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Protein

Nucleoporin GLE1

Gene

Gle1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC) (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA transport, Protein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoporin GLE1
Alternative name(s):
GLE1-like protein
Gene namesi
Name:Gle1
Synonyms:Gle1l
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1307329. Gle1.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity
  • Nucleusnuclear pore complex By similarity

  • Note: Shuttles between the nucleus and the cytoplasm. Shuttling is essential for its mRNA export function.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 698698Nucleoporin GLE1PRO_0000204825Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei90 – 901PhosphoserineBy similarity
Modified residuei100 – 1001PhosphoserineBy similarity
Modified residuei351 – 3511PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ4KLN4.
PRIDEiQ4KLN4.

PTM databases

iPTMnetiQ4KLN4.
PhosphoSiteiQ4KLN4.

Expressioni

Gene expression databases

GenevisibleiQ4KLN4. RN.

Interactioni

Subunit structurei

Associated with the NPC, it however may not be a stable component of the NPC complex since it shuttles between the nucleus and the cytoplasm. Interacts with nuclear pore complex proteins NUP155 and NUPL2 (By similarity).By similarity

Protein-protein interaction databases

MINTiMINT-4997151.
STRINGi10116.ENSRNOP00000020630.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2929Interaction with NUP155By similarityAdd
BLAST
Regioni444 – 48340Mediates the shuttling between the nucleus and the cytoplasmBy similarityAdd
BLAST
Regioni656 – 69843Interaction with NUPL2By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili152 – 274123Sequence analysisAdd
BLAST
Coiled coili305 – 35551Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi70 – 11344Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the GLE1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2412. Eukaryota.
ENOG410XT57. LUCA.
GeneTreeiENSGT00390000012903.
HOGENOMiHOG000246966.
HOVERGENiHBG081558.
InParanoidiQ4KLN4.
KOiK18723.
OMAiGNQLCSQ.
OrthoDBiEOG7FFMRB.
PhylomeDBiQ4KLN4.
TreeFamiTF324158.

Family and domain databases

InterProiIPR012476. GLE1.
[Graphical view]
PANTHERiPTHR12960. PTHR12960. 1 hit.
PfamiPF07817. GLE1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4KLN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSDGRCWET LRALRNSSKG RLRYDREWLL RYEDVLEECM SLPKLSSYSG
60 70 80 90 100
WVVDHILPNT SHHTQENAPS SDNSPSSGSA SGLYQSTLKS PVRSSPQSPS
110 120 130 140 150
PSTPSGTQSA HESPFTEPIA LQSSRAIKVE GCIRMYELAH RMRGTEGLRQ
160 170 180 190 200
WQEEQERKVQ ALSEMASEQL KRFDELKELK LHKEFRDLQE VMEKSTREAL
210 220 230 240 250
GHQEKLKAEH RHRAKILNLK LREAEQQRVK QAEQEQLRKE EGQIRLRSLY
260 270 280 290 300
TLQEEVLQLN QQLDASSQHK DLLNVDLAAF QTRGNQLCGL ISGIIRTTLE
310 320 330 340 350
SGYPTAENQA EAERVLQEMR DLLSNLEQEI TRASEMKKKD EEEARVKLQE
360 370 380 390 400
SQVQQGPGAP TKTSAPSPSL VGTQSEDLQV KVQDSTMQWY QQLQDASAKC
410 420 430 440 450
VLAFEDLTSS KDSQIKKIKM DLQKAATIPV SQISTIAGSK LKEVFDKIHS
460 470 480 490 500
LLSGKPVQSG GRSVCVTLNP QGLDFVQYKL AEKFVKQGEE EVASHHEAAF
510 520 530 540 550
PIAVVASGIW MLHPKVGDLI LAHLHKKCPY SVPFYPAFKE GMPLEDYQRM
560 570 580 590 600
LGYQVTDSKV EQQDNFLKRM SGMIRLYAAI IQLQWPYGSR QEAHPHGLNH
610 620 630 640 650
GWRWLAQILN MEPLSDVTAT LLFDFLEVCG NALMKQYQVQ FWKMILLIKE
660 670 680 690
DYFPRIEAIT SSGQMGSFIR LKQFLEKCLQ RREIPVPKGF LTPSFWRS
Length:698
Mass (Da):79,492
Last modified:August 2, 2005 - v1
Checksum:i71F45043656B8331
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099088 mRNA. Translation: AAH99088.1.
RefSeqiNP_001020902.1. NM_001025731.1.
UniGeneiRn.162648.

Genome annotation databases

EnsembliENSRNOT00000020630; ENSRNOP00000020630; ENSRNOG00000015237.
GeneIDi362098.
KEGGirno:362098.
UCSCiRGD:1307329. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099088 mRNA. Translation: AAH99088.1.
RefSeqiNP_001020902.1. NM_001025731.1.
UniGeneiRn.162648.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4997151.
STRINGi10116.ENSRNOP00000020630.

PTM databases

iPTMnetiQ4KLN4.
PhosphoSiteiQ4KLN4.

Proteomic databases

PaxDbiQ4KLN4.
PRIDEiQ4KLN4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000020630; ENSRNOP00000020630; ENSRNOG00000015237.
GeneIDi362098.
KEGGirno:362098.
UCSCiRGD:1307329. rat.

Organism-specific databases

CTDi2733.
RGDi1307329. Gle1.

Phylogenomic databases

eggNOGiKOG2412. Eukaryota.
ENOG410XT57. LUCA.
GeneTreeiENSGT00390000012903.
HOGENOMiHOG000246966.
HOVERGENiHBG081558.
InParanoidiQ4KLN4.
KOiK18723.
OMAiGNQLCSQ.
OrthoDBiEOG7FFMRB.
PhylomeDBiQ4KLN4.
TreeFamiTF324158.

Miscellaneous databases

PROiQ4KLN4.

Gene expression databases

GenevisibleiQ4KLN4. RN.

Family and domain databases

InterProiIPR012476. GLE1.
[Graphical view]
PANTHERiPTHR12960. PTHR12960. 1 hit.
PfamiPF07817. GLE1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiGLE1_RAT
AccessioniPrimary (citable) accession number: Q4KLN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: August 2, 2005
Last modified: June 8, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.