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Protein

Nucleoporin GLE1

Gene

Gle1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-RNO-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoporin GLE1
Alternative name(s):
GLE1-like protein
Gene namesi
Name:Gle1
Synonyms:Gle1l
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1307329 Gle1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002048251 – 698Nucleoporin GLE1Add BLAST698

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41PhosphoserineBy similarity1
Modified residuei90PhosphoserineBy similarity1
Modified residuei100PhosphoserineBy similarity1
Modified residuei351PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ4KLN4
PRIDEiQ4KLN4

PTM databases

iPTMnetiQ4KLN4
PhosphoSitePlusiQ4KLN4

Expressioni

Gene expression databases

BgeeiENSRNOG00000015237
GenevisibleiQ4KLN4 RN

Interactioni

Subunit structurei

Associated with the NPC, it however may not be a stable component of the NPC complex since it shuttles between the nucleus and the cytoplasm. Interacts with nuclear pore complex proteins NUP155 and NUPL2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020630

Structurei

3D structure databases

SMRiQ4KLN4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 29Interaction with NUP155By similarityAdd BLAST29
Regioni444 – 483Mediates the shuttling between the nucleus and the cytoplasmBy similarityAdd BLAST40
Regioni656 – 698Interaction with NUPL2By similarityAdd BLAST43

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili152 – 274Sequence analysisAdd BLAST123
Coiled coili305 – 355Sequence analysisAdd BLAST51

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi70 – 113Ser-richAdd BLAST44

Sequence similaritiesi

Belongs to the GLE1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2412 Eukaryota
ENOG410XT57 LUCA
GeneTreeiENSGT00390000012903
HOGENOMiHOG000246966
HOVERGENiHBG081558
InParanoidiQ4KLN4
KOiK18723
OMAiFWKLLPD
OrthoDBiEOG091G0AZV
PhylomeDBiQ4KLN4
TreeFamiTF324158

Family and domain databases

Gene3Di1.25.40.510, 1 hit
InterProiView protein in InterPro
IPR012476 GLE1
IPR038506 GLE1-like_sf
PANTHERiPTHR12960 PTHR12960, 1 hit
PfamiView protein in Pfam
PF07817 GLE1, 1 hit

Sequencei

Sequence statusi: Complete.

Q4KLN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSDGRCWET LRALRNSSKG RLRYDREWLL RYEDVLEECM SLPKLSSYSG
60 70 80 90 100
WVVDHILPNT SHHTQENAPS SDNSPSSGSA SGLYQSTLKS PVRSSPQSPS
110 120 130 140 150
PSTPSGTQSA HESPFTEPIA LQSSRAIKVE GCIRMYELAH RMRGTEGLRQ
160 170 180 190 200
WQEEQERKVQ ALSEMASEQL KRFDELKELK LHKEFRDLQE VMEKSTREAL
210 220 230 240 250
GHQEKLKAEH RHRAKILNLK LREAEQQRVK QAEQEQLRKE EGQIRLRSLY
260 270 280 290 300
TLQEEVLQLN QQLDASSQHK DLLNVDLAAF QTRGNQLCGL ISGIIRTTLE
310 320 330 340 350
SGYPTAENQA EAERVLQEMR DLLSNLEQEI TRASEMKKKD EEEARVKLQE
360 370 380 390 400
SQVQQGPGAP TKTSAPSPSL VGTQSEDLQV KVQDSTMQWY QQLQDASAKC
410 420 430 440 450
VLAFEDLTSS KDSQIKKIKM DLQKAATIPV SQISTIAGSK LKEVFDKIHS
460 470 480 490 500
LLSGKPVQSG GRSVCVTLNP QGLDFVQYKL AEKFVKQGEE EVASHHEAAF
510 520 530 540 550
PIAVVASGIW MLHPKVGDLI LAHLHKKCPY SVPFYPAFKE GMPLEDYQRM
560 570 580 590 600
LGYQVTDSKV EQQDNFLKRM SGMIRLYAAI IQLQWPYGSR QEAHPHGLNH
610 620 630 640 650
GWRWLAQILN MEPLSDVTAT LLFDFLEVCG NALMKQYQVQ FWKMILLIKE
660 670 680 690
DYFPRIEAIT SSGQMGSFIR LKQFLEKCLQ RREIPVPKGF LTPSFWRS
Length:698
Mass (Da):79,492
Last modified:August 2, 2005 - v1
Checksum:i71F45043656B8331
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099088 mRNA Translation: AAH99088.1
RefSeqiNP_001020902.1, NM_001025731.1
UniGeneiRn.162648

Genome annotation databases

EnsembliENSRNOT00000020630; ENSRNOP00000020630; ENSRNOG00000015237
GeneIDi362098
KEGGirno:362098
UCSCiRGD:1307329 rat

Similar proteinsi

Entry informationi

Entry nameiGLE1_RAT
AccessioniPrimary (citable) accession number: Q4KLN4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: August 2, 2005
Last modified: May 23, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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