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Q4KMG0

- CDON_HUMAN

UniProt

Q4KMG0 - CDON_HUMAN

Protein

Cell adhesion molecule-related/down-regulated by oncogenes

Gene

CDON

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 2 (05 Oct 2010)
      Previous versions | rss
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    Functioni

    Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. anterior/posterior pattern specification Source: Ensembl
    2. cell adhesion Source: UniProtKB
    3. cell fate specification Source: Ensembl
    4. cerebral cortex development Source: Ensembl
    5. embryonic body morphogenesis Source: Ensembl
    6. embryonic retina morphogenesis in camera-type eye Source: Ensembl
    7. lens development in camera-type eye Source: Ensembl
    8. muscle cell differentiation Source: Reactome
    9. myoblast fusion Source: Ensembl
    10. positive regulation of MAPK cascade Source: Ensembl
    11. positive regulation of muscle cell differentiation Source: Reactome
    12. positive regulation of neural precursor cell proliferation Source: Ensembl
    13. positive regulation of neuron differentiation Source: Ensembl
    14. positive regulation of protein phosphorylation Source: Ensembl
    15. positive regulation of skeletal muscle tissue development Source: Ensembl
    16. positive regulation of small GTPase mediated signal transduction Source: Ensembl
    17. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    18. regulation of protein heterodimerization activity Source: Ensembl
    19. skeletal muscle satellite cell differentiation Source: Ensembl
    20. smoothened signaling pathway Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_21402. CDO in myogenesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cell adhesion molecule-related/down-regulated by oncogenes
    Gene namesi
    Name:CDON
    Synonyms:CDO
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:17104. CDON.

    Subcellular locationi

    Cell membrane By similarity; Single-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Holoprosencephaly 11 (HPE11) [MIM:614226]: A structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti684 – 6841T → S in HPE11. 1 Publication
    Corresponds to variant rs145983470 [ dbSNP | Ensembl ].
    VAR_066497
    Natural varianti689 – 6891P → A in HPE11. 1 Publication
    VAR_066498
    Natural varianti691 – 6911V → M in HPE11. 1 Publication
    VAR_066499
    Natural varianti780 – 7801V → E in HPE11. 1 Publication
    VAR_066500
    Natural varianti790 – 7901T → A in HPE11. 1 Publication
    VAR_066501
    Natural varianti940 – 9401S → R in HPE11. 1 Publication
    VAR_066502

    Keywords - Diseasei

    Disease mutation, Holoprosencephaly

    Organism-specific databases

    MIMi614226. phenotype.
    Orphaneti93925. Alobar holoprosencephaly.
    93924. Lobar holoprosencephaly.
    280200. Microform holoprosencephaly.
    93926. Midline interhemispheric variant of holoprosencephaly.
    220386. Semilobar holoprosencephaly.
    280195. Septopreoptic holoprosencephaly.
    PharmGKBiPA26328.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 12871262Cell adhesion molecule-related/down-regulated by oncogenesPRO_0000234054Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi50 ↔ 97PROSITE-ProRule annotation
    Glycosylationi88 – 881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi141 ↔ 191PROSITE-ProRule annotation
    Glycosylationi180 – 1801N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi243 ↔ 290PROSITE-ProRule annotation
    Glycosylationi287 – 2871N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi294 – 2941N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi333 ↔ 380PROSITE-ProRule annotation
    Glycosylationi342 – 3421N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi426 ↔ 500PROSITE-ProRule annotation
    Glycosylationi427 – 4271N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi570 – 5701N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi873 – 8731N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ4KMG0.
    PaxDbiQ4KMG0.
    PRIDEiQ4KMG0.

    PTM databases

    PhosphoSiteiQ4KMG0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ4KMG0.
    BgeeiQ4KMG0.
    CleanExiHS_CDON.
    GenevestigatoriQ4KMG0.

    Organism-specific databases

    HPAiCAB012422.
    HPA017377.

    Interactioni

    Subunit structurei

    Part of a complex that contains BOC, CDON, NEO1, cadherins and CTNNB1. Interacts with NTN3 By similarity. Interacts with PTCH1 By similarity. Interacts with GAS1 By similarity. Interacts with DHH, IHH and SHH.By similarity2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ABL1P005192EBI-7016840,EBI-375543

    Protein-protein interaction databases

    BioGridi119165. 4 interactions.
    DIPiDIP-57226N.
    IntActiQ4KMG0. 1 interaction.
    MINTiMINT-2795255.
    STRINGi9606.ENSP00000263577.

