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Q4KLN6

- RIR2_RAT

UniProt

Q4KLN6 - RIR2_RAT

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Protein

Ribonucleoside-diphosphate reductase subunit M2

Gene
Rrm2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity. Inhibits Wnt signaling By similarity.

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactori

Binds 2 iron ions per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi139 – 1391Iron 1 By similarity
Metal bindingi170 – 1701Iron 1 By similarity
Metal bindingi170 – 1701Iron 2 By similarity
Metal bindingi173 – 1731Iron 1 By similarity
Active sitei177 – 1771 By similarity
Metal bindingi233 – 2331Iron 2 By similarity
Metal bindingi267 – 2671Iron 1 By similarity
Metal bindingi267 – 2671Iron 2 By similarity
Metal bindingi270 – 2701Iron 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB

GO - Biological processi

  1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
  2. deoxyribonucleotide biosynthetic process Source: UniProtKB
  3. DNA replication Source: UniProtKB-UniPathway
  4. mitotic cell cycle Source: RGD
  5. positive regulation of cell proliferation Source: RGD
  6. pyrimidine nucleobase metabolic process Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_196414. G1/S-Specific Transcription.
REACT_215006. Synthesis and interconversion of nucleotide di- and triphosphates.
UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase subunit M2 (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase small chain
Ribonucleotide reductase small subunit
Gene namesi
Name:Rrm2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 6

Organism-specific databases

RGDi1598310. Rrm2.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nuclear envelope Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 390390Ribonucleoside-diphosphate reductase subunit M2PRO_0000190451Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei20 – 201Phosphoserine By similarity
Modified residuei33 – 331Phosphothreonine By similarity

Post-translational modificationi

Phosphorylation on Ser-20 relieves the inhibitory effect on Wnt signaling By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ4KLN6.

Expressioni

Gene expression databases

GenevestigatoriQ4KLN6.

Interactioni

Subunit structurei

Heterodimer of a large and a small subunit.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000037227.

Structurei

3D structure databases

ProteinModelPortaliQ4KLN6.
SMRiQ4KLN6. Positions 7-353.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0208.
GeneTreeiENSGT00390000013305.
HOGENOMiHOG000255975.
HOVERGENiHBG001647.
InParanoidiQ4KLN6.
KOiK10808.
OMAiXFHELIS.
OrthoDBiEOG7VMP5N.
PhylomeDBiQ4KLN6.
TreeFamiTF300465.

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4KLN6-1 [UniParc]FASTAAdd to Basket

« Hide

MLSVRAPLAT IADQQQLHLS PLKRLSLADK ENTPPTLSSA RVLASKAARR    50
IFQDSAELES KAPTKPSIEE EPLLRENPRR FVVFPIEYHD IWQMYKKAEA 100
SFWTAEEVDL SKDIQHWEAL KPDERHFISH VLAFFAASDG IVNENLVERF 150
SQEVQVTEAR CFYGFQIAME NIHSEMYSLL IDTYIKDSKE REYLFNAIET 200
MPCVKKKADW ALRWIGDKEA TYGERVVAFA AVEGIFFSGS FASIFWLKKR 250
GLMPGLTFSN ELISRDEGLH CDFACLMFKH LVHKPSEQRV KEIITNSVRI 300
EQEFLTEALP VKLIGMNCTL MKQYIEFVAD RLMLELGFNK IFKVENPFDF 350
MENISLEGKT NFFEKRVGEY QRMGVMSNST ENSFTLDADF 390
Length:390
Mass (Da):45,039
Last modified:August 2, 2005 - v1
Checksum:iA1BD4EABB7920F69
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC099082 mRNA. Translation: AAH99082.1.
RefSeqiNP_001020911.1. NM_001025740.1.
UniGeneiRn.144946.

Genome annotation databases

EnsembliENSRNOT00000037387; ENSRNOP00000037227; ENSRNOG00000023272.
GeneIDi362720.
KEGGirno:362720.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC099082 mRNA. Translation: AAH99082.1 .
RefSeqi NP_001020911.1. NM_001025740.1.
UniGenei Rn.144946.

3D structure databases

ProteinModelPortali Q4KLN6.
SMRi Q4KLN6. Positions 7-353.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000037227.

Proteomic databases

PRIDEi Q4KLN6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000037387 ; ENSRNOP00000037227 ; ENSRNOG00000023272 .
GeneIDi 362720.
KEGGi rno:362720.

Organism-specific databases

CTDi 6241.
RGDi 1598310. Rrm2.

Phylogenomic databases

eggNOGi COG0208.
GeneTreei ENSGT00390000013305.
HOGENOMi HOG000255975.
HOVERGENi HBG001647.
InParanoidi Q4KLN6.
KOi K10808.
OMAi XFHELIS.
OrthoDBi EOG7VMP5N.
PhylomeDBi Q4KLN6.
TreeFami TF300465.

Enzyme and pathway databases

UniPathwayi UPA00326 .
Reactomei REACT_196414. G1/S-Specific Transcription.
REACT_215006. Synthesis and interconversion of nucleotide di- and triphosphates.

Miscellaneous databases

NextBioi 680993.

Gene expression databases

Genevestigatori Q4KLN6.

Family and domain databases

Gene3Di 1.10.620.20. 1 hit.
InterProi IPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view ]
PANTHERi PTHR23409. PTHR23409. 1 hit.
Pfami PF00268. Ribonuc_red_sm. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS00368. RIBORED_SMALL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.

Entry informationi

Entry nameiRIR2_RAT
AccessioniPrimary (citable) accession number: Q4KLN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: August 2, 2005
Last modified: September 3, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Two distinct regulatory sites have been defined: the specificity site, which controls substrate specificity, and the activity site which regulates overall catalytic activity. A substrate-binding catalytic site, located on M1, is formed only in the presence of the second subunit M2 By similarity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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