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Protein

Cyclin-dependent kinase 10

Gene

Cdk10

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei66 – 661ATPPROSITE-ProRule annotation
Active sitei161 – 1611Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi43 – 519ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. positive regulation of MAPK cascade Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 10 (EC:2.7.11.22)
Alternative name(s):
Cell division protein kinase 10
Gene namesi
Name:Cdk10
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1304851. Cdk10.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 358358Cyclin-dependent kinase 10PRO_0000261029Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei194 – 1941PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

PTM databases

PhosphoSiteiQ4KM47.

Expressioni

Gene expression databases

ExpressionAtlasiQ4KM47. baseline and differential.
GenevestigatoriQ4KM47.

Interactioni

Subunit structurei

Heterodimer with FAM58A/Cyclin-M, the interaction is required for kinase activity. Interacts with ETS2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000059465.

Structurei

3D structure databases

ProteinModelPortaliQ4KM47.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 321285Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.
InParanoidiQ4KM47.
KOiK02449.
PhylomeDBiQ4KM47.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4KM47-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQCQIWVRH HLCCSFQIPT LAASLFQLGR CRSVKEFEKL NRIGEGTYGI
60 70 80 90 100
VYRARDTQTD EIVALKKVRM DKEKDGIPIS SLREITLLLR LRHPNIVELK
110 120 130 140 150
EVVVGNHLES IFLVMGYCEQ DLASLLENMP TPFSEAQVKC ILLQVLRGLQ
160 170 180 190 200
YLHRSFIIHR DLKVSNLLMT DKGCVKTADF GLARAYGVPV KPMTPKVVTL
210 220 230 240 250
WYRAPELLLG TTTQTTSIDM WAVGCILAEL LAHKPLLPGT SEIHQIDLIV
260 270 280 290 300
QLLGTPSENI WPGFSKLPLA GQYSLRKQPY NNLKHKFPWL SEAGLRLLNF
310 320 330 340 350
LFMYDPKKRA TAGDCLESSY FKEKPLPCEP ELMPTFPHHR NKRAAPAATE

GQSKRCRP
Length:358
Mass (Da):40,634
Last modified:August 2, 2005 - v1
Checksum:iF10590B86C4D4782
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098804 mRNA. Translation: AAH98804.1.
RefSeqiNP_001020893.2. NM_001025722.2.
NP_001103406.1. NM_001109936.1.
NP_001103407.1. NM_001109937.1.
UniGeneiRn.20472.

Genome annotation databases

GeneIDi361434.
KEGGirno:361434.
UCSCiRGD:1304851. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098804 mRNA. Translation: AAH98804.1.
RefSeqiNP_001020893.2. NM_001025722.2.
NP_001103406.1. NM_001109936.1.
NP_001103407.1. NM_001109937.1.
UniGeneiRn.20472.

3D structure databases

ProteinModelPortaliQ4KM47.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000059465.

PTM databases

PhosphoSiteiQ4KM47.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi361434.
KEGGirno:361434.
UCSCiRGD:1304851. rat.

Organism-specific databases

CTDi8558.
RGDi1304851. Cdk10.

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.
InParanoidiQ4KM47.
KOiK02449.
PhylomeDBiQ4KM47.

Miscellaneous databases

NextBioi676292.
PROiQ4KM47.

Gene expression databases

ExpressionAtlasiQ4KM47. baseline and differential.
GenevestigatoriQ4KM47.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Spleen.

Entry informationi

Entry nameiCDK10_RAT
AccessioniPrimary (citable) accession number: Q4KM47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: August 2, 2005
Last modified: March 4, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.