Q4KLA0 (CCNC_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cyclin-C

Gene names

Name:

ccnc

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	283 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase cdk8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex By similarity.
Subunit structure	Component of the Mediator complex. The cylin/CDK pair formed by ccnc/cdk8 also associates with the large subunit of RNA polymerase II By similarity.
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the cyclin family. Cyclin C subfamily. Contains 1 cyclin N-terminal domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Molecular function	Activator Cyclin Repressor
Gene Ontology (GO)
Biological_process	regulation of cyclin-dependent protein serine/threonine kinase activity Inferred from electronic annotation. Source: InterPro regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	DNA-directed RNA polymerase II, holoenzyme Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 283	283	Cyclin-C		PRO_0000314258
Regions
	Domain	46 – 144	99	Cyclin N-terminal

Sequences

	Sequence		Length	Mass (Da)
	Q4KLA0 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: 22E6BA13A7AA4797	FASTA	283	33,178
	10 20 30 40 50 60 MAGNFWQSSH YLQWILDKQD LLKERQKDLK FLSEEEYWKL QIFFTNVIQA LGEHLKLRQQ 70 80 90 100 110 120 VIATATVYFK RFYARYSLKS IDPVLMAPTC VFLASKVEEF GVVSNTRLIS AATSVLKTRF 130 140 150 160 170 180 SYAFPKEFPY RMNHILECEF YLLELMDCCL IVYHPYRPLL QYVQDMGQED MLLPLAWRIV 190 200 210 220 230 240 NDTYRTDLCL LYPPFMIALA CLHVACVVQQ KDARQWFAEL SVDMEKILEI IRVILKLYEQ 250 260 270 280 WKNFDERKEM ASILSKMPKP KPPPNSDGEQ GTNGSQSSGY SQS

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Tadpole.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC099287 mRNA. Translation: AAH99287.1. BC099330 mRNA. Translation: AAH99330.1.
RefSeq	NP_001089618.1. NM_001096149.1.
UniGene	Xl.51208.
3D structure databases
HSSP	HSSP built from PDB template 1ZP2 based on UniProtKB O94503.
ProteinModelPortal	Q4KLA0.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	734677.
KEGG	xla:734677.
Organism-specific databases
CTD	892.
Xenbase	XB-GENE-922018. ccnc.
Phylogenomic databases
HOVERGEN	HBG050836.
KO	K15161.
Family and domain databases
Gene3D	1.10.472.10. 1 hit.
InterPro	IPR013763. Cyclin-like. IPR015429. Cyclin_C/H/T/L. IPR006671. Cyclin_N. IPR023598. CyclinC. [Graphical view]
PANTHER	PTHR10026. PTHR10026. 1 hit.
Pfam	PF00134. Cyclin_N. 1 hit. [Graphical view]
PIRSF	PIRSF028758. PIRSF028758. 1 hit.
SMART	SM00385. CYCLIN. 2 hits. [Graphical view]
SUPFAM	SSF47954. Cyclin_like. 2 hits.
PROSITE	PS00292. CYCLINS. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CCNC_XENLA

Accession

Primary (citable) accession number: Q4KLA0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	August 2, 2005
Last modified:	May 1, 2013
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program