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Protein

Phosducin-like protein 3

Gene

Pdcl3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, controlling its abundance and inhibiting its ubiquitination and degradation. Modulates the activation of caspases during apoptosis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAngiogenesis, Apoptosis, Host-virus interaction

Names & Taxonomyi

Protein namesi
Recommended name:
Phosducin-like protein 3
Gene namesi
Name:Pdcl3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi1309663 Pdcl3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002461601 – 240Phosducin-like protein 3Add BLAST240

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei44PhosphoserineBy similarity1
Modified residuei65PhosphoserineCombined sources1
Modified residuei235PhosphoserineBy similarity1
Modified residuei237PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ4KLJ8
PRIDEiQ4KLJ8

PTM databases

iPTMnetiQ4KLJ8
PhosphoSitePlusiQ4KLJ8

Expressioni

Gene expression databases

BgeeiENSRNOG00000013286
GenevisibleiQ4KLJ8 RN

Interactioni

Subunit structurei

Interacts (via thioredoxin fold region) with KDR/VEGFR2 (via juxtamembrane domain).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017882

Structurei

3D structure databases

ProteinModelPortaliQ4KLJ8
SMRiQ4KLJ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni92 – 240Thioredoxin foldBy similarityAdd BLAST149

Sequence similaritiesi

Belongs to the phosducin family.Curated

Phylogenomic databases

eggNOGiKOG3170 Eukaryota
ENOG4111H24 LUCA
GeneTreeiENSGT00910000144176
HOGENOMiHOG000184445
HOVERGENiHBG108238
InParanoidiQ4KLJ8
OMAiIKFCEIR
OrthoDBiEOG091G0QP8
PhylomeDBiQ4KLJ8
TreeFamiTF315179

Family and domain databases

InterProiView protein in InterPro
IPR024253 Phosducin_thioredoxin-like_dom
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF02114 Phosducin, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit

Sequencei

Sequence statusi: Complete.

Q4KLJ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQDPNADTEW NDILRKKGIL PPKESLKELE EEEEGKEEQR LQQSVVKTYE
60 70 80 90 100
DMTLEELQEN EDEFSEEDER AIEMYRQQRL AEWKATQLRN KFGEVLEISG
110 120 130 140 150
KDYVQEVTKA GEGLWVVLHL YKQGIPLCSL INHHLSGLAR KFPDVKFIKA
160 170 180 190 200
ISTTCIPNYP DRNLPTVFVY REGDIKAQFI GPLVFGGMNL TIDELEWKLS
210 220 230 240
ESGAIKTELE ENPKKAIKDV LLSSVRDPVP MRRDSDSEDD
Length:240
Mass (Da):27,699
Last modified:August 2, 2005 - v1
Checksum:i950F1D9C0A4498E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099162 mRNA Translation: AAH99162.1
RefSeqiNP_001020880.1, NM_001025709.1
UniGeneiRn.103207

Genome annotation databases

EnsembliENSRNOT00000017882; ENSRNOP00000017882; ENSRNOG00000013286
GeneIDi316348
KEGGirno:316348

Similar proteinsi

Entry informationi

Entry nameiPDCL3_RAT
AccessioniPrimary (citable) accession number: Q4KLJ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: August 2, 2005
Last modified: May 23, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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