    Structurei

    Secondary structure

    1
    1287
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi831 – 8377
    Beta strandi839 – 8413
    Beta strandi843 – 8486
    Beta strandi861 – 8688
    Helixi874 – 8763
    Beta strandi878 – 8836
    Beta strandi887 – 8915
    Beta strandi899 – 90810
    Beta strandi919 – 9224

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3D1MX-ray1.70C/D826-924[»]
    3N1FX-ray1.60C/D826-924[»]
    3N1QX-ray2.89C/D/F826-924[»]
    ProteinModelPortaliQ4KMG0.
    SMRiQ4KMG0. Positions 27-924.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ4KMG0.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini26 – 963938ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini985 – 1287303CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei964 – 98421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini29 – 11486Ig-like C2-type 1Add
    BLAST
    Domaini120 – 20485Ig-like C2-type 2Add
    BLAST
    Domaini225 – 30379Ig-like C2-type 3Add
    BLAST
    Domaini310 – 39687Ig-like C2-type 4Add
    BLAST
    Domaini405 – 516112Ig-like C2-type 5Add
    BLAST
    Domaini579 – 67799Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini723 – 82199Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini826 – 926101Fibronectin type-III 3PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 3 fibronectin type-III domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG150729.
    HOGENOMiHOG000060072.
    HOVERGENiHBG081073.
    InParanoidiQ4KMG0.
    OMAiVSDTQIM.
    OrthoDBiEOG7MD4PB.
    PhylomeDBiQ4KMG0.
    TreeFamiTF332268.

    Family and domain databases

    Gene3Di2.60.40.10. 8 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    [Graphical view]
    PfamiPF00041. fn3. 3 hits.
    PF07679. I-set. 3 hits.
    [Graphical view]
    SMARTiSM00060. FN3. 3 hits.
    SM00409. IG. 1 hit.
    SM00408. IGc2. 4 hits.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 2 hits.
    PROSITEiPS50853. FN3. 3 hits.
    PS50835. IG_LIKE. 5 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q4KMG0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MHPDLGPLCT LLYVTLTILC SSVSSDLAPY FTSEPLSAVQ KLGGPVVLHC     50
    SAQPVTTRIS WLHNGKTLDG NLEHVKIHQG TLTILSLNSS LLGYYQCLAN 100
    NSIGAIVSGP ATVSVAVLGD FGSSTKHVIT AEEKSAGFIG CRVPESNPKA 150
    EVRYKIRGKW LEHSTENYLI LPSGNLQILN VSLEDKGSYK CAAYNPVTHQ 200
    LKVEPIGRKL LVSRPSSDDV HILHPTHSQA LAVLSRSPVT LECVVSGVPA 250
    PQVYWLKDGQ DIAPGSNWRR LYSHLATDSV DPADSGNYSC MAGNKSGDVK 300
    YVTYMVNVLE HASISKGLQD QIVSLGATVH FTCDVHGNPA PNCTWFHNAQ 350
    PIHPSARHLT AGNGLKISGV TVEDVGMYQC VADNGIGFMH STGRLEIEND 400
    GGFKPVIITA PVSAKVADGD FVTLSCNASG LPVPVIRWYD SHGLITSHPS 450
    QVLRSKSRKS QLSRPEGLNL EPVYFVLSQA GASSLHIQAV TQEHAGKYIC 500
    EAANEHGTTQ AEASLMVVPF ETNTKAETVT LPDAAQNDDR SKRDGSETGL 550
    LSSFPVKVHP SAVESAPEKN ASGISVPDAP IILSPPQTHT PDTYNLVWRA 600
    GKDGGLPINA YFVKYRKLDD GVGMLGSWHT VRVPGSENEL HLAELEPSSL 650
    YEVLMVARSA AGEGQPAMLT FRTSKEKTAS SKNTQASSPP VGIPKYPVVS 700
    EAANNNFGVV LTDSSRHSGV PEAPDRPTIS TASETSVYVT WIPRANGGSP 750
    ITAFKVEYKR MRTSNWLVAA EDIPPSKLSV EVRSLEPGST YKFRVIAINH 800
    YGESFRSSAS RPYQVVGFPN RFSSRPITGP HIAYTEAVSD TQIMLKWTYI 850
    PSSNNNTPIQ GFYIYYRPTD SDNDSDYKRD VVEGSKQWHM IGHLQPETSY 900
    DIKMQCFNEG GESEFSNVMI CETKVKRVPG ASEYPVKDLS TPPNSLGSGG 950
    NVGPATSPAR SSDMLYLIVG CVLGVMVLIL MVFIAMCLWK NRQQNTIQKY 1000
    DPPGYLYQGS DMNGQMVDYT TLSGASQING NVHGGFLTNG GLSSGYSHLH 1050
    HKVPNAVNGI VNGSLNGGLY SGHSNSLTRT HVDFEHPHHL VNGGGMYTAV 1100
    PQIDPLECVN CRNCRNNNRC FTKTNSTFSS SPPPVVPVVA PYPQDGLEMK 1150
    PLSHVKVPVC LTSAVPDCGQ LPEESVKDNV EPVPTQRTCC QDIVNDVSSD 1200
    GSEDPAEFSR GQEGMINLRI PDHLQLAKSC VWEGDSCAHS ETEINIVSWN 1250
    ALILPPVPEG CAEKTMWSPP GIPLDSPTEV LQQPRET 1287
    Length:1,287
    Mass (Da):139,147
    Last modified:October 5, 2010 - v2
    Checksum:iB7870C66F5224BBE
    GO
    Isoform 2 (identifier: Q4KMG0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1212-1234: Missing.

