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Protein

Histidine protein methyltransferase 1 homolog

Gene

Mettl18

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Probable histidine methyltransferase.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine protein methyltransferase 1 homolog
Alternative name(s):
Methyltransferase-like protein 18 (EC:2.1.1.-)
Gene namesi
Name:Mettl18
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi1306783. Mettl18.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 362362Histidine protein methyltransferase 1 homologPRO_0000247201Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei62 – 621PhosphoserineBy similarity
Modified residuei67 – 671PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ4KM84.
PRIDEiQ4KM84.

PTM databases

PhosphoSiteiQ4KM84.

Expressioni

Gene expression databases

BgeeiENSRNOG00000025189.
GenevisibleiQ4KM84. RN.

Interactioni

Subunit structurei

Interacts with GRWD1, RPL3 and members of the heat shock protein 90 and 70 families; these proteins may possibly be methylation substrates for the enzyme.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003480.

Structurei

3D structure databases

ProteinModelPortaliQ4KM84.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2920. Eukaryota.
ENOG4111NE8. LUCA.
GeneTreeiENSGT00390000000464.
HOVERGENiHBG053309.
InParanoidiQ4KM84.
OMAiEWSEFCK.
OrthoDBiEOG091G0J2W.
PhylomeDBiQ4KM84.
TreeFamiTF320884.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR019410. Methyltransf_16.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF10294. Methyltransf_16. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 3 hits.

Sequencei

Sequence statusi: Complete.

Q4KM84-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFQFNFSIE EDLENKLTSL DDGTCVLKSQ KGKEDKNQST ELPGLPQDRL
60 70 80 90 100
WKCSSLGSAA SSEDTDSPPS TADRSGVPEA CEKQPSLKPA KEHVIPKDCD
110 120 130 140 150
QVLENKVLEM LPGSQHVSTA VVKTISLKEK FPGENIVSQS FSSHSDLIPG
160 170 180 190 200
VYEGGLKIWE CTFDLMTYFT KAKVKFAGQK VLDLGCGSGL LGITASKGGA
210 220 230 240 250
REVHFQDYNG LVIDEVTLPN VVANVPLQGD SNGINEPAGK RQRKSEVAQE
260 270 280 290 300
TCKCRLFSGE WAEFCKLVLS EKLFVKYDLI LTSETIYNPD YYSTLHETLL
310 320 330 340 350
RLLSRNGRVL LASKAHYFGV GGGVHLFQKF VEEKGVFETR TLEVIDEGLK
360
RFLMEMTFKC PS
Length:362
Mass (Da):40,009
Last modified:August 2, 2005 - v1
Checksum:i5C3B48F4573B2CED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098702 mRNA. Translation: AAH98702.1.
RefSeqiNP_001020839.1. NM_001025668.1.
XP_006250217.1. XM_006250155.2.
UniGeneiRn.206031.

Genome annotation databases

EnsembliENSRNOT00000003636; ENSRNOP00000003480; ENSRNOG00000025189.
GeneIDi304928.
KEGGirno:304928.
UCSCiRGD:1306783. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098702 mRNA. Translation: AAH98702.1.
RefSeqiNP_001020839.1. NM_001025668.1.
XP_006250217.1. XM_006250155.2.
UniGeneiRn.206031.

3D structure databases

ProteinModelPortaliQ4KM84.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003480.

PTM databases

PhosphoSiteiQ4KM84.

Proteomic databases

PaxDbiQ4KM84.
PRIDEiQ4KM84.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000003636; ENSRNOP00000003480; ENSRNOG00000025189.
GeneIDi304928.
KEGGirno:304928.
UCSCiRGD:1306783. rat.

Organism-specific databases

CTDi92342.
RGDi1306783. Mettl18.

Phylogenomic databases

eggNOGiKOG2920. Eukaryota.
ENOG4111NE8. LUCA.
GeneTreeiENSGT00390000000464.
HOVERGENiHBG053309.
InParanoidiQ4KM84.
OMAiEWSEFCK.
OrthoDBiEOG091G0J2W.
PhylomeDBiQ4KM84.
TreeFamiTF320884.

Miscellaneous databases

PROiQ4KM84.

Gene expression databases

BgeeiENSRNOG00000025189.
GenevisibleiQ4KM84. RN.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR019410. Methyltransf_16.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF10294. Methyltransf_16. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiMET18_RAT
AccessioniPrimary (citable) accession number: Q4KM84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: August 2, 2005
Last modified: September 7, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.