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Q4KLK9

- SSU72_RAT

UniProt

Q4KLK9 - SSU72_RAT

Protein

RNA polymerase II subunit A C-terminal domain phosphatase SSU72

Gene

Ssu72

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (02 Aug 2005)
      Previous versions | rss
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    Functioni

    Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK By similarity.By similarity

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    GO - Molecular functioni

    1. CTD phosphatase activity Source: UniProtKB

    GO - Biological processi

    1. dephosphorylation of RNA polymerase II C-terminal domain Source: UniProtKB
    2. mRNA polyadenylation Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    mRNA processing

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (EC:3.1.3.16)
    Short name:
    CTD phosphatase SSU72
    Gene namesi
    Name:Ssu72
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 5

    Organism-specific databases

    RGDi1307854. Ssu72.

    Subcellular locationi

    Nucleus By similarity. Cytoplasm By similarity
    Note: Predominantly in the cytosol.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 194194RNA polymerase II subunit A C-terminal domain phosphatase SSU72PRO_0000330014Add
    BLAST

    Proteomic databases

    PRIDEiQ4KLK9.

    Expressioni

    Gene expression databases

    GenevestigatoriQ4KLK9.

    Interactioni

    Subunit structurei

    Interacts with RB1. Interacts with GTF2B and CD226. Interacts with SYMPK By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000024349.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4KLK9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili160 – 18728Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SSU72 phosphatase family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG5211.
    GeneTreeiENSGT00390000010165.
    HOGENOMiHOG000183445.
    HOVERGENiHBG059831.
    InParanoidiQ4KLK9.
    KOiK15544.
    OMAiNRPFLHT.
    OrthoDBiEOG7C2R2M.
    PhylomeDBiQ4KLK9.
    TreeFamiTF300194.

    Family and domain databases

    InterProiIPR006811. RNA_pol_II_suA.
    [Graphical view]
    PANTHERiPTHR20383. PTHR20383. 1 hit.
    PfamiPF04722. Ssu72. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4KLK9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPSSPLRVAV VCSSNQNRSM EAHNILSKRG FSVRSFGTGT HVKLPGPAPD    50
    KPNVYDFKTT YDQMYNDLLR KDKELYTQNG ILHMLDRNKR IKPRPERFQN 100
    CKDLFDLILT CEERVYDQVV EDLNSREQET CQPVHVVNVD IQDNHEEATL 150
    GAFLICELCQ CIQHTEDMEN EIDELLQEFE EKSGRAFLHT VCFY 194
    Length:194
    Mass (Da):22,544
    Last modified:August 2, 2005 - v1
    Checksum:iDA3B3157A2388A77
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC099142 mRNA. Translation: AAH99142.1.
    RefSeqiNP_001020828.1. NM_001025657.1.
    UniGeneiRn.103950.

    Genome annotation databases

    EnsembliENSRNOT00000024349; ENSRNOP00000024349; ENSRNOG00000017829.
    GeneIDi298681.
    KEGGirno:298681.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC099142 mRNA. Translation: AAH99142.1 .
    RefSeqi NP_001020828.1. NM_001025657.1.
    UniGenei Rn.103950.

    3D structure databases

    ProteinModelPortali Q4KLK9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000024349.

    Proteomic databases

    PRIDEi Q4KLK9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000024349 ; ENSRNOP00000024349 ; ENSRNOG00000017829 .
    GeneIDi 298681.
    KEGGi rno:298681.

    Organism-specific databases

    CTDi 29101.
    RGDi 1307854. Ssu72.

    Phylogenomic databases

    eggNOGi COG5211.
    GeneTreei ENSGT00390000010165.
    HOGENOMi HOG000183445.
    HOVERGENi HBG059831.
    InParanoidi Q4KLK9.
    KOi K15544.
    OMAi NRPFLHT.
    OrthoDBi EOG7C2R2M.
    PhylomeDBi Q4KLK9.
    TreeFami TF300194.

    Miscellaneous databases

    NextBioi 644160.
    PROi Q4KLK9.

    Gene expression databases

    Genevestigatori Q4KLK9.

    Family and domain databases

    InterProi IPR006811. RNA_pol_II_suA.
    [Graphical view ]
    PANTHERi PTHR20383. PTHR20383. 1 hit.
    Pfami PF04722. Ssu72. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Ovary.

    Entry informationi

    Entry nameiSSU72_RAT
    AccessioniPrimary (citable) accession number: Q4KLK9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: August 2, 2005
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3