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Q4KLN6

- RIR2_RAT

UniProt

Q4KLN6 - RIR2_RAT

Protein

Ribonucleoside-diphosphate reductase subunit M2

Gene

Rrm2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (02 Aug 2005)
      Previous versions | rss
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    Functioni

    Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity. Inhibits Wnt signaling By similarity.By similarity

    Catalytic activityi

    2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.PROSITE-ProRule annotation

    Cofactori

    Binds 2 iron ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi139 – 1391Iron 1PROSITE-ProRule annotation
    Metal bindingi170 – 1701Iron 1PROSITE-ProRule annotation
    Metal bindingi170 – 1701Iron 2By similarity
    Metal bindingi173 – 1731Iron 1PROSITE-ProRule annotation
    Active sitei177 – 1771PROSITE-ProRule annotation
    Metal bindingi233 – 2331Iron 2By similarity
    Metal bindingi267 – 2671Iron 1PROSITE-ProRule annotation
    Metal bindingi267 – 2671Iron 2By similarity
    Metal bindingi270 – 2701Iron 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB

    GO - Biological processi

    1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
    2. deoxyribonucleotide biosynthetic process Source: UniProtKB
    3. DNA replication Source: UniProtKB-UniPathway
    4. mitotic cell cycle Source: RGD
    5. positive regulation of cell proliferation Source: RGD
    6. pyrimidine nucleobase metabolic process Source: RGD

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_196414. G1/S-Specific Transcription.
    REACT_215006. Synthesis and interconversion of nucleotide di- and triphosphates.
    UniPathwayiUPA00326.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonucleoside-diphosphate reductase subunit M2 (EC:1.17.4.1)
    Alternative name(s):
    Ribonucleotide reductase small chain
    Ribonucleotide reductase small subunit
    Gene namesi
    Name:Rrm2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 6

    Organism-specific databases

    RGDi1598310. Rrm2.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nuclear envelope Source: RGD

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 390390Ribonucleoside-diphosphate reductase subunit M2PRO_0000190451Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei20 – 201PhosphoserineBy similarity
    Modified residuei33 – 331PhosphothreonineBy similarity

    Post-translational modificationi

    Phosphorylation on Ser-20 relieves the inhibitory effect on Wnt signaling.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ4KLN6.

    Expressioni

    Gene expression databases

    GenevestigatoriQ4KLN6.

    Interactioni

    Subunit structurei

    Heterodimer of a large and a small subunit.

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000037227.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4KLN6.
    SMRiQ4KLN6. Positions 7-353.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0208.
    GeneTreeiENSGT00390000013305.
    HOGENOMiHOG000255975.
    HOVERGENiHBG001647.
    InParanoidiQ4KLN6.
    KOiK10808.
    OMAiXFHELIS.
    OrthoDBiEOG7VMP5N.
    PhylomeDBiQ4KLN6.
    TreeFamiTF300465.

    Family and domain databases

    Gene3Di1.10.620.20. 1 hit.
    InterProiIPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR000358. RNR_small.
    [Graphical view]
    PANTHERiPTHR23409. PTHR23409. 1 hit.
    PfamiPF00268. Ribonuc_red_sm. 1 hit.
    [Graphical view]
    SUPFAMiSSF47240. SSF47240. 1 hit.
    PROSITEiPS00368. RIBORED_SMALL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4KLN6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLSVRAPLAT IADQQQLHLS PLKRLSLADK ENTPPTLSSA RVLASKAARR    50
    IFQDSAELES KAPTKPSIEE EPLLRENPRR FVVFPIEYHD IWQMYKKAEA 100
    SFWTAEEVDL SKDIQHWEAL KPDERHFISH VLAFFAASDG IVNENLVERF 150
    SQEVQVTEAR CFYGFQIAME NIHSEMYSLL IDTYIKDSKE REYLFNAIET 200
    MPCVKKKADW ALRWIGDKEA TYGERVVAFA AVEGIFFSGS FASIFWLKKR 250
    GLMPGLTFSN ELISRDEGLH CDFACLMFKH LVHKPSEQRV KEIITNSVRI 300
    EQEFLTEALP VKLIGMNCTL MKQYIEFVAD RLMLELGFNK IFKVENPFDF 350
    MENISLEGKT NFFEKRVGEY QRMGVMSNST ENSFTLDADF 390
    Length:390
    Mass (Da):45,039
    Last modified:August 2, 2005 - v1
    Checksum:iA1BD4EABB7920F69
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC099082 mRNA. Translation: AAH99082.1.
    RefSeqiNP_001020911.1. NM_001025740.1.
    UniGeneiRn.144946.

    Genome annotation databases

    EnsembliENSRNOT00000037387; ENSRNOP00000037227; ENSRNOG00000023272.
    GeneIDi362720.
    KEGGirno:362720.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC099082 mRNA. Translation: AAH99082.1 .
    RefSeqi NP_001020911.1. NM_001025740.1.
    UniGenei Rn.144946.

    3D structure databases

    ProteinModelPortali Q4KLN6.
    SMRi Q4KLN6. Positions 7-353.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000037227.

    Proteomic databases

    PRIDEi Q4KLN6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000037387 ; ENSRNOP00000037227 ; ENSRNOG00000023272 .
    GeneIDi 362720.
    KEGGi rno:362720.

    Organism-specific databases

    CTDi 6241.
    RGDi 1598310. Rrm2.

    Phylogenomic databases

    eggNOGi COG0208.
    GeneTreei ENSGT00390000013305.
    HOGENOMi HOG000255975.
    HOVERGENi HBG001647.
    InParanoidi Q4KLN6.
    KOi K10808.
    OMAi XFHELIS.
    OrthoDBi EOG7VMP5N.
    PhylomeDBi Q4KLN6.
    TreeFami TF300465.

    Enzyme and pathway databases

    UniPathwayi UPA00326 .
    Reactomei REACT_196414. G1/S-Specific Transcription.
    REACT_215006. Synthesis and interconversion of nucleotide di- and triphosphates.

    Miscellaneous databases

    NextBioi 680993.

    Gene expression databases

    Genevestigatori Q4KLN6.

    Family and domain databases

    Gene3Di 1.10.620.20. 1 hit.
    InterProi IPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR000358. RNR_small.
    [Graphical view ]
    PANTHERi PTHR23409. PTHR23409. 1 hit.
    Pfami PF00268. Ribonuc_red_sm. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47240. SSF47240. 1 hit.
    PROSITEi PS00368. RIBORED_SMALL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.

    Entry informationi

    Entry nameiRIR2_RAT
    AccessioniPrimary (citable) accession number: Q4KLN6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2005
    Last sequence update: August 2, 2005
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Two distinct regulatory sites have been defined: the specificity site, which controls substrate specificity, and the activity site which regulates overall catalytic activity. A substrate-binding catalytic site, located on M1, is formed only in the presence of the second subunit M2 By similarity.By similarity

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3