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Q4KHG3

- LPXB_PSEF5

UniProt

Q4KHG3 - LPXB_PSEF5

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Protein

Lipid-A-disaccharide synthase

Gene
lpxB, PFL_1189
Organism
Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciPFLU220664:GIX8-1194-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:PFL_1189
OrganismiPseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
Taxonomic identifieri220664 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000008540: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 374374Lipid-A-disaccharide synthaseUniRule annotationPRO_0000255207Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi220664.PFL_1189.

Structurei

3D structure databases

ProteinModelPortaliQ4KHG3.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiEWTINPP.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4KHG3-1 [UniParc]FASTAAdd to Basket

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MSTLRIALVA GEASGDILGA GLMRALKVQH PAVEFIGVGG PLMEAEGLVS    50
YFPMERLAVM GLVEVLGRLR ELLARRKKLI QTLIAEKPDV FIGIDAPDFT 100
LNIELKLRQA RIKTVHYVSP SVWAWRQKRV LKIREGCDLM LTLFPFEARF 150
YEEKGVPVKF VGHSLADAIP LEADRAAARA ELGLPEGPLV ALMPGSRGGE 200
VGRLGALFLD AAQRLRAMRP GVRFIMPCAS PERRVQLEQL LANRDLPLTL 250
LDGQSHKALA ACDAVLIASG TATLEALLYK RPMVVAYRLA PLTFWILKRM 300
VKSPYISLPN LLAQRLLVPE LLQDDATADA LAQTLSPLIE GGEEQTRGFD 350
EIHRTLRRDA SNQAAQAVLG LIGK 374
Length:374
Mass (Da):40,998
Last modified:August 2, 2005 - v1
Checksum:iD7AF220CC85D5B13
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000076 Genomic DNA. Translation: AAY90476.1.
RefSeqiYP_258320.1. NC_004129.6.

Genome annotation databases

EnsemblBacteriaiAAY90476; AAY90476; PFL_1189.
GeneIDi3477211.
KEGGipfl:PFL_1189.
PATRICi19871585. VBIPseFlu72549_1221.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000076 Genomic DNA. Translation: AAY90476.1 .
RefSeqi YP_258320.1. NC_004129.6.

3D structure databases

ProteinModelPortali Q4KHG3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 220664.PFL_1189.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY90476 ; AAY90476 ; PFL_1189 .
GeneIDi 3477211.
KEGGi pfl:PFL_1189.
PATRICi 19871585. VBIPseFlu72549_1221.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi EWTINPP.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci PFLU220664:GIX8-1194-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pf-5 / ATCC BAA-477.

Entry informationi

Entry nameiLPXB_PSEF5
AccessioniPrimary (citable) accession number: Q4KHG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: August 2, 2005
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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