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Protein

Zinc finger protein with KRAB and SCAN domains 1

Gene

Zkscan1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri376 – 398C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri404 – 426C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri432 – 454C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri460 – 482C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri488 – 510C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri516 – 538C2H2-type 6PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein with KRAB and SCAN domains 1
Gene namesi
Name:Zkscan1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi1560616. Zkscan1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000477561 – 562Zinc finger protein with KRAB and SCAN domains 1Add BLAST562

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13PhosphoserineCombined sources1
Cross-linki278Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki337Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki559Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ4KLI1.
PRIDEiQ4KLI1.

PTM databases

iPTMnetiQ4KLI1.
PhosphoSitePlusiQ4KLI1.

Expressioni

Gene expression databases

BgeeiENSRNOG00000001335.
GenevisibleiQ4KLI1. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051042.

Structurei

3D structure databases

ProteinModelPortaliQ4KLI1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 138SCAN boxPROSITE-ProRule annotationAdd BLAST83
Domaini226 – 305KRABAdd BLAST80

Sequence similaritiesi

Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.Curated
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri376 – 398C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri404 – 426C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri432 – 454C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri460 – 482C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri488 – 510C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri516 – 538C2H2-type 6PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118881.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiQ4KLI1.
KOiK09229.
OMAiEKREQQG.
OrthoDBiEOG091G046Q.
PhylomeDBiQ4KLI1.
TreeFamiTF350830.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 6 hits.
InterProiIPR001909. KRAB.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 5 hits.
PF16622. zf-C2H2_11. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 6 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4KLI1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMTAESREAT GLSPQAAQEK DGIVIVKVEE EDEEDHMWGQ DASLQETPPP
60 70 80 90 100
DPEVFRQRFR RFCYQNTFGP REALNRLKEL CHQWLRPEVN TKEQILELLV
110 120 130 140 150
LEQFLSILPK ELQVWLQEYR PDSGEEAVTL LEDLELDLSG QQVPGQVHGP
160 170 180 190 200
EMLARGVVPL DPVQESSSFD HHEAAQSHFK HSSRKPRLLS PRALPATHVP
210 220 230 240 250
APQHEGNPRD QAMASALLTA DSQAMVKIED MAVSLILEEW GCQNLARRNL
260 270 280 290 300
NRDSRQMNLG TVFSQGSENR NGSESTSKAE VKGDSTSHGE IAGRFQKEFG
310 320 330 340 350
EKREQQGRVI ERQQKNPEEK TGKEKKAPGP PTAKEKKPTT GERGPREKGK
360 370 380 390 400
GLGRSFSLSA NFNNTPEEIP SGAKTHRCDE CGKCFTRSSS LIRHKIIHTG
410 420 430 440 450
EKPYECNECG KAFSLNSNLV LHQRIHTGEK PHECNECGKA FSHSSNLILH
460 470 480 490 500
QRIHSGEKPY ECNECGKAFS QSSDLTKHQR IHTGEKPYEC SECGKAFNRN
510 520 530 540 550
SYLILHRRIH TREKPYKCTK CGKAFTRSST LTLHHRIHAR ERASEYSPAS
560
LDTFGAFLKS CV
Length:562
Mass (Da):63,365
Last modified:August 2, 2005 - v1
Checksum:i06DE99D78EBB4572
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099191 mRNA. Translation: AAH99191.1.
RefSeqiNP_001020931.1. NM_001025760.1.
UniGeneiRn.113295.

Genome annotation databases

EnsembliENSRNOT00000045379; ENSRNOP00000051042; ENSRNOG00000001335.
GeneIDi498160.
KEGGirno:498160.
UCSCiRGD:1560616. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099191 mRNA. Translation: AAH99191.1.
RefSeqiNP_001020931.1. NM_001025760.1.
UniGeneiRn.113295.

3D structure databases

ProteinModelPortaliQ4KLI1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051042.

PTM databases

iPTMnetiQ4KLI1.
PhosphoSitePlusiQ4KLI1.

Proteomic databases

PaxDbiQ4KLI1.
PRIDEiQ4KLI1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000045379; ENSRNOP00000051042; ENSRNOG00000001335.
GeneIDi498160.
KEGGirno:498160.
UCSCiRGD:1560616. rat.

Organism-specific databases

CTDi7586.
RGDi1560616. Zkscan1.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118881.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiQ4KLI1.
KOiK09229.
OMAiEKREQQG.
OrthoDBiEOG091G046Q.
PhylomeDBiQ4KLI1.
TreeFamiTF350830.

Miscellaneous databases

PROiQ4KLI1.

Gene expression databases

BgeeiENSRNOG00000001335.
GenevisibleiQ4KLI1. RN.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 6 hits.
InterProiIPR001909. KRAB.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 5 hits.
PF16622. zf-C2H2_11. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 6 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZKSC1_RAT
AccessioniPrimary (citable) accession number: Q4KLI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: August 2, 2005
Last modified: November 2, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.