ID   SC22B_RAT               Reviewed;         215 AA.
AC   Q4KM74;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-NOV-2009, entry version 39.
DE   RecName: Full=Vesicle-trafficking protein SEC22b;
DE   AltName: Full=SEC22 vesicle-trafficking protein homolog B;
DE   AltName: Full=SEC22 vesicle-trafficking protein-like 1;
DE   AltName: Full=ERS24;
DE   AltName: Full=ERS-24;
GN   Name=Sec22b; Synonyms=Sec22l1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   FUNCTION, AND INTERACTION WITH BET1; GOSR2 AND STX5.
RX   PubMed=11035026; DOI=10.1074/jbc.M007684200;
RA   Xu D., Joglekar A.P., Williams A.L., Hay J.C.;
RT   "Subunit structure of a mammalian ER/Golgi SNARE complex.";
RL   J. Biol. Chem. 275:39631-39639(2000).
RN   [3]
RP   SUBCELLULAR LOCATION.
RX   PubMed=14742712; DOI=10.1091/mbc.E03-08-0625;
RA   Volchuk A., Ravazzola M., Perrelet A., Eng W.S., Di Liberto M.,
RA   Varlamov O., Fukasawa M., Engel T., Sollner T.H., Rothman J.E.,
RA   Orci L.;
RT   "Countercurrent distribution of two distinct SNARE complexes mediating
RT   transport within the Golgi stack.";
RL   Mol. Biol. Cell 15:1506-1518(2004).
CC   -!- FUNCTION: SNARE involved in targeting and fusion of ER-derived
CC       transport vesicles with the Golgi complex as well as Golgi-derived
CC       retrograde transport vesicles with the ER.
CC   -!- SUBUNIT: Component of two distinct SNARE complexes consisting of
CC       STX5, GOSR2/BOS1, BET1 and SEC22B or STX18, USE1L, BNIP1/SEC20L
CC       and SEC22B. YKT6 can probably replace SEC22B as subunit of either
CC       complex.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum-Golgi intermediate
CC       compartment membrane; Single-pass type IV membrane protein. Golgi
CC       apparatus membrane; Single-pass type IV membrane protein.
CC       Endoplasmic reticulum membrane; Single-pass type IV membrane
CC       protein (Potential). Melanosome (By similarity).
CC   -!- PTM: Phosphorylated upon DNA damage, probably by ATM or ATR (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the synaptobrevin family.
CC   -!- SIMILARITY: Contains 1 longin domain.
CC   -!- SIMILARITY: Contains 1 v-SNARE coiled-coil homology domain.
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DR   EMBL; BC098725; AAH98725.1; -; mRNA.
DR   IPI; IPI00193522; -.
DR   RefSeq; NP_001020857.1; -.
DR   UniGene; Rn.102384; -.
DR   SMR; Q4KM74; 1-126, 2-127.
DR   STRING; Q4KM74; -.
DR   PRIDE; Q4KM74; -.
DR   Ensembl; ENSRNOT00000025327; ENSRNOP00000025327; ENSRNOG00000018673; Rattus norvegicus.
DR   GeneID; 310710; -.
DR   KEGG; rno:310710; -.
DR   UCSC; NM_001025686; rat.
DR   CTD; 310710; -.
DR   RGD; 1309988; Sec22b.
DR   HOVERGEN; Q4KM74; -.
DR   OMA; NQAKMLF; -.
DR   NextBio; 662501; -.
DR   ArrayExpress; Q4KM74; -.
DR   Genevestigator; Q4KM74; -.
DR   GermOnline; ENSRNOG00000018673; Rattus norvegicus.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW.
DR   InterPro; IPR010908; Longin.
DR   InterPro; IPR001388; Synaptobrevin.
DR   Pfam; PF00957; Synaptobrevin; 1.
DR   PRINTS; PR00219; SYNAPTOBREVN.
DR   PROSITE; PS50859; LONGIN; 1.
DR   PROSITE; PS50892; V_SNARE; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Coiled coil; Endoplasmic reticulum; ER-Golgi transport;
KW   Golgi apparatus; Membrane; Phosphoprotein; Protein transport;
KW   Transmembrane; Transport.
FT   INIT_MET      1      1       Removed (By similarity).
FT   CHAIN         2    215       Vesicle-trafficking protein SEC22b.
FT                                /FTId=PRO_0000253048.
FT   TOPO_DOM      2    194       Cytoplasmic (Potential).
FT   TRANSMEM    195    215       Anchor for type IV membrane protein
FT                                (Potential).
FT   DOMAIN        6    119       Longin.
FT   DOMAIN      134    194       v-SNARE coiled-coil homology.
FT   MOD_RES      35     35       Phosphoserine (By similarity).
FT   MOD_RES      38     38       N6-acetyllysine (By similarity).
FT   MOD_RES      48     48       Phosphoserine (By similarity).
FT   MOD_RES     137    137       Phosphoserine (By similarity).
FT   MOD_RES     168    168       Phosphoserine (By similarity).
SQ   SEQUENCE   215 AA;  24741 MW;  29B4C55961C5A044 CRC64;
     MVLLTMIARV ADGLPLAASM QEDEQSGRDL QQYQSQAKQL FRKLNEQSPT RCTLEAGAMT
     FHYIIEQGVC YLVLCEAAFP KKLAFAYLED LHSEFDEQHG KKVPTVSRPY SFIEFDTFIQ
     KTKKLYIDSR ARRNLGSINT ELQDVQRIMV ANIEEVLQRG EALSALDSKA NNLSSLSKKY
     RQDAKYLNMR STYAKLAAVA VFFIMLIVYV RFWWL
//