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Protein

Transcription elongation factor A protein 1

Gene

Tcea1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus (By similarity).By similarity

Miscellaneous

S-II binds to RNA-polymerase II in the absence of transcription.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri259 – 299TFIIS-typePROSITE-ProRule annotationAdd BLAST41

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-674695 RNA Polymerase II Pre-transcription Events
R-RNO-6781823 Formation of TC-NER Pre-Incision Complex
R-RNO-6782135 Dual incision in TC-NER
R-RNO-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-RNO-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-RNO-75955 RNA Polymerase II Transcription Elongation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription elongation factor A protein 1
Alternative name(s):
Transcription elongation factor S-II protein 1
Gene namesi
Name:Tcea1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1309880 Tcea1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001214481 – 301Transcription elongation factor A protein 1Add BLAST301

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Cross-linki55Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei57PhosphoserineBy similarity1
Modified residuei81PhosphoserineBy similarity1
Modified residuei97PhosphoserineBy similarity1
Modified residuei100PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ4KLL0
PRIDEiQ4KLL0

PTM databases

iPTMnetiQ4KLL0
PhosphoSitePlusiQ4KLL0

Expressioni

Gene expression databases

BgeeiENSRNOG00000022323
GenevisibleiQ4KLL0 RN

Interactioni

Subunit structurei

Interacts with EAF2. Associates with UBR5 and forms a transcription regulatory complex made of CDK9, RNAP II, UBR5 and TFIIS/TCEA1 that can stimulate target gene transcription by recruiting their promoters.By similarity

Protein-protein interaction databases

BioGridi263480, 1 interactor
STRINGi10116.ENSRNOP00000010893

Structurei

3D structure databases

ProteinModelPortaliQ4KLL0
SMRiQ4KLL0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 80TFIIS N-terminalPROSITE-ProRule annotationAdd BLAST78
Domaini140 – 256TFIIS centralPROSITE-ProRule annotationAdd BLAST117

Sequence similaritiesi

Belongs to the TFS-II family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri259 – 299TFIIS-typePROSITE-ProRule annotationAdd BLAST41

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1105 Eukaryota
COG1594 LUCA
GeneTreeiENSGT00390000017794
HOGENOMiHOG000195015
HOVERGENiHBG055022
InParanoidiQ4KLL0
KOiK03145
OMAiKKAQVPM
OrthoDBiEOG091G10EJ
PhylomeDBiQ4KLL0
TreeFamiTF314970

Family and domain databases

Gene3Di1.10.472.30, 1 hit
1.20.930.10, 1 hit
InterProiView protein in InterPro
IPR035100 TF_IIS-typ
IPR003617 TFIIS/CRSP70_N_sub
IPR035441 TFIIS/LEDGF_dom_sf
IPR003618 TFIIS_cen_dom
IPR036575 TFIIS_cen_dom_sf
IPR017923 TFIIS_N
IPR006289 TFSII
IPR001222 Znf_TFIIS
PfamiView protein in Pfam
PF08711 Med26, 1 hit
PF01096 TFIIS_C, 1 hit
PF07500 TFIIS_M, 1 hit
PIRSFiPIRSF006704 TF_IIS, 1 hit
SMARTiView protein in SMART
SM00510 TFS2M, 1 hit
SM00509 TFS2N, 1 hit
SM00440 ZnF_C2C2, 1 hit
SUPFAMiSSF46942 SSF46942, 1 hit
SSF47676 SSF47676, 1 hit
TIGRFAMsiTIGR01385 TFSII, 1 hit
PROSITEiView protein in PROSITE
PS51321 TFIIS_CENTRAL, 1 hit
PS51319 TFIIS_N, 1 hit
PS00466 ZF_TFIIS_1, 1 hit
PS51133 ZF_TFIIS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q4KLL0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDEVVRIAK KMDKMVQKKN AAGALDLLKE LKNIPMTLEL LQSTRIGMSV
60 70 80 90 100
NAIRKQSTDE EVTSLAKSLI KSWKKLLDGP STDKDSEEKK KEPAISSQNS
110 120 130 140 150
PEAREESSSS SHVSSRKDET NARDTYVSSF PRAPSTSDSV RLKCREMLAA
160 170 180 190 200
ALRTGDDYVA IGADEEELGS QIEEAIYQEI RNTDMKYKNR VRSRISNLKD
210 220 230 240 250
AKNPNLRKNV LCGNIPPDLF ARMTAEEMAS DELKEMRKNL TKEAIREHQM
260 270 280 290 300
AKTGGTQTDL FTCGKCKKKN CTYTQVQTRS ADEPMTTFVV CNECGNRWKF

C
Length:301
Mass (Da):33,893
Last modified:August 2, 2005 - v1
Checksum:iAD85071FBB589CB5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099141 mRNA Translation: AAH99141.1
RefSeqiNP_001020906.1, NM_001025735.1
XP_003752832.1, XM_003752784.4
XP_006237878.1, XM_006237816.3
XP_006251782.1, XM_006251720.3
UniGeneiRn.6738

Genome annotation databases

EnsembliENSRNOT00000010893; ENSRNOP00000010893; ENSRNOG00000022323
GeneIDi362479
498453
KEGGirno:362479
rno:498453
UCSCiRGD:1309880 rat

Similar proteinsi

Entry informationi

Entry nameiTCEA1_RAT
AccessioniPrimary (citable) accession number: Q4KLL0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: August 2, 2005
Last modified: May 23, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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