723 – 821Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST99
Domaini826 – 926Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST101

Sequence similaritiesi

Contains 3 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHIH. Eukaryota.
ENOG410XSVT. LUCA.
GeneTreeiENSGT00840000129688.
HOGENOMiHOG000060072.
HOVERGENiHBG081073.
InParanoidiQ4KMG0.
KOiK20033.
OMAiVSDTQIM.
OrthoDBiEOG091G00TB.
PhylomeDBiQ4KMG0.
TreeFamiTF332268.

Family and domain databases

CDDicd00063. FN3. 3 hits.
Gene3Di2.60.40.10. 8 hits.
InterProiIPR032983. CDO.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PANTHERiPTHR10489:SF12. PTHR10489:SF12. 5 hits.
PfamiPF00041. fn3. 3 hits.
PF07679. I-set. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 3 hits.
SM00409. IG. 5 hits.
SM00408. IGc2. 5 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 5 hits.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q4KMG0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHPDLGPLCT LLYVTLTILC SSVSSDLAPY FTSEPLSAVQ KLGGPVVLHC
60 70 80 90 100
SAQPVTTRIS WLHNGKTLDG NLEHVKIHQG TLTILSLNSS LLGYYQCLAN
110 120 130 140 150
NSIGAIVSGP ATVSVAVLGD FGSSTKHVIT AEEKSAGFIG CRVPESNPKA
160 170 180 190 200
EVRYKIRGKW LEHSTENYLI LPSGNLQILN VSLEDKGSYK CAAYNPVTHQ
210 220 230 240 250
LKVEPIGRKL LVSRPSSDDV HILHPTHSQA LAVLSRSPVT LECVVSGVPA
260 270 280 290 300
PQVYWLKDGQ DIAPGSNWRR LYSHLATDSV DPADSGNYSC MAGNKSGDVK
310 320 330 340 350
YVTYMVNVLE HASISKGLQD QIVSLGATVH FTCDVHGNPA PNCTWFHNAQ
360 370 380 390 400
PIHPSARHLT AGNGLKISGV TVEDVGMYQC VADNGIGFMH STGRLEIEND
410 420 430 440 450
GGFKPVIITA PVSAKVADGD FVTLSCNASG LPVPVIRWYD SHGLITSHPS
460 470 480 490 500
QVLRSKSRKS QLSRPEGLNL EPVYFVLSQA GASSLHIQAV TQEHAGKYIC
510 520 530 540 550
EAANEHGTTQ AEASLMVVPF ETNTKAETVT LPDAAQNDDR SKRDGSETGL
560 570 580 590 600
LSSFPVKVHP SAVESAPEKN ASGISVPDAP IILSPPQTHT PDTYNLVWRA
610 620 630 640 650
GKDGGLPINA YFVKYRKLDD GVGMLGSWHT VRVPGSENEL HLAELEPSSL
660 670 680 690 700
YEVLMVARSA AGEGQPAMLT FRTSKEKTAS SKNTQASSPP VGIPKYPVVS
710 720 730 740 750
EAANNNFGVV LTDSSRHSGV PEAPDRPTIS TASETSVYVT WIPRANGGSP
760 770 780 790 800
ITAFKVEYKR MRTSNWLVAA EDIPPSKLSV EVRSLEPGST YKFRVIAINH
810 820 830 840 850
YGESFRSSAS RPYQVVGFPN RFSSRPITGP HIAYTEAVSD TQIMLKWTYI
860 870 880 890 900
PSSNNNTPIQ GFYIYYRPTD SDNDSDYKRD VVEGSKQWHM IGHLQPETSY
910 920 930 940 950
DIKMQCFNEG GESEFSNVMI CETKVKRVPG ASEYPVKDLS TPPNSLGSGG
960 970 980 990 1000
NVGPATSPAR SSDMLYLIVG CVLGVMVLIL MVFIAMCLWK NRQQNTIQKY
1010 1020 1030 1040 1050
DPPGYLYQGS DMNGQMVDYT TLSGASQING NVHGGFLTNG GLSSGYSHLH
1060 1070 1080 1090 1100
HKVPNAVNGI VNGSLNGGLY SGHSNSLTRT HVDFEHPHHL VNGGGMYTAV
1110 1120 1130 1140 1150
PQIDPLECVN CRNCRNNNRC FTKTNSTFSS SPPPVVPVVA PYPQDGLEMK
1160 1170 1180 1190 1200
PLSHVKVPVC LTSAVPDCGQ LPEESVKDNV EPVPTQRTCC QDIVNDVSSD
1210 1220 1230 1240 1250
GSEDPAEFSR GQEGMINLRI PDHLQLAKSC VWEGDSCAHS ETEINIVSWN
1260 1270 1280
ALILPPVPEG CAEKTMWSPP GIPLDSPTEV LQQPRET
Length:1,287
Mass (Da):139,147
Last modified:October 5, 2010 - v2
Checksum:iB7870C66F5224BBE
GO
Isoform 2 (identifier: Q4KMG0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1212-1234: Missing.

