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Q4KLJ8

- PDCL3_RAT

UniProt

Q4KLJ8 - PDCL3_RAT

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Protein

Phosducin-like protein 3

Gene

Pdcl3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, controlling its abundance and inhibiting its ubiquitination and degradation. Modulates the activation of caspases during apoptosis (By similarity).By similarity

GO - Biological processi

  1. angiogenesis Source: UniProtKB-KW
  2. apoptotic process Source: UniProtKB-KW
  3. negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: Ensembl
  4. positive regulation of angiogenesis Source: Ensembl
  5. positive regulation of endothelial cell proliferation Source: Ensembl
  6. protein folding Source: Ensembl
  7. regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
  8. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Angiogenesis, Apoptosis, Host-virus interaction

Names & Taxonomyi

Protein namesi
Recommended name:
Phosducin-like protein 3
Gene namesi
Name:Pdcl3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 9

Organism-specific databases

RGDi1309663. Pdcl3.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 240240Phosducin-like protein 3PRO_0000246160Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei235 – 2351PhosphoserineBy similarity
Modified residuei237 – 2371PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ4KLJ8.

Expressioni

Gene expression databases

GenevestigatoriQ4KLJ8.

Interactioni

Subunit structurei

Interacts (via thioredoxin fold region) with KDR/VEGFR2 (via juxtamembrane domain).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017882.

Structurei

3D structure databases

ProteinModelPortaliQ4KLJ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni92 – 240149Thioredoxin foldBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the phosducin family.Curated

Phylogenomic databases

eggNOGiNOG294106.
GeneTreeiENSGT00530000062970.
HOGENOMiHOG000184445.
HOVERGENiHBG108238.
InParanoidiQ4KLJ8.
OMAiHFSGLAR.
OrthoDBiEOG7DRJ41.
PhylomeDBiQ4KLJ8.
TreeFamiTF315179.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR006442. Antitoxin_Phd/YefM.
IPR024253. Phosducin_thioredoxin-like_dom.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF02114. Phosducin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01552. phd_fam. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4KLJ8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQDPNADTEW NDILRKKGIL PPKESLKELE EEEEGKEEQR LQQSVVKTYE
60 70 80 90 100
DMTLEELQEN EDEFSEEDER AIEMYRQQRL AEWKATQLRN KFGEVLEISG
110 120 130 140 150
KDYVQEVTKA GEGLWVVLHL YKQGIPLCSL INHHLSGLAR KFPDVKFIKA
160 170 180 190 200
ISTTCIPNYP DRNLPTVFVY REGDIKAQFI GPLVFGGMNL TIDELEWKLS
210 220 230 240
ESGAIKTELE ENPKKAIKDV LLSSVRDPVP MRRDSDSEDD
Length:240
Mass (Da):27,699
Last modified:August 2, 2005 - v1
Checksum:i950F1D9C0A4498E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099162 mRNA. Translation: AAH99162.1.
RefSeqiNP_001020880.1. NM_001025709.1.
UniGeneiRn.103207.

Genome annotation databases

EnsembliENSRNOT00000017882; ENSRNOP00000017882; ENSRNOG00000013286.
GeneIDi316348.
KEGGirno:316348.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099162 mRNA. Translation: AAH99162.1 .
RefSeqi NP_001020880.1. NM_001025709.1.
UniGenei Rn.103207.

3D structure databases

ProteinModelPortali Q4KLJ8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000017882.

Proteomic databases

PRIDEi Q4KLJ8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000017882 ; ENSRNOP00000017882 ; ENSRNOG00000013286 .
GeneIDi 316348.
KEGGi rno:316348.

Organism-specific databases

CTDi 79031.
RGDi 1309663. Pdcl3.

Phylogenomic databases

eggNOGi NOG294106.
GeneTreei ENSGT00530000062970.
HOGENOMi HOG000184445.
HOVERGENi HBG108238.
InParanoidi Q4KLJ8.
OMAi HFSGLAR.
OrthoDBi EOG7DRJ41.
PhylomeDBi Q4KLJ8.
TreeFami TF315179.

Miscellaneous databases

NextBioi 670753.
PROi Q4KLJ8.

Gene expression databases

Genevestigatori Q4KLJ8.

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR006442. Antitoxin_Phd/YefM.
IPR024253. Phosducin_thioredoxin-like_dom.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF02114. Phosducin. 1 hit.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 1 hit.
TIGRFAMsi TIGR01552. phd_fam. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.

Entry informationi

Entry nameiPDCL3_RAT
AccessioniPrimary (citable) accession number: Q4KLJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: August 2, 2005
Last modified: October 29, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3