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Q4KM47

- CDK10_RAT

UniProt

Q4KM47 - CDK10_RAT

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Protein
Cyclin-dependent kinase 10
Gene
Cdk10
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells) By similarity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei66 – 661ATP By similarity
Active sitei161 – 1611Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi43 – 519ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase 10 (EC:2.7.11.22)
    Alternative name(s):
    Cell division protein kinase 10
    Gene namesi
    Name:Cdk10
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi1304851. Cdk10.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 358358Cyclin-dependent kinase 10
    PRO_0000261029Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei194 – 1941Phosphothreonine By similarity

    Keywords - PTMi

    Phosphoprotein

    PTM databases

    PhosphoSiteiQ4KM47.

    Expressioni

    Gene expression databases

    GenevestigatoriQ4KM47.

    Interactioni

    Subunit structurei

    Heterodimer with FAM58A/Cyclin-M, the interaction is required for kinase activity. Interacts with ETS2 By similarity.

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000059465.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4KM47.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini37 – 321285Protein kinase
    Add
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000233024.
    HOVERGENiHBG014652.
    InParanoidiQ4KM47.
    KOiK02449.
    PhylomeDBiQ4KM47.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4KM47-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQCQIWVRH HLCCSFQIPT LAASLFQLGR CRSVKEFEKL NRIGEGTYGI    50
    VYRARDTQTD EIVALKKVRM DKEKDGIPIS SLREITLLLR LRHPNIVELK 100
    EVVVGNHLES IFLVMGYCEQ DLASLLENMP TPFSEAQVKC ILLQVLRGLQ 150
    YLHRSFIIHR DLKVSNLLMT DKGCVKTADF GLARAYGVPV KPMTPKVVTL 200
    WYRAPELLLG TTTQTTSIDM WAVGCILAEL LAHKPLLPGT SEIHQIDLIV 250
    QLLGTPSENI WPGFSKLPLA GQYSLRKQPY NNLKHKFPWL SEAGLRLLNF 300
    LFMYDPKKRA TAGDCLESSY FKEKPLPCEP ELMPTFPHHR NKRAAPAATE 350
    GQSKRCRP 358
    Length:358
    Mass (Da):40,634
    Last modified:August 2, 2005 - v1
    Checksum:iF10590B86C4D4782
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC098804 mRNA. Translation: AAH98804.1.
    RefSeqiNP_001020893.2. NM_001025722.2.
    NP_001103406.1. NM_001109936.1.
    NP_001103407.1. NM_001109937.1.
    UniGeneiRn.20472.

    Genome annotation databases

    GeneIDi361434.
    KEGGirno:361434.
    UCSCiRGD:1304851. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC098804 mRNA. Translation: AAH98804.1 .
    RefSeqi NP_001020893.2. NM_001025722.2.
    NP_001103406.1. NM_001109936.1.
    NP_001103407.1. NM_001109937.1.
    UniGenei Rn.20472.

    3D structure databases

    ProteinModelPortali Q4KM47.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000059465.

    PTM databases

    PhosphoSitei Q4KM47.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 361434.
    KEGGi rno:361434.
    UCSCi RGD:1304851. rat.

    Organism-specific databases

    CTDi 8558.
    RGDi 1304851. Cdk10.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000233024.
    HOVERGENi HBG014652.
    InParanoidi Q4KM47.
    KOi K02449.
    PhylomeDBi Q4KM47.

    Miscellaneous databases

    NextBioi 676292.
    PROi Q4KM47.

    Gene expression databases

    Genevestigatori Q4KM47.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Spleen.

    Entry informationi

    Entry nameiCDK10_RAT
    AccessioniPrimary (citable) accession number: Q4KM47
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: August 2, 2005
    Last modified: July 9, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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