Q4KMC8 (ALDCA_DANRE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fructose-bisphosphate aldolase C-A
EC=4.1.2.13

Alternative name(s):
Aldolase C-like
Brain-type aldolase-A

Gene names

Name:	aldoca
Synonyms:	aldocl, zebrin II
ORF Names:	zgc:112357

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Otocephala › Ostariophysi › Otophysi › Cypriniphysi › Cypriniformes › Cyprinoidea › Cyprinidae › Danio

Protein attributes

Sequence length	364 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.
Subunit structure	Homotetramer By similarity. UniProtKB P09117
Tissue specificity	Expressed specifically in Purkinje cells in the brain. Ref.3
Induction	By phenylethyl alcohol (PEA) in the olfactory sensory epithelium. Ref.2
Sequence similarities	Belongs to the class I fructose-bisphosphate aldolase family.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	fructose-bisphosphate aldolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity UniProtKB P09117
	Chain	2 – 364	363	Fructose-bisphosphate aldolase C-A		PRO_0000389523
Sites
	Active site	188	1	Proton acceptor By similarity UniProtKB P00883
	Active site	230	1	Schiff-base intermediate with dihydroxyacetone-P By similarity UniProtKB P09117
	Binding site	56	1	Substrate By similarity UniProtKB P09117
	Binding site	147	1	Substrate By similarity UniProtKB P09117
	Site	364	1	Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate By similarity UniProtKB P09117

Sequences

	Sequence		Length	Mass (Da)
	Q4KMC8 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: 7AB3C287EAF1862E	FASTA	364	39,870
	10 20 30 40 50 60 MTHQFPPLTT EQKKELHEIA LRIVSPGKGI LAADESIGSM GKRLNQIGVE NNEENRRLFR 70 80 90 100 110 120 QVLFTADDRI DNCIGGVIFF HETLYQNSDD GVPFVKMIKD KGITIGIKVD KGVVPLPGTN 130 140 150 160 170 180 GETATQGLDG LSERCAQYKK DGADFAKWRC VMKISETTPS NLCITENAKV LARYASICQQ 190 200 210 220 230 240 HGIVPIVEPE ILPDGDHNLK RCQFVTERVL AAVYKAMFDH HVYLEGTLLK PNMVTPGHGC 250 260 270 280 290 300 PTKYSAEEVA MATVTALRRT VPPAVTGVTF LSGGQSEEEA SINLSAINNC RLVKPWALTF 310 320 330 340 350 360 SFGRALQASA LKTWRGQREN EAAATEEFIK RAEINSLASQ GKYTVCGDSS GATGLSHYLS SYAY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[2]	"Olfactory imprinting is correlated with changes in gene expression in the olfactory epithelia of the zebrafish." Harden M.V., Newton L.A., Lloyd R.C., Whitlock K.E. J. Neurobiol. 66:1452-1466(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION.
[3]	"Anatomy of zebrafish cerebellum and screen for mutations affecting its development." Bae Y.-K., Kani S., Shimizu T., Tanabe K., Nojima H., Kimura Y., Higashijima S., Hibi M. Dev. Biol. 330:406-426(2009) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC098624 mRNA. Translation: AAH98624.1.
IPI	IPI00772941.
RefSeq	NP_001025123.1. NM_001029952.1.
UniGene	Dr.118183.
3D structure databases
HSSP	HSSP built from PDB template 1XDM based on UniProtKB P05062.
ProteinModelPortal	Q4KMC8.
SMR	Q4KMC8. Positions 3-343.
ModBase	Search...
Protein-protein interaction databases
STRING	7955.ENSDARP00000074827.
Proteomic databases
PRIDE	Q4KMC8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	792692.
KEGG	dre:792692.
Organism-specific databases
CTD	792692.
ZFIN	ZDB-GENE-050706-128. aldoca.
Phylogenomic databases
eggNOG	COG3588.
HOGENOM	HOG000220876.
HOVERGEN	HBG002386.
InParanoid	Q4KMC8.
KO	K01623.
OrthoDB	EOG441QBP.
Enzyme and pathway databases
UniPathway	UPA00109; UER00183.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
InterPro	IPR000741. Aldolase_I. IPR013785. Aldolase_TIM. [Graphical view]
PANTHER	PTHR11627. PTHR11627. 1 hit.
Pfam	PF00274. Glycolytic. 1 hit. [Graphical view]
PROSITE	PS00158. ALDOLASE_CLASS_I. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20931154.

Entry information

Entry name

ALDCA_DANRE

Accession

Primary (citable) accession number: Q4KMC8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 24, 2009
Last sequence update:	August 2, 2005
Last modified:	April 3, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program