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Protein

Gamma-glutamylaminecyclotransferase

Gene

Ggact

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Contributes to degradation of proteins cross-linked by transglutaminases. Degrades the cross-link between a lysine and a glutamic acid residue from two proteins that have been cross-linked by transglutaminases. Catalyzes the formation of 5-oxoproline from L-gamma-glutamyl-L-epsilon-lysine. Inactive with L-gamma-glutamyl-alpha-amino acid substrates such as L-gamma-glutamyl-L-alpha-cysteine and L-gamma-glutamyl-L-alpha-alanine (By similarity).By similarity

Catalytic activityi

(Gamma-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei82 – 821Proton acceptorBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-glutamylaminecyclotransferase (EC:2.3.2.4)
Short name:
GGACT
Alternative name(s):
AIG2-like domain-containing protein 1
Gamma-glutamylamine cyclotransferase
Gene namesi
Name:Ggact
Synonyms:A2ld1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi1304748. Ggact.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 149149Gamma-glutamylaminecyclotransferasePRO_0000320205Add
BLAST

Proteomic databases

PaxDbiQ4KM86.
PRIDEiQ4KM86.

Expressioni

Gene expression databases

BgeeiENSRNOG00000027040.
GenevisibleiQ4KM86. RN.

Interactioni

Subunit structurei

Monomer.Curated

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000118.

Structurei

3D structure databases

ProteinModelPortaliQ4KM86.
SMRiQ4KM86. Positions 1-149.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni7 – 104Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4450. Eukaryota.
ENOG4111N8W. LUCA.
GeneTreeiENSGT00390000010543.
HOGENOMiHOG000261862.
HOVERGENiHBG105481.
InParanoidiQ4KM86.
OMAiRIQVVEW.
OrthoDBiEOG091G0S6A.
PhylomeDBiQ4KM86.
TreeFamiTF323258.

Family and domain databases

Gene3Di3.10.490.10. 1 hit.
InterProiIPR009288. AIG2-like.
IPR013024. Butirosin_synth_BtrG-like.
[Graphical view]
PfamiPF06094. GGACT. 1 hit.
[Graphical view]
SUPFAMiSSF110857. SSF110857. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4KM86-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHIFVYGTL KRGQPNHKVM LDQSHGLATF RGRGCTVESF PLVIAGEHNI
60 70 80 90 100
PWLLHLPGKG HCVAGEIYEV DEQMLRFLDD FEGCPSMYQR TALQVRVLEW
110 120 130 140
EGAGGPGDSV QCFVYSTATY APEWLFLPYH KNYDSEGPHG LRYNPRENR
Length:149
Mass (Da):16,925
Last modified:August 2, 2005 - v1
Checksum:i6E68E8CFDA42F77D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098699 mRNA. Translation: AAH98699.1.
UniGeneiRn.17263.

Genome annotation databases

EnsembliENSRNOT00000019158; ENSRNOP00000000118; ENSRNOG00000027040.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098699 mRNA. Translation: AAH98699.1.
UniGeneiRn.17263.

3D structure databases

ProteinModelPortaliQ4KM86.
SMRiQ4KM86. Positions 1-149.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000118.

Proteomic databases

PaxDbiQ4KM86.
PRIDEiQ4KM86.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000019158; ENSRNOP00000000118; ENSRNOG00000027040.

Organism-specific databases

RGDi1304748. Ggact.

Phylogenomic databases

eggNOGiKOG4450. Eukaryota.
ENOG4111N8W. LUCA.
GeneTreeiENSGT00390000010543.
HOGENOMiHOG000261862.
HOVERGENiHBG105481.
InParanoidiQ4KM86.
OMAiRIQVVEW.
OrthoDBiEOG091G0S6A.
PhylomeDBiQ4KM86.
TreeFamiTF323258.

Miscellaneous databases

PROiQ4KM86.

Gene expression databases

BgeeiENSRNOG00000027040.
GenevisibleiQ4KM86. RN.

Family and domain databases

Gene3Di3.10.490.10. 1 hit.
InterProiIPR009288. AIG2-like.
IPR013024. Butirosin_synth_BtrG-like.
[Graphical view]
PfamiPF06094. GGACT. 1 hit.
[Graphical view]
SUPFAMiSSF110857. SSF110857. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGGACT_RAT
AccessioniPrimary (citable) accession number: Q4KM86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: August 2, 2005
Last modified: September 7, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.