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Protein

Actin-related protein 2/3 complex subunit 5

Gene

Arpc5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.By similarity

GO - Molecular functioni

GO - Biological processi

  • actin filament network formation Source: RGD
  • Arp2/3 complex-mediated actin nucleation Source: RGD
  • cell migration Source: RGD
  • lamellipodium organization Source: RGD
  • maintenance of cell polarity Source: RGD
  • microtubule organizing center localization Source: RGD
  • orbitofrontal cortex development Source: RGD
  • smooth muscle cell migration Source: RGD

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

ReactomeiR-RNO-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-RNO-3928662. EPHB-mediated forward signaling.
R-RNO-5663213. RHO GTPases Activate WASPs and WAVEs.
R-RNO-6798695. Neutrophil degranulation.
R-RNO-8856828. Clathrin-mediated endocytosis.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 5
Alternative name(s):
Arp2/3 complex 16 kDa subunit
Short name:
p16-ARC
Gene namesi
Name:Arpc5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi1311791. Arpc5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002695642 – 151Actin-related protein 2/3 complex subunit 5Add BLAST150

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1

Post-translational modificationi

Polyubiquitinated by RNF128 with 'Lys-63'-linked chains, leading to proteasomal degradation.By similarity

Keywords - PTMi

Acetylation, Ubl conjugation

Proteomic databases

PaxDbiQ4KLF8.
PRIDEiQ4KLF8.

PTM databases

iPTMnetiQ4KLF8.
PhosphoSitePlusiQ4KLF8.

Expressioni

Gene expression databases

BgeeiENSRNOG00000028062.
ExpressionAtlasiQ4KLF8. baseline and differential.
GenevisibleiQ4KLF8. RN.

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi262257. 2 interactors.
STRINGi10116.ENSRNOP00000061516.

Structurei

3D structure databases

ProteinModelPortaliQ4KLF8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ARPC5 family.Curated

Phylogenomic databases

eggNOGiKOG3380. Eukaryota.
ENOG4111FGV. LUCA.
GeneTreeiENSGT00390000014806.
HOGENOMiHOG000197215.
HOVERGENiHBG050583.
InParanoidiQ4KLF8.
KOiK05754.
OMAiKYIYKGM.
PhylomeDBiQ4KLF8.
TreeFamiTF319716.

Family and domain databases

Gene3Di1.25.40.190. 1 hit.
InterProiView protein in InterPro
IPR006789. ARPC5.
IPR036743. ARPC5_sf.
PANTHERiPTHR12644. PTHR12644. 1 hit.
PfamiView protein in Pfam
PF04699. P16-Arc. 1 hit.
PIRSFiPIRSF039096. p16-ARC. 1 hit.
SUPFAMiSSF69103. SSF69103. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4KLF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKNTVSSAR FRKVDVDEYD ENKFVDEEDG GDGQAGPDEG EVDSCLRQGN
60 70 80 90 100
MTAALQAALK NPPINTKSQA VKDRAGSIVL KVLISFKAND IEKAVQSLDK
110 120 130 140 150
NGVDLLMKYI YKGFESPSDN SSAMLLQWHE KALAAGGVGS IVRVLTARKT

V
Length:151
Mass (Da):16,320
Last modified:January 23, 2007 - v3
Checksum:iF050B11774EA6E66
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti103V → I AA sequence (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099238 mRNA. Translation: AAH99238.1.
RefSeqiNP_001020888.1. NM_001025717.1.
UniGeneiRn.1639.

Genome annotation databases

EnsembliENSRNOT00000064068; ENSRNOP00000061516; ENSRNOG00000028062.
GeneIDi360854.
KEGGirno:360854.
UCSCiRGD:1311791. rat.

Similar proteinsi

Entry informationi

Entry nameiARPC5_RAT
AccessioniPrimary (citable) accession number: Q4KLF8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: January 23, 2007
Last modified: February 28, 2018
This is version 90 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome