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Q4KI73

- HISX_PSEF5

UniProt

Q4KI73 - HISX_PSEF5

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 2 (10 Jan 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei136 – 1361NADUniRule annotation
    Binding sitei197 – 1971NADUniRule annotation
    Binding sitei220 – 2201NADUniRule annotation
    Binding sitei243 – 2431SubstrateUniRule annotation
    Metal bindingi265 – 2651ZincUniRule annotation
    Binding sitei265 – 2651SubstrateUniRule annotation
    Metal bindingi268 – 2681ZincUniRule annotation
    Binding sitei268 – 2681SubstrateUniRule annotation
    Active sitei333 – 3331Proton acceptorUniRule annotation
    Active sitei334 – 3341Proton acceptorUniRule annotation
    Binding sitei334 – 3341SubstrateUniRule annotation
    Metal bindingi367 – 3671ZincUniRule annotation
    Binding sitei367 – 3671SubstrateUniRule annotation
    Binding sitei421 – 4211SubstrateUniRule annotation
    Metal bindingi426 – 4261ZincUniRule annotation
    Binding sitei426 – 4261SubstrateUniRule annotation

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    BioCyciPFLU220664:GIX8-932-MONOMER.
    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
    Short name:
    HDHUniRule annotation
    Gene namesi
    Name:hisDUniRule annotation
    Ordered Locus Names:PFL_0929
    OrganismiPseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
    Taxonomic identifieri220664 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000008540: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 442442Histidinol dehydrogenasePRO_0000135820Add
    BLAST

    2D gel databases

    World-2DPAGE0008:Q4KI73.

    Interactioni

    Protein-protein interaction databases

    STRINGi220664.PFL_0929.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4KI73.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4KI73-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTAPTAIRRL NAADPDFARH LDHLLSWESV SDDSVNQRVL DIIKAVRERG    50
    DAALVEFTQR FDGLQVASMA DLILPRERLE LALTRITVAQ REALEKAAAR 100
    VRSYHEKQKQ DSWTYTEADG TVLGQKVTPL DRAGLYVPGG KASYPSSVLM 150
    NAIPAKVAGV TEVVMVVPTP RGEVNELVLA AACIAGVDRV FTIGGAQAVA 200
    ALAYGTESVP QVDKVVGPGN IYVATAKRHV FGQVGIDMIA GPSEILVVCD 250
    GQTDPDWIAM DLFSQAEHDE DAQAILVSPD AEFLDKVAAS IAKLLPTMER 300
    AEIINTSING RGALIKVRDM QQAIEVANRI APEHLELSVA DPQAWLPQIR 350
    HAGAIFMGRH TSEALGDYCA GPNHVLPTSG TARFSSPLGV YDFQKRSSII 400
    FCSEQGASEL GRTASVLARG ESLTAHARSA EYRIVDDQDQ GQ 442
    Length:442
    Mass (Da):47,611
    Last modified:January 10, 2006 - v2
    Checksum:i3A870C6065ADEEEE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000076 Genomic DNA. Translation: AAY90216.2.
    RefSeqiYP_258060.2. NC_004129.6.

    Genome annotation databases

    EnsemblBacteriaiAAY90216; AAY90216; PFL_0929.
    GeneIDi3475457.
    KEGGipfl:PFL_0929.
    PATRICi19871047. VBIPseFlu72549_0952.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000076 Genomic DNA. Translation: AAY90216.2 .
    RefSeqi YP_258060.2. NC_004129.6.

    3D structure databases

    ProteinModelPortali Q4KI73.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 220664.PFL_0929.

    2D gel databases

    World-2DPAGE 0008:Q4KI73.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY90216 ; AAY90216 ; PFL_0929 .
    GeneIDi 3475457.
    KEGGi pfl:PFL_0929.
    PATRICi 19871047. VBIPseFlu72549_0952.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .
    BioCyci PFLU220664:GIX8-932-MONOMER.

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Pf-5 / ATCC BAA-477.

    Entry informationi

    Entry nameiHISX_PSEF5
    AccessioniPrimary (citable) accession number: Q4KI73
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: January 10, 2006
    Last modified: October 1, 2014
    This is version 68 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3