ID   ADD_PSEF5               Reviewed;         317 AA.
AC   Q4KIS2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   16-JUN-2009, entry version 21.
DE   RecName: Full=Adenosine deaminase;
DE            EC=3.5.4.4;
DE   AltName: Full=Adenosine aminohydrolase;
GN   Name=add; OrderedLocusNames=PFL_0719;
OS   Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=220664;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15980861; DOI=10.1038/nbt1110;
RA   Paulsen I.T., Press C.M., Ravel J., Kobayashi D.Y., Myers G.S.A.,
RA   Mavrodi D.V., DeBoy R.T., Seshadri R., Ren Q., Madupu R., Dodson R.J.,
RA   Durkin A.S., Brinkac L.M., Daugherty S.C., Sullivan S.A.,
RA   Rosovitz M.J., Gwinn M.L., Zhou L., Schneider D.J., Cartinhour S.W.,
RA   Nelson W.C., Weidman J., Watkins K., Tran K., Khouri H., Pierson E.A.,
RA   Pierson L.S. III, Thomashow L.S., Loper J.E.;
RT   "Complete genome sequence of the plant commensal Pseudomonas
RT   fluorescens Pf-5.";
RL   Nat. Biotechnol. 23:873-878(2005).
CC   -!- CATALYTIC ACTIVITY: Adenosine + H(2)O = inosine + NH(3).
CC   -!- SIMILARITY: Belongs to the adenosine and AMP deaminases family.
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DR   EMBL; CP000076; AAY96126.1; -; Genomic_DNA.
DR   RefSeq; YP_257861.1; -.
DR   GeneID; 3481308; -.
DR   GenomeReviews; CP000076_GR; PFL_0719.
DR   KEGG; pfl:PFL_0719; -.
DR   NMPDR; fig|220664.3.peg.2174; -.
DR   HOGENOM; Q4KIS2; -.
DR   OMA; Q4KIS2; LAQNSLD.
DR   BioCyc; PFLU220664:PFL_0719-MON; -.
DR   GO; GO:0004000; F:adenosine deaminase activity; IEA:HAMAP.
DR   GO; GO:0009168; P:purine ribonucleoside monophosphate biosynt...; IEA:HAMAP.
DR   HAMAP; MF_00540; -; 1.
DR   InterPro; IPR006650; A/AMP_deam_AS.
DR   InterPro; IPR001365; A/AMP_deaminase.
DR   InterPro; IPR006330; A_deaminase.
DR   PANTHER; PTHR11409; A/AMP_deaminase; 1.
DR   Pfam; PF00962; A_deaminase; 1.
DR   TIGRFAMs; TIGR01430; aden_deam; 1.
DR   PROSITE; PS00485; A_DEAMINASE; FALSE_NEG.
PE   3: Inferred from homology;
KW   Complete proteome; Hydrolase; Nucleotide metabolism.
FT   CHAIN         1    317       Adenosine deaminase.
FT                                /FTId=PRO_1000017680.
FT   ACT_SITE    194    194       Potential.
FT   ACT_SITE    242    242       Potential.
FT   ACT_SITE    275    275       Potential.
FT   ACT_SITE    276    276       Potential.
SQ   SEQUENCE   317 AA;  36168 MW;  04EF5E90A5E9465B CRC64;
     MYDWLNALPK AELHLHLEGS LEPELLFALA ERNKIALPWS DVETLRKAYA FNNLQEFLDL
     YYQGADVLRT SQDFYDLTWA YLLRCKEQNV IHTEPFFDPQ THTDRGVPFE VVLNGIASAL
     KDGEQQLGIT SGLILSFLRH LSEEEAQKTL DQALPFRDAF VAVGLDSSEM GHPPSKFQRV
     FDRARSEGFL TVAHAGEEGP PEYIWEALDL LKIQRIDHGV RAFEDERLMQ RIIDEQIPLT
     VCPLSNTKLC VFDHMSQHNI LQMLERGVKV TVNSDDPAYF GGYVTENFHA LHTDLGMTQD
     QARRLAQNSL DARLVKP
//