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Protein

F-box only protein 46

Gene

Fbxo46

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 46
Gene namesi
Name:Fbxo46
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1308393. Fbxo46.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002397371 – 603F-box only protein 46Add BLAST603

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei347PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ4KLY2.
PRIDEiQ4KLY2.

PTM databases

PhosphoSitePlusiQ4KLY2.

Expressioni

Gene expression databases

BgeeiENSRNOG00000008815.
GenevisibleiQ4KLY2. RN.

Interactioni

Subunit structurei

Interacts with SKP1 and CUL1.By similarity

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini470 – 522F-boxPROSITE-ProRule annotationAdd BLAST53

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IJQD. Eukaryota.
ENOG410ZZJ3. LUCA.
GeneTreeiENSGT00530000064222.
HOGENOMiHOG000112549.
HOVERGENiHBG051583.
InParanoidiQ4KLY2.
KOiK10320.
OMAiYSQNQPR.
OrthoDBiEOG091G04LZ.
PhylomeDBiQ4KLY2.
TreeFamiTF331673.

Family and domain databases

InterProiIPR001810. F-box_dom.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4KLY2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRGSLLPFQ LWCPRPFSKY SQNQPRPPSA TLKPPVCPDT SSGTEPDHRP
60 70 80 90 100
AHLESTPPAL AAEAPTSQHA PLLSTAASGD EGRVLLDTWY VIKPGNTKEK
110 120 130 140 150
VAFFVAHQCG GGSRASSMKV KGHWGSDSSK AKRRRRCLEP TKAPPDQGGQ
160 170 180 190 200
EGTPATEVAP TSSGDDVDLL SVAEMVALVE QRAALALQSY PRPSTPAPVV
210 220 230 240 250
FVSAEQGGPA KGLGSERRSG GGDCSRVAEA VAHFEAQRDS PPTKGLRKEE
260 270 280 290 300
RPGPGPGEVR IAFRISNVRE PQSPDGSLAN GGGGRPACPY PGSPGPGTRA
310 320 330 340 350
KDKITCDLYQ LISPSRDALP SNVEFLLARA DEASEGETPA PARPEDTPPA
360 370 380 390 400
PPPPPARDCG ASGFHVDVVV TGVVDACIFF GKDGTKNVKE ETVCLTVSPE
410 420 430 440 450
EPPPPGQLFF LQSRGPEGPP EPPPADTASK VPGPEDSEGT TDTSLCRLYR
460 470 480 490 500
HVSHDFLEIR FKIQRLLEPR QYMLLLPEHV LVKIFSFLPT RALAALKCTC
510 520 530 540 550
HHFKGIIEAF GVRATDSRWS RDPLYRDDPC KQCRKRYEKG DVSLCRWHPK
560 570 580 590 600
PYHHDLPYGR SYWMCCRRAD RETPGCRLGL HDNNWVLPCN GVGGGRAGRE

EGR
Length:603
Mass (Da):65,239
Last modified:August 2, 2005 - v1
Checksum:iE11F541FFDB8751B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098945 mRNA. Translation: AAH98945.1.
RefSeqiNP_001020813.1. NM_001025642.1.
XP_006228461.1. XM_006228399.3.
XP_006228462.1. XM_006228400.3.
XP_006228463.1. XM_006228401.3.
XP_008757132.1. XM_008758910.2.
XP_017444383.1. XM_017588894.1.
UniGeneiRn.64160.

Genome annotation databases

EnsembliENSRNOT00000012082; ENSRNOP00000012082; ENSRNOG00000008815.
GeneIDi292686.
KEGGirno:292686.
UCSCiRGD:1308393. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098945 mRNA. Translation: AAH98945.1.
RefSeqiNP_001020813.1. NM_001025642.1.
XP_006228461.1. XM_006228399.3.
XP_006228462.1. XM_006228400.3.
XP_006228463.1. XM_006228401.3.
XP_008757132.1. XM_008758910.2.
XP_017444383.1. XM_017588894.1.
UniGeneiRn.64160.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSitePlusiQ4KLY2.

Proteomic databases

PaxDbiQ4KLY2.
PRIDEiQ4KLY2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000012082; ENSRNOP00000012082; ENSRNOG00000008815.
GeneIDi292686.
KEGGirno:292686.
UCSCiRGD:1308393. rat.

Organism-specific databases

CTDi23403.
RGDi1308393. Fbxo46.

Phylogenomic databases

eggNOGiENOG410IJQD. Eukaryota.
ENOG410ZZJ3. LUCA.
GeneTreeiENSGT00530000064222.
HOGENOMiHOG000112549.
HOVERGENiHBG051583.
InParanoidiQ4KLY2.
KOiK10320.
OMAiYSQNQPR.
OrthoDBiEOG091G04LZ.
PhylomeDBiQ4KLY2.
TreeFamiTF331673.

Miscellaneous databases

PROiQ4KLY2.

Gene expression databases

BgeeiENSRNOG00000008815.
GenevisibleiQ4KLY2. RN.

Family and domain databases

InterProiIPR001810. F-box_dom.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFBX46_RAT
AccessioniPrimary (citable) accession number: Q4KLY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: August 2, 2005
Last modified: November 30, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.