Show »
Length:1,264
Mass (Da):136,527
Checksum:i79AB36E0B52C61D7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti75V → I in AAC34901 (PubMed:9214393).Curated1
Sequence conflicti75V → I in AAH98583 (PubMed:15489334).Curated1
Sequence conflicti265G → E in AAH98583 (PubMed:15489334).Curated1
Sequence conflicti300K → E in AAC34901 (PubMed:9214393).Curated1
Sequence conflicti669L → I in AAC34901 (PubMed:9214393).Curated1
Sequence conflicti1244I → N in AAH98583 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05603866K → R.Corresponds to variant rs7122277dbSNPEnsembl.1
Natural variantiVAR_056039162E → K.Corresponds to variant rs3740909dbSNPEnsembl.1
Natural variantiVAR_056040351P → A.Corresponds to variant rs35665264dbSNPEnsembl.1
Natural variantiVAR_066497684T → S in HPE11. 1 PublicationCorresponds to variant rs145983470dbSNPEnsembl.1
Natural variantiVAR_056041686A → V.Corresponds to variant rs12274923dbSNPEnsembl.1
Natural variantiVAR_066498689P → A in HPE11. 1 PublicationCorresponds to variant rs387906995dbSNPEnsembl.1
Natural variantiVAR_066499691V → M in HPE11. 1 PublicationCorresponds to variant rs139323558dbSNPEnsembl.1
Natural variantiVAR_066500780V → E in HPE11. 1 PublicationCorresponds to variant rs387906996dbSNPEnsembl.1
Natural variantiVAR_066501790T → A in HPE11. 1 PublicationCorresponds to variant rs387906997dbSNPEnsembl.1
Natural variantiVAR_066502940S → R in HPE11. 1 PublicationCorresponds to variant rs369673018dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0182011212 – 1234Missing in isoform 2. 1 PublicationAdd BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004841 mRNA. Translation: AAC34901.2.
AP000821 Genomic DNA. No translation available.
AP000842 Genomic DNA. No translation available.
BC098583 mRNA. Translation: AAH98583.1.
CCDSiCCDS58192.1. [Q4KMG0-1]
CCDS8468.1. [Q4KMG0-2]
PIRiT03097.
RefSeqiNP_001230526.1. NM_001243597.1. [Q4KMG0-1]
NP_058648.4. NM_016952.4. [Q4KMG0-2]
XP_011541164.1. XM_011542862.2. [Q4KMG0-1]
XP_011541165.1. XM_011542863.2. [Q4KMG0-1]
XP_011541166.1. XM_011542864.2. [Q4KMG0-1]
XP_011541167.1. XM_011542865.2. [Q4KMG0-1]
XP_011541168.1. XM_011542866.2. [Q4KMG0-2]
XP_016873362.1. XM_017017873.1. [Q4KMG0-1]
UniGeneiHs.38034.

