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Protein

Interleukin-34

Gene

Il34

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1 (By similarity).By similarity

GO - Molecular functioni

  • macrophage colony-stimulating factor receptor binding Source: UniProtKB

GO - Biological processi

  • inflammatory response Source: UniProtKB-KW
  • innate immune response Source: UniProtKB-KW
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of protein phosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Keywords - Biological processi

Immunity, Inflammatory response, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-34
Short name:
IL-34
Gene namesi
Name:Il34
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1586038. Il34.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 234214Interleukin-34PRO_0000294350Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi99 – 991N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ4KM46.

Expressioni

Gene expression databases

GenevisibleiQ4KM46. RN.

Interactioni

Subunit structurei

Homodimer. Interacts with CSF1R (By similarity).By similarity

GO - Molecular functioni

  • macrophage colony-stimulating factor receptor binding Source: UniProtKB

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023823.

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-34 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IX9Y. Eukaryota.
ENOG410Z6RS. LUCA.
HOGENOMiHOG000113048.
HOVERGENiHBG108003.
InParanoidiQ4KM46.
OMAiYEGVFRI.
OrthoDBiEOG7H7936.
PhylomeDBiQ4KM46.

Family and domain databases

InterProiIPR020415. IL-34.
[Graphical view]
PfamiPF15036. IL34. 1 hit.
[Graphical view]
PRINTSiPR01938. INTRLEUKIN34.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4KM46-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPWGLAWLYC LGILLDVALG NENLEIWTLA QDKECDLTGY LRGKLQYKNR
60 70 80 90 100
LQYMKHYFPI NYRIAVPYEG VLRVANITRL KAHVSERELR YLWVLVSLNA
110 120 130 140 150
TESVLDVLLE GHPSWKYLQE VQTLLENVQR SLMDVEIGPH VEAVLSLLST
160 170 180 190 200
PGLSLKLVRP KALLDNCFRV MELLYCSCCK QSPILKWQDC ELPRLHPHSP
210 220 230
ESLMQCAATN VYPLPRQPPT SLPRSPSSNH GPLP
Length:234
Mass (Da):26,772
Last modified:August 2, 2005 - v1
Checksum:i3AC004AEEFFB5608
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098808 mRNA. Translation: AAH98808.1.
RefSeqiNP_001020937.1. NM_001025766.1.
XP_006255662.1. XM_006255600.2.
UniGeneiRn.16799.

Genome annotation databases

GeneIDi498951.
KEGGirno:498951.
UCSCiRGD:1586038. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098808 mRNA. Translation: AAH98808.1.
RefSeqiNP_001020937.1. NM_001025766.1.
XP_006255662.1. XM_006255600.2.
UniGeneiRn.16799.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023823.

Proteomic databases

PaxDbiQ4KM46.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi498951.
KEGGirno:498951.
UCSCiRGD:1586038. rat.

Organism-specific databases

CTDi146433.
RGDi1586038. Il34.

Phylogenomic databases

eggNOGiENOG410IX9Y. Eukaryota.
ENOG410Z6RS. LUCA.
HOGENOMiHOG000113048.
HOVERGENiHBG108003.
InParanoidiQ4KM46.
OMAiYEGVFRI.
OrthoDBiEOG7H7936.
PhylomeDBiQ4KM46.

Miscellaneous databases

NextBioi701363.
PROiQ4KM46.

Gene expression databases

GenevisibleiQ4KM46. RN.

Family and domain databases

InterProiIPR020415. IL-34.
[Graphical view]
PfamiPF15036. IL34. 1 hit.
[Graphical view]
PRINTSiPR01938. INTRLEUKIN34.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Spleen.

Entry informationi

Entry nameiIL34_RAT
AccessioniPrimary (citable) accession number: Q4KM46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: August 2, 2005
Last modified: February 17, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.