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Q4KL92 (DUPD1_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dual specificity phosphatase DUPD1

EC=3.1.3.16
EC=3.1.3.48
Gene names
Name:dupd1
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length209 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Contains 1 tyrosine-protein phosphatase domain.

Sequence caution

The sequence AAH99351.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAI33236.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionHydrolase
Protein phosphatase
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionprotein tyrosine phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

protein tyrosine/serine/threonine phosphatase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 209209Dual specificity phosphatase DUPD1
PRO_0000295891

Regions

Domain45 – 192148Tyrosine-protein phosphatase
Region137 – 1448Substrate binding By similarity

Sites

Active site1381Phosphocysteine intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4KL92 [UniParc].

Last modified July 24, 2007. Version 2.
Checksum: 6BB945FAF4E4A539

FASTA20923,750
        10         20         30         40         50         60 
MPADTPIRKK PNAYASVVDP DTGYCTPGAF ELERLFWHGA PKYTHVNEVW PNLYIGDEKT 

        70         80         90        100        110        120 
ALDRYSLEKN GFTHILNAAH GRWNVDTGPE YYSDMTVEYY GVEAEDLPSF NLSQFFYPAA 

       130        140        150        160        170        180 
QFIHKALSTP NSKLLVNCAM GRSRSASLVL AYLMIYKNMT VVESITQVLK HRCILPNRGF 

       190        200 
LKQLRELDIK LALEKRDTHG TANKAQKDD 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC099351 mRNA. Translation: AAH99351.1. Different initiation.
BC133235 mRNA. Translation: AAI33236.1. Different initiation.
RefSeqNP_001153482.1. NM_001160010.1.
UniGeneXl.51670.

3D structure databases

ProteinModelPortalQ4KL92.
SMRQ4KL92. Positions 27-192.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID733311.
KEGGxla:733311.

Organism-specific databases

CTD338599.
XenbaseXB-GENE-5944548. dupd1.

Phylogenomic databases

HOVERGENHBG001524.
KOK14165.

Family and domain databases

InterProIPR020417. Atypical_DUSP.
IPR020405. Atypical_DUSP_famA.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view]
PANTHERPTHR10159. PTHR10159. 1 hit.
PfamPF00782. DSPc. 1 hit.
[Graphical view]
PRINTSPR01908. ADSPHPHTASE.
PR01909. ADSPHPHTASEA.
SMARTSM00195. DSPc. 1 hit.
[Graphical view]
PROSITEPS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDUPD1_XENLA
AccessionPrimary (citable) accession number: Q4KL92
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: April 16, 2014
This is version 46 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families