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Q4KLJ8 (PDCL3_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosducin-like protein 3
Gene names
Name:Pdcl3
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length240 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, controlling its abundance and inhibiting its ubiquitination and degradation. Modulates the activation of caspases during apoptosis By similarity.

Subunit structure

Interacts (via thioredoxin fold region) with KDR/VEGFR2 (via juxtamembrane domain) By similarity.

Subcellular location

Cytoplasm By similarity.

Post-translational modification

Phosphorylated By similarity.

Sequence similarities

Belongs to the phosducin family.

Ontologies

Keywords
   Biological processAngiogenesis
Apoptosis
Host-virus interaction
   Cellular componentCytoplasm
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processangiogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

apoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

viral process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 240240Phosducin-like protein 3
PRO_0000246160

Regions

Region92 – 240149Thioredoxin fold By similarity

Amino acid modifications

Modified residue2351Phosphoserine By similarity
Modified residue2371Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4KLJ8 [UniParc].

Last modified August 2, 2005. Version 1.
Checksum: 950F1D9C0A4498E8

FASTA24027,699
        10         20         30         40         50         60 
MQDPNADTEW NDILRKKGIL PPKESLKELE EEEEGKEEQR LQQSVVKTYE DMTLEELQEN 

        70         80         90        100        110        120 
EDEFSEEDER AIEMYRQQRL AEWKATQLRN KFGEVLEISG KDYVQEVTKA GEGLWVVLHL 

       130        140        150        160        170        180 
YKQGIPLCSL INHHLSGLAR KFPDVKFIKA ISTTCIPNYP DRNLPTVFVY REGDIKAQFI 

       190        200        210        220        230        240 
GPLVFGGMNL TIDELEWKLS ESGAIKTELE ENPKKAIKDV LLSSVRDPVP MRRDSDSEDD 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Thymus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC099162 mRNA. Translation: AAH99162.1.
RefSeqNP_001020880.1. NM_001025709.1.
UniGeneRn.103207.

3D structure databases

ProteinModelPortalQ4KLJ8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000017882.

Proteomic databases

PRIDEQ4KLJ8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000017882; ENSRNOP00000017882; ENSRNOG00000013286.
GeneID316348.
KEGGrno:316348.

Organism-specific databases

CTD79031.
RGD1309663. Pdcl3.

Phylogenomic databases

eggNOGNOG294106.
GeneTreeENSGT00530000062970.
HOGENOMHOG000184445.
HOVERGENHBG108238.
InParanoidQ4KLJ8.
OMAHFSGLAR.
OrthoDBEOG7DRJ41.
PhylomeDBQ4KLJ8.
TreeFamTF315179.

Gene expression databases

GenevestigatorQ4KLJ8.

Family and domain databases

Gene3D3.40.30.10. 1 hit.
InterProIPR006442. Antitoxin_Phd/YefM.
IPR024253. Phosducin_thioredoxin-like_dom.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF02114. Phosducin. 1 hit.
[Graphical view]
SUPFAMSSF52833. SSF52833. 1 hit.
TIGRFAMsTIGR01552. phd_fam. 1 hit.
ProtoNetSearch...

Other

NextBio670753.
PROQ4KLJ8.

Entry information

Entry namePDCL3_RAT
AccessionPrimary (citable) accession number: Q4KLJ8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: August 2, 2005
Last modified: May 14, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families