Reviewed, UniProtKB/Swiss-Prot Q4KDI5 (IOLG_PSEF5)

Names and origin

Protein names

Recommended name:
    Inositol 2-dehydrogenase
    EC=1.1.1.18
Alternative name(s):
    Myo-inositol 2-dehydrogenase
      Short name=MI 2-dehydrogenase

Gene names

Name:	iolG
Ordered Locus Names:	PFL_2591

Organism

Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477) [Complete proteome] [HAMAP]

Taxonomic identifier

220664 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	336 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose) By similarity. HAMAP MF_01671
Catalytic activity	Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP MF_01671
Subunit structure	Homotetramer By similarity. HAMAP MF_01671
Sequence similarities	Belongs to the gfo/idh/mocA family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	inositol catabolic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro inositol 2-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 336	336	Inositol 2-dehydrogenase HAMAP MF_01671		PRO_0000352580

Sequences

	Sequence		Length	Mass (Da)
	Q4KDI5-1 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: 417E76D912A153FF	FASTA	336	36,253
	10 20 30 40 50 60 MSLQLGVIGT GAIGQDHIRR CSQTLQGCRV VAVTDIDPQQ AARVLAGLTL EAEVYPDGHA 70 80 90 100 110 120 LIQAPEVQAL LVTSWGPSHE EFVLAAIAAG KPVFCEKPLA VTAAGCRRIV EAEIAQGRRL 130 140 150 160 170 180 VQVGFMRPYD AGYQALKAVV DSGRIGEPLM LHCAHRNPRV GENYKTDMAI TDTLIHELDV 190 200 210 220 230 240 LRWLLADDYV SVQVLFPRKT GKAHAQLRDP QIVLLETARG TRIDVEIFVN CQYGYDIQCE 250 260 270 280 290 300 VVGESGIARL PEPPQVQLRS AASLSSAILM DWKERFIAAY DVELQAFVDG VRAGRVGGPS 310 320 330 AWDGLAAAVA ADACIEAQQS GAIVPISLPQ RPALYA

References

[1]

"Complete genome sequence of the plant commensal Pseudomonas fluorescens Pf-5." Paulsen I.T., Press C.M., Ravel J., Kobayashi D.Y., Myers G.S.A., Mavrodi D.V., DeBoy R.T., Seshadri R., Ren Q., Madupu R., Dodson R.J., Durkin A.S., Brinkac L.M., Daugherty S.C., Sullivan S.A., Rosovitz M.J., Gwinn M.L., Zhou L. , Schneider D.J., Cartinhour S.W., Nelson W.C., Weidman J., Watkins K., Tran K., Khouri H., Pierson E.A., Pierson L.S. III, Thomashow L.S., Loper J.E. Nat. Biotechnol. 23:873-878(2005) [PubMed: 15980861] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000076 Genomic DNA. Translation: AAY91864.1.
RefSeq	YP_259698.1.
3D structure databases
SMR	Q4KDI5. Positions 2-328.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4KDI5.
Genome annotation databases
GeneID	3476480.
GenomeReviews	Gene locus PFL_2591 in contig CP000076_GR.
KEGG	pfl:PFL_2591.
NMPDR	fig|220664.3.peg.3943.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0673.
HOGENOM	HBG612336.
OMA	DWKDRFI.
Enzyme and pathway databases
BioCyc	PFLU220664:PFL_2591-MONOMER.
Family and domain databases
HAMAP	MF_01671. IolG. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. IPR004104. OxRdtase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. PF02894. GFO_IDH_MocA_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOLG_PSEF5

Accession

Primary (citable) accession number: Q4KDI5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 14, 2008
Last sequence update:	August 2, 2005
Last modified:	January 19, 2010
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)