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Protein

V-set and immunoglobulin domain-containing protein 1

Gene

Vsig1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
V-set and immunoglobulin domain-containing protein 1
Gene namesi
Name:Vsig1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi1565570. Vsig1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 233ExtracellularSequence analysisAdd BLAST211
Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
Topological domaini255 – 404CytoplasmicSequence analysisAdd BLAST150

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000031357523 – 404V-set and immunoglobulin domain-containing protein 1Add BLAST382

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi39N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi44 ↔ 117PROSITE-ProRule annotation
Disulfide bondi162 ↔ 212PROSITE-ProRule annotation
Glycosylationi201N-linked (GlcNAc...)Sequence analysis1
Glycosylationi220N-linked (GlcNAc...)Sequence analysis1
Modified residuei271PhosphoserineBy similarity1
Modified residuei272PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ4KLY3.

PTM databases

iPTMnetiQ4KLY3.
PhosphoSitePlusiQ4KLY3.

Expressioni

Gene expression databases

BgeeiENSRNOG00000015037.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020974.

Structurei

3D structure databases

ProteinModelPortaliQ4KLY3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 133Ig-like V-typeAdd BLAST111
Domaini141 – 228Ig-like C2-typeAdd BLAST88

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi319 – 400Glu-richAdd BLAST82

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IINS. Eukaryota.
ENOG4111JZM. LUCA.
GeneTreeiENSGT00760000119145.
HOGENOMiHOG000154830.
HOVERGENiHBG106684.
InParanoidiQ4KLY3.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR000920. Myelin_P0-rel.
IPR029861. VSIG1.
[Graphical view]
PANTHERiPTHR12231:SF115. PTHR12231:SF115. 1 hit.
PfamiPF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR00213. MYELINP0.
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4KLY3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMVFAFWKVF LILNCLAGQV NMVQVTIPDT FVNVTVGSNV TLLCLYTTTV
60 70 80 90 100
TSLEKLSIQW SFFHNKEMEP ISIYYSEGGQ ASAIGQFKDR IIGATNPGNA
110 120 130 140 150
SITILHMQPA DSGIYICDVN NPPDFFGKNQ GILDVTVLVK PSKPFCSIQG
160 170 180 190 200
RPEAGHPISL SCLSAFGTPS PVYYWYKIEG NTIVPVKESF NSATGVLDIG
210 220 230 240 250
NLTNFEKGYY QCTAINSLGN SSCEIDLTSS DPEVGIIIGA LVGALTGAAI
260 270 280 290 300
IICVVYFARN KVKSKQKNLN SSTELEPMTK VHHSRQNEAI PAGGIQLEGT
310 320 330 340 350
LPSSIHASHN TEPTTAVLEP EYEPNPPLET ATQPDPEPEG SGPMPVPETE
360 370 380 390 400
IQLQPEMELE PETEPEPEPE PEPQPELESE LEPDPQSGVI VEPMREEEKE

TVKA
Length:404
Mass (Da):43,938
Last modified:August 2, 2005 - v1
Checksum:iF24F85AAD66E36FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098943 mRNA. Translation: AAH98943.1.
RefSeqiNP_001032873.1. NM_001037784.1.
XP_006234306.1. XM_006234244.3.
UniGeneiRn.53068.

Genome annotation databases

EnsembliENSRNOT00000082652; ENSRNOP00000075185; ENSRNOG00000054219.
GeneIDi315920.
KEGGirno:315920.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098943 mRNA. Translation: AAH98943.1.
RefSeqiNP_001032873.1. NM_001037784.1.
XP_006234306.1. XM_006234244.3.
UniGeneiRn.53068.

3D structure databases

ProteinModelPortaliQ4KLY3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020974.

PTM databases

iPTMnetiQ4KLY3.
PhosphoSitePlusiQ4KLY3.

Proteomic databases

PaxDbiQ4KLY3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000082652; ENSRNOP00000075185; ENSRNOG00000054219.
GeneIDi315920.
KEGGirno:315920.

Organism-specific databases

CTDi340547.
RGDi1565570. Vsig1.

Phylogenomic databases

eggNOGiENOG410IINS. Eukaryota.
ENOG4111JZM. LUCA.
GeneTreeiENSGT00760000119145.
HOGENOMiHOG000154830.
HOVERGENiHBG106684.
InParanoidiQ4KLY3.

Miscellaneous databases

PROiQ4KLY3.

Gene expression databases

BgeeiENSRNOG00000015037.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR000920. Myelin_P0-rel.
IPR029861. VSIG1.
[Graphical view]
PANTHERiPTHR12231:SF115. PTHR12231:SF115. 1 hit.
PfamiPF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR00213. MYELINP0.
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVSIG1_RAT
AccessioniPrimary (citable) accession number: Q4KLY3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 2, 2005
Last modified: November 2, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.