ID   CCRK_RAT                Reviewed;         346 AA.
AC   Q4KM34;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 2.
DT   16-JUN-2009, entry version 42.
DE   RecName: Full=Cell cycle-related kinase;
DE            EC=2.7.11.22;
GN   Name=Ccrk;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Involved in cell growth. Activates CDK2, a kinase
CC       involved in the control of the cell cycle, by phosphorylating
CC       residue 'Thr-160' (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- SUBUNIT: Monomer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus (By similarity).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. CMGC
CC       Ser/Thr protein kinase family. CDC2/CDKX subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH98838.1; Type=Miscellaneous discrepancy; Note=Intron retention;
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DR   EMBL; BC098838; AAH98838.1; ALT_SEQ; mRNA.
DR   IPI; IPI00191082; -.
DR   RefSeq; NP_001020923.2; -.
DR   UniGene; Rn.7013; -.
DR   PRIDE; Q4KM34; -.
DR   Ensembl; ENSRNOG00000017991; Rattus norvegicus.
DR   GeneID; 364666; -.
DR   KEGG; rno:364666; -.
DR   NMPDR; fig|10116.3.peg.12883; -.
DR   RGD; 1305219; Ccrk.
DR   HOVERGEN; Q4KM34; -.
DR   OMA; Q4KM34; QRIAASK.
DR   BRENDA; 2.7.11.22; 248.
DR   NextBio; 685773; -.
DR   ArrayExpress; Q4KM34; -.
DR   GermOnline; ENSRNOG00000017991; Rattus norvegicus.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0006468; P:protein amino acid phosphorylation; IEA:InterPro.
DR   InterPro; IPR000719; Prot_kinase_core.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_pkinase-rel.
DR   InterPro; IPR008271; Ser_thr_pkin_AS.
DR   InterPro; IPR002290; Ser_thr_pkinase.
DR   Pfam; PF00069; Pkinase; 1.
DR   ProDom; PD000001; Prot_kinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Cell cycle; Cell division; Kinase; Nucleotide-binding;
KW   Nucleus; Serine/threonine-protein kinase; Transferase.
FT   CHAIN         1    346       Cell cycle-related kinase.
FT                                /FTId=PRO_0000085705.
FT   DOMAIN        4    288       Protein kinase.
FT   NP_BIND      10     18       ATP (By similarity).
FT   ACT_SITE    127    127       Proton acceptor (By similarity).
FT   BINDING      33     33       ATP (By similarity).
SQ   SEQUENCE   346 AA;  38449 MW;  E4D34F943BEA6350 CRC64;
     MDQYCILGRI GEGAHGIVFK AKHVETGEIV ALKKVALRRL EDGIPNQALR EIKALQEIED
     SQYVVQLKAV FPHGAGFVLA FEFMLSDLAE VVRHAQRPLA PAQVKSYLQM LLKGVAFCHA
     NNIVHRDLKP ANLLISASGQ LKIADFGLAR VFSPDGGRLY THQVATRWYR APELLYGARQ
     YDQGVDLWAV GCIMGELLNG SPLFPGENDI EQLCCVLRIL GTPSPRVWPE ITELPDYNKI
     SFKEQAPVPL EEVLPDASHQ ALDLLGQFLL YPPRQRIAAS QALLHQYFFT APLPAHPSEL
     PIPQRPGGPT PKAHPGPPHV HDFHVDRPLE ESLLNPELIR PFIPEG
//