Q4KI53 (Q4KI53_PSEF5) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
GTP cyclohydrolase 1 1 HAMAP MF_00223
EC=3.5.4.16 HAMAP MF_00223

Alternative name(s):
GTP cyclohydrolase I 1 HAMAP MF_00223

Gene names

Name:	folE1 HAMAP MF_00223
Ordered Locus Names:	PFL_0949

Organism

Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477) [Complete proteome] [HAMAP]

Taxonomic identifier

220664 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	186 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP MF_00223 SAAS SAAS001474
Pathway	Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP MF_00223 SAAS SAAS001474
Subunit structure	Homopolymer By similarity. HAMAP MF_00223
Sequence similarities	Belongs to the GTP cyclohydrolase I family. HAMAP MF_00223

Ontologies

Keywords
Biological process	One-carbon metabolism HAMAP MF_00223
Ligand	GTP-binding HAMAP MF_00223 Metal-binding HAMAP MF_00223 SAAS SAAS001474 Nucleotide-binding Zinc HAMAP MF_00223 SAAS SAAS001474
Molecular function	Hydrolase HAMAP MF_00223 SAAS SAAS001474 EMBL AAY90236.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP tetrahydrofolate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTP cyclohydrolase I activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Metal binding	75	1	Zinc By similarity HAMAP MF_00223
	Metal binding	78	1	Zinc By similarity HAMAP MF_00223
	Metal binding	146	1	Zinc By similarity HAMAP MF_00223

Sequences

	Sequence		Length	Mass (Da)
	Q4KI53 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: 8F81B0B903F3BE58	FASTA	186	20,719
	10 20 30 40 50 60 MTLSLPQHYR EILKDLGEDP EREGLLDTPK RAAKAMQYLC HGYGQSLEDI VNGALFASDS 70 80 90 100 110 120 DEMVIVADIE LYSLCEHHLL PFIGKAHVAY IPTGKVLGLS KIARIVDMFA RRLQIQENLT 130 140 150 160 170 180 REIADAVQSV TQAAGVAVVI EAKHMCMMMR GVEKQNSTMH TSVMLGAFRD SSTTRQEFLQ LIGRSK

References

[1]

"Complete genome sequence of the plant commensal Pseudomonas fluorescens Pf-5." Paulsen I.T., Press C.M., Ravel J., Kobayashi D.Y., Myers G.S.A., Mavrodi D.V., DeBoy R.T., Seshadri R., Ren Q., Madupu R., Dodson R.J., Durkin A.S., Brinkac L.M., Daugherty S.C., Sullivan S.A., Rosovitz M.J., Gwinn M.L., Zhou L. , Schneider D.J., Cartinhour S.W., Nelson W.C., Weidman J., Watkins K., Tran K., Khouri H., Pierson E.A., Pierson L.S. III, Thomashow L.S., Loper J.E. Nat. Biotechnol. 23:873-878(2005) [PubMed: 15980861] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Pf-5 / ATCC BAA-477.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000076 Genomic DNA. Translation: AAY90236.1.
RefSeq	YP_258080.1. NC_004129.6.
3D structure databases
ProteinModelPortal	Q4KI53.
SMR	Q4KI53. Positions 11-179.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4KI53.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3475807.
GenomeReviews	Gene locus PFL_0949 in contig CP000076_GR.
KEGG	pfl:PFL_0949.
NMPDR	fig|220664.3.peg.2393.
PATRIC	19871089. VBIPseFlu72549_0973.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0302.
HOGENOM	HBG370191.
OMA	GAFRESS.
PhylomeDB	Q4KI53.
ProtClustDB	PRK12606.
Enzyme and pathway databases
BioCyc	PFLU220664:PFL_0949-MONOMER.
Family and domain databases
HAMAP	MF_00223. FolE. [Tree]
InterPro	IPR001474. GTP_CycHdrlase_I. IPR020602. GTP_CycHdrlase_I/CN_OxRdtase. IPR018234. GTP_CycHdrlase_I_CS. [Graphical view]
KO	K01495.
PANTHER	PTHR11109. GTP_cyclohydro_I. 1 hit.
Pfam	PF01227. GTP_cyclohydroI. 1 hit. [Graphical view]
TIGRFAMs	TIGR00063. FolE. 1 hit.
PROSITE	PS00860. GTP_CYCLOHYDROL_1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q4KI53_PSEF5

Accession

Primary (citable) accession number: Q4KI53

Entry history

Integrated into UniProtKB/TrEMBL:	August 2, 2005
Last sequence update:	August 2, 2005
Last modified:	January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)