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Protein

Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial

Gene

Dhtkd1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactori

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: GO_Central
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. generation of precursor metabolites and energy Source: UniProtKB
  2. glycolytic process Source: UniProtKB-KW
  3. tricarboxylic acid cycle Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial (EC:1.2.4.2)
Alternative name(s):
Dehydrogenase E1 and transketolase domain-containing protein 1
Gene namesi
Name:Dhtkd1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1308092. Dhtkd1.

Subcellular locationi

  1. Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB
  2. oxoglutarate dehydrogenase complex Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 920Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrialPRO_0000307939
Transit peptidei1 – ?MitochondrionSequence Analysis

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei183 – 1831N6-succinyllysineBy similarity
Modified residuei188 – 1881N6-succinyllysineBy similarity
Modified residuei800 – 8001N6-succinyllysineBy similarity
Modified residuei818 – 8181N6-succinyllysineBy similarity

Proteomic databases

PaxDbiQ4KLP0.
PRIDEiQ4KLP0.

PTM databases

PhosphoSiteiQ4KLP0.

Expressioni

Gene expression databases

GenevestigatoriQ4KLP0.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000037032.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259586.
HOVERGENiHBG001892.
InParanoidiQ4KLP0.
KOiK15791.
PhylomeDBiQ4KLP0.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4KLP0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASATVAAAG RALRRAVPLL RRSYQTERGV YGYRPRKAGS GEPRGDRARP
60 70 80 90 100
SVDHGLARLV TVYCEHGHKA AQINPLFPGQ ALLDTVPEIQ ALVQTLQGPF
110 120 130 140 150
TTTGLLNMGK EEASLEEVLA YLNHIYCGPI SIETAQLQSQ EEKDWFARRF
160 170 180 190 200
EELKKETFTT EERKHLSKLL LESQEFDHFL ATKFATVKRY GGEGAESMMG
210 220 230 240 250
FFHELLKLSA YGGITDIIIG MPHRGRLNLL TGLLQLPPEL MFRKMRGLSE
260 270 280 290 300
FPENVAAIGD VLSHLTSSVD LDFGAHRPLH VTMLPNPSHL EAINPVAVGK
310 320 330 340 350
TRGRQQSQED GDYSPNGSAQ PGDKVICLQV HGDASFCGQG IVLETFTLSN
360 370 380 390 400
LPHFRIGGSI HLIVNNQLGY TTPAERGRSS LYSSDIGKLV GCAIIHVNGD
410 420 430 440 450
SPEEVVRATR LAFEYQRQFR KDVIIDLLCY RQWGHNELDE PFFTNPVMYK
460 470 480 490 500
IIRARKSIPD TYAEHLIASG LMTQEEVSDI KASYYAKLNG HLANVAHYSP
510 520 530 540 550
PAPHLQARWQ GLVQPAACVT TWDTGVPLEL LRFVGVKSVE VPEELQLHSH
560 570 580 590 600
LLKMYVQSRM EKVKNGTNLD WATAETLALG SLLAQGFNVR LSGQDVGRGT
610 620 630 640 650
FSQRHAMVVC QNTDDVYIPL NHMDPNQKGF LEVSNSPLSE EAVLGFEYGM
660 670 680 690 700
SIESPKLLPL WEAQFGDFFN GAQIIFDTFI SGGEAKWLLQ SGLVILLPHG
710 720 730 740 750
YDGAGPDHSS CRIERFLQMC DSAEEGVDSD TVNMFVVHPT TPAQYFHLLR
760 770 780 790 800
RQMMRNFRKP LIVASPKMLL RYPVAVSTLE EMAPGTAFKP VIGDSSVDPK
810 820 830 840 850
NVKTLIFCSG KHFYALLKQR ESLGAKKRDF AIIRLEELCP FPLDSLQQEM
860 870 880 890 900
GKYKHVQDII WSQEEPQNMG PWSFVYPRFE KQLACKLRLV SRPPLPAPAV
910 920
GIGTVHQQQH EAILFKTFTS
Length:920
Mass (Da):102,642
Last modified:August 2, 2005 - v1
Checksum:iAA4A70E36AA41104
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099075 mRNA. Translation: AAH99075.1.
RefSeqiNP_001020891.1. NM_001025720.1.
UniGeneiRn.13539.

Genome annotation databases

GeneIDi361272.
KEGGirno:361272.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099075 mRNA. Translation: AAH99075.1.
RefSeqiNP_001020891.1. NM_001025720.1.
UniGeneiRn.13539.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000037032.

PTM databases

PhosphoSiteiQ4KLP0.

Proteomic databases

PaxDbiQ4KLP0.
PRIDEiQ4KLP0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi361272.
KEGGirno:361272.

Organism-specific databases

CTDi55526.
RGDi1308092. Dhtkd1.

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259586.
HOVERGENiHBG001892.
InParanoidiQ4KLP0.
KOiK15791.
PhylomeDBiQ4KLP0.

Miscellaneous databases

NextBioi675775.
PROiQ4KLP0.

Gene expression databases

GenevestigatoriQ4KLP0.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.

Entry informationi

Entry nameiDHTK1_RAT
AccessioniPrimary (citable) accession number: Q4KLP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: August 2, 2005
Last modified: April 29, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.