Q4KL92 (DUPD1_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dual specificity phosphatase DUPD1
EC=3.1.3.16
EC=3.1.3.48

Gene names

Name:

dupd1

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	209 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. A phosphoprotein + H2O = a protein + phosphate.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Contains 1 tyrosine-protein phosphatase domain.
Sequence caution	The sequence AAH99351.1 differs from that shown. Reason: Erroneous initiation. The sequence AAI33236.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase Protein phosphatase
Gene Ontology (GO)
Biological_process	peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC protein tyrosine/serine/threonine phosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 209	209	Dual specificity phosphatase DUPD1		PRO_0000295891
Regions
	Domain	45 – 192	148	Tyrosine-protein phosphatase
	Region	137 – 144	8	Substrate binding By similarity
Sites
	Active site	138	1	Phosphocysteine intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4KL92 [UniParc]. Last modified July 24, 2007. Version 2. Checksum: 6BB945FAF4E4A539	FASTA	209	23,750
	10 20 30 40 50 60 MPADTPIRKK PNAYASVVDP DTGYCTPGAF ELERLFWHGA PKYTHVNEVW PNLYIGDEKT 70 80 90 100 110 120 ALDRYSLEKN GFTHILNAAH GRWNVDTGPE YYSDMTVEYY GVEAEDLPSF NLSQFFYPAA 130 140 150 160 170 180 QFIHKALSTP NSKLLVNCAM GRSRSASLVL AYLMIYKNMT VVESITQVLK HRCILPNRGF 190 200 LKQLRELDIK LALEKRDTHG TANKAQKDD

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC099351 mRNA. Translation: AAH99351.1. Different initiation. BC133235 mRNA. Translation: AAI33236.1. Different initiation.
RefSeq	NP_001153482.1. NM_001160010.1.
UniGene	Xl.51670.
3D structure databases
HSSP	HSSP built from PDB template 1VHR based on UniProtKB P51452.
ProteinModelPortal	Q4KL92.
SMR	Q4KL92. Positions 27-192.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	733311.
KEGG	xla:733311.
Organism-specific databases
CTD	338599.
Xenbase	XB-GENE-5944548. dupd1.
Phylogenomic databases
HOVERGEN	HBG001524.
KO	K14165.
Family and domain databases
InterPro	IPR020417. Atypical_DUSP. IPR020405. Atypical_DUSP_famA. IPR000340. Dual-sp_phosphatase_cat-dom. IPR020422. Dual-sp_phosphatase_subgr_cat. IPR024950. DUSP. IPR000387. Tyr/Dual-sp_Pase. [Graphical view]
PANTHER	PTHR10159. PTHR10159. 1 hit.
Pfam	PF00782. DSPc. 1 hit. [Graphical view]
PRINTS	PR01908. ADSPHPHTASE. PR01909. ADSPHPHTASEA.
SMART	SM00195. DSPc. 1 hit. [Graphical view]
PROSITE	PS00383. TYR_PHOSPHATASE_1. False negative. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50054. TYR_PHOSPHATASE_DUAL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DUPD1_XENLA

Accession

Primary (citable) accession number: Q4KL92

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 24, 2007
Last sequence update:	July 24, 2007
Last modified:	March 6, 2013
This is version 42 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program