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Protein

V-set and immunoglobulin domain-containing protein 1

Gene

Vsig1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
V-set and immunoglobulin domain-containing protein 1
Gene namesi
Name:Vsig1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi1565570. Vsig1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 233ExtracellularSequence analysisAdd BLAST211
Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
Topological domaini255 – 404CytoplasmicSequence analysisAdd BLAST150

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000031357523 – 404V-set and immunoglobulin domain-containing protein 1Add BLAST382

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi39N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi44 ↔ 117PROSITE-ProRule annotation
Disulfide bondi162 ↔ 212PROSITE-ProRule annotation
Glycosylationi201N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi220N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei271PhosphoserineBy similarity1
Modified residuei272PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ4KLY3.

PTM databases

iPTMnetiQ4KLY3.
PhosphoSitePlusiQ4KLY3.

Expressioni

Gene expression databases

BgeeiENSRNOG00000054219.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020974.

Structurei

3D structure databases

ProteinModelPortaliQ4KLY3.
SMRiQ4KLY3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 133Ig-like V-typeAdd BLAST111
Domaini141 – 228Ig-like C2-typeAdd BLAST88

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi319 – 400Glu-richAdd BLAST82

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IINS. Eukaryota.
ENOG4111JZM. LUCA.
GeneTreeiENSGT00760000119145.
HOGENOMiHOG000154830.
HOVERGENiHBG106684.
InParanoidiQ4KLY3.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR000920. Myelin_P0-rel.
IPR029861. VSIG1.
PANTHERiPTHR12231:SF195. PTHR12231:SF195. 1 hit.
PfamiView protein in Pfam
PF07686. V-set. 1 hit.
PRINTSiPR00213. MYELINP0.
SMARTiView protein in SMART
SM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4KLY3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMVFAFWKVF LILNCLAGQV NMVQVTIPDT FVNVTVGSNV TLLCLYTTTV
60 70 80 90 100
TSLEKLSIQW SFFHNKEMEP ISIYYSEGGQ ASAIGQFKDR IIGATNPGNA
110 120 130 140 150
SITILHMQPA DSGIYICDVN NPPDFFGKNQ GILDVTVLVK PSKPFCSIQG
160 170 180 190 200
RPEAGHPISL SCLSAFGTPS PVYYWYKIEG NTIVPVKESF NSATGVLDIG
210 220 230 240 250
NLTNFEKGYY QCTAINSLGN SSCEIDLTSS DPEVGIIIGA LVGALTGAAI
260 270 280 290 300
IICVVYFARN KVKSKQKNLN SSTELEPMTK VHHSRQNEAI PAGGIQLEGT
310 320 330 340 350
LPSSIHASHN TEPTTAVLEP EYEPNPPLET ATQPDPEPEG SGPMPVPETE
360 370 380 390 400
IQLQPEMELE PETEPEPEPE PEPQPELESE LEPDPQSGVI VEPMREEEKE

TVKA
Length:404
Mass (Da):43,938
Last modified:August 2, 2005 - v1
Checksum:iF24F85AAD66E36FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098943 mRNA. Translation: AAH98943.1.
RefSeqiNP_001032873.1. NM_001037784.1.
XP_006234306.1. XM_006234244.3.
UniGeneiRn.53068.

Genome annotation databases

EnsembliENSRNOT00000082652; ENSRNOP00000075185; ENSRNOG00000054219.
GeneIDi315920.
KEGGirno:315920.

Similar proteinsi

Entry informationi

Entry nameiVSIG1_RAT
AccessioniPrimary (citable) accession number: Q4KLY3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 2, 2005
Last modified: August 30, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome