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Protein

GTPase IMAP family member 8

Gene

Gimap8

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei76 – 761GTPBy similarity
Binding sitei208 – 2081GTPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi55 – 639GTPBy similarity
Nucleotide bindingi172 – 1743GTPBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase IMAP family member 8
Alternative name(s):
Immune-associated nucleotide-binding protein 9
Short name:
IAN-9
Protein IanT
Gene namesi
Name:Gimap8
Synonyms:Ian9, Iant
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1564570. Gimap8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 688688GTPase IMAP family member 8PRO_0000341972Add
BLAST

Proteomic databases

PaxDbiQ4KLG2.
PRIDEiQ4KLG2.

Expressioni

Tissue specificityi

Spleen, thymus and T-cells. Greatly reduced in T-cells from lymphopenic rats.1 Publication

Gene expression databases

BgeeiENSRNOG00000020169.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000055946.

Structurei

3D structure databases

ProteinModelPortaliQ4KLG2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 249204AIG1-type G 1Add
BLAST
Domaini281 – 471191AIG1-type G 2Add
BLAST
Domaini472 – 688217AIG1-type G 3Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi49 – 546Poly-Leu

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IJSD. Eukaryota.
ENOG410XWIP. LUCA.
HOGENOMiHOG000112722.
HOVERGENiHBG095690.
InParanoidiQ4KLG2.
OrthoDBiEOG091G0I0X.
PhylomeDBiQ4KLG2.
TreeFamiTF330845.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR006703. G_AIG1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF04548. AIG1. 3 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS51720. G_AIG1. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4KLG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATSSHQGAA AGSQMEHRLC ETSIGQGERP RASRGQESNF KQSQGTSTLR
60 70 80 90 100
LLLLGKQGAG KSATGNTILG KAVFESRFSH HMVTKRCQSE SVSVRGKQVI
110 120 130 140 150
VIDTPDLFSS LGCPEVQQQN LRQCLDLLAD PYVLLLVTPI GHSTEEDKKT
160 170 180 190 200
IEGIQGVFGP QAYRHMIVVF TREDELGEDT LQNHIESKKY LKKLIENIGS
210 220 230 240 250
QRCCAFNNKA DKKQQELQVS QFLDAIEFLM MESPGTYFEP LKTENSGVQG
260 270 280 290 300
CGTGVTYKGD NLCGSKKRQP QITGPGWDRD TPELRVLLMG KRGVGKSAAG
310 320 330 340 350
NSILGKQVFK TQFSEKQRVT EAFASHSRLW NQKKFLIIDS PEISSWKLDE
360 370 380 390 400
SDVKEHTFPG PHAFLLVTPL GSSLKSGDSV FSIIKRIFGE KFIKFTIILF
410 420 430 440 450
TRKEDFEGQD LDTFTKENDA LCNLIQIFEG RYAVFNYRAT VEEEQSQVGK
460 470 480 490 500
LLSQIESVVQ HHNNKPCVIR EKELLNIILL GRSGVGKSAT GNTILGRPAF
510 520 530 540 550
VSQLRAQPVT SRSQSGRRTL DWQDIVVVDT PSLNQMSGTE KNPAQLKKEI
560 570 580 590 600
KQCLLQNCEE GMKVFVLVFQ LGRFTQEDEA VVEQLEASFE ENIMKYMIVL
610 620 630 640 650
FTRKEDLGDG DLYDFTNNTK NKVLKRIFKK CKGRVCAFNN KETGEDQETQ
660 670 680
VKALLTIAND LKRSYDEHST SWMDQLKSAV GQITTVFK
Length:688
Mass (Da):77,072
Last modified:August 2, 2005 - v1
Checksum:i4897B08BB5535B03
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti151 – 1511I → F in CAG17880 (PubMed:16103028).Curated
Sequence conflicti243 – 2431T → A in CAG17880 (PubMed:16103028).Curated
Sequence conflicti417 – 4171E → G in CAG17880 (PubMed:16103028).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ633685 mRNA. Translation: CAG17880.1.
DQ125335 mRNA. Translation: ABB03698.1.
DQ125336 mRNA. Translation: ABB03699.1.
BC099228 mRNA. Translation: AAH99228.1.
RefSeqiNP_001029095.1. NM_001033923.1.
UniGeneiRn.117838.

Genome annotation databases

GeneIDi500112.
KEGGirno:500112.
UCSCiRGD:1564570. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ633685 mRNA. Translation: CAG17880.1.
DQ125335 mRNA. Translation: ABB03698.1.
DQ125336 mRNA. Translation: ABB03699.1.
BC099228 mRNA. Translation: AAH99228.1.
RefSeqiNP_001029095.1. NM_001033923.1.
UniGeneiRn.117838.

3D structure databases

ProteinModelPortaliQ4KLG2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000055946.

Proteomic databases

PaxDbiQ4KLG2.
PRIDEiQ4KLG2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi500112.
KEGGirno:500112.
UCSCiRGD:1564570. rat.

Organism-specific databases

CTDi155038.
RGDi1564570. Gimap8.

Phylogenomic databases

eggNOGiENOG410IJSD. Eukaryota.
ENOG410XWIP. LUCA.
HOGENOMiHOG000112722.
HOVERGENiHBG095690.
InParanoidiQ4KLG2.
OrthoDBiEOG091G0I0X.
PhylomeDBiQ4KLG2.
TreeFamiTF330845.

Miscellaneous databases

PROiQ4KLG2.

Gene expression databases

BgeeiENSRNOG00000020169.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR006703. G_AIG1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF04548. AIG1. 3 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS51720. G_AIG1. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGIMA8_RAT
AccessioniPrimary (citable) accession number: Q4KLG2
Secondary accession number(s): Q3LF72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: August 2, 2005
Last modified: September 7, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.