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Protein

ADP-ribosylation factor GTPase-activating protein 3

Gene

Arfgap3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes (By similarity).By similarity

Enzyme regulationi

GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri25 – 48C4-typePROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation
Biological processER-Golgi transport, Protein transport, Transport
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor GTPase-activating protein 3
Short name:
ARF GAP 3
Gene namesi
Name:Arfgap3By similarity
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1560066 Arfgap3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003140551 – 525ADP-ribosylation factor GTPase-activating protein 3Add BLAST525

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei232PhosphoserineBy similarity1
Modified residuei242PhosphoserineCombined sources1
Modified residuei271PhosphoserineBy similarity1
Modified residuei275PhosphoserineBy similarity1
Modified residuei332PhosphoserineBy similarity1
Modified residuei379PhosphoserineBy similarity1
Modified residuei437PhosphoserineBy similarity1
Modified residuei460PhosphoserineBy similarity1
Modified residuei462PhosphoserineBy similarity1
Modified residuei464PhosphoserineBy similarity1
Modified residuei466PhosphoserineBy similarity1
Modified residuei467PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ4KLN7
PRIDEiQ4KLN7

PTM databases

iPTMnetiQ4KLN7
PhosphoSitePlusiQ4KLN7

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000065256

Structurei

3D structure databases

ProteinModelPortaliQ4KLN7
SMRiQ4KLN7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 126Arf-GAPPROSITE-ProRule annotationAdd BLAST117

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi349 – 411Ser-richSequence analysisAdd BLAST63

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri25 – 48C4-typePROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG0706 Eukaryota
COG5347 LUCA
HOVERGENiHBG050563
InParanoidiQ4KLN7
KOiK12493
PhylomeDBiQ4KLN7

Family and domain databases

Gene3Di3.30.40.160, 1 hit
InterProiView protein in InterPro
IPR037278 ARFGAP/RecO
IPR001164 ArfGAP_dom
IPR038508 ArfGAP_dom_sf
PfamiView protein in Pfam
PF01412 ArfGap, 1 hit
PRINTSiPR00405 REVINTRACTNG
SMARTiView protein in SMART
SM00105 ArfGap, 1 hit
SUPFAMiSSF57863 SSF57863, 1 hit
PROSITEiView protein in PROSITE
PS50115 ARFGAP, 1 hit

Sequencei

Sequence statusi: Complete.

Q4KLN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDPSKQDIL AIFKRLRSVP TNKVCFDCGA KNPSWASISY GVFLCIDCSG
60 70 80 90 100
SHRSLGVHLS FIRSTELDSN WSWFQLRCMQ VGGNANASSF FHQHGCATKD
110 120 130 140 150
TNAKYNSRAA QLYREKIKTL ATQATRRHGT DLWLDSCAAP PASPPPKEED
160 170 180 190 200
FFASHASLEV SGATQASAQP EPASSTPWGL ETTPEKHEGG PGQGPSVEGL
210 220 230 240 250
NTPGKTAPAE VSSIIKKKPN QAKKGLGAKK GSLGAQKLTN TSFTEIEKQA
260 270 280 290 300
QAVDKRKEQE DLARGTPKEE SIVSSLRLAY KDLEIHKKQD ERLNLSGQKK
310 320 330 340 350
AEAERLGMGF GSCRGGISHS VTSDMQTIEQ ESPTLAKPRR KYQEDPEDSY
360 370 380 390 400
FSSSSKWSEQ SSSRYFDDPM ELRSSHFSSW DDSADSYWKK DSSRDPEPAT
410 420 430 440 450
KSTGSSDRPS SRRKPEYEPV GNTDEAQKKF GNVKAISSDM YFGIQSQTDF
460 470 480 490 500
ETRARLERLS TSSSISSADL FDEQRKQTTG NYNLSNVLPN APDMAQFKQG
510 520
VRSVAGKLSV FANGVMTSIQ DRYGS
Length:525
Mass (Da):57,671
Last modified:August 2, 2005 - v1
Checksum:iB8E97FA335876CBB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099081 mRNA Translation: AAH99081.1
RefSeqiNP_001037738.1, NM_001044273.1
XP_017450552.1, XM_017595063.1
UniGeneiRn.161999

Genome annotation databases

GeneIDi503165
KEGGirno:503165

Similar proteinsi

Entry informationi

Entry nameiARFG3_RAT
AccessioniPrimary (citable) accession number: Q4KLN7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 2, 2005
Last modified: May 23, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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