ID   HIS31_PSEF5             Reviewed;         130 AA.
AC   Q4KJL5;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   16-JUN-2009, entry version 22.
DE   RecName: Full=Phosphoribosyl-AMP cyclohydrolase 1;
DE            Short=PRA-CH 1;
DE            EC=3.5.4.19;
GN   Name=hisI1; OrderedLocusNames=PFL_0424;
OS   Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=220664;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15980861; DOI=10.1038/nbt1110;
RA   Paulsen I.T., Press C.M., Ravel J., Kobayashi D.Y., Myers G.S.A.,
RA   Mavrodi D.V., DeBoy R.T., Seshadri R., Ren Q., Madupu R., Dodson R.J.,
RA   Durkin A.S., Brinkac L.M., Daugherty S.C., Sullivan S.A.,
RA   Rosovitz M.J., Gwinn M.L., Zhou L., Schneider D.J., Cartinhour S.W.,
RA   Nelson W.C., Weidman J., Watkins K., Tran K., Khouri H., Pierson E.A.,
RA   Pierson L.S. III, Thomashow L.S., Loper J.E.;
RT   "Complete genome sequence of the plant commensal Pseudomonas
RT   fluorescens Pf-5.";
RL   Nat. Biotechnol. 23:873-878(2005).
CC   -!- CATALYTIC ACTIVITY: 1-(5-phosphoribosyl)-AMP + H(2)O = 1-(5-
CC       phosphoribosyl)-5-((5-
CC       phosphoribosylamino)methylideneamino)imidazole-4-carboxamide.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-
CC       histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the PRA-CH family.
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DR   EMBL; CP000076; AAY95833.1; -; Genomic_DNA.
DR   RefSeq; YP_257568.1; -.
DR   GeneID; 3481015; -.
DR   GenomeReviews; CP000076_GR; PFL_0424.
DR   KEGG; pfl:PFL_0424; -.
DR   NMPDR; fig|220664.3.peg.1906; -.
DR   HOGENOM; Q4KJL5; -.
DR   OMA; Q4KJL5; LWLKGES.
DR   BioCyc; PFLU220664:PFL_0424-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004635; F:phosphoribosyl-AMP cyclohydrolase activity; IEA:HAMAP.
DR   GO; GO:0000105; P:histidine biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_01021; -; 1.
DR   InterPro; IPR002496; PRA_CycHdrlase.
DR   Pfam; PF01502; PRA-CH; 1.
DR   ProDom; PD002610; PRA_cyclohydro; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Complete proteome; Cytoplasm;
KW   Histidine biosynthesis; Hydrolase.
FT   CHAIN         1    130       Phosphoribosyl-AMP cyclohydrolase 1.
FT                                /FTId=PRO_0000229834.
SQ   SEQUENCE   130 AA;  15006 MW;  90667CFECE9C6990 CRC64;
     MKDWLDQIKW DADGLVPAIA QDHKTGRVLM MAWMNREALS LTAAENRAIY WSRSRGKLWR
     KGEESGHVQK LHEMRLDCDA DVIILMVEQI GDIACHTGRH SCFYRVYEDG EWKTVEPVLK
     DPHAIYSAGH
//