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Protein

AN1-type zinc finger protein 2B

Gene

Zfand2b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri7 – 5246AN1-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri97 – 14549AN1-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
AN1-type zinc finger protein 2B
Alternative name(s):
Arsenite-inducible RNA-associated protein-like protein
Short name:
AIRAP-like protein
Gene namesi
Name:Zfand2b
Synonyms:Airapl
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi1306260. Zfand2b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 257257AN1-type zinc finger protein 2BPRO_0000232878Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei187 – 1871PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ4KLG9.

PTM databases

iPTMnetiQ4KLG9.
PhosphoSiteiQ4KLG9.

Expressioni

Gene expression databases

GenevisibleiQ4KLG9. RN.

Interactioni

Subunit structurei

Interacts (via VIM motif) with VCP. Upon exposure to arsenite, associates with proteasomes.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025219.

Structurei

3D structure databases

ProteinModelPortaliQ4KLG9.
SMRiQ4KLG9. Positions 93-142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini197 – 21620UIM 1PROSITE-ProRule annotationAdd
BLAST
Domaini221 – 24020UIM 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni141 – 15111VCP/p97-interacting motif (VIM)By similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi170 – 1756Poly-Ser

Sequence similaritiesi

Contains 2 AN1-type zinc fingers.PROSITE-ProRule annotation
Contains 2 UIM (ubiquitin-interacting motif) domains.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri7 – 5246AN1-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri97 – 14549AN1-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG3183. Eukaryota.
ENOG4111JCH. LUCA.
GeneTreeiENSGT00730000110968.
HOGENOMiHOG000243115.
HOVERGENiHBG061194.
InParanoidiQ4KLG9.
OMAiNPRPVSN.
OrthoDBiEOG7FV3RM.
PhylomeDBiQ4KLG9.
TreeFamiTF314219.

Family and domain databases

Gene3Di4.10.1110.10. 2 hits.
InterProiIPR003903. UIM_dom.
IPR000058. Znf_AN1.
[Graphical view]
PfamiPF01428. zf-AN1. 2 hits.
[Graphical view]
SMARTiSM00726. UIM. 2 hits.
SM00154. ZnF_AN1. 2 hits.
[Graphical view]
PROSITEiPS50330. UIM. 2 hits.
PS51039. ZF_AN1. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4KLG9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFPDLGAHC SEPSCQRLDF LPLKCDACSG IFCADHVAYA HHHCGSAYQK
60 70 80 90 100
DIQVPVCPLC NVPVPVARGE PPDRAVGEHI DRDCRSDPAQ QKRKIFTNKC
110 120 130 140 150
ERSGCRQREM MKLTCDRCGR NFCIKHRHPL DHDCSGEGHP TSRAGLAAIS
160 170 180 190 200
RAQGLASTST VPSPSRTLPS SSSPSRATPQ LPPRTTSPVI ALQNGLSEDE
210 220 230 240 250
ALQRALELSL AEAKPQIPSS QEEEDLALAQ ALSASEAEYQ QQQAQSRSLK

PSNCSLC
Length:257
Mass (Da):27,925
Last modified:August 2, 2005 - v1
Checksum:iD8A7A132511C1357
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099215 mRNA. Translation: AAH99215.1.
RefSeqiNP_001020916.1. NM_001025745.1.
UniGeneiRn.32162.

Genome annotation databases

EnsembliENSRNOT00000025219; ENSRNOP00000025219; ENSRNOG00000018639.
GeneIDi363253.
KEGGirno:363253.
UCSCiRGD:1306260. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099215 mRNA. Translation: AAH99215.1.
RefSeqiNP_001020916.1. NM_001025745.1.
UniGeneiRn.32162.

3D structure databases

ProteinModelPortaliQ4KLG9.
SMRiQ4KLG9. Positions 93-142.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025219.

PTM databases

iPTMnetiQ4KLG9.
PhosphoSiteiQ4KLG9.

Proteomic databases

PaxDbiQ4KLG9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000025219; ENSRNOP00000025219; ENSRNOG00000018639.
GeneIDi363253.
KEGGirno:363253.
UCSCiRGD:1306260. rat.

Organism-specific databases

CTDi130617.
RGDi1306260. Zfand2b.

Phylogenomic databases

eggNOGiKOG3183. Eukaryota.
ENOG4111JCH. LUCA.
GeneTreeiENSGT00730000110968.
HOGENOMiHOG000243115.
HOVERGENiHBG061194.
InParanoidiQ4KLG9.
OMAiNPRPVSN.
OrthoDBiEOG7FV3RM.
PhylomeDBiQ4KLG9.
TreeFamiTF314219.

Miscellaneous databases

PROiQ4KLG9.

Gene expression databases

GenevisibleiQ4KLG9. RN.

Family and domain databases

Gene3Di4.10.1110.10. 2 hits.
InterProiIPR003903. UIM_dom.
IPR000058. Znf_AN1.
[Graphical view]
PfamiPF01428. zf-AN1. 2 hits.
[Graphical view]
SMARTiSM00726. UIM. 2 hits.
SM00154. ZnF_AN1. 2 hits.
[Graphical view]
PROSITEiPS50330. UIM. 2 hits.
PS51039. ZF_AN1. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-187, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZFN2B_RAT
AccessioniPrimary (citable) accession number: Q4KLG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: August 2, 2005
Last modified: June 8, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.