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Q4KM34 (CDK20_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclin-dependent kinase 20

EC=2.7.11.22
Alternative name(s):
Cell cycle-related kinase
Cell division protein kinase 20
Gene names
Name:Cdk20
Synonyms:Ccrk
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length346 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling. Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160' By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subunit structure

Monomer By similarity. Interacts with TBC1D32 and MAK By similarity.

Subcellular location

Nucleus By similarity. Cytoplasm By similarity. Cell projectioncilium By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence caution

The sequence AAH98838.1 differs from that shown. Reason: Intron retention.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 346346Cyclin-dependent kinase 20
PRO_0000085705

Regions

Domain4 – 288285Protein kinase
Nucleotide binding10 – 189ATP By similarity

Sites

Active site1271Proton acceptor By similarity
Binding site331ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4KM34 [UniParc].

Last modified December 20, 2005. Version 2.
Checksum: E4D34F943BEA6350

FASTA34638,449
        10         20         30         40         50         60 
MDQYCILGRI GEGAHGIVFK AKHVETGEIV ALKKVALRRL EDGIPNQALR EIKALQEIED 

        70         80         90        100        110        120 
SQYVVQLKAV FPHGAGFVLA FEFMLSDLAE VVRHAQRPLA PAQVKSYLQM LLKGVAFCHA 

       130        140        150        160        170        180 
NNIVHRDLKP ANLLISASGQ LKIADFGLAR VFSPDGGRLY THQVATRWYR APELLYGARQ 

       190        200        210        220        230        240 
YDQGVDLWAV GCIMGELLNG SPLFPGENDI EQLCCVLRIL GTPSPRVWPE ITELPDYNKI 

       250        260        270        280        290        300 
SFKEQAPVPL EEVLPDASHQ ALDLLGQFLL YPPRQRIAAS QALLHQYFFT APLPAHPSEL 

       310        320        330        340 
PIPQRPGGPT PKAHPGPPHV HDFHVDRPLE ESLLNPELIR PFIPEG 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Spleen.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC098838 mRNA. Translation: AAH98838.1. Sequence problems.
RefSeqNP_001020923.2. NM_001025752.2.
UniGeneRn.7013.

3D structure databases

ProteinModelPortalQ4KM34.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000024466.

Proteomic databases

PaxDbQ4KM34.
PRIDEQ4KM34.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000024466; ENSRNOP00000024466; ENSRNOG00000017991.
GeneID364666.
KEGGrno:364666.
UCSCRGD:1305219. rat.

Organism-specific databases

CTD23552.
RGD1305219. Cdk20.

Phylogenomic databases

eggNOGCOG0515.
GeneTreeENSGT00740000115348.
HOGENOMHOG000233024.
HOVERGENHBG014652.
InParanoidQ4KM34.
KOK08817.
OMARPFIPEG.
OrthoDBEOG75J0NH.
PhylomeDBQ4KM34.
TreeFamTF327240.

Gene expression databases

GenevestigatorQ4KM34.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio685773.
PROQ4KM34.

Entry information

Entry nameCDK20_RAT
AccessionPrimary (citable) accession number: Q4KM34
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: May 14, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families