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Protein

Phosducin-like protein 3

Gene

Pdcl3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, controlling its abundance and inhibiting its ubiquitination and degradation. Modulates the activation of caspases during apoptosis (By similarity).By similarity

GO - Biological processi

  1. angiogenesis Source: UniProtKB-KW
  2. apoptotic process Source: UniProtKB-KW
  3. negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: Ensembl
  4. positive regulation of angiogenesis Source: Ensembl
  5. positive regulation of endothelial cell proliferation Source: Ensembl
  6. protein folding Source: Ensembl
  7. regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
  8. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Angiogenesis, Apoptosis, Host-virus interaction

Names & Taxonomyi

Protein namesi
Recommended name:
Phosducin-like protein 3
Gene namesi
Name:Pdcl3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi1309663. Pdcl3.

Subcellular locationi

  1. Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 240240Phosducin-like protein 3PRO_0000246160Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei235 – 2351PhosphoserineBy similarity
Modified residuei237 – 2371PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ4KLJ8.

Expressioni

Gene expression databases

GenevestigatoriQ4KLJ8.

Interactioni

Subunit structurei

Interacts (via thioredoxin fold region) with KDR/VEGFR2 (via juxtamembrane domain).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017882.

Structurei

3D structure databases

ProteinModelPortaliQ4KLJ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni92 – 240149Thioredoxin foldBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the phosducin family.Curated

Phylogenomic databases

eggNOGiNOG294106.
GeneTreeiENSGT00530000062970.
HOGENOMiHOG000184445.
HOVERGENiHBG108238.
InParanoidiQ4KLJ8.
OMAiPLCSLIN.
OrthoDBiEOG7DRJ41.
PhylomeDBiQ4KLJ8.
TreeFamiTF315179.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR006442. Antitoxin_Phd/YefM.
IPR024253. Phosducin_thioredoxin-like_dom.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF02114. Phosducin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01552. phd_fam. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4KLJ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQDPNADTEW NDILRKKGIL PPKESLKELE EEEEGKEEQR LQQSVVKTYE
60 70 80 90 100
DMTLEELQEN EDEFSEEDER AIEMYRQQRL AEWKATQLRN KFGEVLEISG
110 120 130 140 150
KDYVQEVTKA GEGLWVVLHL YKQGIPLCSL INHHLSGLAR KFPDVKFIKA
160 170 180 190 200
ISTTCIPNYP DRNLPTVFVY REGDIKAQFI GPLVFGGMNL TIDELEWKLS
210 220 230 240
ESGAIKTELE ENPKKAIKDV LLSSVRDPVP MRRDSDSEDD
Length:240
Mass (Da):27,699
Last modified:August 2, 2005 - v1
Checksum:i950F1D9C0A4498E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099162 mRNA. Translation: AAH99162.1.
RefSeqiNP_001020880.1. NM_001025709.1.
UniGeneiRn.103207.

Genome annotation databases

EnsembliENSRNOT00000017882; ENSRNOP00000017882; ENSRNOG00000013286.
GeneIDi316348.
KEGGirno:316348.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099162 mRNA. Translation: AAH99162.1.
RefSeqiNP_001020880.1. NM_001025709.1.
UniGeneiRn.103207.

3D structure databases

ProteinModelPortaliQ4KLJ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017882.

Proteomic databases

PRIDEiQ4KLJ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000017882; ENSRNOP00000017882; ENSRNOG00000013286.
GeneIDi316348.
KEGGirno:316348.

Organism-specific databases

CTDi79031.
RGDi1309663. Pdcl3.

Phylogenomic databases

eggNOGiNOG294106.
GeneTreeiENSGT00530000062970.
HOGENOMiHOG000184445.
HOVERGENiHBG108238.
InParanoidiQ4KLJ8.
OMAiPLCSLIN.
OrthoDBiEOG7DRJ41.
PhylomeDBiQ4KLJ8.
TreeFamiTF315179.

Miscellaneous databases

NextBioi670753.
PROiQ4KLJ8.

Gene expression databases

GenevestigatoriQ4KLJ8.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR006442. Antitoxin_Phd/YefM.
IPR024253. Phosducin_thioredoxin-like_dom.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF02114. Phosducin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01552. phd_fam. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.

Entry informationi

Entry nameiPDCL3_RAT
AccessioniPrimary (citable) accession number: Q4KLJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: August 2, 2005
Last modified: March 4, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.