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Q4KLA0 (CCNC_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclin-C
Gene names
Name:ccnc
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length283 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase cdk8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex By similarity.

Subunit structure

Component of the Mediator complex. The cylin/CDK pair formed by ccnc/cdk8 also associates with the large subunit of RNA polymerase II By similarity.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the cyclin family. Cyclin C subfamily.

Contains 1 cyclin N-terminal domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 283283Cyclin-C
PRO_0000314258

Regions

Domain46 – 14499Cyclin N-terminal

Sequences

Sequence LengthMass (Da)Tools
Q4KLA0 [UniParc].

Last modified August 2, 2005. Version 1.
Checksum: 22E6BA13A7AA4797

FASTA28333,178
        10         20         30         40         50         60 
MAGNFWQSSH YLQWILDKQD LLKERQKDLK FLSEEEYWKL QIFFTNVIQA LGEHLKLRQQ 

        70         80         90        100        110        120 
VIATATVYFK RFYARYSLKS IDPVLMAPTC VFLASKVEEF GVVSNTRLIS AATSVLKTRF 

       130        140        150        160        170        180 
SYAFPKEFPY RMNHILECEF YLLELMDCCL IVYHPYRPLL QYVQDMGQED MLLPLAWRIV 

       190        200        210        220        230        240 
NDTYRTDLCL LYPPFMIALA CLHVACVVQQ KDARQWFAEL SVDMEKILEI IRVILKLYEQ 

       250        260        270        280 
WKNFDERKEM ASILSKMPKP KPPPNSDGEQ GTNGSQSSGY SQS 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Tadpole.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC099287 mRNA. Translation: AAH99287.1.
BC099330 mRNA. Translation: AAH99330.1.
RefSeqNP_001089618.1. NM_001096149.1.
UniGeneXl.51208.

3D structure databases

ProteinModelPortalQ4KLA0.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID734677.
KEGGxla:734677.

Organism-specific databases

CTD892.
XenbaseXB-GENE-922018. ccnc.

Phylogenomic databases

HOVERGENHBG050836.
KOK15161.

Family and domain databases

Gene3D1.10.472.10. 1 hit.
InterProIPR013763. Cyclin-like.
IPR015429. Cyclin_C/H/T/L.
IPR006671. Cyclin_N.
IPR023598. CyclinC.
[Graphical view]
PANTHERPTHR10026. PTHR10026. 1 hit.
PfamPF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFPIRSF028758. PIRSF028758. 1 hit.
SMARTSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMSSF47954. SSF47954. 2 hits.
ProtoNetSearch...

Entry information

Entry nameCCNC_XENLA
AccessionPrimary (citable) accession number: Q4KLA0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 2, 2005
Last modified: February 19, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families