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Q4KM47 (CDK10_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclin-dependent kinase 10

EC=2.7.11.22
Alternative name(s):
Cell division protein kinase 10
Gene names
Name:Cdk10
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length358 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells) By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subunit structure

Heterodimer with FAM58A/Cyclin-M, the interaction is required for kinase activity. Interacts with ETS2 By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 358358Cyclin-dependent kinase 10
PRO_0000261029

Regions

Domain37 – 321285Protein kinase
Nucleotide binding43 – 519ATP By similarity

Sites

Active site1611Proton acceptor By similarity
Binding site661ATP By similarity

Amino acid modifications

Modified residue1941Phosphothreonine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4KM47 [UniParc].

Last modified August 2, 2005. Version 1.
Checksum: F10590B86C4D4782

FASTA35840,634
        10         20         30         40         50         60 
MSQCQIWVRH HLCCSFQIPT LAASLFQLGR CRSVKEFEKL NRIGEGTYGI VYRARDTQTD 

        70         80         90        100        110        120 
EIVALKKVRM DKEKDGIPIS SLREITLLLR LRHPNIVELK EVVVGNHLES IFLVMGYCEQ 

       130        140        150        160        170        180 
DLASLLENMP TPFSEAQVKC ILLQVLRGLQ YLHRSFIIHR DLKVSNLLMT DKGCVKTADF 

       190        200        210        220        230        240 
GLARAYGVPV KPMTPKVVTL WYRAPELLLG TTTQTTSIDM WAVGCILAEL LAHKPLLPGT 

       250        260        270        280        290        300 
SEIHQIDLIV QLLGTPSENI WPGFSKLPLA GQYSLRKQPY NNLKHKFPWL SEAGLRLLNF 

       310        320        330        340        350 
LFMYDPKKRA TAGDCLESSY FKEKPLPCEP ELMPTFPHHR NKRAAPAATE GQSKRCRP 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Spleen.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC098804 mRNA. Translation: AAH98804.1.
RefSeqNP_001020893.2. NM_001025722.2.
NP_001103406.1. NM_001109936.1.
NP_001103407.1. NM_001109937.1.
UniGeneRn.20472.

3D structure databases

ProteinModelPortalQ4KM47.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000059465.

PTM databases

PhosphoSiteQ4KM47.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID361434.
KEGGrno:361434.
UCSCRGD:1304851. rat.

Organism-specific databases

CTD8558.
RGD1304851. Cdk10.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000233024.
HOVERGENHBG014652.
InParanoidQ4KM47.
KOK02449.
PhylomeDBQ4KM47.

Gene expression databases

GenevestigatorQ4KM47.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio676292.
PROQ4KM47.

Entry information

Entry nameCDK10_RAT
AccessionPrimary (citable) accession number: Q4KM47
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: August 2, 2005
Last modified: July 9, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families