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Protein

Mitochondrial fission factor

Gene

Mff

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial fission factor
Gene namesi
Name:Mff
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1310230. Mff.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 198198CytoplasmicSequence analysisAdd
BLAST
Transmembranei199 – 21618Helical; Anchor for type IV membrane proteinSequence analysisAdd
BLAST
Topological domaini217 – 2182Mitochondrial intermembraneSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Mitochondrion, Mitochondrion outer membrane, Peroxisome, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 218218Mitochondrial fission factorPRO_0000289187Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei89 – 891PhosphothreonineBy similarity
Modified residuei129 – 1291PhosphoserineBy similarity
Modified residuei131 – 1311PhosphoserineCombined sources
Modified residuei146 – 1461PhosphoserineBy similarity
Modified residuei171 – 1711PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ4KM98.
PRIDEiQ4KM98.

PTM databases

iPTMnetiQ4KM98.

Expressioni

Gene expression databases

BgeeiENSRNOG00000015428.
GenevisibleiQ4KM98. RN.

Interactioni

Subunit structurei

Homodimer. Interacts with DNM1L.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-60704N.
STRINGi10116.ENSRNOP00000020712.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili167 – 19832Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the Tango11 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410III7. Eukaryota.
ENOG410XSQR. LUCA.
HOGENOMiHOG000285976.
HOVERGENiHBG105704.
InParanoidiQ4KM98.

Family and domain databases

InterProiIPR008518. FATE/Miff/Tango-11.
[Graphical view]
PANTHERiPTHR16501. PTHR16501. 1 hit.
PfamiPF05644. Miff. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4KM98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEISRIQYE MEYTEGISQR MRVPEKLKVA PPNADLEQGF QDGVPNASVI
60 70 80 90 100
MQVPERIVVT GNNEDISFSR PADLDLIQST PFKPLALKTP PRVLTLSERP
110 120 130 140 150
LDFLDLERPP PTPQSEEIRA VGRLKRERSM SENAVRQNGQ LVRNDSMYGI
160 170 180 190 200
SSLDAAVEGA SEDMSVVDAA SLRRQIIKLN RRLQLLEEEN KERAKREMVM
210
YSITVAFWLL NSWLWFRR
Length:218
Mass (Da):24,971
Last modified:August 2, 2005 - v1
Checksum:i4CAF8F7309D707CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098682 mRNA. Translation: AAH98682.1.
RefSeqiNP_001034104.1. NM_001039015.2.
NP_001258213.1. NM_001271284.1.
NP_001263330.1. NM_001276401.1.
XP_008765547.1. XM_008767325.1.
UniGeneiRn.229030.
Rn.93479.

Genome annotation databases

GeneIDi102556337.
301563.
KEGGirno:102556337.
rno:301563.
UCSCiRGD:1310230. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098682 mRNA. Translation: AAH98682.1.
RefSeqiNP_001034104.1. NM_001039015.2.
NP_001258213.1. NM_001271284.1.
NP_001263330.1. NM_001276401.1.
XP_008765547.1. XM_008767325.1.
UniGeneiRn.229030.
Rn.93479.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60704N.
STRINGi10116.ENSRNOP00000020712.

PTM databases

iPTMnetiQ4KM98.

Proteomic databases

PaxDbiQ4KM98.
PRIDEiQ4KM98.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi102556337.
301563.
KEGGirno:102556337.
rno:301563.
UCSCiRGD:1310230. rat.

Organism-specific databases

CTDi56947.
RGDi1310230. Mff.

Phylogenomic databases

eggNOGiENOG410III7. Eukaryota.
ENOG410XSQR. LUCA.
HOGENOMiHOG000285976.
HOVERGENiHBG105704.
InParanoidiQ4KM98.

Miscellaneous databases

PROiQ4KM98.

Gene expression databases

BgeeiENSRNOG00000015428.
GenevisibleiQ4KM98. RN.

Family and domain databases

InterProiIPR008518. FATE/Miff/Tango-11.
[Graphical view]
PANTHERiPTHR16501. PTHR16501. 1 hit.
PfamiPF05644. Miff. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMFF_RAT
AccessioniPrimary (citable) accession number: Q4KM98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: August 2, 2005
Last modified: September 7, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.