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Q4KLP0

- DHTK1_RAT

UniProt

Q4KLP0 - DHTK1_RAT

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Protein

Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial

Gene
Dhtkd1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactori

Thiamine pyrophosphate By similarity.

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. generation of precursor metabolites and energy Source: UniProtKB
  2. glycolytic process Source: UniProtKB-KW
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial (EC:1.2.4.2)
Alternative name(s):
Dehydrogenase E1 and transketolase domain-containing protein 1
Gene namesi
Name:Dhtkd1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi1308092. Dhtkd1.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 920Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrialPRO_0000307939
Transit peptidei1 – ?Mitochondrion Reviewed prediction

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei183 – 1831N6-succinyllysine By similarity
Modified residuei188 – 1881N6-succinyllysine By similarity
Modified residuei800 – 8001N6-succinyllysine By similarity
Modified residuei818 – 8181N6-succinyllysine By similarity

Proteomic databases

PaxDbiQ4KLP0.
PRIDEiQ4KLP0.

PTM databases

PhosphoSiteiQ4KLP0.

Expressioni

Gene expression databases

GenevestigatoriQ4KLP0.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000037032.

Structurei

3D structure databases

ProteinModelPortaliQ4KLP0.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259586.
HOVERGENiHBG001892.
KOiK15791.
PhylomeDBiQ4KLP0.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4KLP0-1 [UniParc]FASTAAdd to Basket

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MASATVAAAG RALRRAVPLL RRSYQTERGV YGYRPRKAGS GEPRGDRARP    50
SVDHGLARLV TVYCEHGHKA AQINPLFPGQ ALLDTVPEIQ ALVQTLQGPF 100
TTTGLLNMGK EEASLEEVLA YLNHIYCGPI SIETAQLQSQ EEKDWFARRF 150
EELKKETFTT EERKHLSKLL LESQEFDHFL ATKFATVKRY GGEGAESMMG 200
FFHELLKLSA YGGITDIIIG MPHRGRLNLL TGLLQLPPEL MFRKMRGLSE 250
FPENVAAIGD VLSHLTSSVD LDFGAHRPLH VTMLPNPSHL EAINPVAVGK 300
TRGRQQSQED GDYSPNGSAQ PGDKVICLQV HGDASFCGQG IVLETFTLSN 350
LPHFRIGGSI HLIVNNQLGY TTPAERGRSS LYSSDIGKLV GCAIIHVNGD 400
SPEEVVRATR LAFEYQRQFR KDVIIDLLCY RQWGHNELDE PFFTNPVMYK 450
IIRARKSIPD TYAEHLIASG LMTQEEVSDI KASYYAKLNG HLANVAHYSP 500
PAPHLQARWQ GLVQPAACVT TWDTGVPLEL LRFVGVKSVE VPEELQLHSH 550
LLKMYVQSRM EKVKNGTNLD WATAETLALG SLLAQGFNVR LSGQDVGRGT 600
FSQRHAMVVC QNTDDVYIPL NHMDPNQKGF LEVSNSPLSE EAVLGFEYGM 650
SIESPKLLPL WEAQFGDFFN GAQIIFDTFI SGGEAKWLLQ SGLVILLPHG 700
YDGAGPDHSS CRIERFLQMC DSAEEGVDSD TVNMFVVHPT TPAQYFHLLR 750
RQMMRNFRKP LIVASPKMLL RYPVAVSTLE EMAPGTAFKP VIGDSSVDPK 800
NVKTLIFCSG KHFYALLKQR ESLGAKKRDF AIIRLEELCP FPLDSLQQEM 850
GKYKHVQDII WSQEEPQNMG PWSFVYPRFE KQLACKLRLV SRPPLPAPAV 900
GIGTVHQQQH EAILFKTFTS 920
Length:920
Mass (Da):102,642
Last modified:August 2, 2005 - v1
Checksum:iAA4A70E36AA41104
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC099075 mRNA. Translation: AAH99075.1.
RefSeqiNP_001020891.1. NM_001025720.1.
UniGeneiRn.13539.

Genome annotation databases

GeneIDi361272.
KEGGirno:361272.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC099075 mRNA. Translation: AAH99075.1 .
RefSeqi NP_001020891.1. NM_001025720.1.
UniGenei Rn.13539.

3D structure databases

ProteinModelPortali Q4KLP0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000037032.

PTM databases

PhosphoSitei Q4KLP0.

Proteomic databases

PaxDbi Q4KLP0.
PRIDEi Q4KLP0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 361272.
KEGGi rno:361272.

Organism-specific databases

CTDi 55526.
RGDi 1308092. Dhtkd1.

Phylogenomic databases

eggNOGi COG0567.
HOGENOMi HOG000259586.
HOVERGENi HBG001892.
KOi K15791.
PhylomeDBi Q4KLP0.

Miscellaneous databases

NextBioi 675775.

Gene expression databases

Genevestigatori Q4KLP0.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.

Entry informationi

Entry nameiDHTK1_RAT
AccessioniPrimary (citable) accession number: Q4KLP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: August 2, 2005
Last modified: June 11, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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