Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Gamma-glutamylaminecyclotransferase

Gene

Ggact

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Contributes to degradation of proteins cross-linked by transglutaminases by degrading the cross-link between a lysine and a glutamic acid residue. Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine. Inactive with L-gamma-glutamyl-alpha-amino acid substrates such as L-gamma-glutamyl-L-alpha-cysteine and L-gamma-glutamyl-L-alpha-alanine.By similarity

Catalytic activityi

Epsilon-(gamma-L-glutamyl)-L-lysine = L-lysine + 5-oxo-L-proline.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei82Proton acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-10043

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-glutamylaminecyclotransferase (EC:4.3.2.8By similarity)
Short name:
GGACT
Alternative name(s):
AIG2-like domain-containing protein 1
Gamma-glutamylamine cyclotransferase
Gene namesi
Name:Ggact
Synonyms:A2ld1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi1304748 Ggact

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003202051 – 149Gamma-glutamylaminecyclotransferaseAdd BLAST149

Proteomic databases

PaxDbiQ4KM86
PRIDEiQ4KM86

Expressioni

Gene expression databases

BgeeiENSRNOG00000027040
GenevisibleiQ4KM86 RN

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000118

Structurei

3D structure databases

ProteinModelPortaliQ4KM86
SMRiQ4KM86
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni7 – 10Substrate bindingBy similarity4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4450 Eukaryota
ENOG4111N8W LUCA
GeneTreeiENSGT00390000010543
HOGENOMiHOG000261862
HOVERGENiHBG105481
InParanoidiQ4KM86
OMAiRYNPREN
OrthoDBiEOG091G0S6A
PhylomeDBiQ4KM86
TreeFamiTF323258

Family and domain databases

CDDicd06661 GGCT_like, 1 hit
InterProiView protein in InterPro
IPR009288 AIG2-like
IPR013024 GGCT-like
IPR036568 GGCT-like_sf
PfamiView protein in Pfam
PF06094 GGACT, 1 hit
SUPFAMiSSF110857 SSF110857, 1 hit

Sequencei

Sequence statusi: Complete.

Q4KM86-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHIFVYGTL KRGQPNHKVM LDQSHGLATF RGRGCTVESF PLVIAGEHNI
60 70 80 90 100
PWLLHLPGKG HCVAGEIYEV DEQMLRFLDD FEGCPSMYQR TALQVRVLEW
110 120 130 140
EGAGGPGDSV QCFVYSTATY APEWLFLPYH KNYDSEGPHG LRYNPRENR
Length:149
Mass (Da):16,925
Last modified:August 2, 2005 - v1
Checksum:i6E68E8CFDA42F77D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098699 mRNA Translation: AAH98699.1
UniGeneiRn.17263

Genome annotation databases

EnsembliENSRNOT00000019158; ENSRNOP00000000118; ENSRNOG00000027040

Similar proteinsi

Entry informationi

Entry nameiGGACT_RAT
AccessioniPrimary (citable) accession number: Q4KM86
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: August 2, 2005
Last modified: May 23, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health