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Protein

5-azacytidine-induced protein 2

Gene

Azi2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1 (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
5-azacytidine-induced protein 2
Gene namesi
Name:Azi2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1310530. Azi2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4044045-azacytidine-induced protein 2PRO_0000280606Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei330 – 3301PhosphoserineCombined sources
Modified residuei365 – 3651PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ4KMA0.
PRIDEiQ4KMA0.

PTM databases

iPTMnetiQ4KMA0.
PhosphoSiteiQ4KMA0.

Interactioni

Subunit structurei

Homodimer. Interacts with IKBKE, TBK1 and TICAM1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013449.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 198198HomodimerizationBy similarityAdd
BLAST
Regioni229 – 26941Interaction with TBK1 and IKBKEBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili40 – 198159Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IG4Z. Eukaryota.
ENOG4111IT0. LUCA.
HOGENOMiHOG000013059.
HOVERGENiHBG067551.
InParanoidiQ4KMA0.
KOiK12651.
PhylomeDBiQ4KMA0.

Family and domain databases

InterProiIPR024581. TBD.
[Graphical view]
PfamiPF12845. TBD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4KMA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTLVEDDIC ILNHEKAHKR EAVTPLSAYP GDESVASHFA LVTAYEDIKK
60 70 80 90 100
RLKDSEKENS FLKKRIRALE EKLVGARVEE ETSSVGREQV NKAYHAYREV
110 120 130 140 150
CIDRDNLKSR LEKISKDNSE SLRALTEQLQ CKEVELLQLR TEVETQQVMR
160 170 180 190 200
NLNPPSSNWE VEKLSCDLKI HGLEQELELL RKECSDLRTE LQKARQTGPS
210 220 230 240 250
QEDILQDRDV IRPSLPREEH VPHQGPHHSD HMQHAYWELR REMANLHLVT
260 270 280 290 300
RVQAELLRQL KTAAAGKACT QVGCVEDLGR DSAKLHLANC TAAYKRHPPL
310 320 330 340 350
SPHGKATCYA PPSTLPGDRK AFSDKAVLQS WTDNERLTPN DGADFQEHNS
360 370 380 390 400
YGRNSLEDNS WVFPSPPKSS ETAFGESKSK ILPSPNLPPL HYLDQHNQNC

LYKS
Length:404
Mass (Da):45,986
Last modified:August 2, 2005 - v1
Checksum:i7F438E9E15BAC1DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098680 mRNA. Translation: AAH98680.1.
RefSeqiNP_001020876.1. NM_001025705.1.
UniGeneiRn.14812.

Genome annotation databases

GeneIDi316051.
KEGGirno:316051.
UCSCiRGD:1310530. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098680 mRNA. Translation: AAH98680.1.
RefSeqiNP_001020876.1. NM_001025705.1.
UniGeneiRn.14812.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013449.

PTM databases

iPTMnetiQ4KMA0.
PhosphoSiteiQ4KMA0.

Proteomic databases

PaxDbiQ4KMA0.
PRIDEiQ4KMA0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi316051.
KEGGirno:316051.
UCSCiRGD:1310530. rat.

Organism-specific databases

CTDi64343.
RGDi1310530. Azi2.

Phylogenomic databases

eggNOGiENOG410IG4Z. Eukaryota.
ENOG4111IT0. LUCA.
HOGENOMiHOG000013059.
HOVERGENiHBG067551.
InParanoidiQ4KMA0.
KOiK12651.
PhylomeDBiQ4KMA0.

Miscellaneous databases

PROiQ4KMA0.

Family and domain databases

InterProiIPR024581. TBD.
[Graphical view]
PfamiPF12845. TBD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-330, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiAZI2_RAT
AccessioniPrimary (citable) accession number: Q4KMA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: August 2, 2005
Last modified: June 8, 2016
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.