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Protein

Vesicle-trafficking protein SEC22b

Gene

Sec22b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.By similarity2 Publications

GO - Molecular functioni

  • SNAP receptor activity Source: GO_Central
  • syntaxin binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-RNO-5694530. Cargo concentration in the ER.
R-RNO-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle-trafficking protein SEC22b
Alternative name(s):
ER-Golgi SNARE of 24 kDa
Short name:
ERS-24
Short name:
ERS24
SEC22 vesicle-trafficking protein homolog B
SEC22 vesicle-trafficking protein-like 1
Gene namesi
Name:Sec22b
Synonyms:Sec22l1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1309988. Sec22b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 194193CytoplasmicSequence analysisAdd
BLAST
Transmembranei195 – 21521Helical; Anchor for type IV membrane proteinSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 215214Vesicle-trafficking protein SEC22bPRO_0000253048Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei38 – 381N6-acetyllysineBy similarity
Modified residuei137 – 1371PhosphoserineCombined sources
Modified residuei140 – 1401PhosphothreonineBy similarity
Modified residuei164 – 1641PhosphoserineBy similarity
Modified residuei168 – 1681PhosphoserineCombined sources
Modified residuei174 – 1741PhosphoserineBy similarity
Modified residuei177 – 1771PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ4KM74.
PRIDEiQ4KM74.

PTM databases

iPTMnetiQ4KM74.
PhosphoSiteiQ4KM74.

Expressioni

Gene expression databases

BgeeiENSRNOG00000018673.
GenevisibleiQ4KM74. RN.

Interactioni

Subunit structurei

Interacts with STX17 (Probable). Component of two distinct SNARE complexes consisting of STX5, GOSR2/BOS1, BET1 and SEC22B or STX18, USE1L, BNIP1/SEC20L and SEC22B. YKT6 can probably replace SEC22B as subunit of either complex.Curated2 Publications

GO - Molecular functioni

  • SNAP receptor activity Source: GO_Central
  • syntaxin binding Source: UniProtKB

Protein-protein interaction databases

IntActiQ4KM74. 4 interactions.
MINTiMINT-4579370.
STRINGi10116.ENSRNOP00000025327.

Structurei

3D structure databases

ProteinModelPortaliQ4KM74.
SMRiQ4KM74. Positions 1-188.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 119114LonginPROSITE-ProRule annotationAdd
BLAST
Domaini134 – 19461v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the synaptobrevin family.Sequence analysis
Contains 1 longin domain.PROSITE-ProRule annotation
Contains 1 v-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0862. Eukaryota.
COG5143. LUCA.
GeneTreeiENSGT00510000046833.
HOGENOMiHOG000044957.
HOVERGENiHBG052748.
InParanoidiQ4KM74.
KOiK08517.
OMAiVLYFWVL.
OrthoDBiEOG091G0MPE.
PhylomeDBiQ4KM74.
TreeFamiTF105933.

Family and domain databases

Gene3Di1.10.3840.10. 1 hit.
3.30.450.50. 1 hit.
InterProiIPR011012. Longin-like_dom.
IPR010908. Longin_dom.
IPR001388. Synaptobrevin.
[Graphical view]
PfamiPF13774. Longin. 1 hit.
PF00957. Synaptobrevin. 1 hit.
[Graphical view]
PRINTSiPR00219. SYNAPTOBREVN.
SMARTiSM01270. Longin. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.
PROSITEiPS50859. LONGIN. 1 hit.
PS50892. V_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4KM74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLLTMIARV ADGLPLAASM QEDEQSGRDL QQYQSQAKQL FRKLNEQSPT
60 70 80 90 100
RCTLEAGAMT FHYIIEQGVC YLVLCEAAFP KKLAFAYLED LHSEFDEQHG
110 120 130 140 150
KKVPTVSRPY SFIEFDTFIQ KTKKLYIDSR ARRNLGSINT ELQDVQRIMV
160 170 180 190 200
ANIEEVLQRG EALSALDSKA NNLSSLSKKY RQDAKYLNMR STYAKLAAVA
210
VFFIMLIVYV RFWWL
Length:215
Mass (Da):24,741
Last modified:January 23, 2007 - v3
Checksum:i29B4C55961C5A044
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098725 mRNA. Translation: AAH98725.1.
RefSeqiNP_001020857.1. NM_001025686.1.
UniGeneiRn.102384.

Genome annotation databases

EnsembliENSRNOT00000025327; ENSRNOP00000025327; ENSRNOG00000018673.
GeneIDi310710.
KEGGirno:310710.
UCSCiRGD:1309988. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098725 mRNA. Translation: AAH98725.1.
RefSeqiNP_001020857.1. NM_001025686.1.
UniGeneiRn.102384.

3D structure databases

ProteinModelPortaliQ4KM74.
SMRiQ4KM74. Positions 1-188.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ4KM74. 4 interactions.
MINTiMINT-4579370.
STRINGi10116.ENSRNOP00000025327.

PTM databases

iPTMnetiQ4KM74.
PhosphoSiteiQ4KM74.

Proteomic databases

PaxDbiQ4KM74.
PRIDEiQ4KM74.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000025327; ENSRNOP00000025327; ENSRNOG00000018673.
GeneIDi310710.
KEGGirno:310710.
UCSCiRGD:1309988. rat.

Organism-specific databases

CTDi9554.
RGDi1309988. Sec22b.

Phylogenomic databases

eggNOGiKOG0862. Eukaryota.
COG5143. LUCA.
GeneTreeiENSGT00510000046833.
HOGENOMiHOG000044957.
HOVERGENiHBG052748.
InParanoidiQ4KM74.
KOiK08517.
OMAiVLYFWVL.
OrthoDBiEOG091G0MPE.
PhylomeDBiQ4KM74.
TreeFamiTF105933.

Enzyme and pathway databases

ReactomeiR-RNO-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-RNO-5694530. Cargo concentration in the ER.
R-RNO-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Miscellaneous databases

PROiQ4KM74.

Gene expression databases

BgeeiENSRNOG00000018673.
GenevisibleiQ4KM74. RN.

Family and domain databases

Gene3Di1.10.3840.10. 1 hit.
3.30.450.50. 1 hit.
InterProiIPR011012. Longin-like_dom.
IPR010908. Longin_dom.
IPR001388. Synaptobrevin.
[Graphical view]
PfamiPF13774. Longin. 1 hit.
PF00957. Synaptobrevin. 1 hit.
[Graphical view]
PRINTSiPR00219. SYNAPTOBREVN.
SMARTiSM01270. Longin. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.
PROSITEiPS50859. LONGIN. 1 hit.
PS50892. V_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSC22B_RAT
AccessioniPrimary (citable) accession number: Q4KM74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 93 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.