Reviewed, UniProtKB/Swiss-Prot Q4KM47 (CDK10_RAT)

Names and origin

Protein names

Recommended name:
    Cell division protein kinase 10
    EC=2.7.11.22

Gene names

Name:

Cdk10

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	358 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Sequence similarities	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cyclin-dependent protein kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 358	358	Cell division protein kinase 10		PRO_0000261029
Regions
	Domain	37 – 321	285	Protein kinase
	Nucleotide binding	43 – 51	9	ATP By similarity
Sites
	Active site	161	1	Proton acceptor By similarity
	Binding site	66	1	ATP By similarity
Amino acid modifications
	Modified residue	194	1	Phosphothreonine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4KM47-1 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: F10590B86C4D4782	FASTA	358	40,634
	10 20 30 40 50 60 MSQCQIWVRH HLCCSFQIPT LAASLFQLGR CRSVKEFEKL NRIGEGTYGI VYRARDTQTD 70 80 90 100 110 120 EIVALKKVRM DKEKDGIPIS SLREITLLLR LRHPNIVELK EVVVGNHLES IFLVMGYCEQ 130 140 150 160 170 180 DLASLLENMP TPFSEAQVKC ILLQVLRGLQ YLHRSFIIHR DLKVSNLLMT DKGCVKTADF 190 200 210 220 230 240 GLARAYGVPV KPMTPKVVTL WYRAPELLLG TTTQTTSIDM WAVGCILAEL LAHKPLLPGT 250 260 270 280 290 300 SEIHQIDLIV QLLGTPSENI WPGFSKLPLA GQYSLRKQPY NNLKHKFPWL SEAGLRLLNF 310 320 330 340 350 LFMYDPKKRA TAGDCLESSY FKEKPLPCEP ELMPTFPHHR NKRAAPAATE GQSKRCRP

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Spleen.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC098804 mRNA. Translation: AAH98804.1.
IPI	IPI00365341.
RefSeq	NP_001020893.2. NP_001103406.1. NP_001103407.1.
UniGene	Rn.20472
3D structure databases
HSSP	HSSP built from PDB template 1URW based on UniProtKB P24941.
SMR	Q4KM47. Positions 38-334.
ModBase	Search...
PTM databases
PhosphoSite	Q4KM47.
Genome annotation databases
Ensembl	ENSRNOT00000066552; ENSRNOP00000059465; ENSRNOG00000016088; Rattus norvegicus. [Genome view]
GeneID	361434.
KEGG	rno:361434.
UCSC	NM_001025722. rat.
Organism-specific databases
CTD	361434.
RGD	1304851. Cdk10.
Phylogenomic databases
eggNOG	roNOG10925.
HOVERGEN	Q4KM47.
InParanoid	Q4KM47.
PhylomeDB	Q4KM47.
Enzyme and pathway databases
BRENDA	2.7.11.22. 248.
Gene expression databases
ArrayExpress	Q4KM47.
Genevestigator	Q4KM47.
GermOnline	ENSRNOG00000016088. Rattus norvegicus.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_prot_kinase-like_dom. IPR008271. Ser/Thr_prot_kinase_AS. IPR002290. Ser/Thr_prot_kinase_dom. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	676292.

Entry information

Entry name

CDK10_RAT

Accession

Primary (citable) accession number: Q4KM47

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	August 2, 2005
Last modified:	January 19, 2010
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)