ID   CDK10_RAT               Reviewed;         358 AA.
AC   Q4KM47;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   16-JUN-2009, entry version 36.
DE   RecName: Full=Cell division protein kinase 10;
DE            EC=2.7.11.22;
GN   Name=Cdk10;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. CMGC
CC       Ser/Thr protein kinase family. CDC2/CDKX subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; BC098804; AAH98804.1; -; mRNA.
DR   IPI; IPI00365341; -.
DR   RefSeq; NP_001020893.2; -.
DR   RefSeq; NP_001103406.1; -.
DR   RefSeq; NP_001103407.1; -.
DR   UniGene; Rn.20472; -.
DR   PhosphoSite; Q4KM47; -.
DR   Ensembl; ENSRNOG00000016088; Rattus norvegicus.
DR   GeneID; 361434; -.
DR   KEGG; rno:361434; -.
DR   RGD; 1304851; Cdk10.
DR   HOVERGEN; Q4KM47; -.
DR   BRENDA; 2.7.11.22; 248.
DR   NextBio; 676292; -.
DR   ArrayExpress; Q4KM47; -.
DR   GermOnline; ENSRNOG00000016088; Rattus norvegicus.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC.
DR   GO; GO:0006468; P:protein amino acid phosphorylation; IEA:InterPro.
DR   InterPro; IPR000719; Prot_kinase_core.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_pkinase-rel.
DR   InterPro; IPR008271; Ser_thr_pkin_AS.
DR   InterPro; IPR002290; Ser_thr_pkinase.
DR   Pfam; PF00069; Pkinase; 1.
DR   ProDom; PD000001; Prot_kinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Kinase; Nucleotide-binding; Phosphoprotein;
KW   Serine/threonine-protein kinase; Transferase.
FT   CHAIN         1    358       Cell division protein kinase 10.
FT                                /FTId=PRO_0000261029.
FT   DOMAIN       37    321       Protein kinase.
FT   NP_BIND      43     51       ATP (By similarity).
FT   ACT_SITE    161    161       Proton acceptor (By similarity).
FT   BINDING      66     66       ATP (By similarity).
FT   MOD_RES     194    194       Phosphothreonine (By similarity).
SQ   SEQUENCE   358 AA;  40634 MW;  F10590B86C4D4782 CRC64;
     MSQCQIWVRH HLCCSFQIPT LAASLFQLGR CRSVKEFEKL NRIGEGTYGI VYRARDTQTD
     EIVALKKVRM DKEKDGIPIS SLREITLLLR LRHPNIVELK EVVVGNHLES IFLVMGYCEQ
     DLASLLENMP TPFSEAQVKC ILLQVLRGLQ YLHRSFIIHR DLKVSNLLMT DKGCVKTADF
     GLARAYGVPV KPMTPKVVTL WYRAPELLLG TTTQTTSIDM WAVGCILAEL LAHKPLLPGT
     SEIHQIDLIV QLLGTPSENI WPGFSKLPLA GQYSLRKQPY NNLKHKFPWL SEAGLRLLNF
     LFMYDPKKRA TAGDCLESSY FKEKPLPCEP ELMPTFPHHR NKRAAPAATE GQSKRCRP
//