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Q4KHG3 (LPXB_PSEF5) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lipid-A-disaccharide synthase

EC=2.4.1.182
Gene names
Name:lpxB
Ordered Locus Names:PFL_1189
OrganismPseudomonas fluorescens (strain Pf-5 / ATCC BAA-477) [Complete proteome] [HAMAP]
Taxonomic identifier220664 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length374 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00392

Catalytic activity

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP-Rule MF_00392

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP-Rule MF_00392

Sequence similarities

Belongs to the LpxB family.

Ontologies

Keywords
   Biological processLipid A biosynthesis
Lipid biosynthesis
Lipid metabolism
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processlipid A biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionlipid-A-disaccharide synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 374374Lipid-A-disaccharide synthase HAMAP-Rule MF_00392
PRO_0000255207

Sequences

Sequence LengthMass (Da)Tools
Q4KHG3 [UniParc].

Last modified August 2, 2005. Version 1.
Checksum: D7AF220CC85D5B13

FASTA37440,998
        10         20         30         40         50         60 
MSTLRIALVA GEASGDILGA GLMRALKVQH PAVEFIGVGG PLMEAEGLVS YFPMERLAVM 

        70         80         90        100        110        120 
GLVEVLGRLR ELLARRKKLI QTLIAEKPDV FIGIDAPDFT LNIELKLRQA RIKTVHYVSP 

       130        140        150        160        170        180 
SVWAWRQKRV LKIREGCDLM LTLFPFEARF YEEKGVPVKF VGHSLADAIP LEADRAAARA 

       190        200        210        220        230        240 
ELGLPEGPLV ALMPGSRGGE VGRLGALFLD AAQRLRAMRP GVRFIMPCAS PERRVQLEQL 

       250        260        270        280        290        300 
LANRDLPLTL LDGQSHKALA ACDAVLIASG TATLEALLYK RPMVVAYRLA PLTFWILKRM 

       310        320        330        340        350        360 
VKSPYISLPN LLAQRLLVPE LLQDDATADA LAQTLSPLIE GGEEQTRGFD EIHRTLRRDA 

       370 
SNQAAQAVLG LIGK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000076 Genomic DNA. Translation: AAY90476.1.
RefSeqYP_258320.1. NC_004129.6.

3D structure databases

ProteinModelPortalQ4KHG3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING220664.PFL_1189.

Protein family/group databases

CAZyGT19. Glycosyltransferase Family 19.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAY90476; AAY90476; PFL_1189.
GeneID3477211.
KEGGpfl:PFL_1189.
PATRIC19871585. VBIPseFlu72549_1221.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0763.
HOGENOMHOG000018003.
KOK00748.
OMAEWTINPP.
OrthoDBEOG6FBWZR.

Enzyme and pathway databases

BioCycPFLU220664:GIX8-1194-MONOMER.
UniPathwayUPA00359; UER00481.

Family and domain databases

HAMAPMF_00392. LpxB.
InterProIPR003835. Glyco_trans_19.
[Graphical view]
PfamPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00215. lpxB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLPXB_PSEF5
AccessionPrimary (citable) accession number: Q4KHG3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: August 2, 2005
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways