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Q4KHG4

- LPXA_PSEF5

UniProt

Q4KHG4 - LPXA_PSEF5

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Protein

Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene

lpxA

Organism
Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

(R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-N-acetyl-alpha-D-glucosamine = [acyl-carrier-protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetyl-alpha-D-glucosamine.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciPFLU220664:GIX8-1193-MONOMER.
UniPathwayiUPA00359; UER00477.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferaseUniRule annotation (EC:2.3.1.129UniRule annotation)
Short name:
UDP-N-acetylglucosamine acyltransferaseUniRule annotation
Gene namesi
Name:lpxAUniRule annotation
Ordered Locus Names:PFL_1188
OrganismiPseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
Taxonomic identifieri220664 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000008540: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 258258Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferasePRO_0000302587Add
BLAST

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi220664.PFL_1188.

Structurei

3D structure databases

ProteinModelPortaliQ4KHG4.
SMRiQ4KHG4. Positions 2-258.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the transferase hexapeptide repeat family. LpxA subfamily.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG1043.
HOGENOMiHOG000294326.
KOiK00677.
OMAiDCQDKKY.
OrthoDBiEOG6F81P1.

Family and domain databases

Gene3Di1.20.1180.10. 1 hit.
HAMAPiMF_00387. LpxA.
InterProiIPR029098. Acetyltransf_C.
IPR001451. Hexapep_transf.
IPR018357. Hexapep_transf_CS.
IPR010137. Lipid_A_LpxA.
IPR011004. Trimer_LpxA-like.
[Graphical view]
PfamiPF13720. Acetyltransf_11. 1 hit.
PF00132. Hexapep. 2 hits.
[Graphical view]
PIRSFiPIRSF000456. UDP-GlcNAc_acltr. 1 hit.
SUPFAMiSSF51161. SSF51161. 1 hit.
TIGRFAMsiTIGR01852. lipid_A_lpxA. 1 hit.
PROSITEiPS00101. HEXAPEP_TRANSFERASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4KHG4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLIDPRAII DPTAVLADDV EVGPWSIVGA GVEIGEGTVI GPHVILKGPT
60 70 80 90 100
RIGKHNRIYQ FSSVGEDTPD LKYKGEETRL VIGDHNVIRE GVTIHRGTVQ
110 120 130 140 150
DRSETTLGDH NLVMAYAHIG HDSVIGNHCI LVNNTALAGH VHVDDWAILS
160 170 180 190 200
GFTLVHQYCH IGAHSFSGMG TAIGKDVPAF VTVFGNPAEA RSMNFEGMRR
210 220 230 240 250
RGFSEDAIHA LRRAYKTVYR QGLTVDQALA ELAEPAAQFP EVAVFRDSIQ

SSTRGITR
Length:258
Mass (Da):27,996
Last modified:August 2, 2005 - v1
Checksum:i484F0742E753F75D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000076 Genomic DNA. Translation: AAY90475.1.
RefSeqiYP_258319.1. NC_004129.6.

Genome annotation databases

EnsemblBacteriaiAAY90475; AAY90475; PFL_1188.
GeneIDi3477210.
KEGGipfl:PFL_1188.
PATRICi19871583. VBIPseFlu72549_1220.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000076 Genomic DNA. Translation: AAY90475.1 .
RefSeqi YP_258319.1. NC_004129.6.

3D structure databases

ProteinModelPortali Q4KHG4.
SMRi Q4KHG4. Positions 2-258.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 220664.PFL_1188.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY90475 ; AAY90475 ; PFL_1188 .
GeneIDi 3477210.
KEGGi pfl:PFL_1188.
PATRICi 19871583. VBIPseFlu72549_1220.

Phylogenomic databases

eggNOGi COG1043.
HOGENOMi HOG000294326.
KOi K00677.
OMAi DCQDKKY.
OrthoDBi EOG6F81P1.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00477 .
BioCyci PFLU220664:GIX8-1193-MONOMER.

Family and domain databases

Gene3Di 1.20.1180.10. 1 hit.
HAMAPi MF_00387. LpxA.
InterProi IPR029098. Acetyltransf_C.
IPR001451. Hexapep_transf.
IPR018357. Hexapep_transf_CS.
IPR010137. Lipid_A_LpxA.
IPR011004. Trimer_LpxA-like.
[Graphical view ]
Pfami PF13720. Acetyltransf_11. 1 hit.
PF00132. Hexapep. 2 hits.
[Graphical view ]
PIRSFi PIRSF000456. UDP-GlcNAc_acltr. 1 hit.
SUPFAMi SSF51161. SSF51161. 1 hit.
TIGRFAMsi TIGR01852. lipid_A_lpxA. 1 hit.
PROSITEi PS00101. HEXAPEP_TRANSFERASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pf-5 / ATCC BAA-477.

Entry informationi

Entry nameiLPXA_PSEF5
AccessioniPrimary (citable) accession number: Q4KHG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: August 2, 2005
Last modified: October 29, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3