Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Interleukin-34

Gene

Il34

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1 (By similarity).By similarity

GO - Molecular functioni

  • cytokine activity Source: UniProtKB-KW
  • growth factor activity Source: UniProtKB-KW
  • macrophage colony-stimulating factor receptor binding Source: UniProtKB

GO - Biological processi

  • inflammatory response Source: UniProtKB-KW
  • innate immune response Source: UniProtKB-KW
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of protein phosphorylation Source: UniProtKB

Keywordsi

Molecular functionCytokine, Growth factor
Biological processImmunity, Inflammatory response, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-34
Short name:
IL-34
Gene namesi
Name:Il34
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1586038 Il34

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000029435021 – 234Interleukin-34Add BLAST214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ4KM46
PRIDEiQ4KM46

Expressioni

Gene expression databases

GenevisibleiQ4KM46 RN

Interactioni

Subunit structurei

Homodimer. Interacts with CSF1R (By similarity).By similarity

GO - Molecular functioni

  • cytokine activity Source: UniProtKB-KW
  • growth factor activity Source: UniProtKB-KW
  • macrophage colony-stimulating factor receptor binding Source: UniProtKB

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023823

Structurei

3D structure databases

SMRiQ4KM46
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-34 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IX9Y Eukaryota
ENOG410Z6RS LUCA
HOGENOMiHOG000113048
HOVERGENiHBG108003
InParanoidiQ4KM46
KOiK22633
OrthoDBiEOG091G0I1D
PhylomeDBiQ4KM46

Family and domain databases

Gene3Di1.20.1250.80, 1 hit
InterProiView protein in InterPro
IPR020415 IL-34
IPR038328 IL-34_sf
PANTHERiPTHR28606 PTHR28606, 1 hit
PfamiView protein in Pfam
PF15036 IL34, 1 hit
PRINTSiPR01938 INTRLEUKIN34

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4KM46-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPWGLAWLYC LGILLDVALG NENLEIWTLA QDKECDLTGY LRGKLQYKNR
60 70 80 90 100
LQYMKHYFPI NYRIAVPYEG VLRVANITRL KAHVSERELR YLWVLVSLNA
110 120 130 140 150
TESVLDVLLE GHPSWKYLQE VQTLLENVQR SLMDVEIGPH VEAVLSLLST
160 170 180 190 200
PGLSLKLVRP KALLDNCFRV MELLYCSCCK QSPILKWQDC ELPRLHPHSP
210 220 230
ESLMQCAATN VYPLPRQPPT SLPRSPSSNH GPLP
Length:234
Mass (Da):26,772
Last modified:August 2, 2005 - v1
Checksum:i3AC004AEEFFB5608
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098808 mRNA Translation: AAH98808.1
RefSeqiNP_001020937.1, NM_001025766.1
XP_006255662.1, XM_006255600.3
UniGeneiRn.16799

Genome annotation databases

GeneIDi498951
KEGGirno:498951
UCSCiRGD:1586038 rat

Similar proteinsi

Entry informationi

Entry nameiIL34_RAT
AccessioniPrimary (citable) accession number: Q4KM46
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: August 2, 2005
Last modified: June 20, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health