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Q4KMC8

- ALDCA_DANRE

UniProt

Q4KMC8 - ALDCA_DANRE

Protein

Fructose-bisphosphate aldolase C-A

Gene

aldoca

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (02 Aug 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.Curated

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei56 – 561SubstrateBy similarity
    Binding sitei147 – 1471SubstrateBy similarity
    Active sitei188 – 1881Proton acceptorBy similarity
    Active sitei230 – 2301Schiff-base intermediate with dihydroxyacetone-PBy similarity
    Sitei364 – 3641Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphateBy similarity

    GO - Molecular functioni

    1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Schiff base

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00183.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fructose-bisphosphate aldolase C-AImported (EC:4.1.2.13)
    Alternative name(s):
    Aldolase C-likeImported
    Brain-type aldolase-ABy similarity
    Gene namesi
    Name:aldocaImported
    Synonyms:aldoclImported, zebrin II1 Publication
    ORF Names:zgc:112357
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Unplaced

    Organism-specific databases

    ZFINiZDB-GENE-050706-128. aldoca.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 364363Fructose-bisphosphate aldolase C-ASequence AnalysisPRO_0000389523Add
    BLAST

    Proteomic databases

    PRIDEiQ4KMC8.

    Expressioni

    Tissue specificityi

    Expressed specifically in Purkinje cells in the brain.1 Publication

    Inductioni

    By phenylethyl alcohol (PEA) in the olfactory sensory epithelium.1 Publication

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000074827.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4KMC8.
    SMRiQ4KMC8. Positions 3-343.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class I fructose-bisphosphate aldolase family.Sequence Analysis

    Phylogenomic databases

    eggNOGiCOG3588.
    HOGENOMiHOG000220876.
    HOVERGENiHBG002386.
    InParanoidiQ4KMC8.
    KOiK01623.
    PhylomeDBiQ4KMC8.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR000741. FBA_I.
    [Graphical view]
    PfamiPF00274. Glycolytic. 1 hit.
    [Graphical view]
    PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q4KMC8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTHQFPPLTT EQKKELHEIA LRIVSPGKGI LAADESIGSM GKRLNQIGVE    50
    NNEENRRLFR QVLFTADDRI DNCIGGVIFF HETLYQNSDD GVPFVKMIKD 100
    KGITIGIKVD KGVVPLPGTN GETATQGLDG LSERCAQYKK DGADFAKWRC 150
    VMKISETTPS NLCITENAKV LARYASICQQ HGIVPIVEPE ILPDGDHNLK 200
    RCQFVTERVL AAVYKAMFDH HVYLEGTLLK PNMVTPGHGC PTKYSAEEVA 250
    MATVTALRRT VPPAVTGVTF LSGGQSEEEA SINLSAINNC RLVKPWALTF 300
    SFGRALQASA LKTWRGQREN EAAATEEFIK RAEINSLASQ GKYTVCGDSS 350
    GATGLSHYLS SYAY 364
    Length:364
    Mass (Da):39,870
    Last modified:August 2, 2005 - v1
    Checksum:i7AB3C287EAF1862E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC098624 mRNA. Translation: AAH98624.1.
    RefSeqiNP_001025123.1. NM_001029952.1.
    UniGeneiDr.118183.

    Genome annotation databases

    GeneIDi792692.
    KEGGidre:792692.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC098624 mRNA. Translation: AAH98624.1 .
    RefSeqi NP_001025123.1. NM_001029952.1.
    UniGenei Dr.118183.

    3D structure databases

    ProteinModelPortali Q4KMC8.
    SMRi Q4KMC8. Positions 3-343.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000074827.

    Proteomic databases

    PRIDEi Q4KMC8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 792692.
    KEGGi dre:792692.

    Organism-specific databases

    CTDi 792692.
    ZFINi ZDB-GENE-050706-128. aldoca.

    Phylogenomic databases

    eggNOGi COG3588.
    HOGENOMi HOG000220876.
    HOVERGENi HBG002386.
    InParanoidi Q4KMC8.
    KOi K01623.
    PhylomeDBi Q4KMC8.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00183 .

    Miscellaneous databases

    NextBioi 20931154.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR000741. FBA_I.
    [Graphical view ]
    Pfami PF00274. Glycolytic. 1 hit.
    [Graphical view ]
    PROSITEi PS00158. ALDOLASE_CLASS_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: BrainImported.
    2. "Olfactory imprinting is correlated with changes in gene expression in the olfactory epithelia of the zebrafish."
      Harden M.V., Newton L.A., Lloyd R.C., Whitlock K.E.
      J. Neurobiol. 66:1452-1466(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    3. "Anatomy of zebrafish cerebellum and screen for mutations affecting its development."
      Bae Y.-K., Kani S., Shimizu T., Tanabe K., Nojima H., Kimura Y., Higashijima S., Hibi M.
      Dev. Biol. 330:406-426(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiALDCA_DANRE
    AccessioniPrimary (citable) accession number: Q4KMC8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 24, 2009
    Last sequence update: August 2, 2005
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3