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Q4KLL0 (TCEA1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription elongation factor A protein 1
Alternative name(s):
Transcription elongation factor S-II protein 1
Gene names
Name:Tcea1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length301 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus By similarity.

Subunit structure

Interacts with EAF2 By similarity. Associates with UBR5 and forms a transcription regulatory complex made of CDK9, RNAP II, UBR5 and TFIIS/TCEA1 that can stimulate target gene transcription by recruiting their promoters By similarity.

Subcellular location

Nucleus By similarity.

Miscellaneous

S-II binds to RNA-polymerase II in the absence of transcription.

Sequence similarities

Belongs to the TFS-II family.

Contains 1 TFIIS central domain.

Contains 1 TFIIS N-terminal domain.

Contains 1 TFIIS-type zinc finger.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 301301Transcription elongation factor A protein 1
PRO_0000121448

Regions

Domain3 – 8078TFIIS N-terminal
Domain140 – 256117TFIIS central
Zinc finger259 – 29941TFIIS-type

Amino acid modifications

Modified residue11N-acetylmethionine By similarity
Modified residue971Phosphoserine By similarity
Modified residue1001Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4KLL0 [UniParc].

Last modified August 2, 2005. Version 1.
Checksum: AD85071FBB589CB5

FASTA30133,893
        10         20         30         40         50         60 
MEDEVVRIAK KMDKMVQKKN AAGALDLLKE LKNIPMTLEL LQSTRIGMSV NAIRKQSTDE 

        70         80         90        100        110        120 
EVTSLAKSLI KSWKKLLDGP STDKDSEEKK KEPAISSQNS PEAREESSSS SHVSSRKDET 

       130        140        150        160        170        180 
NARDTYVSSF PRAPSTSDSV RLKCREMLAA ALRTGDDYVA IGADEEELGS QIEEAIYQEI 

       190        200        210        220        230        240 
RNTDMKYKNR VRSRISNLKD AKNPNLRKNV LCGNIPPDLF ARMTAEEMAS DELKEMRKNL 

       250        260        270        280        290        300 
TKEAIREHQM AKTGGTQTDL FTCGKCKKKN CTYTQVQTRS ADEPMTTFVV CNECGNRWKF 


C 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC099141 mRNA. Translation: AAH99141.1.
RefSeqNP_001020906.1. NM_001025735.1.
XP_003752832.1. XM_003752784.2.
XP_006237878.1. XM_006237816.1.
XP_006251782.1. XM_006251720.1.
UniGeneRn.6738.

3D structure databases

ProteinModelPortalQ4KLL0.
SMRQ4KLL0. Positions 1-87, 252-301.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid263480. 2 interactions.
STRING10116.ENSRNOP00000010893.

PTM databases

PhosphoSiteQ4KLL0.

Proteomic databases

PaxDbQ4KLL0.
PRIDEQ4KLL0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000010893; ENSRNOP00000010893; ENSRNOG00000022323.
GeneID362479.
498453.
KEGGrno:362479.
rno:498453.
UCSCRGD:1309880. rat.

Organism-specific databases

CTD6917.
RGD1309880. Tcea1.

Phylogenomic databases

eggNOGCOG1594.
GeneTreeENSGT00390000017794.
HOGENOMHOG000195015.
HOVERGENHBG055022.
InParanoidQ4KLL0.
KOK03145.
OMARAMISFW.
OrthoDBEOG7GQXWQ.
PhylomeDBQ4KLL0.
TreeFamTF314970.

Gene expression databases

GenevestigatorQ4KLL0.

Family and domain databases

Gene3D1.10.472.30. 1 hit.
1.20.930.10. 1 hit.
InterProIPR016492. TF_IIS-rel.
IPR003617. TFIIS/CRSP70_N_sub.
IPR003618. TFIIS_cen_dom.
IPR017923. TFIIS_N.
IPR017890. TFS2M.
IPR006289. TFSII.
IPR001222. Znf_TFIIS.
[Graphical view]
PfamPF08711. Med26. 1 hit.
PF01096. TFIIS_C. 1 hit.
PF07500. TFIIS_M. 1 hit.
[Graphical view]
PIRSFPIRSF006704. TF_IIS. 1 hit.
SMARTSM00510. TFS2M. 1 hit.
SM00509. TFS2N. 1 hit.
SM00440. ZnF_C2C2. 1 hit.
[Graphical view]
SUPFAMSSF46942. SSF46942. 1 hit.
SSF47676. SSF47676. 1 hit.
TIGRFAMsTIGR01385. TFSII. 1 hit.
PROSITEPS51321. TFIIS_CENTRAL. 1 hit.
PS51319. TFIIS_N. 1 hit.
PS00466. ZF_TFIIS_1. 1 hit.
PS51133. ZF_TFIIS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio680080.

Entry information

Entry nameTCEA1_RAT
AccessionPrimary (citable) accession number: Q4KLL0
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: August 2, 2005
Last modified: May 14, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families