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Q4KM34

- CDK20_RAT

UniProt

Q4KM34 - CDK20_RAT

Protein

Cyclin-dependent kinase 20

Gene

Cdk20

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 2 (20 Dec 2005)
      Previous versions | rss
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    Functioni

    Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling. Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160' By similarity.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei33 – 331ATPPROSITE-ProRule annotation
    Active sitei127 – 1271Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 189ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. multicellular organismal development Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Cell cycle, Cell division

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase 20 (EC:2.7.11.22)
    Alternative name(s):
    Cell cycle-related kinase
    Cell division protein kinase 20
    Gene namesi
    Name:Cdk20
    Synonyms:Ccrk
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 17

    Organism-specific databases

    RGDi1305219. Cdk20.

    Subcellular locationi

    Nucleus By similarity. Cytoplasm By similarity. Cell projectioncilium By similarity

    GO - Cellular componenti

    1. cilium Source: UniProtKB-SubCell
    2. cytoplasm Source: UniProtKB-SubCell
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell projection, Cilium, Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 346346Cyclin-dependent kinase 20PRO_0000085705Add
    BLAST

    Proteomic databases

    PaxDbiQ4KM34.
    PRIDEiQ4KM34.

    Expressioni

    Gene expression databases

    GenevestigatoriQ4KM34.

    Interactioni

    Subunit structurei

    Monomer. Interacts with TBC1D32 and MAK.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000024466.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4KM34.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 288285Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00740000115348.
    HOGENOMiHOG000233024.
    HOVERGENiHBG014652.
    InParanoidiQ4KM34.
    KOiK08817.
    OMAiRPFIPEG.
    OrthoDBiEOG75J0NH.
    PhylomeDBiQ4KM34.
    TreeFamiTF327240.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4KM34-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDQYCILGRI GEGAHGIVFK AKHVETGEIV ALKKVALRRL EDGIPNQALR    50
    EIKALQEIED SQYVVQLKAV FPHGAGFVLA FEFMLSDLAE VVRHAQRPLA 100
    PAQVKSYLQM LLKGVAFCHA NNIVHRDLKP ANLLISASGQ LKIADFGLAR 150
    VFSPDGGRLY THQVATRWYR APELLYGARQ YDQGVDLWAV GCIMGELLNG 200
    SPLFPGENDI EQLCCVLRIL GTPSPRVWPE ITELPDYNKI SFKEQAPVPL 250
    EEVLPDASHQ ALDLLGQFLL YPPRQRIAAS QALLHQYFFT APLPAHPSEL 300
    PIPQRPGGPT PKAHPGPPHV HDFHVDRPLE ESLLNPELIR PFIPEG 346
    Length:346
    Mass (Da):38,449
    Last modified:December 20, 2005 - v2
    Checksum:iE4D34F943BEA6350
    GO

    Sequence cautioni

    The sequence AAH98838.1 differs from that shown. Reason: Intron retention.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC098838 mRNA. Translation: AAH98838.1. Sequence problems.
    RefSeqiNP_001020923.2. NM_001025752.2.
    UniGeneiRn.7013.

    Genome annotation databases

    EnsembliENSRNOT00000024466; ENSRNOP00000024466; ENSRNOG00000017991.
    GeneIDi364666.
    KEGGirno:364666.
    UCSCiRGD:1305219. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC098838 mRNA. Translation: AAH98838.1 . Sequence problems.
    RefSeqi NP_001020923.2. NM_001025752.2.
    UniGenei Rn.7013.

    3D structure databases

    ProteinModelPortali Q4KM34.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000024466.

    Proteomic databases

    PaxDbi Q4KM34.
    PRIDEi Q4KM34.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000024466 ; ENSRNOP00000024466 ; ENSRNOG00000017991 .
    GeneIDi 364666.
    KEGGi rno:364666.
    UCSCi RGD:1305219. rat.

    Organism-specific databases

    CTDi 23552.
    RGDi 1305219. Cdk20.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00740000115348.
    HOGENOMi HOG000233024.
    HOVERGENi HBG014652.
    InParanoidi Q4KM34.
    KOi K08817.
    OMAi RPFIPEG.
    OrthoDBi EOG75J0NH.
    PhylomeDBi Q4KM34.
    TreeFami TF327240.

    Miscellaneous databases

    NextBioi 685773.
    PROi Q4KM34.

    Gene expression databases

    Genevestigatori Q4KM34.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Spleen.

    Entry informationi

    Entry nameiCDK20_RAT
    AccessioniPrimary (citable) accession number: Q4KM34
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: December 20, 2005
    Last modified: October 1, 2014
    This is version 88 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3