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Q4KJD1

- Q4KJD1_PSEF5

UniProt

Q4KJD1 - Q4KJD1_PSEF5

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Protein
Acetyltransferase component of pyruvate dehydrogenase complex
Gene
aceF, PFL_0508
Organism
Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2 By similarity.UniRule annotation

Catalytic activityi

Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

Binds 1 lipoyl cofactor covalently By similarity.UniRule annotation
Binds 2 lipoyl cofactors covalently By similarity.UniRule annotation
Binds 3 lipoyl cofactors covalently By similarity.UniRule annotation

GO - Molecular functioni

  1. dihydrolipoyllysine-residue acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseUniRule annotationImported, Transferase

Keywords - Biological processi

GlycolysisUniRule annotation

Keywords - Ligandi

PyruvateImported

Enzyme and pathway databases

BioCyciPFLU220664:GIX8-509-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
Name:aceFImported
Ordered Locus Names:PFL_0508Imported
OrganismiPseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)Imported
Taxonomic identifieri220664 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000008540: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. pyruvate dehydrogenase complex Source: InterPro
Complete GO annotation...

Interactioni

Subunit structurei

Forms a 24-polypeptide structural core with octahedral symmetry By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi220664.PFL_0508.

Structurei

3D structure databases

ProteinModelPortaliQ4KJD1.
SMRiQ4KJD1. Positions 2-80, 407-649.

Family & Domainsi

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation
Contains 3 lipoyl-binding domains.UniRule annotation

Keywords - Domaini

LipoylUniRule annotationSAAS annotations

Phylogenomic databases

eggNOGiCOG0508.
HOGENOMiHOG000281562.
KOiK00627.
OMAiTEIMVAV.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR006256. AcTrfase_Pyrv_DH_cplx.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 3 hits.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 3 hits.
TIGRFAMsiTIGR01348. PDHac_trf_long. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 3 hits.
PS00189. LIPOYL. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4KJD1-1 [UniParc]FASTAAdd to Basket

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MSELIRVPDI GSGEGEVIEL FVKVGDRIEA DQSILTLESD KASMEVPAPK    50
AGVIKSLKVK LGDRLKEGDE LLELEVEGAA AAAPAAAPAA KAEAKPAAAP 100
AAASAPAAAP AAASVQQVHV PDIGSSGKAQ IIEIQVKVGD KVEADQSLIT 150
LESDKASMEI PSPAAGVVKA ISVKLNDEVG TGDLILDLEV AGAAAPAAAP 200
AQAAAPAAAA APAPAAAPAA PVADSVQDIH VPDIGSAGKA KIIEVLVKAG 250
DSVEADQSLI TLESDKASME IPSPAAGVVE SVSIKLDDEV GTGDLILKLK 300
VKGAAPAAAP APAAAPSAPA PAAAAAPAAA APAAAPAAAP AKPGAKVHAG 350
PAVRQLAREF GVELSAVGAS GPHGRILKED VQVYVKAMMQ KAKEAPAAGG 400
ATGGAGIPPI PVVDFSRFGE IEEVPMTRLM QAGAANLHRS WLNVPHVTQF 450
DSADITELEA FRVAQKAVAE KAGVKLTILP LLLKSCAHLL KELPDFNSSL 500
APSGKAIIRK KYVNIGFAVD TPDGLLVPVI KNVDQKSLLQ LAAEAASLAE 550
KARTKKLSAD EMQGACFTIS SLGHIGGTGF TPIVNAPEVA ILGVSKATIQ 600
PVWDGKAFQP KLMLPLSLSY DHRVINGAAA ARFTKRLSDL LADIRTILL 649
Length:649
Mass (Da):65,685
Last modified:August 2, 2005 - v1
Checksum:i8089F14059C1D2BF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000076 Genomic DNA. Translation: AAY95917.1.
RefSeqiYP_257652.1. NC_004129.6.

Genome annotation databases

EnsemblBacteriaiAAY95917; AAY95917; PFL_0508.
GeneIDi3481099.
KEGGipfl:PFL_0508.
PATRICi19870169. VBIPseFlu72549_0523.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000076 Genomic DNA. Translation: AAY95917.1 .
RefSeqi YP_257652.1. NC_004129.6.

3D structure databases

ProteinModelPortali Q4KJD1.
SMRi Q4KJD1. Positions 2-80, 407-649.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 220664.PFL_0508.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY95917 ; AAY95917 ; PFL_0508 .
GeneIDi 3481099.
KEGGi pfl:PFL_0508.
PATRICi 19870169. VBIPseFlu72549_0523.

Phylogenomic databases

eggNOGi COG0508.
HOGENOMi HOG000281562.
KOi K00627.
OMAi TEIMVAV.

Enzyme and pathway databases

BioCyci PFLU220664:GIX8-509-MONOMER.

Family and domain databases

Gene3Di 3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProi IPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR006256. AcTrfase_Pyrv_DH_cplx.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR011053. Single_hybrid_motif.
[Graphical view ]
Pfami PF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 3 hits.
PF02817. E3_binding. 1 hit.
[Graphical view ]
SUPFAMi SSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 3 hits.
TIGRFAMsi TIGR01348. PDHac_trf_long. 1 hit.
PROSITEi PS50968. BIOTINYL_LIPOYL. 3 hits.
PS00189. LIPOYL. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pf-5 / ATCC BAA-477.

Entry informationi

Entry nameiQ4KJD1_PSEF5
AccessioniPrimary (citable) accession number: Q4KJD1
Entry historyi
Integrated into UniProtKB/TrEMBL: August 2, 2005
Last sequence update: August 2, 2005
Last modified: July 9, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi