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Protein

G-protein coupled receptor 4

Gene

Gpr4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Proton-sensing receptor coupled to several G-proteins, including G(s), G(13) and G(q)/G(11) proteins, leading to cAMP production.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-373076. Class A/1 (Rhodopsin-like receptors).
R-RNO-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 4
Gene namesi
Name:Gpr4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1311604. Gpr4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424ExtracellularSequence analysisAdd
BLAST
Transmembranei25 – 4521Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini46 – 5510CytoplasmicSequence analysis
Transmembranei56 – 7621Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini77 – 9418ExtracellularSequence analysisAdd
BLAST
Transmembranei95 – 11521Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini116 – 13520CytoplasmicSequence analysisAdd
BLAST
Transmembranei136 – 15621Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini157 – 17923ExtracellularSequence analysisAdd
BLAST
Transmembranei180 – 20021Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini201 – 22626CytoplasmicSequence analysisAdd
BLAST
Transmembranei227 – 24721Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini248 – 27326ExtracellularSequence analysisAdd
BLAST
Transmembranei274 – 29118Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini292 – 36574CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 365365G-protein coupled receptor 4PRO_0000379520Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence analysis
Disulfide bondi92 ↔ 170PROSITE-ProRule annotation
Glycosylationi166 – 1661N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ4KLH9.
PRIDEiQ4KLH9.

Expressioni

Gene expression databases

GenevisibleiQ4KLH9. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021894.

Structurei

3D structure databases

ProteinModelPortaliQ4KLH9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH5V. Eukaryota.
ENOG410Z8KI. LUCA.
GeneTreeiENSGT00760000119001.
HOGENOMiHOG000004801.
InParanoidiQ4KLH9.
KOiK04312.
OMAiLYCFVNE.
OrthoDBiEOG7992QK.
PhylomeDBiQ4KLH9.
TreeFamiTF331803.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002276. GPR4_orph.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01147. GPR4RECEPTOR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4KLH9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNSTGTWEG CHVDSRVDHL FPPSLYIFVI GVGLPTNCLA LWAAYRQVRQ
60 70 80 90 100
RNELGVYLMN LSIADLLYIC TLPLWVDYFL HHDNWIHGPG SCKLFGFIFY
110 120 130 140 150
SNIYISIAFL CCISVDRYLA VAHPLRFARL RRVKTAVAVS SVVWATELGA
160 170 180 190 200
NSAPLFHDEL FRDRYNHTFC FEKFPMERWV AWMNLYRVFV GFLFPWALML
210 220 230 240 250
LCYRGILRAV QSSVSTERQE KVKIKRLALS LIAIVLVCFA PYHALLLSRS
260 270 280 290 300
AVYLGRPWDC GFEERVFSAY HSSLAFTSLN CVADPILYCL VNEGARSDVA
310 320 330 340 350
KALHNLLRFL ASNKPQEMAN ASLTLETPLT SKRSTTGKTS GAVWAVPPTA
360
QGDQVPLKVL LPPAQ
Length:365
Mass (Da):41,267
Last modified:August 2, 2005 - v1
Checksum:iC198D70B2117559B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099196 mRNA. Translation: AAH99196.1.
RefSeqiNP_001020851.1. NM_001025680.1.
XP_006228480.1. XM_006228418.1.
XP_006228481.1. XM_006228419.1.
UniGeneiRn.23364.

Genome annotation databases

EnsembliENSRNOT00000021893; ENSRNOP00000021894; ENSRNOG00000016362.
GeneIDi308408.
KEGGirno:308408.
UCSCiRGD:1311604. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099196 mRNA. Translation: AAH99196.1.
RefSeqiNP_001020851.1. NM_001025680.1.
XP_006228480.1. XM_006228418.1.
XP_006228481.1. XM_006228419.1.
UniGeneiRn.23364.

3D structure databases

ProteinModelPortaliQ4KLH9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021894.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ4KLH9.
PRIDEiQ4KLH9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000021893; ENSRNOP00000021894; ENSRNOG00000016362.
GeneIDi308408.
KEGGirno:308408.
UCSCiRGD:1311604. rat.

Organism-specific databases

CTDi2828.
RGDi1311604. Gpr4.

Phylogenomic databases

eggNOGiENOG410IH5V. Eukaryota.
ENOG410Z8KI. LUCA.
GeneTreeiENSGT00760000119001.
HOGENOMiHOG000004801.
InParanoidiQ4KLH9.
KOiK04312.
OMAiLYCFVNE.
OrthoDBiEOG7992QK.
PhylomeDBiQ4KLH9.
TreeFamiTF331803.

Enzyme and pathway databases

ReactomeiR-RNO-373076. Class A/1 (Rhodopsin-like receptors).
R-RNO-416476. G alpha (q) signalling events.

Miscellaneous databases

NextBioi658796.
PROiQ4KLH9.

Gene expression databases

GenevisibleiQ4KLH9. RN.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002276. GPR4_orph.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01147. GPR4RECEPTOR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.

Entry informationi

Entry nameiGPR4_RAT
AccessioniPrimary (citable) accession number: Q4KLH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: August 2, 2005
Last modified: May 11, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.