Reviewed, UniProtKB/Swiss-Prot Q4KM34 (CDK20_RAT)

Names and origin

Protein names

Recommended name:
    Cell division protein kinase 20
    EC=2.7.11.22
Alternative name(s):
    Cell cycle-related kinase

Gene names

Name:	Cdk20
Synonyms:	Ccrk

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	346 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160' By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subunit structure	Monomer By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Contains 1 protein kinase domain.
Sequence caution	The sequence AAH98838.1 differs from that shown. Reason: Miscellaneous discrepancy. Intron retention.

Ontologies

Keywords
Biological process	Cell cycle Cell division
Cellular component	Nucleus
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cyclin-dependent protein kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 346	346	Cell division protein kinase 20		PRO_0000085705
Regions
	Domain	4 – 288	285	Protein kinase
	Nucleotide binding	10 – 18	9	ATP By similarity
Sites
	Active site	127	1	Proton acceptor By similarity
	Binding site	33	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4KM34-1 [UniParc]. Last modified December 20, 2005. Version 2. Checksum: E4D34F943BEA6350	FASTA	346	38,449
	10 20 30 40 50 60 MDQYCILGRI GEGAHGIVFK AKHVETGEIV ALKKVALRRL EDGIPNQALR EIKALQEIED 70 80 90 100 110 120 SQYVVQLKAV FPHGAGFVLA FEFMLSDLAE VVRHAQRPLA PAQVKSYLQM LLKGVAFCHA 130 140 150 160 170 180 NNIVHRDLKP ANLLISASGQ LKIADFGLAR VFSPDGGRLY THQVATRWYR APELLYGARQ 190 200 210 220 230 240 YDQGVDLWAV GCIMGELLNG SPLFPGENDI EQLCCVLRIL GTPSPRVWPE ITELPDYNKI 250 260 270 280 290 300 SFKEQAPVPL EEVLPDASHQ ALDLLGQFLL YPPRQRIAAS QALLHQYFFT APLPAHPSEL 310 320 330 340 PIPQRPGGPT PKAHPGPPHV HDFHVDRPLE ESLLNPELIR PFIPEG

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Spleen.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC098838 mRNA. Translation: AAH98838.1. Sequence problems.
IPI	IPI00191082.
RefSeq	NP_001020923.2.
UniGene	Rn.7013
3D structure databases
SMR	Q4KM34. Positions 6-303.
ModBase	Search...
Proteomic databases
PRIDE	Q4KM34.
Genome annotation databases
Ensembl	ENSRNOT00000024466; ENSRNOP00000024466; ENSRNOG00000017991; Rattus norvegicus. [Genome view]
GeneID	364666.
KEGG	rno:364666.
NMPDR	fig|10116.3.peg.12883.
UCSC	BC098838. rat.
Organism-specific databases
CTD	364666.
RGD	1305219. Ccrk.
Phylogenomic databases
eggNOG	roNOG11932.
HOVERGEN	Q4KM34.
InParanoid	Q4KM34.
OMA	QRIAASK.
OrthoDB	EOG90CM34.
PhylomeDB	Q4KM34.
Enzyme and pathway databases
BRENDA	2.7.11.22. 248.
Gene expression databases
ArrayExpress	Q4KM34.
Genevestigator	Q4KM34.
GermOnline	ENSRNOG00000017991. Rattus norvegicus.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_prot_kinase-like_dom. IPR008271. Ser/Thr_prot_kinase_AS. IPR002290. Ser/Thr_prot_kinase_dom. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	685773.

Entry information

Entry name

CDK20_RAT

Accession

Primary (citable) accession number: Q4KM34

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	December 20, 2005
Last modified:	February 9, 2010
This is version 50 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)