Q4KLK9 (SSU72_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
RNA polymerase II subunit A C-terminal domain phosphatase SSU72
Short name=CTD phosphatase SSU72
EC=3.1.3.16

Gene names

Name:

Ssu72

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	194 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK By similarity.
Catalytic activity	A phosphoprotein + H2O = a protein + phosphate.
Subunit structure	Interacts with RB1. Interacts with GTF2B and CD226. Interacts with SYMPK By similarity.
Subcellular location	Nucleus By similarity. Cytoplasm By similarity. Note: Predominantly in the cytosol By similarity.
Sequence similarities	Belongs to the SSU72 phosphatase family.

Ontologies

Keywords
Biological process	mRNA processing
Cellular component	Cytoplasm Nucleus
Domain	Coiled coil
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	dephosphorylation of RNA polymerase II C-terminal domain Inferred from sequence or structural similarity. Source: UniProtKB mRNA polyadenylation Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	CTD phosphatase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 194	194	RNA polymerase II subunit A C-terminal domain phosphatase SSU72		PRO_0000330014
Regions
	Coiled coil	160 – 187	28	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q4KLK9 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: DA3B3157A2388A77	FASTA	194	22,544
	10 20 30 40 50 60 MPSSPLRVAV VCSSNQNRSM EAHNILSKRG FSVRSFGTGT HVKLPGPAPD KPNVYDFKTT 70 80 90 100 110 120 YDQMYNDLLR KDKELYTQNG ILHMLDRNKR IKPRPERFQN CKDLFDLILT CEERVYDQVV 130 140 150 160 170 180 EDLNSREQET CQPVHVVNVD IQDNHEEATL GAFLICELCQ CIQHTEDMEN EIDELLQEFE 190 EKSGRAFLHT VCFY

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC099142 mRNA. Translation: AAH99142.1.
IPI	IPI00190022.
RefSeq	NP_001020828.1. NM_001025657.1.
UniGene	Rn.103950.
3D structure databases
ProteinModelPortal	Q4KLK9.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000024349.
Proteomic databases
PRIDE	Q4KLK9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000024349; ENSRNOP00000024349; ENSRNOG00000017829.
GeneID	298681.
KEGG	rno:298681.
Organism-specific databases
CTD	29101.
RGD	1307854. Ssu72.
Phylogenomic databases
eggNOG	COG5211.
GeneTree	ENSGT00390000010165.
HOGENOM	HOG000183445.
HOVERGEN	HBG059831.
InParanoid	Q4KLK9.
KO	K15544.
OMA	SMEAHNF.
OrthoDB	EOG49PB0D.
Gene expression databases
Genevestigator	Q4KLK9.
Family and domain databases
InterPro	IPR006811. RNA_pol_II_suA. [Graphical view]
PANTHER	PTHR20383. PTHR20383. 1 hit.
Pfam	PF04722. Ssu72. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	644160.

Entry information

Entry name

SSU72_RAT

Accession

Primary (citable) accession number: Q4KLK9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	August 2, 2005
Last modified:	April 3, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program