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Q4KMC4

- GFPT2_RAT

UniProt

Q4KMC4 - GFPT2_RAT

Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2

Gene

Gfpt2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins.

    Catalytic activityi

    L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei2 – 21For GATase activityBy similarity

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate biosynthetic process Source: InterPro
    2. glutamine metabolic process Source: UniProtKB-KW
    3. UDP-N-acetylglucosamine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Enzyme and pathway databases

    ReactomeiREACT_196379. Synthesis of UDP-N-acetyl-glucosamine.
    SABIO-RKQ4KMC4.
    UniPathwayiUPA00113; UER00528.

    Protein family/group databases

    MEROPSiC44.975.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 (EC:2.6.1.16)
    Alternative name(s):
    D-fructose-6-phosphate amidotransferase 2
    Glutamine:fructose-6-phosphate amidotransferase 2
    Short name:
    GFAT 2
    Short name:
    GFAT2
    Hexosephosphate aminotransferase 2
    Gene namesi
    Name:Gfpt2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 10

    Organism-specific databases

    RGDi1303097. Gfpt2.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 682681Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2PRO_0000135285Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei245 – 2451PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ4KMC4.
    PRIDEiQ4KMC4.

    Expressioni

    Gene expression databases

    GenevestigatoriQ4KMC4.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000003770.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4KMC4.
    SMRiQ4KMC4. Positions 322-670.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 288287Glutamine amidotransferase type-2PROSITE-ProRule annotationAdd
    BLAST
    Domaini360 – 499140SIS 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini531 – 672142SIS 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 glutamine amidotransferase type-2 domain.PROSITE-ProRule annotation
    Contains 2 SIS domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Glutamine amidotransferase, Repeat

    Phylogenomic databases

    eggNOGiCOG0449.
    GeneTreeiENSGT00390000010049.
    HOGENOMiHOG000258898.
    HOVERGENiHBG051724.
    InParanoidiQ4KMC4.
    KOiK00820.
    OMAiRCLPEMI.
    OrthoDBiEOG73NG2S.
    PhylomeDBiQ4KMC4.

    Family and domain databases

    Gene3Di3.60.20.10. 2 hits.
    InterProiIPR017932. GATase_2_dom.
    IPR000583. GATase_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view]
    PfamiPF00310. GATase_2. 2 hits.
    PF01380. SIS. 2 hits.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 2 hits.
    TIGRFAMsiTIGR01135. glmS. 1 hit.
    PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q4KMC4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCGIFAYMNY RVPKTRKEIF ETLIRGLQRL EYRGYDSAGV AIDGNNHEVK    50
    ERHIHLVKKK GKVKALDEEL YKQDSMDLKV EFETHFGIAH TRWATHGVPN 100
    VVNSHPQRSD KDNEFVVIHN GIITNYKDLR KFLESKGYEF ESETDTETIA 150
    KLIKYVFDNR ETEDITFSTL VERVIQQLEG AFALVFKSIH YPGEAVATRR 200
    GSPLLIGVRS KYKLSTEQIP VLYRTCTIEN VKNICKTRLK RLDSSTCLHA 250
    VGDKAVEFFF ASDASAIIEH TNRVIFLEDD DIAAVADGKL SIHRVKRSAS 300
    DDPSRAIQTL QMELQQIMKG NFSAFMQKEI FEQPESVFNT MRGRVNFETN 350
    TVLLGGLKDH LKEIRRCRRL IVIGCGTSYH AAVATRQVLE ELTELPVMVE 400
    LASDFLDRNT PVFRDDVCFF ISQSGETADT LLALRYCKDR GALTVGITNT 450
    VGSSISRETD CGVHINAGPE IGVASTKAYT SQFISLVMFG LMMSEDRISL 500
    QTRRQEIIRG LRSLPELIKE VLSLDEKIHD LALELYTQRS LLVMGRGYNY 550
    ATCLEGALKI KEITYMHSEG ILAGELKHGP LALVDKQMPV IMVIMKDPCF 600
    AKCQNALQQV TARQGRPIIL CSKDDTESSK FAYKTIELPH TVDCLQGILS 650
    VIPLQLLSFH LAVLRGYDVD FPRNLAKSVT VE 682
    Length:682
    Mass (Da):77,010
    Last modified:January 23, 2007 - v3
    Checksum:iE4B4B656999F667A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC098630 mRNA. Translation: AAH98630.1.
    RefSeqiNP_001002819.2. NM_001002819.2.
    UniGeneiRn.16089.

    Genome annotation databases

    EnsembliENSRNOT00000003770; ENSRNOP00000003770; ENSRNOG00000002810.
    GeneIDi360518.
    KEGGirno:360518.
    UCSCiRGD:1303097. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC098630 mRNA. Translation: AAH98630.1 .
    RefSeqi NP_001002819.2. NM_001002819.2.
    UniGenei Rn.16089.

    3D structure databases

    ProteinModelPortali Q4KMC4.
    SMRi Q4KMC4. Positions 322-670.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000003770.

    Protein family/group databases

    MEROPSi C44.975.

    Proteomic databases

    PaxDbi Q4KMC4.
    PRIDEi Q4KMC4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000003770 ; ENSRNOP00000003770 ; ENSRNOG00000002810 .
    GeneIDi 360518.
    KEGGi rno:360518.
    UCSCi RGD:1303097. rat.

    Organism-specific databases

    CTDi 9945.
    RGDi 1303097. Gfpt2.

    Phylogenomic databases

    eggNOGi COG0449.
    GeneTreei ENSGT00390000010049.
    HOGENOMi HOG000258898.
    HOVERGENi HBG051724.
    InParanoidi Q4KMC4.
    KOi K00820.
    OMAi RCLPEMI.
    OrthoDBi EOG73NG2S.
    PhylomeDBi Q4KMC4.

    Enzyme and pathway databases

    UniPathwayi UPA00113 ; UER00528 .
    Reactomei REACT_196379. Synthesis of UDP-N-acetyl-glucosamine.
    SABIO-RK Q4KMC4.

    Miscellaneous databases

    NextBioi 673062.
    PROi Q4KMC4.

    Gene expression databases

    Genevestigatori Q4KMC4.

    Family and domain databases

    Gene3Di 3.60.20.10. 2 hits.
    InterProi IPR017932. GATase_2_dom.
    IPR000583. GATase_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view ]
    Pfami PF00310. GATase_2. 2 hits.
    PF01380. SIS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 2 hits.
    TIGRFAMsi TIGR01135. glmS. 1 hit.
    PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Heart.

    Entry informationi

    Entry nameiGFPT2_RAT
    AccessioniPrimary (citable) accession number: Q4KMC4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2005
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 71 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3