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Q4KLJ8

- PDCL3_RAT

UniProt

Q4KLJ8 - PDCL3_RAT

Protein

Phosducin-like protein 3

Gene

Pdcl3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (02 Aug 2005)
      Previous versions | rss
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    Functioni

    Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, controlling its abundance and inhibiting its ubiquitination and degradation. Modulates the activation of caspases during apoptosis By similarity.By similarity

    GO - Biological processi

    1. angiogenesis Source: UniProtKB-KW
    2. apoptotic process Source: UniProtKB-KW
    3. viral process Source: UniProtKB-KW

    Keywords - Biological processi

    Angiogenesis, Apoptosis, Host-virus interaction

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosducin-like protein 3
    Gene namesi
    Name:Pdcl3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 9

    Organism-specific databases

    RGDi1309663. Pdcl3.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 240240Phosducin-like protein 3PRO_0000246160Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei235 – 2351PhosphoserineBy similarity
    Modified residuei237 – 2371PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylated.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ4KLJ8.

    Expressioni

    Gene expression databases

    GenevestigatoriQ4KLJ8.

    Interactioni

    Subunit structurei

    Interacts (via thioredoxin fold region) with KDR/VEGFR2 (via juxtamembrane domain).By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000017882.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4KLJ8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni92 – 240149Thioredoxin foldBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the phosducin family.Curated

    Phylogenomic databases

    eggNOGiNOG294106.
    GeneTreeiENSGT00530000062970.
    HOGENOMiHOG000184445.
    HOVERGENiHBG108238.
    InParanoidiQ4KLJ8.
    OMAiHFSGLAR.
    OrthoDBiEOG7DRJ41.
    PhylomeDBiQ4KLJ8.
    TreeFamiTF315179.

    Family and domain databases

    Gene3Di3.40.30.10. 1 hit.
    InterProiIPR006442. Antitoxin_Phd/YefM.
    IPR024253. Phosducin_thioredoxin-like_dom.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF02114. Phosducin. 1 hit.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 1 hit.
    TIGRFAMsiTIGR01552. phd_fam. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q4KLJ8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQDPNADTEW NDILRKKGIL PPKESLKELE EEEEGKEEQR LQQSVVKTYE    50
    DMTLEELQEN EDEFSEEDER AIEMYRQQRL AEWKATQLRN KFGEVLEISG 100
    KDYVQEVTKA GEGLWVVLHL YKQGIPLCSL INHHLSGLAR KFPDVKFIKA 150
    ISTTCIPNYP DRNLPTVFVY REGDIKAQFI GPLVFGGMNL TIDELEWKLS 200
    ESGAIKTELE ENPKKAIKDV LLSSVRDPVP MRRDSDSEDD 240
    Length:240
    Mass (Da):27,699
    Last modified:August 2, 2005 - v1
    Checksum:i950F1D9C0A4498E8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC099162 mRNA. Translation: AAH99162.1.
    RefSeqiNP_001020880.1. NM_001025709.1.
    UniGeneiRn.103207.

    Genome annotation databases

    EnsembliENSRNOT00000017882; ENSRNOP00000017882; ENSRNOG00000013286.
    GeneIDi316348.
    KEGGirno:316348.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC099162 mRNA. Translation: AAH99162.1 .
    RefSeqi NP_001020880.1. NM_001025709.1.
    UniGenei Rn.103207.

    3D structure databases

    ProteinModelPortali Q4KLJ8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000017882.

    Proteomic databases

    PRIDEi Q4KLJ8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000017882 ; ENSRNOP00000017882 ; ENSRNOG00000013286 .
    GeneIDi 316348.
    KEGGi rno:316348.

    Organism-specific databases

    CTDi 79031.
    RGDi 1309663. Pdcl3.

    Phylogenomic databases

    eggNOGi NOG294106.
    GeneTreei ENSGT00530000062970.
    HOGENOMi HOG000184445.
    HOVERGENi HBG108238.
    InParanoidi Q4KLJ8.
    OMAi HFSGLAR.
    OrthoDBi EOG7DRJ41.
    PhylomeDBi Q4KLJ8.
    TreeFami TF315179.

    Miscellaneous databases

    NextBioi 670753.
    PROi Q4KLJ8.

    Gene expression databases

    Genevestigatori Q4KLJ8.

    Family and domain databases

    Gene3Di 3.40.30.10. 1 hit.
    InterProi IPR006442. Antitoxin_Phd/YefM.
    IPR024253. Phosducin_thioredoxin-like_dom.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF02114. Phosducin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 1 hit.
    TIGRFAMsi TIGR01552. phd_fam. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Thymus.

    Entry informationi

    Entry nameiPDCL3_RAT
    AccessioniPrimary (citable) accession number: Q4KLJ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: August 2, 2005
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3