    Show »
    Length:1,264
    Mass (Da):136,527
    Checksum:i79AB36E0B52C61D7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti75 – 751V → I in AAC34901. (PubMed:9214393)Curated
    Sequence conflicti75 – 751V → I in AAH98583. (PubMed:15489334)Curated
    Sequence conflicti265 – 2651G → E in AAH98583. (PubMed:15489334)Curated
    Sequence conflicti300 – 3001K → E in AAC34901. (PubMed:9214393)Curated
    Sequence conflicti669 – 6691L → I in AAC34901. (PubMed:9214393)Curated
    Sequence conflicti1244 – 12441I → N in AAH98583. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti66 – 661K → R.
    Corresponds to variant rs7122277 [ dbSNP | Ensembl ].
    VAR_056038
    Natural varianti162 – 1621E → K.
    Corresponds to variant rs3740909 [ dbSNP | Ensembl ].
    VAR_056039
    Natural varianti351 – 3511P → A.
    Corresponds to variant rs35665264 [ dbSNP | Ensembl ].
    VAR_056040
    Natural varianti684 – 6841T → S in HPE11. 1 Publication
    Corresponds to variant rs145983470 [ dbSNP | Ensembl ].
    VAR_066497
    Natural varianti686 – 6861A → V.
    Corresponds to variant rs12274923 [ dbSNP | Ensembl ].
    VAR_056041
    Natural varianti689 – 6891P → A in HPE11. 1 Publication
    VAR_066498
    Natural varianti691 – 6911V → M in HPE11. 1 Publication
    VAR_066499
    Natural varianti780 – 7801V → E in HPE11. 1 Publication
    VAR_066500
    Natural varianti790 – 7901T → A in HPE11. 1 Publication
    VAR_066501
    Natural varianti940 – 9401S → R in HPE11. 1 Publication
    VAR_066502

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1212 – 123423Missing in isoform 2. 1 PublicationVSP_018201Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF004841 mRNA. Translation: AAC34901.2.
    AP000821 Genomic DNA. No translation available.
    AP000842 Genomic DNA. No translation available.
    BC098583 mRNA. Translation: AAH98583.1.
    CCDSiCCDS58192.1. [Q4KMG0-1]
    CCDS8468.1. [Q4KMG0-2]
    PIRiT03097.
    RefSeqiNP_001230526.1. NM_001243597.1. [Q4KMG0-1]
    NP_058648.4. NM_016952.4. [Q4KMG0-2]
    UniGeneiHs.38034.

    Genome annotation databases

    EnsembliENST00000263577; ENSP00000263577; ENSG00000064309. [Q4KMG0-2]
    ENST00000392693; ENSP00000376458; ENSG00000064309. [Q4KMG0-1]
    GeneIDi50937.
    KEGGihsa:50937.
    UCSCiuc001qdc.4. human. [Q4KMG0-2]
    uc009zbw.3. human. [Q4KMG0-1]

    Polymorphism databases

    DMDMi308153422.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF004841 mRNA. Translation: AAC34901.2 .
    AP000821 Genomic DNA. No translation available.
    AP000842 Genomic DNA. No translation available.
    BC098583 mRNA. Translation: AAH98583.1 .
    CCDSi CCDS58192.1. [Q4KMG0-1 ]
    CCDS8468.1. [Q4KMG0-2 ]
    PIRi T03097.
    RefSeqi NP_001230526.1. NM_001243597.1. [Q4KMG0-1 ]
    NP_058648.4. NM_016952.4. [Q4KMG0-2 ]
    UniGenei Hs.38034.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3D1M X-ray 1.70 C/D 826-924 [» ]
    3N1F X-ray 1.60 C/D 826-924 [» ]
    3N1Q X-ray 2.89 C/D/F 826-924 [» ]
    ProteinModelPortali Q4KMG0.
    SMRi Q4KMG0. Positions 27-924.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119165. 4 interactions.
    DIPi DIP-57226N.
    IntActi Q4KMG0. 1 interaction.
    MINTi MINT-2795255.
    STRINGi 9606.ENSP00000263577.

