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Q4KMC8 (ALDCA_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fructose-bisphosphate aldolase C-A

EC=4.1.2.13
Alternative name(s):
Aldolase C-like
Brain-type aldolase-A
Gene names
Name:aldoca
Synonyms:aldocl, zebrin II
ORF Names:zgc:112357
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length364 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.

Subunit structure

Homotetramer By similarity. UniProtKB P09117

Tissue specificity

Expressed specifically in Purkinje cells in the brain. Ref.3

Induction

By phenylethyl alcohol (PEA) in the olfactory sensory epithelium. Ref.2

Sequence similarities

Belongs to the class I fructose-bisphosphate aldolase family.

Ontologies

Keywords
   Biological processGlycolysis
   LigandSchiff base
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglycolysis

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionfructose-bisphosphate aldolase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity UniProtKB P09117
Chain2 – 364363Fructose-bisphosphate aldolase C-A
PRO_0000389523

Sites

Active site1881Proton acceptor By similarity UniProtKB P00883
Active site2301Schiff-base intermediate with dihydroxyacetone-P By similarity UniProtKB P09117
Binding site561Substrate By similarity UniProtKB P09117
Binding site1471Substrate By similarity UniProtKB P09117
Site3641Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate By similarity UniProtKB P09117

Sequences

Sequence LengthMass (Da)Tools
Q4KMC8 [UniParc].

Last modified August 2, 2005. Version 1.
Checksum: 7AB3C287EAF1862E

FASTA36439,870
        10         20         30         40         50         60 
MTHQFPPLTT EQKKELHEIA LRIVSPGKGI LAADESIGSM GKRLNQIGVE NNEENRRLFR 

        70         80         90        100        110        120 
QVLFTADDRI DNCIGGVIFF HETLYQNSDD GVPFVKMIKD KGITIGIKVD KGVVPLPGTN 

       130        140        150        160        170        180 
GETATQGLDG LSERCAQYKK DGADFAKWRC VMKISETTPS NLCITENAKV LARYASICQQ 

       190        200        210        220        230        240 
HGIVPIVEPE ILPDGDHNLK RCQFVTERVL AAVYKAMFDH HVYLEGTLLK PNMVTPGHGC 

       250        260        270        280        290        300 
PTKYSAEEVA MATVTALRRT VPPAVTGVTF LSGGQSEEEA SINLSAINNC RLVKPWALTF 

       310        320        330        340        350        360 
SFGRALQASA LKTWRGQREN EAAATEEFIK RAEINSLASQ GKYTVCGDSS GATGLSHYLS 


SYAY 

« Hide

References

« Hide 'large scale' references
[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[2]"Olfactory imprinting is correlated with changes in gene expression in the olfactory epithelia of the zebrafish."
Harden M.V., Newton L.A., Lloyd R.C., Whitlock K.E.
J. Neurobiol. 66:1452-1466(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[3]"Anatomy of zebrafish cerebellum and screen for mutations affecting its development."
Bae Y.-K., Kani S., Shimizu T., Tanabe K., Nojima H., Kimura Y., Higashijima S., Hibi M.
Dev. Biol. 330:406-426(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC098624 mRNA. Translation: AAH98624.1.
RefSeqNP_001025123.1. NM_001029952.1.
UniGeneDr.118183.

3D structure databases

ProteinModelPortalQ4KMC8.
SMRQ4KMC8. Positions 3-343.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7955.ENSDARP00000074827.

Proteomic databases

PRIDEQ4KMC8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID792692.
KEGGdre:792692.

Organism-specific databases

CTD792692.
ZFINZDB-GENE-050706-128. aldoca.

Phylogenomic databases

eggNOGCOG3588.
HOGENOMHOG000220876.
HOVERGENHBG002386.
InParanoidQ4KMC8.
KOK01623.
PhylomeDBQ4KMC8.

Enzyme and pathway databases

UniPathwayUPA00109; UER00183.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR000741. Aldolase_I.
IPR013785. Aldolase_TIM.
[Graphical view]
PANTHERPTHR11627. PTHR11627. 1 hit.
PfamPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20931154.

Entry information

Entry nameALDCA_DANRE
AccessionPrimary (citable) accession number: Q4KMC8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: August 2, 2005
Last modified: April 16, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways