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Q4KLL0

- TCEA1_RAT

UniProt

Q4KLL0 - TCEA1_RAT

Protein

Transcription elongation factor A protein 1

Gene

Tcea1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (02 Aug 2005)
      Previous versions | rss
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    Functioni

    Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri259 – 29941TFIIS-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. regulation of DNA-templated transcription, elongation Source: InterPro
    2. regulation of transcription from RNA polymerase II promoter Source: InterPro
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_216241. RNA Polymerase II Pre-transcription Events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription elongation factor A protein 1
    Alternative name(s):
    Transcription elongation factor S-II protein 1
    Gene namesi
    Name:Tcea1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 5

    Organism-specific databases

    RGDi1309880. Tcea1.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 301301Transcription elongation factor A protein 1PRO_0000121448Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Modified residuei97 – 971PhosphoserineBy similarity
    Modified residuei100 – 1001PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiQ4KLL0.
    PRIDEiQ4KLL0.

    PTM databases

    PhosphoSiteiQ4KLL0.

    Expressioni

    Gene expression databases

    GenevestigatoriQ4KLL0.

    Interactioni

    Subunit structurei

    Interacts with EAF2. Associates with UBR5 and forms a transcription regulatory complex made of CDK9, RNAP II, UBR5 and TFIIS/TCEA1 that can stimulate target gene transcription by recruiting their promoters.By similarity

    Protein-protein interaction databases

    BioGridi263480. 2 interactions.
    STRINGi10116.ENSRNOP00000010893.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4KLL0.
    SMRiQ4KLL0. Positions 1-87, 252-301.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini3 – 8078TFIIS N-terminalPROSITE-ProRule annotationAdd
    BLAST
    Domaini140 – 256117TFIIS centralPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TFS-II family.Curated
    Contains 1 TFIIS central domain.PROSITE-ProRule annotation
    Contains 1 TFIIS N-terminal domain.PROSITE-ProRule annotation
    Contains 1 TFIIS-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri259 – 29941TFIIS-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG1594.
    GeneTreeiENSGT00390000017794.
    HOGENOMiHOG000195015.
    HOVERGENiHBG055022.
    InParanoidiQ4KLL0.
    KOiK03145.
    OMAiRAMISFW.
    OrthoDBiEOG7GQXWQ.
    PhylomeDBiQ4KLL0.
    TreeFamiTF314970.

    Family and domain databases

    Gene3Di1.10.472.30. 1 hit.
    1.20.930.10. 1 hit.
    InterProiIPR016492. TF_IIS-rel.
    IPR003617. TFIIS/CRSP70_N_sub.
    IPR003618. TFIIS_cen_dom.
    IPR017923. TFIIS_N.
    IPR017890. TFS2M.
    IPR006289. TFSII.
    IPR001222. Znf_TFIIS.
    [Graphical view]
    PfamiPF08711. Med26. 1 hit.
    PF01096. TFIIS_C. 1 hit.
    PF07500. TFIIS_M. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006704. TF_IIS. 1 hit.
    SMARTiSM00510. TFS2M. 1 hit.
    SM00509. TFS2N. 1 hit.
    SM00440. ZnF_C2C2. 1 hit.
    [Graphical view]
    SUPFAMiSSF46942. SSF46942. 1 hit.
    SSF47676. SSF47676. 1 hit.
    TIGRFAMsiTIGR01385. TFSII. 1 hit.
    PROSITEiPS51321. TFIIS_CENTRAL. 1 hit.
    PS51319. TFIIS_N. 1 hit.
    PS00466. ZF_TFIIS_1. 1 hit.
    PS51133. ZF_TFIIS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4KLL0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEDEVVRIAK KMDKMVQKKN AAGALDLLKE LKNIPMTLEL LQSTRIGMSV    50
    NAIRKQSTDE EVTSLAKSLI KSWKKLLDGP STDKDSEEKK KEPAISSQNS 100
    PEAREESSSS SHVSSRKDET NARDTYVSSF PRAPSTSDSV RLKCREMLAA 150
    ALRTGDDYVA IGADEEELGS QIEEAIYQEI RNTDMKYKNR VRSRISNLKD 200
    AKNPNLRKNV LCGNIPPDLF ARMTAEEMAS DELKEMRKNL TKEAIREHQM 250
    AKTGGTQTDL FTCGKCKKKN CTYTQVQTRS ADEPMTTFVV CNECGNRWKF 300
    C 301
    Length:301
    Mass (Da):33,893
    Last modified:August 2, 2005 - v1
    Checksum:iAD85071FBB589CB5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC099141 mRNA. Translation: AAH99141.1.
    RefSeqiNP_001020906.1. NM_001025735.1.
    XP_003752832.1. XM_003752784.2.
    XP_006237878.1. XM_006237816.1.
    XP_006251782.1. XM_006251720.1.
    UniGeneiRn.6738.

