Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Kinesin-like protein KIF18B

Gene

Kif18b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi111 – 1188ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF18B
Gene namesi
Name:Kif18b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1310360. Kif18b.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity
  • Cytoplasmcytoskeleton Curated

  • Note: Present predominantly in the nucleus and to a lesser extent in the cytoplasm of interphase cells. During mitosis, found to be closely associated with astral microtubule plus ends emanating from the spindle pole during prometaphase and metaphase (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 826826Kinesin-like protein KIF18BPRO_0000318971Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei483 – 4831PhosphoserineBy similarity
Modified residuei633 – 6331PhosphoserineBy similarity
Modified residuei656 – 6561PhosphoserineBy similarity
Modified residuei668 – 6681PhosphothreonineBy similarity
Modified residuei814 – 8141PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ4KLL9.
PRIDEiQ4KLL9.

PTM databases

PhosphoSiteiQ4KLL9.

Expressioni

Gene expression databases

GenevisibleiQ4KLL9. RN.

Interactioni

Subunit structurei

Interacts with MAPRE1; this interaction is required for efficient accumulation at microtubule plus ends. Interacts with KIF2C at microtubule tips; this interaction increases the affinity of both partners for microtubule plus ends and is required for robust microtubule depolymerization. KIF2C phosphorylation by AURKA or AURKB strongly reduces KIF18B-binding.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000034491.

Structurei

3D structure databases

ProteinModelPortaliQ4KLL9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 353345Kinesin motorPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili368 – 40336Sequence analysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi618 – 6269Nuclear localization signalBy similarity

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0242. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00840000129683.
HOGENOMiHOG000231436.
HOVERGENiHBG108062.
InParanoidiQ4KLL9.
OMAiWENVPQE.
OrthoDBiEOG7Z95KM.
PhylomeDBiQ4KLL9.
TreeFamiTF105231.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 4 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4KLL9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVMAVEDSVV RVVVRVRPPT PKELESQRRP VIQVVDERML VFDPEECDGG
60 70 80 90 100
FPGLKWSGSL SGPKKKGKDL TFVFDRVFSE VATQQDVFQH TTHNILDSFL
110 120 130 140 150
QGYNCSVFAY GATGAGKTHT MLGREGDPGI MYLTTMELYR RLEACQEEKQ
160 170 180 190 200
FEVLISYLEV YNEQIYDLLE PKGPLTIRED PDKGVVVPGL SFHQPASAQQ
210 220 230 240 250
LLEMLTRGNC SRTQHPTDAN ATSSRSHAIF QIFVKQQDRV PGLTQALRVA
260 270 280 290 300
KMSLIDLAGS ERASSTHAKG ERLREGANIN RSLLALINVL NALADAKGRK
310 320 330 340 350
SHVPYRDSKL TRLLKDSIGG NCRTVMIAAV SPSSLTYEDT YNTLKYADRA
360 370 380 390 400
KEIRLTLKSN VISLDHHISQ YATICQQLQA EVAALREKLQ TYEAGAQALQ
410 420 430 440 450
QRSPQPPKLS IPQNLSSSPL QPGHSSQSCA PEFHAKYDAP QEESLGTDSQ
460 470 480 490 500
GQGTVEENAP EQEQPPQDKQ FPTQMPEPNL PGSPCPTVQA KQGMNQHSLQ
510 520 530 540 550
RLDAEHSKQL ALRVLRLAQR QYSLLQAANL LTPDMISEFE TLQQLVLEES
560 570 580 590 600
MEHGAESPRS PGLARGIPLA QELCSESKSS RYCGPVTRTM AKQLSGLTHT
610 620 630 640 650
LGIPLAPDCT SDKTSQKPTK EKKRKLNLEE PGSLPAPSVE MKRQRQSFLP
660 670 680 690 700
CLRRGSLPKI QPSSEPRTPK GERASSPSPS SRVCPATVIK SRVPLGPSAL
710 720 730 740 750
QNCSTPLTLP TRDLNTTFNV SEESPSKPSF PEPIDWEKVS PELNGTDQPF
760 770 780 790 800
LPSAPVFIFT TKGRKPSLPT TTASKKRRTV RPSVSRGRSC IARLPSSTLK
810 820
KPDRPFTVPD PPLSLHCLDD HQVIRD
Length:826
Mass (Da):91,195
Last modified:August 2, 2005 - v1
Checksum:i0CD86CDECC8C59DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099126 mRNA. Translation: AAH99126.1.
RefSeqiNP_001034108.1. NM_001039019.1.
XP_006247567.1. XM_006247505.2.
UniGeneiRn.112739.

Genome annotation databases

EnsembliENSRNOT00000032339; ENSRNOP00000034491; ENSRNOG00000021713.
ENSRNOT00000084128; ENSRNOP00000070718; ENSRNOG00000021713.
GeneIDi303575.
KEGGirno:303575.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099126 mRNA. Translation: AAH99126.1.
RefSeqiNP_001034108.1. NM_001039019.1.
XP_006247567.1. XM_006247505.2.
UniGeneiRn.112739.

3D structure databases

ProteinModelPortaliQ4KLL9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000034491.

PTM databases

PhosphoSiteiQ4KLL9.

Proteomic databases

PaxDbiQ4KLL9.
PRIDEiQ4KLL9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000032339; ENSRNOP00000034491; ENSRNOG00000021713.
ENSRNOT00000084128; ENSRNOP00000070718; ENSRNOG00000021713.
GeneIDi303575.
KEGGirno:303575.

Organism-specific databases

CTDi146909.
RGDi1310360. Kif18b.

Phylogenomic databases

eggNOGiKOG0242. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00840000129683.
HOGENOMiHOG000231436.
HOVERGENiHBG108062.
InParanoidiQ4KLL9.
OMAiWENVPQE.
OrthoDBiEOG7Z95KM.
PhylomeDBiQ4KLL9.
TreeFamiTF105231.

Miscellaneous databases

PROiQ4KLL9.

Gene expression databases

GenevisibleiQ4KLL9. RN.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 4 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiKI18B_RAT
AccessioniPrimary (citable) accession number: Q4KLL9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: August 2, 2005
Last modified: July 6, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.