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Protein

RNA/RNP complex-1-interacting phosphatase

Gene

Dusp11

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. In addition, has phosphatase activity with ATP, ADP and O-methylfluorescein phosphate (in vitro). Binds to RNA. May participate in nuclear mRNA metabolism (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei150 – 1501Phosphocysteine intermediatePROSITE-ProRule annotation
Active sitei156 – 1561Proton donor/acceptorSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA/RNP complex-1-interacting phosphatase (EC:3.1.3.-)
Alternative name(s):
Dual specificity protein phosphatase 11
Phosphatase that interacts with RNA/RNP complex 1
Gene namesi
Name:Dusp11
Synonyms:Pir1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1307038. Dusp11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326RNA/RNP complex-1-interacting phosphatasePRO_0000379777Add
BLAST

Proteomic databases

PaxDbiQ4KM79.
PRIDEiQ4KM79.

Expressioni

Gene expression databases

GenevisibleiQ4KM79. RN.

Interactioni

Subunit structurei

May interact with SFRS7 and SFRS9/SRP30C.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000054285.

Structurei

3D structure databases

ProteinModelPortaliQ4KM79.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini128 – 19568Tyrosine-protein phosphataseBy similarityAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni151 – 1566Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2386. Eukaryota.
COG5226. LUCA.
GeneTreeiENSGT00530000063473.
HOGENOMiHOG000112295.
InParanoidiQ4KM79.
KOiK14165.
OMAiGPPGEDY.
OrthoDBiEOG72VH64.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4KM79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQWHYGRYS RGRDFTARAP PKKKGKNQIP ERWKDYLPVG QRMPGTRFIA
60 70 80 90 100
FKVPLQKKFE AKLMPEECFS PLDLFNKIQE QNEELGLIID LTYTQRYYKV
110 120 130 140 150
EDLPKTISYI KILTVGHQVP DSGTIFQFKS AVKEFLKRNK NNDKLIGVHC
160 170 180 190 200
THGLNRTGYL ICRYLIDVEG MRPDDAIELF NRCRGHCIER QNYIENLQKR
210 220 230 240 250
RVRKNQNASA SRSGGLEDSA HLTEQVHTTN KPVNKGPKKS RRGGHLESSQ
260 270 280 290 300
HVQTQSSAYS FRKWSQNQSV YQRGFVPPPG PAGEDYSQRR FFWSMRPNGS
310 320
QATHHKKWIA ASYQRPFYPA SWEWNV
Length:326
Mass (Da):38,068
Last modified:August 2, 2005 - v1
Checksum:i57633B0179518CB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098712 mRNA. Translation: AAH98712.1.
RefSeqiNP_001020821.1. NM_001025650.1.
XP_008761323.1. XM_008763101.1.
UniGeneiRn.24649.

Genome annotation databases

EnsembliENSRNOT00000036247; ENSRNOP00000030319; ENSRNOG00000022082.
ENSRNOT00000057475; ENSRNOP00000054285; ENSRNOG00000045539.
GeneIDi103690006.
297412.
KEGGirno:103690006.
rno:297412.
UCSCiRGD:1307038. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098712 mRNA. Translation: AAH98712.1.
RefSeqiNP_001020821.1. NM_001025650.1.
XP_008761323.1. XM_008763101.1.
UniGeneiRn.24649.

3D structure databases

ProteinModelPortaliQ4KM79.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000054285.

Proteomic databases

PaxDbiQ4KM79.
PRIDEiQ4KM79.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000036247; ENSRNOP00000030319; ENSRNOG00000022082.
ENSRNOT00000057475; ENSRNOP00000054285; ENSRNOG00000045539.
GeneIDi103690006.
297412.
KEGGirno:103690006.
rno:297412.
UCSCiRGD:1307038. rat.

Organism-specific databases

CTDi8446.
RGDi1307038. Dusp11.

Phylogenomic databases

eggNOGiKOG2386. Eukaryota.
COG5226. LUCA.
GeneTreeiENSGT00530000063473.
HOGENOMiHOG000112295.
InParanoidiQ4KM79.
KOiK14165.
OMAiGPPGEDY.
OrthoDBiEOG72VH64.

Miscellaneous databases

NextBioi642215.
PROiQ4KM79.

Gene expression databases

GenevisibleiQ4KM79. RN.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiDUS11_RAT
AccessioniPrimary (citable) accession number: Q4KM79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: August 2, 2005
Last modified: May 11, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.