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Q4KMC8

- ALDCA_DANRE

UniProt

Q4KMC8 - ALDCA_DANRE

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Protein

Fructose-bisphosphate aldolase C-A

Gene
aldoca, aldocl, zebrin II, zgc:112357
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei56 – 561Substrate By similarityBy similarity
Binding sitei147 – 1471Substrate By similarityBy similarity
Active sitei188 – 1881Proton acceptor By similarityBy similarity
Active sitei230 – 2301Schiff-base intermediate with dihydroxyacetone-P By similarityBy similarity
Sitei364 – 3641Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate By similarityBy similarity

GO - Molecular functioni

  1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase C-A (EC:4.1.2.13)
Alternative name(s):
Aldolase C-like
Brain-type aldolase-A
Gene namesi
Name:aldoca
Synonyms:aldocl, zebrin II
ORF Names:zgc:112357
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-050706-128. aldoca.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarityBy similarity
Chaini2 – 364363Fructose-bisphosphate aldolase C-APRO_0000389523Add
BLAST

Proteomic databases

PRIDEiQ4KMC8.

Expressioni

Tissue specificityi

Expressed specifically in Purkinje cells in the brain.1 Publication

Inductioni

By phenylethyl alcohol (PEA) in the olfactory sensory epithelium.1 Publication

Interactioni

Subunit structurei

Homotetramer By similarity.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000074827.

Structurei

3D structure databases

ProteinModelPortaliQ4KMC8.
SMRiQ4KMC8. Positions 3-343.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3588.
HOGENOMiHOG000220876.
HOVERGENiHBG002386.
InParanoidiQ4KMC8.
KOiK01623.
PhylomeDBiQ4KMC8.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR000741. FBA_I.
[Graphical view]
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4KMC8-1 [UniParc]FASTAAdd to Basket

« Hide

MTHQFPPLTT EQKKELHEIA LRIVSPGKGI LAADESIGSM GKRLNQIGVE    50
NNEENRRLFR QVLFTADDRI DNCIGGVIFF HETLYQNSDD GVPFVKMIKD 100
KGITIGIKVD KGVVPLPGTN GETATQGLDG LSERCAQYKK DGADFAKWRC 150
VMKISETTPS NLCITENAKV LARYASICQQ HGIVPIVEPE ILPDGDHNLK 200
RCQFVTERVL AAVYKAMFDH HVYLEGTLLK PNMVTPGHGC PTKYSAEEVA 250
MATVTALRRT VPPAVTGVTF LSGGQSEEEA SINLSAINNC RLVKPWALTF 300
SFGRALQASA LKTWRGQREN EAAATEEFIK RAEINSLASQ GKYTVCGDSS 350
GATGLSHYLS SYAY 364
Length:364
Mass (Da):39,870
Last modified:August 2, 2005 - v1
Checksum:i7AB3C287EAF1862E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC098624 mRNA. Translation: AAH98624.1.
RefSeqiNP_001025123.1. NM_001029952.1.
UniGeneiDr.118183.

Genome annotation databases

GeneIDi792692.
KEGGidre:792692.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC098624 mRNA. Translation: AAH98624.1 .
RefSeqi NP_001025123.1. NM_001029952.1.
UniGenei Dr.118183.

3D structure databases

ProteinModelPortali Q4KMC8.
SMRi Q4KMC8. Positions 3-343.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000074827.

Proteomic databases

PRIDEi Q4KMC8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 792692.
KEGGi dre:792692.

Organism-specific databases

CTDi 792692.
ZFINi ZDB-GENE-050706-128. aldoca.

Phylogenomic databases

eggNOGi COG3588.
HOGENOMi HOG000220876.
HOVERGENi HBG002386.
InParanoidi Q4KMC8.
KOi K01623.
PhylomeDBi Q4KMC8.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00183 .

Miscellaneous databases

NextBioi 20931154.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR000741. FBA_I.
[Graphical view ]
Pfami PF00274. Glycolytic. 1 hit.
[Graphical view ]
PROSITEi PS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "Olfactory imprinting is correlated with changes in gene expression in the olfactory epithelia of the zebrafish."
    Harden M.V., Newton L.A., Lloyd R.C., Whitlock K.E.
    J. Neurobiol. 66:1452-1466(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  3. "Anatomy of zebrafish cerebellum and screen for mutations affecting its development."
    Bae Y.-K., Kani S., Shimizu T., Tanabe K., Nojima H., Kimura Y., Higashijima S., Hibi M.
    Dev. Biol. 330:406-426(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiALDCA_DANRE
AccessioniPrimary (citable) accession number: Q4KMC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: August 2, 2005
Last modified: September 3, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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