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Protein

ADP-ribosylation factor GTPase-activating protein 3

Gene

Arfgap3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes (By similarity).By similarity

Enzyme regulationi

GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri25 – 48C4-typePROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor GTPase-activating protein 3
Short name:
ARF GAP 3
Gene namesi
Name:Arfgap3By similarity
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1560066. Arfgap3.

Subcellular locationi

  • Cytoplasm By similarity
  • Golgi apparatus membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity

  • Note: Also found on peripheral punctate structures likely to be endoplasmic reticulum-Golgi intermediate compartment.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003140551 – 525ADP-ribosylation factor GTPase-activating protein 3Add BLAST525

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei232PhosphoserineBy similarity1
Modified residuei242PhosphoserineCombined sources1
Modified residuei271PhosphoserineBy similarity1
Modified residuei275PhosphoserineBy similarity1
Modified residuei332PhosphoserineBy similarity1
Modified residuei379PhosphoserineBy similarity1
Modified residuei437PhosphoserineBy similarity1
Modified residuei460PhosphoserineBy similarity1
Modified residuei462PhosphoserineBy similarity1
Modified residuei464PhosphoserineBy similarity1
Modified residuei466PhosphoserineBy similarity1
Modified residuei467PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ4KLN7.
PRIDEiQ4KLN7.

PTM databases

iPTMnetiQ4KLN7.
PhosphoSitePlusiQ4KLN7.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000065256.

Structurei

3D structure databases

ProteinModelPortaliQ4KLN7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 126Arf-GAPPROSITE-ProRule annotationAdd BLAST117

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi349 – 411Ser-richSequence analysisAdd BLAST63

Sequence similaritiesi

Contains 1 Arf-GAP domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri25 – 48C4-typePROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG0706. Eukaryota.
COG5347. LUCA.
HOVERGENiHBG050563.
InParanoidiQ4KLN7.
KOiK12493.
PhylomeDBiQ4KLN7.

Family and domain databases

InterProiIPR001164. ArfGAP.
[Graphical view]
PfamiPF01412. ArfGap. 1 hit.
[Graphical view]
PRINTSiPR00405. REVINTRACTNG.
SMARTiSM00105. ArfGap. 1 hit.
[Graphical view]
PROSITEiPS50115. ARFGAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4KLN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDPSKQDIL AIFKRLRSVP TNKVCFDCGA KNPSWASISY GVFLCIDCSG
60 70 80 90 100
SHRSLGVHLS FIRSTELDSN WSWFQLRCMQ VGGNANASSF FHQHGCATKD
110 120 130 140 150
TNAKYNSRAA QLYREKIKTL ATQATRRHGT DLWLDSCAAP PASPPPKEED
160 170 180 190 200
FFASHASLEV SGATQASAQP EPASSTPWGL ETTPEKHEGG PGQGPSVEGL
210 220 230 240 250
NTPGKTAPAE VSSIIKKKPN QAKKGLGAKK GSLGAQKLTN TSFTEIEKQA
260 270 280 290 300
QAVDKRKEQE DLARGTPKEE SIVSSLRLAY KDLEIHKKQD ERLNLSGQKK
310 320 330 340 350
AEAERLGMGF GSCRGGISHS VTSDMQTIEQ ESPTLAKPRR KYQEDPEDSY
360 370 380 390 400
FSSSSKWSEQ SSSRYFDDPM ELRSSHFSSW DDSADSYWKK DSSRDPEPAT
410 420 430 440 450
KSTGSSDRPS SRRKPEYEPV GNTDEAQKKF GNVKAISSDM YFGIQSQTDF
460 470 480 490 500
ETRARLERLS TSSSISSADL FDEQRKQTTG NYNLSNVLPN APDMAQFKQG
510 520
VRSVAGKLSV FANGVMTSIQ DRYGS
Length:525
Mass (Da):57,671
Last modified:August 2, 2005 - v1
Checksum:iB8E97FA335876CBB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099081 mRNA. Translation: AAH99081.1.
RefSeqiNP_001037738.1. NM_001044273.1.
XP_017450552.1. XM_017595063.1.
UniGeneiRn.161999.

Genome annotation databases

GeneIDi503165.
KEGGirno:503165.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099081 mRNA. Translation: AAH99081.1.
RefSeqiNP_001037738.1. NM_001044273.1.
XP_017450552.1. XM_017595063.1.
UniGeneiRn.161999.

3D structure databases

ProteinModelPortaliQ4KLN7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000065256.

PTM databases

iPTMnetiQ4KLN7.
PhosphoSitePlusiQ4KLN7.

Proteomic databases

PaxDbiQ4KLN7.
PRIDEiQ4KLN7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi503165.
KEGGirno:503165.

Organism-specific databases

CTDi26286.
RGDi1560066. Arfgap3.

Phylogenomic databases

eggNOGiKOG0706. Eukaryota.
COG5347. LUCA.
HOVERGENiHBG050563.
InParanoidiQ4KLN7.
KOiK12493.
PhylomeDBiQ4KLN7.

Miscellaneous databases

PROiQ4KLN7.

Family and domain databases

InterProiIPR001164. ArfGAP.
[Graphical view]
PfamiPF01412. ArfGap. 1 hit.
[Graphical view]
PRINTSiPR00405. REVINTRACTNG.
SMARTiSM00105. ArfGap. 1 hit.
[Graphical view]
PROSITEiPS50115. ARFGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARFG3_RAT
AccessioniPrimary (citable) accession number: Q4KLN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 2, 2005
Last modified: November 30, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.