    Genome annotation databases

    EnsembliENSRNOT00000010893; ENSRNOP00000010893; ENSRNOG00000022323.
    GeneIDi362479.
    498453.
    KEGGirno:362479.
    rno:498453.
    UCSCiRGD:1309880. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC099141 mRNA. Translation: AAH99141.1 .
    RefSeqi NP_001020906.1. NM_001025735.1.
    XP_003752832.1. XM_003752784.2.
    XP_006237878.1. XM_006237816.1.
    XP_006251782.1. XM_006251720.1.
    UniGenei Rn.6738.

    3D structure databases

    ProteinModelPortali Q4KLL0.
    SMRi Q4KLL0. Positions 1-87, 252-301.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 263480. 2 interactions.
    STRINGi 10116.ENSRNOP00000010893.

    PTM databases

    PhosphoSitei Q4KLL0.

    Proteomic databases

    PaxDbi Q4KLL0.
    PRIDEi Q4KLL0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000010893 ; ENSRNOP00000010893 ; ENSRNOG00000022323 .
    GeneIDi 362479.
    498453.
    KEGGi rno:362479.
    rno:498453.
    UCSCi RGD:1309880. rat.

    Organism-specific databases

    CTDi 6917.
    RGDi 1309880. Tcea1.

    Phylogenomic databases

    eggNOGi COG1594.
    GeneTreei ENSGT00390000017794.
    HOGENOMi HOG000195015.
    HOVERGENi HBG055022.
    InParanoidi Q4KLL0.
    KOi K03145.
    OMAi RAMISFW.
    OrthoDBi EOG7GQXWQ.
    PhylomeDBi Q4KLL0.
    TreeFami TF314970.

    Enzyme and pathway databases

    Reactomei REACT_216241. RNA Polymerase II Pre-transcription Events.

    Miscellaneous databases

    NextBioi 680080.

    Gene expression databases

    Genevestigatori Q4KLL0.

    Family and domain databases

    Gene3Di 1.10.472.30. 1 hit.
    1.20.930.10. 1 hit.
    InterProi IPR016492. TF_IIS-rel.
    IPR003617. TFIIS/CRSP70_N_sub.
    IPR003618. TFIIS_cen_dom.
    IPR017923. TFIIS_N.
    IPR017890. TFS2M.
    IPR006289. TFSII.
    IPR001222. Znf_TFIIS.
    [Graphical view ]
    Pfami PF08711. Med26. 1 hit.
    PF01096. TFIIS_C. 1 hit.
    PF07500. TFIIS_M. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006704. TF_IIS. 1 hit.
    SMARTi SM00510. TFS2M. 1 hit.
    SM00509. TFS2N. 1 hit.
    SM00440. ZnF_C2C2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46942. SSF46942. 1 hit.
    SSF47676. SSF47676. 1 hit.
    TIGRFAMsi TIGR01385. TFSII. 1 hit.
    PROSITEi PS51321. TFIIS_CENTRAL. 1 hit.
    PS51319. TFIIS_N. 1 hit.
    PS00466. ZF_TFIIS_1. 1 hit.
    PS51133. ZF_TFIIS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.

    Entry informationi

    Entry nameiTCEA1_RAT
    AccessioniPrimary (citable) accession number: Q4KLL0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2005
    Last sequence update: August 2, 2005
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    S-II binds to RNA-polymerase II in the absence of transcription.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3