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Q4KHG3

- LPXB_PSEF5

UniProt

Q4KHG3 - LPXB_PSEF5

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (02 Aug 2005)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciPFLU220664:GIX8-1194-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:PFL_1189
    OrganismiPseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
    Taxonomic identifieri220664 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000008540: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 374374Lipid-A-disaccharide synthasePRO_0000255207Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi220664.PFL_1189.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4KHG3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018003.
    KOiK00748.
    OMAiEWTINPP.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q4KHG3-1 [UniParc]FASTAAdd to Basket

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    MSTLRIALVA GEASGDILGA GLMRALKVQH PAVEFIGVGG PLMEAEGLVS    50
    YFPMERLAVM GLVEVLGRLR ELLARRKKLI QTLIAEKPDV FIGIDAPDFT 100
    LNIELKLRQA RIKTVHYVSP SVWAWRQKRV LKIREGCDLM LTLFPFEARF 150
    YEEKGVPVKF VGHSLADAIP LEADRAAARA ELGLPEGPLV ALMPGSRGGE 200
    VGRLGALFLD AAQRLRAMRP GVRFIMPCAS PERRVQLEQL LANRDLPLTL 250
    LDGQSHKALA ACDAVLIASG TATLEALLYK RPMVVAYRLA PLTFWILKRM 300
    VKSPYISLPN LLAQRLLVPE LLQDDATADA LAQTLSPLIE GGEEQTRGFD 350
    EIHRTLRRDA SNQAAQAVLG LIGK 374
    Length:374
    Mass (Da):40,998
    Last modified:August 2, 2005 - v1
    Checksum:iD7AF220CC85D5B13
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000076 Genomic DNA. Translation: AAY90476.1.
    RefSeqiYP_258320.1. NC_004129.6.

    Genome annotation databases

    EnsemblBacteriaiAAY90476; AAY90476; PFL_1189.
    GeneIDi3477211.
    KEGGipfl:PFL_1189.
    PATRICi19871585. VBIPseFlu72549_1221.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000076 Genomic DNA. Translation: AAY90476.1 .
    RefSeqi YP_258320.1. NC_004129.6.

    3D structure databases

    ProteinModelPortali Q4KHG3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 220664.PFL_1189.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY90476 ; AAY90476 ; PFL_1189 .
    GeneIDi 3477211.
    KEGGi pfl:PFL_1189.
    PATRICi 19871585. VBIPseFlu72549_1221.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018003.
    KOi K00748.
    OMAi EWTINPP.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci PFLU220664:GIX8-1194-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Pf-5 / ATCC BAA-477.

    Entry informationi

    Entry nameiLPXB_PSEF5
    AccessioniPrimary (citable) accession number: Q4KHG3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: August 2, 2005
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3