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Q4KJD1 (Q4KJD1_PSEF5) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acetyltransferase component of pyruvate dehydrogenase complex RuleBase RU361137

EC=2.3.1.12 RuleBase RU361137
Gene names
Name:aceF EMBL AAY95917.1
Ordered Locus Names:PFL_0508 EMBL AAY95917.1
OrganismPseudomonas fluorescens (strain Pf-5 / ATCC BAA-477) [Complete proteome] [HAMAP] EMBL AAY95917.1
Taxonomic identifier220664 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length649 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2 By similarity. RuleBase RU361137

Catalytic activity

Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine. RuleBase RU361137

Cofactor

Binds 1 lipoyl cofactor covalently By similarity. RuleBase RU361137

Binds 2 lipoyl cofactors covalently By similarity. RuleBase RU361137

Binds 3 lipoyl cofactors covalently By similarity. RuleBase RU361137

Subunit structure

Forms a 24-polypeptide structural core with octahedral symmetry By similarity. RuleBase RU361137

Sequence similarities

Belongs to the 2-oxoacid dehydrogenase family. RuleBase RU361137

Contains 3 lipoyl-binding domains. RuleBase RU361137

Ontologies

Sequences

Sequence LengthMass (Da)Tools
Q4KJD1 [UniParc].

Last modified August 2, 2005. Version 1.
Checksum: 8089F14059C1D2BF

FASTA64965,685
        10         20         30         40         50         60 
MSELIRVPDI GSGEGEVIEL FVKVGDRIEA DQSILTLESD KASMEVPAPK AGVIKSLKVK 

        70         80         90        100        110        120 
LGDRLKEGDE LLELEVEGAA AAAPAAAPAA KAEAKPAAAP AAASAPAAAP AAASVQQVHV 

       130        140        150        160        170        180 
PDIGSSGKAQ IIEIQVKVGD KVEADQSLIT LESDKASMEI PSPAAGVVKA ISVKLNDEVG 

       190        200        210        220        230        240 
TGDLILDLEV AGAAAPAAAP AQAAAPAAAA APAPAAAPAA PVADSVQDIH VPDIGSAGKA 

       250        260        270        280        290        300 
KIIEVLVKAG DSVEADQSLI TLESDKASME IPSPAAGVVE SVSIKLDDEV GTGDLILKLK 

       310        320        330        340        350        360 
VKGAAPAAAP APAAAPSAPA PAAAAAPAAA APAAAPAAAP AKPGAKVHAG PAVRQLAREF 

       370        380        390        400        410        420 
GVELSAVGAS GPHGRILKED VQVYVKAMMQ KAKEAPAAGG ATGGAGIPPI PVVDFSRFGE 

       430        440        450        460        470        480 
IEEVPMTRLM QAGAANLHRS WLNVPHVTQF DSADITELEA FRVAQKAVAE KAGVKLTILP 

       490        500        510        520        530        540 
LLLKSCAHLL KELPDFNSSL APSGKAIIRK KYVNIGFAVD TPDGLLVPVI KNVDQKSLLQ 

       550        560        570        580        590        600 
LAAEAASLAE KARTKKLSAD EMQGACFTIS SLGHIGGTGF TPIVNAPEVA ILGVSKATIQ 

       610        620        630        640 
PVWDGKAFQP KLMLPLSLSY DHRVINGAAA ARFTKRLSDL LADIRTILL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000076 Genomic DNA. Translation: AAY95917.1.
RefSeqYP_257652.1. NC_004129.6.

3D structure databases

ProteinModelPortalQ4KJD1.
SMRQ4KJD1. Positions 2-80, 407-649.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING220664.PFL_0508.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAY95917; AAY95917; PFL_0508.
GeneID3481099.
KEGGpfl:PFL_0508.
PATRIC19870169. VBIPseFlu72549_0523.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0508.
HOGENOMHOG000281562.
KOK00627.
OMATEIMVAV.

Enzyme and pathway databases

BioCycPFLU220664:GIX8-509-MONOMER.

Family and domain databases

Gene3D3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR006256. AcTrfase_Pyrv_DH_cplx.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 3 hits.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 3 hits.
TIGRFAMsTIGR01348. PDHac_trf_long. 1 hit.
PROSITEPS50968. BIOTINYL_LIPOYL. 3 hits.
PS00189. LIPOYL. 3 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ4KJD1_PSEF5
AccessionPrimary (citable) accession number: Q4KJD1
Entry history
Integrated into UniProtKB/TrEMBL: August 2, 2005
Last sequence update: August 2, 2005
Last modified: July 9, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)