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Q4KI73 (HISX_PSEF5) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histidinol dehydrogenase

Short name=HDH
EC=1.1.1.23
Gene names
Name:hisD
Ordered Locus Names:PFL_0929
OrganismPseudomonas fluorescens (strain Pf-5 / ATCC BAA-477) [Complete proteome] [HAMAP]
Taxonomic identifier220664 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length442 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity. HAMAP-Rule MF_01024

Catalytic activity

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH. HAMAP-Rule MF_01024

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_01024

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. HAMAP-Rule MF_01024

Sequence similarities

Belongs to the histidinol dehydrogenase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Histidine biosynthesis
   LigandMetal-binding
NAD
Zinc
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processhistidine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: InterPro

histidinol dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 442442Histidinol dehydrogenase HAMAP-Rule MF_01024
PRO_0000135820

Sites

Active site3331Proton acceptor By similarity
Active site3341Proton acceptor By similarity
Metal binding2651Zinc By similarity
Metal binding2681Zinc By similarity
Metal binding3671Zinc By similarity
Metal binding4261Zinc By similarity
Binding site1361NAD By similarity
Binding site1971NAD By similarity
Binding site2201NAD By similarity
Binding site2431Substrate By similarity
Binding site2651Substrate By similarity
Binding site2681Substrate By similarity
Binding site3341Substrate By similarity
Binding site3671Substrate By similarity
Binding site4211Substrate By similarity
Binding site4261Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4KI73 [UniParc].

Last modified January 10, 2006. Version 2.
Checksum: 3A870C6065ADEEEE

FASTA44247,611
        10         20         30         40         50         60 
MTAPTAIRRL NAADPDFARH LDHLLSWESV SDDSVNQRVL DIIKAVRERG DAALVEFTQR 

        70         80         90        100        110        120 
FDGLQVASMA DLILPRERLE LALTRITVAQ REALEKAAAR VRSYHEKQKQ DSWTYTEADG 

       130        140        150        160        170        180 
TVLGQKVTPL DRAGLYVPGG KASYPSSVLM NAIPAKVAGV TEVVMVVPTP RGEVNELVLA 

       190        200        210        220        230        240 
AACIAGVDRV FTIGGAQAVA ALAYGTESVP QVDKVVGPGN IYVATAKRHV FGQVGIDMIA 

       250        260        270        280        290        300 
GPSEILVVCD GQTDPDWIAM DLFSQAEHDE DAQAILVSPD AEFLDKVAAS IAKLLPTMER 

       310        320        330        340        350        360 
AEIINTSING RGALIKVRDM QQAIEVANRI APEHLELSVA DPQAWLPQIR HAGAIFMGRH 

       370        380        390        400        410        420 
TSEALGDYCA GPNHVLPTSG TARFSSPLGV YDFQKRSSII FCSEQGASEL GRTASVLARG 

       430        440 
ESLTAHARSA EYRIVDDQDQ GQ 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000076 Genomic DNA. Translation: AAY90216.2.
RefSeqYP_258060.2. NC_004129.6.

3D structure databases

ProteinModelPortalQ4KI73.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING220664.PFL_0929.

2D gel databases

World-2DPAGE0008:Q4KI73.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAY90216; AAY90216; PFL_0929.
GeneID3475457.
KEGGpfl:PFL_0929.
PATRIC19871047. VBIPseFlu72549_0952.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0141.
HOGENOMHOG000243914.
KOK00013.

Enzyme and pathway databases

BioCycPFLU220664:GIX8-932-MONOMER.
UniPathwayUPA00031; UER00014.

Family and domain databases

HAMAPMF_01024. HisD.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000099. Histidinol_dh. 1 hit.
PRINTSPR00083. HOLDHDRGNASE.
SUPFAMSSF53720. SSF53720. 1 hit.
TIGRFAMsTIGR00069. hisD. 1 hit.
PROSITEPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHISX_PSEF5
AccessionPrimary (citable) accession number: Q4KI73
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: January 10, 2006
Last modified: May 14, 2014
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways