Reviewed, UniProtKB/Swiss-Prot Q4KIS2 (ADD_PSEF5)

Names and origin

Protein names

Recommended name:
    Adenosine deaminase
    EC=3.5.4.4
Alternative name(s):
    Adenosine aminohydrolase

Gene names

Name:	add
Ordered Locus Names:	PFL_0719

Organism

Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477) [Complete proteome] [HAMAP]

Taxonomic identifier

220664 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	317 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Adenosine + H2O = inosine + NH3. HAMAP MF_00540
Sequence similarities	Belongs to the adenosine and AMP deaminases family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	adenosine deaminase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 317	317	Adenosine deaminase HAMAP MF_00540		PRO_1000017680
Sites
	Active site	194	1	Potential
	Active site	242	1	Potential
	Active site	275	1	Potential
	Active site	276	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q4KIS2-1 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: 04EF5E90A5E9465B	FASTA	317	36,168
	10 20 30 40 50 60 MYDWLNALPK AELHLHLEGS LEPELLFALA ERNKIALPWS DVETLRKAYA FNNLQEFLDL 70 80 90 100 110 120 YYQGADVLRT SQDFYDLTWA YLLRCKEQNV IHTEPFFDPQ THTDRGVPFE VVLNGIASAL 130 140 150 160 170 180 KDGEQQLGIT SGLILSFLRH LSEEEAQKTL DQALPFRDAF VAVGLDSSEM GHPPSKFQRV 190 200 210 220 230 240 FDRARSEGFL TVAHAGEEGP PEYIWEALDL LKIQRIDHGV RAFEDERLMQ RIIDEQIPLT 250 260 270 280 290 300 VCPLSNTKLC VFDHMSQHNI LQMLERGVKV TVNSDDPAYF GGYVTENFHA LHTDLGMTQD 310 QARRLAQNSL DARLVKP

References

[1]

"Complete genome sequence of the plant commensal Pseudomonas fluorescens Pf-5." Paulsen I.T., Press C.M., Ravel J., Kobayashi D.Y., Myers G.S.A., Mavrodi D.V., DeBoy R.T., Seshadri R., Ren Q., Madupu R., Dodson R.J., Durkin A.S., Brinkac L.M., Daugherty S.C., Sullivan S.A., Rosovitz M.J., Gwinn M.L., Zhou L. , Schneider D.J., Cartinhour S.W., Nelson W.C., Weidman J., Watkins K., Tran K., Khouri H., Pierson E.A., Pierson L.S. III, Thomashow L.S., Loper J.E. Nat. Biotechnol. 23:873-878(2005) [PubMed: 15980861] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000076 Genomic DNA. Translation: AAY96126.1.
RefSeq	YP_257861.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3481308.
GenomeReviews	Gene locus PFL_0719 in contig CP000076_GR.
KEGG	pfl:PFL_0719.
NMPDR	fig|220664.3.peg.2174.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q4KIS2.
OMA	Q4KIS2. LAQNSLD.
Enzyme and pathway databases
BioCyc	PFLU220664:PFL_0719-MON.
Family and domain databases
HAMAP	MF_00540. [Tree]
InterPro	IPR006650. A/AMP_deam_AS. IPR001365. A/AMP_deaminase. IPR006330. A_deaminase. [Graphical view]
PANTHER	PTHR11409. A/AMP_deaminase. 1 hit.
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01430. aden_deam. 1 hit.
PROSITE	PS00485. A_DEAMINASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADD_PSEF5

Accession

Primary (citable) accession number: Q4KIS2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	August 2, 2005
Last modified:	June 16, 2009
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)