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Protein

AN1-type zinc finger protein 2B

Gene

Zfand2b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in protein homeostasis by regulating both the translocation and the ubiquitin-mediated proteasomal degradation of nascent proteins at the endoplasmic reticulum. It is involved in the regulation of signal-mediated translocation of proteins into the endoplasmic reticulum. It also plays a role in the ubiquitin-mediated proteasomal degradation of proteins for which signal-mediated translocation to the endoplasmic reticulum has failed. May therefore function in the endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri7 – 52AN1-type 1PROSITE-ProRule annotationAdd BLAST46
Zinc fingeri97 – 145AN1-type 2PROSITE-ProRule annotationAdd BLAST49

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
AN1-type zinc finger protein 2BCurated
Alternative name(s):
Arsenite-inducible RNA-associated protein-like proteinCurated
Short name:
AIRAP-like proteinCurated
Gene namesi
Name:Zfand2bImported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi1306260 Zfand2b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002328781 – 254AN1-type zinc finger protein 2BBy similarityAdd BLAST254
PropeptideiPRO_0000444337255 – 257Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei163PhosphoserineBy similarity1
Modified residuei173PhosphoserineBy similarity1
Modified residuei187PhosphoserineCombined sources1
Modified residuei254Cysteine methyl esterBy similarity1
Lipidationi254S-geranylgeranyl cysteineBy similarity1

Post-translational modificationi

Phosphorylated by MAPK14. Phosphorylation has no effect on association with the proteasome complex.By similarity

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

PaxDbiQ4KLG9
PRIDEiQ4KLG9

PTM databases

iPTMnetiQ4KLG9
PhosphoSitePlusiQ4KLG9

Expressioni

Gene expression databases

BgeeiENSRNOG00000018639
GenevisibleiQ4KLG9 RN

Interactioni

Subunit structurei

Binds 'Lys-48'-linked polyubiquitin chains of ubiquitinated proteins. Associates with the proteasome complex; upon exposure to arsenite. Interacts (via VIM motif) with VCP; the interaction is direct. Interacts with BAG6. Interacts with IGF1R (nascent precursor form). Interacts with DERL1, FAF2, NPLOC4 and UFD1; probably through VCP.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025219

Structurei

3D structure databases

ProteinModelPortaliQ4KLG9
SMRiQ4KLG9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini197 – 216UIM 1PROSITE-ProRule annotationAdd BLAST20
Domaini221 – 240UIM 2PROSITE-ProRule annotationAdd BLAST20

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni141 – 151VCP/p97-interacting motif (VIM)By similarityAdd BLAST11

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi254 – 257CAAX motifBy similarity4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi170 – 175Poly-Ser6

Domaini

The UIM domains specifically bind 'Lys-48'-linked ubiquitin polymers. The UIM domains mediate interaction with polyubiquitinated proteins.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri7 – 52AN1-type 1PROSITE-ProRule annotationAdd BLAST46
Zinc fingeri97 – 145AN1-type 2PROSITE-ProRule annotationAdd BLAST49

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG3183 Eukaryota
ENOG4111JCH LUCA
GeneTreeiENSGT00730000110968
HOGENOMiHOG000243115
HOVERGENiHBG061194
InParanoidiQ4KLG9
OMAiTNRCSYK
OrthoDBiEOG091G0JWA
PhylomeDBiQ4KLG9
TreeFamiTF314219

Family and domain databases

Gene3Di4.10.1110.10, 2 hits
InterProiView protein in InterPro
IPR035896 AN1-like_Znf
IPR003903 UIM_dom
IPR000058 Znf_AN1
PfamiView protein in Pfam
PF01428 zf-AN1, 2 hits
SMARTiView protein in SMART
SM00726 UIM, 2 hits
SM00154 ZnF_AN1, 2 hits
SUPFAMiSSF118310 SSF118310, 2 hits
PROSITEiView protein in PROSITE
PS50330 UIM, 2 hits
PS51039 ZF_AN1, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4KLG9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFPDLGAHC SEPSCQRLDF LPLKCDACSG IFCADHVAYA HHHCGSAYQK
60 70 80 90 100
DIQVPVCPLC NVPVPVARGE PPDRAVGEHI DRDCRSDPAQ QKRKIFTNKC
110 120 130 140 150
ERSGCRQREM MKLTCDRCGR NFCIKHRHPL DHDCSGEGHP TSRAGLAAIS
160 170 180 190 200
RAQGLASTST VPSPSRTLPS SSSPSRATPQ LPPRTTSPVI ALQNGLSEDE
210 220 230 240 250
ALQRALELSL AEAKPQIPSS QEEEDLALAQ ALSASEAEYQ QQQAQSRSLK

PSNCSLC
Length:257
Mass (Da):27,925
Last modified:August 2, 2005 - v1
Checksum:iD8A7A132511C1357
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099215 mRNA Translation: AAH99215.1
RefSeqiNP_001020916.1, NM_001025745.1
UniGeneiRn.32162

Genome annotation databases

EnsembliENSRNOT00000025219; ENSRNOP00000025219; ENSRNOG00000018639
GeneIDi363253
KEGGirno:363253
UCSCiRGD:1306260 rat

Similar proteinsi

Entry informationi

Entry nameiZFN2B_RAT
AccessioniPrimary (citable) accession number: Q4KLG9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: August 2, 2005
Last modified: May 23, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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