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Reviewed, UniProtKB/Swiss-Prot Q4KM34 (CCRK_RAT)

Last modified June 16, 2009. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Cell cycle-related kinase
    EC=2.7.11.22
Gene names
Name: Ccrk
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

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Protein attributes

Sequence length346 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160' By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subunit structure

Monomer By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence caution

The sequence AAH98838.1 differs from that shown. Reason: Miscellaneous discrepancy. Intron retention.

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Ontologies

Keywords
   Biological processCell cycle
Cell division
   Cellular componentNucleus
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Serine/threonine-protein kinase
Transferase
Gene Ontology (GO)
   Biological processcell cycle

Inferred from electronic annotation. Source: UniProtKB-KW

cell division

Inferred from electronic annotation. Source: UniProtKB-KW

protein amino acid phosphorylation

Inferred from electronic annotation. Source: InterPro

   Cellular componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

cyclin-dependent protein kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 346346Cell cycle-related kinase
PRO_0000085705

Regions

Domain4 – 288285Protein kinase
Nucleotide binding10 – 189ATP By similarity

Sites

Active site1271Proton acceptor By similarity
Binding site331ATP By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q4KM34-1 [UniParc].

Last modified December 20, 2005. Version 2.
Checksum: E4D34F943BEA6350

FASTA34638,449
        10         20         30         40         50         60 
MDQYCILGRI GEGAHGIVFK AKHVETGEIV ALKKVALRRL EDGIPNQALR EIKALQEIED 

        70         80         90        100        110        120 
SQYVVQLKAV FPHGAGFVLA FEFMLSDLAE VVRHAQRPLA PAQVKSYLQM LLKGVAFCHA 

       130        140        150        160        170        180 
NNIVHRDLKP ANLLISASGQ LKIADFGLAR VFSPDGGRLY THQVATRWYR APELLYGARQ 

       190        200        210        220        230        240 
YDQGVDLWAV GCIMGELLNG SPLFPGENDI EQLCCVLRIL GTPSPRVWPE ITELPDYNKI 

       250        260        270        280        290        300 
SFKEQAPVPL EEVLPDASHQ ALDLLGQFLL YPPRQRIAAS QALLHQYFFT APLPAHPSEL 

       310        320        330        340 
PIPQRPGGPT PKAHPGPPHV HDFHVDRPLE ESLLNPELIR PFIPEG

« Hide

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References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Spleen.
+Additional computationally mapped references.

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Cross-references

Sequence databases

BC098838 mRNA. Translation: AAH98838.1. Sequence problems.
IPIIPI00191082.
RefSeqNP_001020923.2.
UniGeneRn.7013

3D structure databases

ModBaseSearch...

Proteomic databases

PRIDEQ4KM34.

Genome annotation databases

EnsemblENSRNOG00000017991. Rattus norvegicus. [Contig view]
GeneID364666.
KEGGrno:364666.
NMPDRfig|10116.3.peg.12883.

Organism-specific databases

RGD1305219. Ccrk.

Phylogenomic databases

HOVERGENQ4KM34.
OMAQ4KM34. QRIAASK.

Enzyme and pathway databases

BRENDA2.7.11.22. 248.

Gene expression databases

ArrayExpressQ4KM34.
GermOnlineENSRNOG00000017991. Rattus norvegicus.

Family and domain databases

InterProIPR000719. Prot_kinase_core.
IPR017441. Protein_kinase_ATP_BS.
IPR017442. Se/Thr_pkinase-rel.
IPR008271. Ser_thr_pkin_AS.
IPR002290. Ser_thr_pkinase.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
ProDomPD000001. Prot_kinase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio685773.

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Entry information

Entry nameCCRK_RAT
AccessionPrimary (citable) accession number: Q4KM34
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: June 16, 2009
This is version 42 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents