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Q4KLK9 (SSU72_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RNA polymerase II subunit A C-terminal domain phosphatase SSU72

Short name=CTD phosphatase SSU72
EC=3.1.3.16
Gene names
Name:Ssu72
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length194 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK By similarity.

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Subunit structure

Interacts with RB1. Interacts with GTF2B and CD226. Interacts with SYMPK By similarity.

Subcellular location

Nucleus By similarity. Cytoplasm By similarity. Note: Predominantly in the cytosol By similarity.

Sequence similarities

Belongs to the SSU72 phosphatase family.

Ontologies

Keywords
   Biological processmRNA processing
   Cellular componentCytoplasm
Nucleus
   DomainCoiled coil
   Molecular functionHydrolase
Protein phosphatase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdephosphorylation of RNA polymerase II C-terminal domain

Inferred from sequence or structural similarity. Source: UniProtKB

mRNA polyadenylation

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionCTD phosphatase activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 194194RNA polymerase II subunit A C-terminal domain phosphatase SSU72
PRO_0000330014

Regions

Coiled coil160 – 18728 Potential

Sequences

Sequence LengthMass (Da)Tools
Q4KLK9 [UniParc].

Last modified August 2, 2005. Version 1.
Checksum: DA3B3157A2388A77

FASTA19422,544
        10         20         30         40         50         60 
MPSSPLRVAV VCSSNQNRSM EAHNILSKRG FSVRSFGTGT HVKLPGPAPD KPNVYDFKTT 

        70         80         90        100        110        120 
YDQMYNDLLR KDKELYTQNG ILHMLDRNKR IKPRPERFQN CKDLFDLILT CEERVYDQVV 

       130        140        150        160        170        180 
EDLNSREQET CQPVHVVNVD IQDNHEEATL GAFLICELCQ CIQHTEDMEN EIDELLQEFE 

       190 
EKSGRAFLHT VCFY 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Ovary.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC099142 mRNA. Translation: AAH99142.1.
RefSeqNP_001020828.1. NM_001025657.1.
UniGeneRn.103950.

3D structure databases

ProteinModelPortalQ4KLK9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000024349.

Proteomic databases

PRIDEQ4KLK9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000024349; ENSRNOP00000024349; ENSRNOG00000017829.
GeneID298681.
KEGGrno:298681.

Organism-specific databases

CTD29101.
RGD1307854. Ssu72.

Phylogenomic databases

eggNOGCOG5211.
GeneTreeENSGT00390000010165.
HOGENOMHOG000183445.
HOVERGENHBG059831.
InParanoidQ4KLK9.
KOK15544.
OMANRPFLHT.
OrthoDBEOG7C2R2M.
PhylomeDBQ4KLK9.
TreeFamTF300194.

Gene expression databases

GenevestigatorQ4KLK9.

Family and domain databases

InterProIPR006811. RNA_pol_II_suA.
[Graphical view]
PANTHERPTHR20383. PTHR20383. 1 hit.
PfamPF04722. Ssu72. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio644160.
PROQ4KLK9.

Entry information

Entry nameSSU72_RAT
AccessionPrimary (citable) accession number: Q4KLK9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: August 2, 2005
Last modified: April 16, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families