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Protein

Zinc finger protein with KRAB and SCAN domains 1

Gene

Zkscan1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri376 – 39823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri404 – 42623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri432 – 45423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri460 – 48223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri488 – 51023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri516 – 53823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein with KRAB and SCAN domains 1
Gene namesi
Name:Zkscan1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi1560616. Zkscan1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 562562Zinc finger protein with KRAB and SCAN domains 1PRO_0000047756Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei13 – 131PhosphoserineCombined sources
Cross-linki278 – 278Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki337 – 337Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki559 – 559Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ4KLI1.
PRIDEiQ4KLI1.

PTM databases

PhosphoSiteiQ4KLI1.

Expressioni

Gene expression databases

GenevisibleiQ4KLI1. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051042.

Structurei

3D structure databases

ProteinModelPortaliQ4KLI1.
SMRiQ4KLI1. Positions 50-134, 374-538.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini56 – 13883SCAN boxPROSITE-ProRule annotationAdd
BLAST
Domaini226 – 30580KRABAdd
BLAST

Sequence similaritiesi

Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.Curated
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri376 – 39823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri404 – 42623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri432 – 45423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri460 – 48223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri488 – 51023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri516 – 53823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118881.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiQ4KLI1.
KOiK09229.
OMAiEKREQQG.
OrthoDBiEOG7SBNN6.
PhylomeDBiQ4KLI1.
TreeFamiTF350830.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR001909. KRAB.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 6 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4KLI1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMTAESREAT GLSPQAAQEK DGIVIVKVEE EDEEDHMWGQ DASLQETPPP
60 70 80 90 100
DPEVFRQRFR RFCYQNTFGP REALNRLKEL CHQWLRPEVN TKEQILELLV
110 120 130 140 150
LEQFLSILPK ELQVWLQEYR PDSGEEAVTL LEDLELDLSG QQVPGQVHGP
160 170 180 190 200
EMLARGVVPL DPVQESSSFD HHEAAQSHFK HSSRKPRLLS PRALPATHVP
210 220 230 240 250
APQHEGNPRD QAMASALLTA DSQAMVKIED MAVSLILEEW GCQNLARRNL
260 270 280 290 300
NRDSRQMNLG TVFSQGSENR NGSESTSKAE VKGDSTSHGE IAGRFQKEFG
310 320 330 340 350
EKREQQGRVI ERQQKNPEEK TGKEKKAPGP PTAKEKKPTT GERGPREKGK
360 370 380 390 400
GLGRSFSLSA NFNNTPEEIP SGAKTHRCDE CGKCFTRSSS LIRHKIIHTG
410 420 430 440 450
EKPYECNECG KAFSLNSNLV LHQRIHTGEK PHECNECGKA FSHSSNLILH
460 470 480 490 500
QRIHSGEKPY ECNECGKAFS QSSDLTKHQR IHTGEKPYEC SECGKAFNRN
510 520 530 540 550
SYLILHRRIH TREKPYKCTK CGKAFTRSST LTLHHRIHAR ERASEYSPAS
560
LDTFGAFLKS CV
Length:562
Mass (Da):63,365
Last modified:August 2, 2005 - v1
Checksum:i06DE99D78EBB4572
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099191 mRNA. Translation: AAH99191.1.
RefSeqiNP_001020931.1. NM_001025760.1.
UniGeneiRn.113295.

Genome annotation databases

EnsembliENSRNOT00000045379; ENSRNOP00000051042; ENSRNOG00000001335.
GeneIDi498160.
KEGGirno:498160.
UCSCiRGD:1560616. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099191 mRNA. Translation: AAH99191.1.
RefSeqiNP_001020931.1. NM_001025760.1.
UniGeneiRn.113295.

3D structure databases

ProteinModelPortaliQ4KLI1.
SMRiQ4KLI1. Positions 50-134, 374-538.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051042.

PTM databases

PhosphoSiteiQ4KLI1.

Proteomic databases

PaxDbiQ4KLI1.
PRIDEiQ4KLI1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000045379; ENSRNOP00000051042; ENSRNOG00000001335.
GeneIDi498160.
KEGGirno:498160.
UCSCiRGD:1560616. rat.

Organism-specific databases

CTDi7586.
RGDi1560616. Zkscan1.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118881.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiQ4KLI1.
KOiK09229.
OMAiEKREQQG.
OrthoDBiEOG7SBNN6.
PhylomeDBiQ4KLI1.
TreeFamiTF350830.

Miscellaneous databases

NextBioi698891.
PROiQ4KLI1.

Gene expression databases

GenevisibleiQ4KLI1. RN.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR001909. KRAB.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 6 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZKSC1_RAT
AccessioniPrimary (citable) accession number: Q4KLI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: August 2, 2005
Last modified: May 11, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.