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Q4KL92

- DUPD1_XENLA

UniProt

Q4KL92 - DUPD1_XENLA

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Protein

Dual specificity phosphatase DUPD1

Gene

dupd1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei138 – 1381Phosphocysteine intermediateBy similarity

GO - Molecular functioni

  1. protein tyrosine/serine/threonine phosphatase activity Source: InterPro
  2. protein tyrosine phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity phosphatase DUPD1 (EC:3.1.3.16, EC:3.1.3.48)
Gene namesi
Name:dupd1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-5944548. dupd1.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 209209Dual specificity phosphatase DUPD1PRO_0000295891Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ4KL92.
SMRiQ4KL92. Positions 27-192.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini45 – 192148Tyrosine-protein phosphataseAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni137 – 1448Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG001524.
KOiK14165.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR020417. Atypical_DUSP.
IPR020405. Atypical_DUSP_famA.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
PRINTSiPR01908. ADSPHPHTASE.
PR01909. ADSPHPHTASEA.
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4KL92-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPADTPIRKK PNAYASVVDP DTGYCTPGAF ELERLFWHGA PKYTHVNEVW
60 70 80 90 100
PNLYIGDEKT ALDRYSLEKN GFTHILNAAH GRWNVDTGPE YYSDMTVEYY
110 120 130 140 150
GVEAEDLPSF NLSQFFYPAA QFIHKALSTP NSKLLVNCAM GRSRSASLVL
160 170 180 190 200
AYLMIYKNMT VVESITQVLK HRCILPNRGF LKQLRELDIK LALEKRDTHG

TANKAQKDD
Length:209
Mass (Da):23,750
Last modified:July 24, 2007 - v2
Checksum:i6BB945FAF4E4A539
GO

Sequence cautioni

The sequence AAH99351.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAI33236.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC099351 mRNA. Translation: AAH99351.1. Different initiation.
BC133235 mRNA. Translation: AAI33236.1. Different initiation.
RefSeqiNP_001153482.1. NM_001160010.1.
UniGeneiXl.51670.

Genome annotation databases

GeneIDi733311.
KEGGixla:733311.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC099351 mRNA. Translation: AAH99351.1 . Different initiation.
BC133235 mRNA. Translation: AAI33236.1 . Different initiation.
RefSeqi NP_001153482.1. NM_001160010.1.
UniGenei Xl.51670.

3D structure databases

ProteinModelPortali Q4KL92.
SMRi Q4KL92. Positions 27-192.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 733311.
KEGGi xla:733311.

Organism-specific databases

CTDi 338599.
Xenbasei XB-GENE-5944548. dupd1.

Phylogenomic databases

HOVERGENi HBG001524.
KOi K14165.

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR020417. Atypical_DUSP.
IPR020405. Atypical_DUSP_famA.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view ]
PANTHERi PTHR10159. PTHR10159. 1 hit.
Pfami PF00782. DSPc. 1 hit.
[Graphical view ]
PRINTSi PR01908. ADSPHPHTASE.
PR01909. ADSPHPHTASEA.
SMARTi SM00195. DSPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiDUPD1_XENLA
AccessioniPrimary (citable) accession number: Q4KL92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: October 29, 2014
This is version 49 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3