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Protein

5-azacytidine-induced protein 2

Gene

Azi2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1 (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
5-azacytidine-induced protein 2
Gene namesi
Name:Azi2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1310530 Azi2

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002806061 – 4045-azacytidine-induced protein 2Add BLAST404

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei330PhosphoserineCombined sources1
Modified residuei365PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ4KMA0
PRIDEiQ4KMA0

PTM databases

iPTMnetiQ4KMA0
PhosphoSitePlusiQ4KMA0

Interactioni

Subunit structurei

Homodimer. Interacts with IKBKE, TBK1 and TICAM1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013449

Structurei

3D structure databases

SMRiQ4KMA0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 198HomodimerizationBy similarityAdd BLAST198
Regioni229 – 269Interaction with TBK1 and IKBKEBy similarityAdd BLAST41

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili40 – 198Sequence analysisAdd BLAST159

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IG4Z Eukaryota
ENOG4111IT0 LUCA
HOGENOMiHOG000013059
HOVERGENiHBG067551
InParanoidiQ4KMA0
KOiK12651
PhylomeDBiQ4KMA0

Family and domain databases

InterProiView protein in InterPro
IPR024581 TBD
PfamiView protein in Pfam
PF12845 TBD, 1 hit

Sequencei

Sequence statusi: Complete.

Q4KMA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTLVEDDIC ILNHEKAHKR EAVTPLSAYP GDESVASHFA LVTAYEDIKK
60 70 80 90 100
RLKDSEKENS FLKKRIRALE EKLVGARVEE ETSSVGREQV NKAYHAYREV
110 120 130 140 150
CIDRDNLKSR LEKISKDNSE SLRALTEQLQ CKEVELLQLR TEVETQQVMR
160 170 180 190 200
NLNPPSSNWE VEKLSCDLKI HGLEQELELL RKECSDLRTE LQKARQTGPS
210 220 230 240 250
QEDILQDRDV IRPSLPREEH VPHQGPHHSD HMQHAYWELR REMANLHLVT
260 270 280 290 300
RVQAELLRQL KTAAAGKACT QVGCVEDLGR DSAKLHLANC TAAYKRHPPL
310 320 330 340 350
SPHGKATCYA PPSTLPGDRK AFSDKAVLQS WTDNERLTPN DGADFQEHNS
360 370 380 390 400
YGRNSLEDNS WVFPSPPKSS ETAFGESKSK ILPSPNLPPL HYLDQHNQNC

LYKS
Length:404
Mass (Da):45,986
Last modified:August 2, 2005 - v1
Checksum:i7F438E9E15BAC1DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098680 mRNA Translation: AAH98680.1
RefSeqiNP_001020876.1, NM_001025705.1
UniGeneiRn.14812

Genome annotation databases

GeneIDi316051
KEGGirno:316051
UCSCiRGD:1310530 rat

Similar proteinsi

Entry informationi

Entry nameiAZI2_RAT
AccessioniPrimary (citable) accession number: Q4KMA0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: August 2, 2005
Last modified: May 23, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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