    PTM databases

    PhosphoSitei Q4KMG0.

    Polymorphism databases

    DMDMi 308153422.

    Proteomic databases

    MaxQBi Q4KMG0.
    PaxDbi Q4KMG0.
    PRIDEi Q4KMG0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000263577 ; ENSP00000263577 ; ENSG00000064309 . [Q4KMG0-2 ]
    ENST00000392693 ; ENSP00000376458 ; ENSG00000064309 . [Q4KMG0-1 ]
    GeneIDi 50937.
    KEGGi hsa:50937.
    UCSCi uc001qdc.4. human. [Q4KMG0-2 ]
    uc009zbw.3. human. [Q4KMG0-1 ]

    Organism-specific databases

    CTDi 50937.
    GeneCardsi GC11M125866.
    H-InvDB HIX0035847.
    HGNCi HGNC:17104. CDON.
    HPAi CAB012422.
    HPA017377.
    MIMi 608707. gene.
    614226. phenotype.
    neXtProti NX_Q4KMG0.
    Orphaneti 93925. Alobar holoprosencephaly.
    93924. Lobar holoprosencephaly.
    280200. Microform holoprosencephaly.
    93926. Midline interhemispheric variant of holoprosencephaly.
    220386. Semilobar holoprosencephaly.
    280195. Septopreoptic holoprosencephaly.
    PharmGKBi PA26328.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG150729.
    HOGENOMi HOG000060072.
    HOVERGENi HBG081073.
    InParanoidi Q4KMG0.
    OMAi VSDTQIM.
    OrthoDBi EOG7MD4PB.
    PhylomeDBi Q4KMG0.
    TreeFami TF332268.

    Enzyme and pathway databases

    Reactomei REACT_21402. CDO in myogenesis.

    Miscellaneous databases

    EvolutionaryTracei Q4KMG0.
    GeneWikii CDON.
    GenomeRNAii 50937.
    NextBioi 53379.
    PROi Q4KMG0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q4KMG0.
    Bgeei Q4KMG0.
    CleanExi HS_CDON.
    Genevestigatori Q4KMG0.

    Family and domain databases

    Gene3Di 2.60.40.10. 8 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    [Graphical view ]
    Pfami PF00041. fn3. 3 hits.
    PF07679. I-set. 3 hits.
    [Graphical view ]
    SMARTi SM00060. FN3. 3 hits.
    SM00409. IG. 1 hit.
    SM00408. IGc2. 4 hits.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 2 hits.
    PROSITEi PS50853. FN3. 3 hits.
    PS50835. IG_LIKE. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "CDO: an oncogene-, serum-, and anchorage-regulated member of the Ig/fibronectin type III repeat family."
      Kang J.-S., Gao M., Feinleib J.L., Cotter P.D., Guadagno S.N., Krauss R.S.
      J. Cell Biol. 138:203-213(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Fetal brain and Fetal lung.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Placenta.
    4. "The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla."
      McLellan J.S., Zheng X., Hauk G., Ghirlando R., Beachy P.A., Leahy D.J.
      Nature 455:979-983(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 826-924 IN COMPLEX WITH SHH, INTERACTION WITH SHH.
    5. "All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner."
      Kavran J.M., Ward M.D., Oladosu O.O., Mulepati S., Leahy D.J.
      J. Biol. Chem. 285:24584-24590(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 826-924 IN COMPLEXES WITH IHH AND DHH, INTERACTION WITH IHH AND DHH.
    6. "Mutations in CDON, encoding a hedgehog receptor, result in holoprosencephaly and defective interactions with other hedgehog receptors."
      Bae G.U., Domene S., Roessler E., Schachter K., Kang J.S., Muenke M., Krauss R.S.
      Am. J. Hum. Genet. 89:231-240(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS HPE11 SER-684; ALA-689; MET-691; GLU-780; ALA-790 AND ARG-940.

    Entry informationi

    Entry nameiCDON_HUMAN
    AccessioniPrimary (citable) accession number: Q4KMG0
    Secondary accession number(s): O14631
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2006
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 92 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3