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Protein

Histidine protein methyltransferase 1 homolog

Gene

Mettl18

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable histidine methyltransferase.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine protein methyltransferase 1 homolog
Alternative name(s):
Methyltransferase-like protein 18 (EC:2.1.1.-)
Gene namesi
Name:Mettl18
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi1306783 Mettl18

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002472011 – 362Histidine protein methyltransferase 1 homologAdd BLAST362

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei62PhosphoserineBy similarity1
Modified residuei67PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ4KM84
PRIDEiQ4KM84

PTM databases

PhosphoSitePlusiQ4KM84

Expressioni

Gene expression databases

BgeeiENSRNOG00000025189
GenevisibleiQ4KM84 RN

Interactioni

Subunit structurei

Interacts with GRWD1, RPL3 and members of the heat shock protein 90 and 70 families; these proteins may possibly be methylation substrates for the enzyme.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003480

Structurei

3D structure databases

ProteinModelPortaliQ4KM84
SMRiQ4KM84
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2920 Eukaryota
ENOG4111NE8 LUCA
GeneTreeiENSGT00390000000464
HOVERGENiHBG053309
InParanoidiQ4KM84
OMAiEWSEFCK
OrthoDBiEOG091G0J2W
PhylomeDBiQ4KM84
TreeFamiTF320884

Family and domain databases

InterProiView protein in InterPro
IPR019410 Methyltransf_16
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF10294 Methyltransf_16, 1 hit
SUPFAMiSSF53335 SSF53335, 3 hits

Sequencei

Sequence statusi: Complete.

Q4KM84-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFQFNFSIE EDLENKLTSL DDGTCVLKSQ KGKEDKNQST ELPGLPQDRL
60 70 80 90 100
WKCSSLGSAA SSEDTDSPPS TADRSGVPEA CEKQPSLKPA KEHVIPKDCD
110 120 130 140 150
QVLENKVLEM LPGSQHVSTA VVKTISLKEK FPGENIVSQS FSSHSDLIPG
160 170 180 190 200
VYEGGLKIWE CTFDLMTYFT KAKVKFAGQK VLDLGCGSGL LGITASKGGA
210 220 230 240 250
REVHFQDYNG LVIDEVTLPN VVANVPLQGD SNGINEPAGK RQRKSEVAQE
260 270 280 290 300
TCKCRLFSGE WAEFCKLVLS EKLFVKYDLI LTSETIYNPD YYSTLHETLL
310 320 330 340 350
RLLSRNGRVL LASKAHYFGV GGGVHLFQKF VEEKGVFETR TLEVIDEGLK
360
RFLMEMTFKC PS
Length:362
Mass (Da):40,009
Last modified:August 2, 2005 - v1
Checksum:i5C3B48F4573B2CED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098702 mRNA Translation: AAH98702.1
RefSeqiNP_001020839.1, NM_001025668.1
XP_006250217.1, XM_006250155.3
UniGeneiRn.206031

Genome annotation databases

EnsembliENSRNOT00000003636; ENSRNOP00000003480; ENSRNOG00000025189
GeneIDi304928
KEGGirno:304928
UCSCiRGD:1306783 rat

Similar proteinsi

Entry informationi

Entry nameiMET18_RAT
AccessioniPrimary (citable) accession number: Q4KM84
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: August 2, 2005
Last modified: May 23, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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