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Protein

Cell division cycle-associated protein 7

Gene

Cdca7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. May play a role as transcriptional regulator (By similarity).By similarity1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division cycle-associated protein 7
Gene namesi
Name:Cdca7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1309363. Cdca7.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity

  • Note: Predominantly nuclear with some expression also seen in the cytoplasm. Predominantly cytoplasmic when phosphorylated at Thr-166 (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 377377Cell division cycle-associated protein 7PRO_0000249312Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei166 – 1661PhosphothreonineBy similarity
Modified residuei193 – 1931PhosphoserineCombined sources
Modified residuei199 – 1991PhosphothreonineBy similarity
Modified residuei220 – 2201PhosphoserineCombined sources

Post-translational modificationi

Phosphorylation at Thr-166 promotes interaction with YWHAE and YWHAZ, dissociation from MYC and sequestration in the cytoplasm.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ4KM91.
PRIDEiQ4KM91.

PTM databases

iPTMnetiQ4KM91.
PhosphoSiteiQ4KM91.

Expressioni

Gene expression databases

GenevisibleiQ4KM91. RN.

Interactioni

Subunit structurei

Interacts with MYC (via C-terminus), YWHAE and YWHAZ.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002066.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni148 – 17326Interaction with MYCBy similarityAdd
BLAST
Regioni253 – 377125Mediates transcriptional activityBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi163 – 17917Nuclear localization signalBy similarityAdd
BLAST

Phylogenomic databases

eggNOGiENOG410IFJD. Eukaryota.
ENOG410ZWEA. LUCA.
GeneTreeiENSGT00390000014657.
HOGENOMiHOG000231812.
HOVERGENiHBG060300.
InParanoidiQ4KM91.
OMAiNPDCWGV.
OrthoDBiEOG7NGQBQ.
PhylomeDBiQ4KM91.
TreeFamiTF101076.

Family and domain databases

InterProiIPR033576. CDCA7.
IPR018866. Znf-4CXXC_R1.
[Graphical view]
PANTHERiPTHR31169:SF2. PTHR31169:SF2. 1 hit.
PfamiPF10497. zf-4CXXC_R1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4KM91-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEARRARQKA LKVKNLKNVR YMKLISVETS SSSDDSCDSF ASDNFANTRL
60 70 80 90 100
QFNREGCRTR SQCRPSGPLR VAMKFPARNT RRAANTKAAP PKPSESSAND
110 120 130 140 150
SHSESDSEEE EDGMNFLEKR ALNIKQNKAM LAKLMSELES FPGIFSGRHS
160 170 180 190 200
LPGHRTKDSK SPRRRTFPGV ASRRNPERRA RPLTRSRSRI LGSLGALPTE
210 220 230 240 250
EEEDEEEEED KYMLVRRRKS VDGYMNDDDV SRSRRPGSMT LPHIIRPVED
260 270 280 290 300
VTEEEIRNIC SNSREKIYNR SLGSTCHQCR QKTTDTKTNC RNPDCWGIRG
310 320 330 340 350
QFCGPCLRNR YGEEVKDALL DPNWHCPPCR GICNCSFCRQ RDGRCATGVL
360 370
VYLAKYHGFG NVHAYLKSLK QEFEMQA
Length:377
Mass (Da):43,024
Last modified:August 2, 2005 - v1
Checksum:i891BD511AC76DC63
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098690 mRNA. Translation: AAH98690.1.
RefSeqiNP_001020864.1. NM_001025693.1.
UniGeneiRn.161800.

Genome annotation databases

EnsembliENSRNOT00000002066; ENSRNOP00000002066; ENSRNOG00000001514.
GeneIDi311742.
KEGGirno:311742.
UCSCiRGD:1309363. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098690 mRNA. Translation: AAH98690.1.
RefSeqiNP_001020864.1. NM_001025693.1.
UniGeneiRn.161800.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002066.

PTM databases

iPTMnetiQ4KM91.
PhosphoSiteiQ4KM91.

Proteomic databases

PaxDbiQ4KM91.
PRIDEiQ4KM91.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000002066; ENSRNOP00000002066; ENSRNOG00000001514.
GeneIDi311742.
KEGGirno:311742.
UCSCiRGD:1309363. rat.

Organism-specific databases

CTDi83879.
RGDi1309363. Cdca7.

Phylogenomic databases

eggNOGiENOG410IFJD. Eukaryota.
ENOG410ZWEA. LUCA.
GeneTreeiENSGT00390000014657.
HOGENOMiHOG000231812.
HOVERGENiHBG060300.
InParanoidiQ4KM91.
OMAiNPDCWGV.
OrthoDBiEOG7NGQBQ.
PhylomeDBiQ4KM91.
TreeFamiTF101076.

Miscellaneous databases

PROiQ4KM91.

Gene expression databases

GenevisibleiQ4KM91. RN.

Family and domain databases

InterProiIPR033576. CDCA7.
IPR018866. Znf-4CXXC_R1.
[Graphical view]
PANTHERiPTHR31169:SF2. PTHR31169:SF2. 1 hit.
PfamiPF10497. zf-4CXXC_R1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.
  2. "A novel c-Myc-responsive gene, JPO1, participates in neoplastic transformation."
    Prescott J.E., Osthus R.C., Lee L.A., Lewis B.C., Shim H., Barrett J.F., Guo Q., Hawkins A.L., Griffin C.A., Dang C.V.
    J. Biol. Chem. 276:48276-48284(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-193 AND SER-220, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCDCA7_RAT
AccessioniPrimary (citable) accession number: Q4KM91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: August 2, 2005
Last modified: July 6, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Cdca7 expression is correlated with MYC expression in fibroblasts and is much higher in attached cells tham in non-attached cells.

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.