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Q4KLK5

- Q4KLK5_RAT

UniProt

Q4KLK5 - Q4KLK5_RAT

Protein
Submitted name:

Itgb2 protein

Gene

Itgb2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (02 Aug 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein complex binding Source: RGD
    2. protein heterodimerization activity Source: RGD
    3. receptor activity Source: InterPro

    GO - Biological processi

    1. aging Source: RGD
    2. cell-matrix adhesion Source: InterPro
    3. cellular extravasation Source: RGD
    4. endothelial cell migration Source: RGD
    5. integrin-mediated signaling pathway Source: InterPro
    6. leukocyte cell-cell adhesion Source: RGD
    7. leukocyte migration involved in inflammatory response Source: RGD
    8. natural killer cell activation Source: RGD
    9. positive regulation of angiogenesis Source: RGD
    10. positive regulation of NF-kappaB transcription factor activity Source: RGD
    11. positive regulation of nitric oxide biosynthetic process Source: RGD
    12. single organismal cell-cell adhesion Source: RGD

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Itgb2 proteinImported
    Gene namesi
    Name:Itgb2Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

    Organism-specific databases

    RGDi1305581. Itgb2.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: RGD
    2. integrin complex Source: InterPro
    3. plasma membrane Source: RGD

    Expressioni

    Gene expression databases

    GenevestigatoriQ4KLK5.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4KLK5.
    SMRiQ4KLK5. Positions 19-122.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    InParanoidiQ4KLK5.
    PhylomeDBiQ4KLK5.

    Family and domain databases

    InterProiIPR015812. Integrin_bsu.
    IPR015439. Integrin_bsu-2.
    IPR014836. Integrin_bsu_cyt_dom.
    IPR012896. Integrin_bsu_tail.
    [Graphical view]
    PANTHERiPTHR10082. PTHR10082. 1 hit.
    PTHR10082:SF15. PTHR10082:SF15. 1 hit.
    PfamiPF08725. Integrin_b_cyt. 1 hit.
    PF07965. Integrin_B_tail. 1 hit.
    [Graphical view]
    PRINTSiPR01186. INTEGRINB.
    SUPFAMiSSF69687. SSF69687. 1 hit.
    PROSITEiPS00243. INTEGRIN_BETA. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4KLK5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGVPIPGADL SATLPHHTRC ESGYIGKNCE CQTQGRSSQE LEGNCRKDNS    50
    SIVCSGLGDC ICGQCVCHTS DIPNKVIFGQ YCECDNFNCE RYDGQVCGGL 100
    KRGSCSCGQC NCKEGFEGSA CQCQRSTTGC LNARLVECSG RGRCQCNRCI 150
    CEKGYQPPLC EECPGCPLPC STYVFCAECL KFDKGPFQKN CSVQCANVTL 200
    QTVPFKKKPC KERDSEGCWI TYTLQQKDGN AYNIHVDDDR ECVKGPNVAA 250
    IIGGTVAGVV LIGVLLLVIW KALTHLTDLN EYRRFEKEKL KSQWNNDNPL 300
    FKSATTTVMN PKFAES 316
    Length:316
    Mass (Da):34,629
    Last modified:August 2, 2005 - v1
    Checksum:i822785BF31B6F2A4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC099151 mRNA. Translation: AAH99151.1.
    UniGeneiRn.42962.

    Genome annotation databases

    UCSCiRGD:1305581. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC099151 mRNA. Translation: AAH99151.1 .
    UniGenei Rn.42962.

    3D structure databases

    ProteinModelPortali Q4KLK5.
    SMRi Q4KLK5. Positions 19-122.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:1305581. rat.

    Organism-specific databases

    RGDi 1305581. Itgb2.

    Phylogenomic databases

    InParanoidi Q4KLK5.
    PhylomeDBi Q4KLK5.

    Gene expression databases

    Genevestigatori Q4KLK5.

    Family and domain databases

    InterProi IPR015812. Integrin_bsu.
    IPR015439. Integrin_bsu-2.
    IPR014836. Integrin_bsu_cyt_dom.
    IPR012896. Integrin_bsu_tail.
    [Graphical view ]
    PANTHERi PTHR10082. PTHR10082. 1 hit.
    PTHR10082:SF15. PTHR10082:SF15. 1 hit.
    Pfami PF08725. Integrin_b_cyt. 1 hit.
    PF07965. Integrin_B_tail. 1 hit.
    [Graphical view ]
    PRINTSi PR01186. INTEGRINB.
    SUPFAMi SSF69687. SSF69687. 1 hit.
    PROSITEi PS00243. INTEGRIN_BETA. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: SpleenImported.

    Entry informationi

    Entry nameiQ4KLK5_RAT
    AccessioniPrimary (citable) accession number: Q4KLK5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 2, 2005
    Last sequence update: August 2, 2005
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)