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Protein

Actin-related protein 2/3 complex subunit 5

Gene

Arpc5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.By similarity

GO - Molecular functioni

GO - Biological processi

  • actin filament network formation Source: RGD
  • Arp2/3 complex-mediated actin nucleation Source: Ensembl
  • lamellipodium organization Source: RGD
  • maintenance of cell polarity Source: RGD
  • microtubule organizing center organization Source: RGD
  • orbitofrontal cortex development Source: RGD
  • smooth muscle cell migration Source: RGD
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

ReactomeiR-RNO-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-RNO-3928662. EPHB-mediated forward signaling.
R-RNO-5663213. RHO GTPases Activate WASPs and WAVEs.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 5
Alternative name(s):
Arp2/3 complex 16 kDa subunit
Short name:
p16-ARC
Gene namesi
Name:Arpc5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi1311791. Arpc5.

Subcellular locationi

GO - Cellular componenti

  • Arp2/3 protein complex Source: Ensembl
  • cytoplasm Source: UniProtKB-KW
  • extracellular exosome Source: Ensembl
  • focal adhesion Source: Ensembl
  • neuron projection Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 151150Actin-related protein 2/3 complex subunit 5PRO_0000269564Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity

Post-translational modificationi

Polyubiquitinated by RNF128 with 'Lys-63'-linked chains, leading to proteasomal degradation.By similarity

Keywords - PTMi

Acetylation, Ubl conjugation

Proteomic databases

PaxDbiQ4KLF8.
PRIDEiQ4KLF8.

PTM databases

iPTMnetiQ4KLF8.
PhosphoSiteiQ4KLF8.

Expressioni

Gene expression databases

BgeeiENSRNOG00000028062.
ExpressionAtlasiQ4KLF8. baseline and differential.
GenevisibleiQ4KLF8. RN.

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.By similarity

Protein-protein interaction databases

BioGridi262257. 2 interactions.
MINTiMINT-4574941.
STRINGi10116.ENSRNOP00000061516.

Structurei

3D structure databases

ProteinModelPortaliQ4KLF8.
SMRiQ4KLF8. Positions 9-150.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ARPC5 family.Curated

Phylogenomic databases

eggNOGiKOG3380. Eukaryota.
ENOG4111FGV. LUCA.
GeneTreeiENSGT00390000014806.
HOGENOMiHOG000197215.
HOVERGENiHBG050583.
InParanoidiQ4KLF8.
KOiK05754.
OMAiADNATCQ.
PhylomeDBiQ4KLF8.
TreeFamiTF319716.

Family and domain databases

Gene3Di1.25.40.190. 1 hit.
InterProiIPR006789. ARPC5.
[Graphical view]
PANTHERiPTHR12644. PTHR12644. 1 hit.
PfamiPF04699. P16-Arc. 1 hit.
[Graphical view]
PIRSFiPIRSF039096. p16-ARC. 1 hit.
SUPFAMiSSF69103. SSF69103. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4KLF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKNTVSSAR FRKVDVDEYD ENKFVDEEDG GDGQAGPDEG EVDSCLRQGN
60 70 80 90 100
MTAALQAALK NPPINTKSQA VKDRAGSIVL KVLISFKAND IEKAVQSLDK
110 120 130 140 150
NGVDLLMKYI YKGFESPSDN SSAMLLQWHE KALAAGGVGS IVRVLTARKT

V
Length:151
Mass (Da):16,320
Last modified:January 23, 2007 - v3
Checksum:iF050B11774EA6E66
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti103 – 1031V → I AA sequence (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099238 mRNA. Translation: AAH99238.1.
RefSeqiNP_001020888.1. NM_001025717.1.
UniGeneiRn.1639.

Genome annotation databases

EnsembliENSRNOT00000064068; ENSRNOP00000061516; ENSRNOG00000028062.
GeneIDi360854.
KEGGirno:360854.
UCSCiRGD:1311791. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099238 mRNA. Translation: AAH99238.1.
RefSeqiNP_001020888.1. NM_001025717.1.
UniGeneiRn.1639.

3D structure databases

ProteinModelPortaliQ4KLF8.
SMRiQ4KLF8. Positions 9-150.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi262257. 2 interactions.
MINTiMINT-4574941.
STRINGi10116.ENSRNOP00000061516.

PTM databases

iPTMnetiQ4KLF8.
PhosphoSiteiQ4KLF8.

Proteomic databases

PaxDbiQ4KLF8.
PRIDEiQ4KLF8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000064068; ENSRNOP00000061516; ENSRNOG00000028062.
GeneIDi360854.
KEGGirno:360854.
UCSCiRGD:1311791. rat.

Organism-specific databases

CTDi10092.
RGDi1311791. Arpc5.

Phylogenomic databases

eggNOGiKOG3380. Eukaryota.
ENOG4111FGV. LUCA.
GeneTreeiENSGT00390000014806.
HOGENOMiHOG000197215.
HOVERGENiHBG050583.
InParanoidiQ4KLF8.
KOiK05754.
OMAiADNATCQ.
PhylomeDBiQ4KLF8.
TreeFamiTF319716.

Enzyme and pathway databases

ReactomeiR-RNO-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-RNO-3928662. EPHB-mediated forward signaling.
R-RNO-5663213. RHO GTPases Activate WASPs and WAVEs.

Miscellaneous databases

PROiQ4KLF8.

Gene expression databases

BgeeiENSRNOG00000028062.
ExpressionAtlasiQ4KLF8. baseline and differential.
GenevisibleiQ4KLF8. RN.

Family and domain databases

Gene3Di1.25.40.190. 1 hit.
InterProiIPR006789. ARPC5.
[Graphical view]
PANTHERiPTHR12644. PTHR12644. 1 hit.
PfamiPF04699. P16-Arc. 1 hit.
[Graphical view]
PIRSFiPIRSF039096. p16-ARC. 1 hit.
SUPFAMiSSF69103. SSF69103. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiARPC5_RAT
AccessioniPrimary (citable) accession number: Q4KLF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 79 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.