Genome annotation databases

EnsembliENST00000263577; ENSP00000263577; ENSG00000064309. [Q4KMG0-2]
ENST00000392693; ENSP00000376458; ENSG00000064309. [Q4KMG0-1]
GeneIDi50937.
KEGGihsa:50937.
UCSCiuc001qdc.5. human. [Q4KMG0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004841 mRNA. Translation: AAC34901.2.
AP000821 Genomic DNA. No translation available.
AP000842 Genomic DNA. No translation available.
BC098583 mRNA. Translation: AAH98583.1.
CCDSiCCDS58192.1. [Q4KMG0-1]
CCDS8468.1. [Q4KMG0-2]
PIRiT03097.
RefSeqiNP_001230526.1. NM_001243597.1. [Q4KMG0-1]
NP_058648.4. NM_016952.4. [Q4KMG0-2]
XP_011541164.1. XM_011542862.2. [Q4KMG0-1]
XP_011541165.1. XM_011542863.2. [Q4KMG0-1]
XP_011541166.1. XM_011542864.2. [Q4KMG0-1]
XP_011541167.1. XM_011542865.2. [Q4KMG0-1]
XP_011541168.1. XM_011542866.2. [Q4KMG0-2]
XP_016873362.1. XM_017017873.1. [Q4KMG0-1]
UniGeneiHs.38034.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3D1MX-ray1.70C/D826-924[»]
3N1FX-ray1.60C/D826-924[»]
3N1QX-ray2.89C/D/F826-924[»]
ProteinModelPortaliQ4KMG0.
SMRiQ4KMG0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119165. 11 interactors.
DIPiDIP-57226N.
IntActiQ4KMG0. 1 interactor.
MINTiMINT-2795255.
STRINGi9606.ENSP00000263577.

PTM databases

iPTMnetiQ4KMG0.
PhosphoSitePlusiQ4KMG0.

Polymorphism and mutation databases

BioMutaiCDON.
DMDMi308153422.

Proteomic databases

EPDiQ4KMG0.
MaxQBiQ4KMG0.
PaxDbiQ4KMG0.
PeptideAtlasiQ4KMG0.
PRIDEiQ4KMG0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263577; ENSP00000263577; ENSG00000064309. [Q4KMG0-2]
ENST00000392693; ENSP00000376458; ENSG00000064309. [Q4KMG0-1]
GeneIDi50937.
KEGGihsa:50937.
UCSCiuc001qdc.5. human. [Q4KMG0-1]

Organism-specific databases

CTDi50937.
DisGeNETi50937.
GeneCardsiCDON.
H-InvDBHIX0035847.
HGNCiHGNC:17104. CDON.
HPAiCAB012422.
HPA017377.
MalaCardsiCDON.
MIMi608707. gene.
614226. phenotype.
neXtProtiNX_Q4KMG0.
OpenTargetsiENSG00000064309.
Orphaneti93925. Alobar holoprosencephaly.
93924. Lobar holoprosencephaly.
280200. Microform holoprosencephaly.
93926. Midline interhemispheric variant of holoprosencephaly.
220386. Semilobar holoprosencephaly.
280195. Septopreoptic holoprosencephaly.
PharmGKBiPA26328.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHIH. Eukaryota.
ENOG410XSVT. LUCA.
GeneTreeiENSGT00840000129688.
HOGENOMiHOG000060072.
HOVERGENiHBG081073.
InParanoidiQ4KMG0.
KOiK20033.
OMAiVSDTQIM.
OrthoDBiEOG091G00TB.
PhylomeDBiQ4KMG0.
TreeFamiTF332268.

Enzyme and pathway databases

ReactomeiR-HSA-375170. CDO in myogenesis.
R-HSA-5632681. Ligand-receptor interactions.
R-HSA-5635838. Activation of SMO.
SIGNORiQ4KMG0.

Miscellaneous databases

ChiTaRSiCDON. human.
EvolutionaryTraceiQ4KMG0.
GeneWikiiCDON.
GenomeRNAii50937.
PROiQ4KMG0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000064309.
CleanExiHS_CDON.
ExpressionAtlasiQ4KMG0. baseline and differential.
GenevisibleiQ4KMG0. HS.

Family and domain databases

CDDicd00063. FN3. 3 hits.
Gene3Di2.60.40.10. 8 hits.
InterProiIPR032983. CDO.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PANTHERiPTHR10489:SF12. PTHR10489:SF12. 5 hits.
PfamiPF00041. fn3. 3 hits.
PF07679. I-set. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 3 hits.
SM00409. IG. 5 hits.
SM00408. IGc2. 5 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 5 hits.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDON_HUMAN
AccessioniPrimary (citable) accession number: Q4KMG0
Secondary accession number(s): O14631
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: October 5, 2010
Last modified: November 30, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.