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Reviewed, UniProtKB/Swiss-Prot Q4KM47 (CDK10_RAT)

Last modified January 19, 2010. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Cell division protein kinase 10
    EC=2.7.11.22
Gene names
Name: Cdk10
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length358 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 358358Cell division protein kinase 10
PRO_0000261029

Regions

Domain37 – 321285Protein kinase
Nucleotide binding43 – 519ATP By similarity

Sites

Active site1611Proton acceptor By similarity
Binding site661ATP By similarity

Amino acid modifications

Modified residue1941Phosphothreonine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4KM47-1 [UniParc].

Last modified August 2, 2005. Version 1.
Checksum: F10590B86C4D4782

FASTA35840,634
        10         20         30         40         50         60 
MSQCQIWVRH HLCCSFQIPT LAASLFQLGR CRSVKEFEKL NRIGEGTYGI VYRARDTQTD 

        70         80         90        100        110        120 
EIVALKKVRM DKEKDGIPIS SLREITLLLR LRHPNIVELK EVVVGNHLES IFLVMGYCEQ 

       130        140        150        160        170        180 
DLASLLENMP TPFSEAQVKC ILLQVLRGLQ YLHRSFIIHR DLKVSNLLMT DKGCVKTADF 

       190        200        210        220        230        240 
GLARAYGVPV KPMTPKVVTL WYRAPELLLG TTTQTTSIDM WAVGCILAEL LAHKPLLPGT 

       250        260        270        280        290        300 
SEIHQIDLIV QLLGTPSENI WPGFSKLPLA GQYSLRKQPY NNLKHKFPWL SEAGLRLLNF 

       310        320        330        340        350 
LFMYDPKKRA TAGDCLESSY FKEKPLPCEP ELMPTFPHHR NKRAAPAATE GQSKRCRP 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Spleen.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC098804 mRNA. Translation: AAH98804.1.
IPIIPI00365341.
RefSeqNP_001020893.2.
NP_001103406.1.
NP_001103407.1.
UniGeneRn.20472

3D structure databases

HSSPHSSP built from PDB template 1URW based on UniProtKB P24941.
SMRQ4KM47. Positions 38-334.
ModBaseSearch...

PTM databases

PhosphoSiteQ4KM47.

Genome annotation databases

EnsemblENSRNOT00000066552; ENSRNOP00000059465; ENSRNOG00000016088; Rattus norvegicus. [Genome view]
GeneID361434.
KEGGrno:361434.
UCSCNM_001025722. rat.

Organism-specific databases

CTD361434.
RGD1304851. Cdk10.

Phylogenomic databases

eggNOGroNOG10925.
HOVERGENQ4KM47.
InParanoidQ4KM47.
PhylomeDBQ4KM47.

Enzyme and pathway databases

BRENDA2.7.11.22. 248.

Gene expression databases

ArrayExpressQ4KM47.
GenevestigatorQ4KM47.
GermOnlineENSRNOG00000016088. Rattus norvegicus.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR017442. Se/Thr_prot_kinase-like_dom.
IPR008271. Ser/Thr_prot_kinase_AS.
IPR002290. Ser/Thr_prot_kinase_dom.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio676292.

Entry information

Entry nameCDK10_RAT
AccessionPrimary (citable) accession number: Q4KM47
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: August 2, 2005
Last modified: January 19, 2010
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents