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Q4KLA0

- CCNC_XENLA

UniProt

Q4KLA0 - CCNC_XENLA

Protein

Cyclin-C

Gene

ccnc

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (02 Aug 2005)
      Previous versions | rss
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    Functioni

    Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase cdk8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex By similarity.By similarity

    GO - Biological processi

    1. regulation of cyclin-dependent protein serine/threonine kinase activity Source: InterPro
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Cyclin, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-C
    Gene namesi
    Name:ccnc
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-922018. ccnc.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. DNA-directed RNA polymerase II, holoenzyme Source: InterPro

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 283283Cyclin-CPRO_0000314258Add
    BLAST

    Interactioni

    Subunit structurei

    Component of the Mediator complex. The cylin/CDK pair formed by ccnc/cdk8 also associates with the large subunit of RNA polymerase II By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ4KLA0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini46 – 14499Cyclin N-terminalAdd
    BLAST

    Sequence similaritiesi

    Belongs to the cyclin family. Cyclin C subfamily.Curated
    Contains 1 cyclin N-terminal domain.Curated

    Phylogenomic databases

    HOVERGENiHBG050836.
    KOiK15161.

    Family and domain databases

    Gene3Di1.10.472.10. 1 hit.
    InterProiIPR013763. Cyclin-like.
    IPR015429. Cyclin_C/H/T/L.
    IPR006671. Cyclin_N.
    IPR023598. CyclinC.
    [Graphical view]
    PANTHERiPTHR10026. PTHR10026. 1 hit.
    PfamiPF00134. Cyclin_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF028758. PIRSF028758. 1 hit.
    SMARTiSM00385. CYCLIN. 2 hits.
    [Graphical view]
    SUPFAMiSSF47954. SSF47954. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Q4KLA0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGNFWQSSH YLQWILDKQD LLKERQKDLK FLSEEEYWKL QIFFTNVIQA    50
    LGEHLKLRQQ VIATATVYFK RFYARYSLKS IDPVLMAPTC VFLASKVEEF 100
    GVVSNTRLIS AATSVLKTRF SYAFPKEFPY RMNHILECEF YLLELMDCCL 150
    IVYHPYRPLL QYVQDMGQED MLLPLAWRIV NDTYRTDLCL LYPPFMIALA 200
    CLHVACVVQQ KDARQWFAEL SVDMEKILEI IRVILKLYEQ WKNFDERKEM 250
    ASILSKMPKP KPPPNSDGEQ GTNGSQSSGY SQS 283
    Length:283
    Mass (Da):33,178
    Last modified:August 2, 2005 - v1
    Checksum:i22E6BA13A7AA4797
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC099287 mRNA. Translation: AAH99287.1.
    BC099330 mRNA. Translation: AAH99330.1.
    RefSeqiNP_001089618.1. NM_001096149.1.
    UniGeneiXl.51208.

    Genome annotation databases

    GeneIDi734677.
    KEGGixla:734677.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC099287 mRNA. Translation: AAH99287.1 .
    BC099330 mRNA. Translation: AAH99330.1 .
    RefSeqi NP_001089618.1. NM_001096149.1.
    UniGenei Xl.51208.

    3D structure databases

    ProteinModelPortali Q4KLA0.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 734677.
    KEGGi xla:734677.

    Organism-specific databases

    CTDi 892.
    Xenbasei XB-GENE-922018. ccnc.

    Phylogenomic databases

    HOVERGENi HBG050836.
    KOi K15161.

    Family and domain databases

    Gene3Di 1.10.472.10. 1 hit.
    InterProi IPR013763. Cyclin-like.
    IPR015429. Cyclin_C/H/T/L.
    IPR006671. Cyclin_N.
    IPR023598. CyclinC.
    [Graphical view ]
    PANTHERi PTHR10026. PTHR10026. 1 hit.
    Pfami PF00134. Cyclin_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF028758. PIRSF028758. 1 hit.
    SMARTi SM00385. CYCLIN. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47954. SSF47954. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Tadpole.

    Entry informationi

    Entry nameiCCNC_XENLA
    AccessioniPrimary (citable) accession number: Q4KLA0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: August 2, 2005
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3