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Q4KLL0

- TCEA1_RAT

UniProt

Q4KLL0 - TCEA1_RAT

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Protein

Transcription elongation factor A protein 1

Gene

Tcea1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus By similarity.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri259 – 29941TFIIS-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. regulation of DNA-templated transcription, elongation Source: InterPro
  2. regulation of transcription from RNA polymerase II promoter Source: InterPro
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_216241. RNA Polymerase II Pre-transcription Events.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription elongation factor A protein 1
Alternative name(s):
Transcription elongation factor S-II protein 1
Gene namesi
Name:Tcea1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 5

Organism-specific databases

RGDi1309880. Tcea1.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 301301Transcription elongation factor A protein 1PRO_0000121448Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei97 – 971PhosphoserineBy similarity
Modified residuei100 – 1001PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ4KLL0.
PRIDEiQ4KLL0.

PTM databases

PhosphoSiteiQ4KLL0.

Expressioni

Gene expression databases

GenevestigatoriQ4KLL0.

Interactioni

Subunit structurei

Interacts with EAF2. Associates with UBR5 and forms a transcription regulatory complex made of CDK9, RNAP II, UBR5 and TFIIS/TCEA1 that can stimulate target gene transcription by recruiting their promoters.By similarity

Protein-protein interaction databases

BioGridi263480. 2 interactions.
STRINGi10116.ENSRNOP00000010893.

Structurei

3D structure databases

ProteinModelPortaliQ4KLL0.
SMRiQ4KLL0. Positions 1-87, 252-301.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 8078TFIIS N-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini140 – 256117TFIIS centralPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TFS-II family.Curated
Contains 1 TFIIS central domain.PROSITE-ProRule annotation
Contains 1 TFIIS N-terminal domain.PROSITE-ProRule annotation
Contains 1 TFIIS-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri259 – 29941TFIIS-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG1594.
GeneTreeiENSGT00390000017794.
HOGENOMiHOG000195015.
HOVERGENiHBG055022.
InParanoidiQ4KLL0.
KOiK03145.
OMAiRAMISFW.
OrthoDBiEOG7GQXWQ.
PhylomeDBiQ4KLL0.
TreeFamiTF314970.

Family and domain databases

Gene3Di1.10.472.30. 1 hit.
1.20.930.10. 1 hit.
InterProiIPR016492. TF_IIS-rel.
IPR003617. TFIIS/CRSP70_N_sub.
IPR003618. TFIIS_cen_dom.
IPR017923. TFIIS_N.
IPR017890. TFS2M.
IPR006289. TFSII.
IPR001222. Znf_TFIIS.
[Graphical view]
PfamiPF08711. Med26. 1 hit.
PF01096. TFIIS_C. 1 hit.
PF07500. TFIIS_M. 1 hit.
[Graphical view]
PIRSFiPIRSF006704. TF_IIS. 1 hit.
SMARTiSM00510. TFS2M. 1 hit.
SM00509. TFS2N. 1 hit.
SM00440. ZnF_C2C2. 1 hit.
[Graphical view]
SUPFAMiSSF46942. SSF46942. 1 hit.
SSF47676. SSF47676. 1 hit.
TIGRFAMsiTIGR01385. TFSII. 1 hit.
PROSITEiPS51321. TFIIS_CENTRAL. 1 hit.
PS51319. TFIIS_N. 1 hit.
PS00466. ZF_TFIIS_1. 1 hit.
PS51133. ZF_TFIIS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4KLL0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEDEVVRIAK KMDKMVQKKN AAGALDLLKE LKNIPMTLEL LQSTRIGMSV
60 70 80 90 100
NAIRKQSTDE EVTSLAKSLI KSWKKLLDGP STDKDSEEKK KEPAISSQNS
110 120 130 140 150
PEAREESSSS SHVSSRKDET NARDTYVSSF PRAPSTSDSV RLKCREMLAA
160 170 180 190 200
ALRTGDDYVA IGADEEELGS QIEEAIYQEI RNTDMKYKNR VRSRISNLKD
210 220 230 240 250
AKNPNLRKNV LCGNIPPDLF ARMTAEEMAS DELKEMRKNL TKEAIREHQM
260 270 280 290 300
AKTGGTQTDL FTCGKCKKKN CTYTQVQTRS ADEPMTTFVV CNECGNRWKF

C
Length:301
Mass (Da):33,893
Last modified:August 2, 2005 - v1
Checksum:iAD85071FBB589CB5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC099141 mRNA. Translation: AAH99141.1.
RefSeqiNP_001020906.1. NM_001025735.1.
XP_003752832.1. XM_003752784.3.
XP_006237878.1. XM_006237816.2.
XP_006251782.1. XM_006251720.2.
UniGeneiRn.6738.

Genome annotation databases

EnsembliENSRNOT00000010893; ENSRNOP00000010893; ENSRNOG00000022323.
GeneIDi362479.
498453.
KEGGirno:362479.
rno:498453.
UCSCiRGD:1309880. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC099141 mRNA. Translation: AAH99141.1 .
RefSeqi NP_001020906.1. NM_001025735.1.
XP_003752832.1. XM_003752784.3.
XP_006237878.1. XM_006237816.2.
XP_006251782.1. XM_006251720.2.
UniGenei Rn.6738.

3D structure databases

ProteinModelPortali Q4KLL0.
SMRi Q4KLL0. Positions 1-87, 252-301.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 263480. 2 interactions.
STRINGi 10116.ENSRNOP00000010893.

PTM databases

PhosphoSitei Q4KLL0.

Proteomic databases

PaxDbi Q4KLL0.
PRIDEi Q4KLL0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000010893 ; ENSRNOP00000010893 ; ENSRNOG00000022323 .
GeneIDi 362479.
498453.
KEGGi rno:362479.
rno:498453.
UCSCi RGD:1309880. rat.

Organism-specific databases

CTDi 6917.
RGDi 1309880. Tcea1.

Phylogenomic databases

eggNOGi COG1594.
GeneTreei ENSGT00390000017794.
HOGENOMi HOG000195015.
HOVERGENi HBG055022.
InParanoidi Q4KLL0.
KOi K03145.
OMAi RAMISFW.
OrthoDBi EOG7GQXWQ.
PhylomeDBi Q4KLL0.
TreeFami TF314970.

Enzyme and pathway databases

Reactomei REACT_216241. RNA Polymerase II Pre-transcription Events.

Miscellaneous databases

NextBioi 680080.

Gene expression databases

Genevestigatori Q4KLL0.

Family and domain databases

Gene3Di 1.10.472.30. 1 hit.
1.20.930.10. 1 hit.
InterProi IPR016492. TF_IIS-rel.
IPR003617. TFIIS/CRSP70_N_sub.
IPR003618. TFIIS_cen_dom.
IPR017923. TFIIS_N.
IPR017890. TFS2M.
IPR006289. TFSII.
IPR001222. Znf_TFIIS.
[Graphical view ]
Pfami PF08711. Med26. 1 hit.
PF01096. TFIIS_C. 1 hit.
PF07500. TFIIS_M. 1 hit.
[Graphical view ]
PIRSFi PIRSF006704. TF_IIS. 1 hit.
SMARTi SM00510. TFS2M. 1 hit.
SM00509. TFS2N. 1 hit.
SM00440. ZnF_C2C2. 1 hit.
[Graphical view ]
SUPFAMi SSF46942. SSF46942. 1 hit.
SSF47676. SSF47676. 1 hit.
TIGRFAMsi TIGR01385. TFSII. 1 hit.
PROSITEi PS51321. TFIIS_CENTRAL. 1 hit.
PS51319. TFIIS_N. 1 hit.
PS00466. ZF_TFIIS_1. 1 hit.
PS51133. ZF_TFIIS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.

Entry informationi

Entry nameiTCEA1_RAT
AccessioniPrimary (citable) accession number: Q4KLL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: August 2, 2005
Last modified: October 29, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

S-II binds to RNA-polymerase II in the absence of transcription.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3