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Q4KLA0

- CCNC_XENLA

UniProt

Q4KLA0 - CCNC_XENLA

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Protein

Cyclin-C

Gene
ccnc
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase cdk8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex By similarity.

GO - Biological processi

  1. regulation of cyclin-dependent protein serine/threonine kinase activity Source: InterPro
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Cyclin, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-C
Gene namesi
Name:ccnc
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-922018. ccnc.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. DNA-directed RNA polymerase II, holoenzyme Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 283283Cyclin-CPRO_0000314258Add
BLAST

Interactioni

Subunit structurei

Component of the Mediator complex. The cylin/CDK pair formed by ccnc/cdk8 also associates with the large subunit of RNA polymerase II By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ4KLA0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 14499Cyclin N-terminalAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG050836.
KOiK15161.

Family and domain databases

Gene3Di1.10.472.10. 1 hit.
InterProiIPR013763. Cyclin-like.
IPR015429. Cyclin_C/H/T/L.
IPR006671. Cyclin_N.
IPR023598. CyclinC.
[Graphical view]
PANTHERiPTHR10026. PTHR10026. 1 hit.
PfamiPF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFiPIRSF028758. PIRSF028758. 1 hit.
SMARTiSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.

Sequencei

Sequence statusi: Complete.

Q4KLA0-1 [UniParc]FASTAAdd to Basket

« Hide

MAGNFWQSSH YLQWILDKQD LLKERQKDLK FLSEEEYWKL QIFFTNVIQA    50
LGEHLKLRQQ VIATATVYFK RFYARYSLKS IDPVLMAPTC VFLASKVEEF 100
GVVSNTRLIS AATSVLKTRF SYAFPKEFPY RMNHILECEF YLLELMDCCL 150
IVYHPYRPLL QYVQDMGQED MLLPLAWRIV NDTYRTDLCL LYPPFMIALA 200
CLHVACVVQQ KDARQWFAEL SVDMEKILEI IRVILKLYEQ WKNFDERKEM 250
ASILSKMPKP KPPPNSDGEQ GTNGSQSSGY SQS 283
Length:283
Mass (Da):33,178
Last modified:August 2, 2005 - v1
Checksum:i22E6BA13A7AA4797
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC099287 mRNA. Translation: AAH99287.1.
BC099330 mRNA. Translation: AAH99330.1.
RefSeqiNP_001089618.1. NM_001096149.1.
UniGeneiXl.51208.

Genome annotation databases

GeneIDi734677.
KEGGixla:734677.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC099287 mRNA. Translation: AAH99287.1 .
BC099330 mRNA. Translation: AAH99330.1 .
RefSeqi NP_001089618.1. NM_001096149.1.
UniGenei Xl.51208.

3D structure databases

ProteinModelPortali Q4KLA0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 734677.
KEGGi xla:734677.

Organism-specific databases

CTDi 892.
Xenbasei XB-GENE-922018. ccnc.

Phylogenomic databases

HOVERGENi HBG050836.
KOi K15161.

Family and domain databases

Gene3Di 1.10.472.10. 1 hit.
InterProi IPR013763. Cyclin-like.
IPR015429. Cyclin_C/H/T/L.
IPR006671. Cyclin_N.
IPR023598. CyclinC.
[Graphical view ]
PANTHERi PTHR10026. PTHR10026. 1 hit.
Pfami PF00134. Cyclin_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF028758. PIRSF028758. 1 hit.
SMARTi SM00385. CYCLIN. 2 hits.
[Graphical view ]
SUPFAMi SSF47954. SSF47954. 2 hits.
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Tadpole.

Entry informationi

Entry nameiCCNC_XENLA
AccessioniPrimary (citable) accession number: Q4KLA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 2, 2005
Last modified: February 19, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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