Q4KLM5 (ABT1_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Activator of basal transcription 1

Gene names

Name:

Abt1

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	268 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes By similarity.
Subunit structure	Interacts with IGHMBP2 By similarity. Interacts with ESF1/ABTAP. Ref.2
Subcellular location	Nucleus By similarity. Nucleus › nucleolus By similarity.
Sequence similarities	Belongs to the ESF2/ABP1 family. Contains 1 RRM (RNA recognition motif) domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Coiled coil
Ligand	DNA-binding RNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleolus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW RNA binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 268	268	Activator of basal transcription 1		PRO_0000233171
Regions
	Domain	47 – 144	98	RRM
	Coiled coil	6 – 38	33	Potential
	Coiled coil	163 – 193	31	Potential
	Compositional bias	91 – 95	5	Poly-Ala

Sequences

	Sequence		Length	Mass (Da)
	Q4KLM5 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: 98E9A2CED07AAD7E	FASTA	268	30,620
	10 20 30 40 50 60 MVKVGKLVEE QKAAMEEEKE VNAEAAEELE EAEEASCNGS KKKVVPGIVY LGHVPPRFRP 70 80 90 100 110 120 LHVRNLLSVY GEVGRVFFQA EDPFVRRKKK AAAAAGGKKG AKYSKDYTEG WVEFRDKRIA 130 140 150 160 170 180 KRVAASLHNT PMGARKRSPF RYDLWNLKYL HRFTWSHLSE HLAFERQVRR QRLRAEVAQA 190 200 210 220 230 240 KRETDFYLRN VEQGQRFLAA DGDATRPNSS WTFTQRPTEQ ELRAQKGARP GGRERARLAT 250 260 VQDQARSNRG LLARIFGASL LAESRKEP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[2]	"A novel TATA-binding protein-binding protein, ABT1, activates basal transcription and has a yeast homolog that is essential for growth." Oda T., Kayukawa K., Hagiwara H., Yudate H.T., Masuho Y., Murakami Y., Tamura T.-A., Muramatsu M.-A. Mol. Cell. Biol. 20:1407-1418(2000) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH ESF1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC099109 mRNA. Translation: AAH99109.1.
IPI	IPI00366354.
RefSeq	NP_001020845.1. NM_001025674.1.
UniGene	Rn.16564.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000023648.
Proteomic databases
PRIDE	Q4KLM5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000023649; ENSRNOP00000023648; ENSRNOG00000017585.
GeneID	306960.
KEGG	rno:306960.
UCSC	RGD:1310785. rat.
Organism-specific databases
CTD	29777.
RGD	1310785. Abt1.
Phylogenomic databases
eggNOG	NOG332037.
GeneTree	ENSGT00390000002062.
HOGENOM	HOG000242500.
HOVERGEN	HBG057308.
InParanoid	Q4KLM5.
KO	K14785.
OMA	HVPPRFR.
OrthoDB	EOG4S1T7W.
Gene expression databases
Genevestigator	Q4KLM5.
GermOnline	ENSRNOG00000017585. Rattus norvegicus.
Family and domain databases
Gene3D	3.30.70.330. 1 hit.
InterPro	IPR012677. Nucleotide-bd_a/b_plait. [Graphical view]
PROSITE	PS50102. RRM. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	656746.

Entry information

Entry name

ABT1_RAT

Accession

Primary (citable) accession number: Q4KLM5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2006
Last sequence update:	August 2, 2005
Last modified:	April 3, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program