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Q4KLP0

- DHTK1_RAT

UniProt

Q4KLP0 - DHTK1_RAT

Protein

Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial

Gene

Dhtkd1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (02 Aug 2005)
      Previous versions | rss
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    Functioni

    The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.By similarity

    Catalytic activityi

    2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

    Cofactori

    Thiamine pyrophosphate.By similarity

    GO - Molecular functioni

    1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
    2. thiamine pyrophosphate binding Source: InterPro

    GO - Biological processi

    1. generation of precursor metabolites and energy Source: UniProtKB
    2. glycolytic process Source: UniProtKB-KW
    3. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Thiamine pyrophosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial (EC:1.2.4.2)
    Alternative name(s):
    Dehydrogenase E1 and transketolase domain-containing protein 1
    Gene namesi
    Name:Dhtkd1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi1308092. Dhtkd1.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 920Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrialPRO_0000307939
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei183 – 1831N6-succinyllysineBy similarity
    Modified residuei188 – 1881N6-succinyllysineBy similarity
    Modified residuei800 – 8001N6-succinyllysineBy similarity
    Modified residuei818 – 8181N6-succinyllysineBy similarity

    Proteomic databases

    PaxDbiQ4KLP0.
    PRIDEiQ4KLP0.

    PTM databases

    PhosphoSiteiQ4KLP0.

    Expressioni

    Gene expression databases

    GenevestigatoriQ4KLP0.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000037032.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4KLP0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0567.
    HOGENOMiHOG000259586.
    HOVERGENiHBG001892.
    KOiK15791.
    PhylomeDBiQ4KLP0.

    Family and domain databases

    Gene3Di3.40.50.970. 2 hits.
    InterProiIPR011603. 2oxoglutarate_DH_E1.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view]
    PANTHERiPTHR23152. PTHR23152. 1 hit.
    PfamiPF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTiSM00861. Transket_pyr. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 2 hits.
    TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q4KLP0-1 [UniParc]FASTAAdd to Basket

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    MASATVAAAG RALRRAVPLL RRSYQTERGV YGYRPRKAGS GEPRGDRARP    50
    SVDHGLARLV TVYCEHGHKA AQINPLFPGQ ALLDTVPEIQ ALVQTLQGPF 100
    TTTGLLNMGK EEASLEEVLA YLNHIYCGPI SIETAQLQSQ EEKDWFARRF 150
    EELKKETFTT EERKHLSKLL LESQEFDHFL ATKFATVKRY GGEGAESMMG 200
    FFHELLKLSA YGGITDIIIG MPHRGRLNLL TGLLQLPPEL MFRKMRGLSE 250
    FPENVAAIGD VLSHLTSSVD LDFGAHRPLH VTMLPNPSHL EAINPVAVGK 300
    TRGRQQSQED GDYSPNGSAQ PGDKVICLQV HGDASFCGQG IVLETFTLSN 350
    LPHFRIGGSI HLIVNNQLGY TTPAERGRSS LYSSDIGKLV GCAIIHVNGD 400
    SPEEVVRATR LAFEYQRQFR KDVIIDLLCY RQWGHNELDE PFFTNPVMYK 450
    IIRARKSIPD TYAEHLIASG LMTQEEVSDI KASYYAKLNG HLANVAHYSP 500
    PAPHLQARWQ GLVQPAACVT TWDTGVPLEL LRFVGVKSVE VPEELQLHSH 550
    LLKMYVQSRM EKVKNGTNLD WATAETLALG SLLAQGFNVR LSGQDVGRGT 600
    FSQRHAMVVC QNTDDVYIPL NHMDPNQKGF LEVSNSPLSE EAVLGFEYGM 650
    SIESPKLLPL WEAQFGDFFN GAQIIFDTFI SGGEAKWLLQ SGLVILLPHG 700
    YDGAGPDHSS CRIERFLQMC DSAEEGVDSD TVNMFVVHPT TPAQYFHLLR 750
    RQMMRNFRKP LIVASPKMLL RYPVAVSTLE EMAPGTAFKP VIGDSSVDPK 800
    NVKTLIFCSG KHFYALLKQR ESLGAKKRDF AIIRLEELCP FPLDSLQQEM 850
    GKYKHVQDII WSQEEPQNMG PWSFVYPRFE KQLACKLRLV SRPPLPAPAV 900
    GIGTVHQQQH EAILFKTFTS 920
    Length:920
    Mass (Da):102,642
    Last modified:August 2, 2005 - v1
    Checksum:iAA4A70E36AA41104
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC099075 mRNA. Translation: AAH99075.1.
    RefSeqiNP_001020891.1. NM_001025720.1.
    UniGeneiRn.13539.

    Genome annotation databases

    GeneIDi361272.
    KEGGirno:361272.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC099075 mRNA. Translation: AAH99075.1 .
    RefSeqi NP_001020891.1. NM_001025720.1.
    UniGenei Rn.13539.

    3D structure databases

    ProteinModelPortali Q4KLP0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000037032.

    PTM databases

    PhosphoSitei Q4KLP0.

    Proteomic databases

    PaxDbi Q4KLP0.
    PRIDEi Q4KLP0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 361272.
    KEGGi rno:361272.

    Organism-specific databases

    CTDi 55526.
    RGDi 1308092. Dhtkd1.

    Phylogenomic databases

    eggNOGi COG0567.
    HOGENOMi HOG000259586.
    HOVERGENi HBG001892.
    KOi K15791.
    PhylomeDBi Q4KLP0.

    Miscellaneous databases

    NextBioi 675775.

    Gene expression databases

    Genevestigatori Q4KLP0.

    Family and domain databases

    Gene3Di 3.40.50.970. 2 hits.
    InterProi IPR011603. 2oxoglutarate_DH_E1.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view ]
    PANTHERi PTHR23152. PTHR23152. 1 hit.
    Pfami PF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTi SM00861. Transket_pyr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 2 hits.
    TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.

    Entry informationi

    Entry nameiDHTK1_RAT
    AccessioniPrimary (citable) accession number: Q4KLP0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: August 2, 2005
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3