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Q4KJD1

- Q4KJD1_PSEF5

UniProt

Q4KJD1 - Q4KJD1_PSEF5

Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

aceF

Organism
Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (02 Aug 2005)
      Previous versions | rss
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    Functioni

    The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

    Catalytic activityi

    Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.

    Cofactori

    Binds 1 lipoyl cofactor covalently.UniRule annotation
    Binds 2 lipoyl cofactors covalently.UniRule annotation
    Binds 3 lipoyl cofactors covalently.UniRule annotation

    GO - Molecular functioni

    1. dihydrolipoyllysine-residue acetyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    AcyltransferaseUniRule annotationImported, Transferase

    Keywords - Biological processi

    GlycolysisUniRule annotation

    Keywords - Ligandi

    PyruvateImported

    Enzyme and pathway databases

    BioCyciPFLU220664:GIX8-509-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
    Gene namesi
    Name:aceFImported
    Ordered Locus Names:PFL_0508Imported
    OrganismiPseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)Imported
    Taxonomic identifieri220664 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000008540: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. pyruvate dehydrogenase complex Source: InterPro

    Interactioni

    Subunit structurei

    Forms a 24-polypeptide structural core with octahedral symmetry.UniRule annotation

    Protein-protein interaction databases

    STRINGi220664.PFL_0508.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4KJD1.
    SMRiQ4KJD1. Positions 2-80, 407-649.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 3 lipoyl-binding domains.UniRule annotation

    Keywords - Domaini

    LipoylUniRule annotationSAAS annotation

    Phylogenomic databases

    eggNOGiCOG0508.
    HOGENOMiHOG000281562.
    KOiK00627.
    OMAiTEIMVAV.

    Family and domain databases

    Gene3Di3.30.559.10. 1 hit.
    4.10.320.10. 1 hit.
    InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
    IPR001078. 2-oxoacid_DH_actylTfrase.
    IPR006256. AcTrfase_Pyrv_DH_cplx.
    IPR000089. Biotin_lipoyl.
    IPR023213. CAT-like_dom.
    IPR004167. E3-bd.
    IPR011053. Single_hybrid_motif.
    [Graphical view]
    PfamiPF00198. 2-oxoacid_dh. 1 hit.
    PF00364. Biotin_lipoyl. 3 hits.
    PF02817. E3_binding. 1 hit.
    [Graphical view]
    SUPFAMiSSF47005. SSF47005. 1 hit.
    SSF51230. SSF51230. 3 hits.
    TIGRFAMsiTIGR01348. PDHac_trf_long. 1 hit.
    PROSITEiPS50968. BIOTINYL_LIPOYL. 3 hits.
    PS00189. LIPOYL. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4KJD1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSELIRVPDI GSGEGEVIEL FVKVGDRIEA DQSILTLESD KASMEVPAPK    50
    AGVIKSLKVK LGDRLKEGDE LLELEVEGAA AAAPAAAPAA KAEAKPAAAP 100
    AAASAPAAAP AAASVQQVHV PDIGSSGKAQ IIEIQVKVGD KVEADQSLIT 150
    LESDKASMEI PSPAAGVVKA ISVKLNDEVG TGDLILDLEV AGAAAPAAAP 200
    AQAAAPAAAA APAPAAAPAA PVADSVQDIH VPDIGSAGKA KIIEVLVKAG 250
    DSVEADQSLI TLESDKASME IPSPAAGVVE SVSIKLDDEV GTGDLILKLK 300
    VKGAAPAAAP APAAAPSAPA PAAAAAPAAA APAAAPAAAP AKPGAKVHAG 350
    PAVRQLAREF GVELSAVGAS GPHGRILKED VQVYVKAMMQ KAKEAPAAGG 400
    ATGGAGIPPI PVVDFSRFGE IEEVPMTRLM QAGAANLHRS WLNVPHVTQF 450
    DSADITELEA FRVAQKAVAE KAGVKLTILP LLLKSCAHLL KELPDFNSSL 500
    APSGKAIIRK KYVNIGFAVD TPDGLLVPVI KNVDQKSLLQ LAAEAASLAE 550
    KARTKKLSAD EMQGACFTIS SLGHIGGTGF TPIVNAPEVA ILGVSKATIQ 600
    PVWDGKAFQP KLMLPLSLSY DHRVINGAAA ARFTKRLSDL LADIRTILL 649
    Length:649
    Mass (Da):65,685
    Last modified:August 2, 2005 - v1
    Checksum:i8089F14059C1D2BF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000076 Genomic DNA. Translation: AAY95917.1.
    RefSeqiYP_257652.1. NC_004129.6.

    Genome annotation databases

    EnsemblBacteriaiAAY95917; AAY95917; PFL_0508.
    GeneIDi3481099.
    KEGGipfl:PFL_0508.
    PATRICi19870169. VBIPseFlu72549_0523.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000076 Genomic DNA. Translation: AAY95917.1 .
    RefSeqi YP_257652.1. NC_004129.6.

    3D structure databases

    ProteinModelPortali Q4KJD1.
    SMRi Q4KJD1. Positions 2-80, 407-649.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 220664.PFL_0508.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY95917 ; AAY95917 ; PFL_0508 .
    GeneIDi 3481099.
    KEGGi pfl:PFL_0508.
    PATRICi 19870169. VBIPseFlu72549_0523.

    Phylogenomic databases

    eggNOGi COG0508.
    HOGENOMi HOG000281562.
    KOi K00627.
    OMAi TEIMVAV.

    Enzyme and pathway databases

    BioCyci PFLU220664:GIX8-509-MONOMER.

    Family and domain databases

    Gene3Di 3.30.559.10. 1 hit.
    4.10.320.10. 1 hit.
    InterProi IPR003016. 2-oxoA_DH_lipoyl-BS.
    IPR001078. 2-oxoacid_DH_actylTfrase.
    IPR006256. AcTrfase_Pyrv_DH_cplx.
    IPR000089. Biotin_lipoyl.
    IPR023213. CAT-like_dom.
    IPR004167. E3-bd.
    IPR011053. Single_hybrid_motif.
    [Graphical view ]
    Pfami PF00198. 2-oxoacid_dh. 1 hit.
    PF00364. Biotin_lipoyl. 3 hits.
    PF02817. E3_binding. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47005. SSF47005. 1 hit.
    SSF51230. SSF51230. 3 hits.
    TIGRFAMsi TIGR01348. PDHac_trf_long. 1 hit.
    PROSITEi PS50968. BIOTINYL_LIPOYL. 3 hits.
    PS00189. LIPOYL. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Pf-5 / ATCC BAA-477Imported.

    Entry informationi

    Entry nameiQ4KJD1_PSEF5
    AccessioniPrimary (citable) accession number: Q4KJD1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 2, 2005
    Last sequence update: August 2, 2005
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3